CN111840407A - Material for promoting wound healing and preparation method thereof - Google Patents

Abstract

The invention discloses a material for promoting wound healing and a preparation method thereof, and relates to the technical field of biological pharmacy. The invention comprises 2-4 parts of radix rehmanniae recen, 2-4 parts of angelica, 1-3 parts of coptis chinensis, 1-3 parts of phellodendron, 1-3 parts of scutellaria baicalensis, 2-4 parts of lumbricus, 5 parts of glycerol, 10-20 parts of fruit vegetable oil, 40 parts of 50% ethanol solution and 40 parts of normal saline. By using the medicinal materials such as the angelica, the earthworm and the like, the Chinese medicinal composition has the effects of promoting blood circulation to remove blood stasis and promoting granulation and astringing, is suitable for the conditions of skin injuries such as scalds and incised wounds, and can greatly promote wound healing; the invention also has the effects of clearing away heat and toxic materials by using the medicinal materials such as the coptis chinensis, the scutellaria baicalensis and the like; by using the fruit vegetable oil and the ethanol solution, the medicine has fruit fragrance, so that a user feels more comfortable and relaxed; in addition, the invention separates the finished solution and the solid medicine, and the finished solution and the solid medicine are stored separately and used separately, thereby improving the utilization rate and avoiding waste.

Description

A kind of material for promoting wound healing and preparation method thereof

technical field

The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a material for promoting wound healing and a preparation method thereof.

Background technique

Wound healing refers to the recovery process after the body is subjected to external force and the skin and other tissues are severed or damaged. The basic process of wound healing: acute inflammation stage → cell proliferation stage → scarring stage → epidermis and other tissue regeneration. According to the degree of injury and the presence or absence of infection, wound healing can be divided into three types: primary healing, secondary healing, and tertiary healing. There are 3 types of wound healing depending on the nature and management of the damaged tissue. Primary healing: It is seen in wounds with few tissue defects, neat wound margins, no infection, and tightly coherent wounds after adhesive or suture, such as surgical incisions. In this type of wound, there is only a small amount of blood clot, the inflammatory reaction is mild, and the re-epithelialization can cover the wound within 24 to 48 hours. Granulation tissue can grow from the edge of the wound on the third day and quickly fill the wound, collagen fibers are formed in 5 to 6 days (the sutures can be removed at this time), and it heals completely in about 2 to 3 weeks, leaving a linear scar . Primary healing time is short and scarring is less.

However, the effect of current wound healing drugs is not good, and the drugs have a pungent odor, and the utilization rate of the drugs is not high. The present invention aims at the above problems to provide a material for promoting wound healing and a preparation method thereof.

SUMMARY OF THE INVENTION

The object of the present invention is to provide a material for promoting wound healing and a preparation method thereof, so as to solve the problems that the effect of the current wound healing medicine is not good, the medicine has a pungent smell, and the utilization rate of the medicine is not high.

In order to solve the above-mentioned technical problems, the present invention is achieved through the following technical solutions:

The present invention is a material for promoting wound healing, which comprises, in parts by weight, 2-4 parts of rehmannia glutinosa, 2-4 parts of angelica, 1-3 parts of rhizoma rhizoma, 1-3 parts of cortex phellodendri, 1-3 parts of scutellaria baicalensis, and earthworm 2-4 parts, 5 parts of glycerin, 10-20 parts of fruit vegetable oil, 40 parts of 50% ethanol solution, 40 parts of normal saline.

Preferably, in parts by weight, it includes 4 parts of Rehmannia glutinosa, 2 parts of Angelica sinensis, 1 part of Rhizoma Coptidis, 1 part of Treat, 1 part of Scutellaria baicalensis, 2 parts of Dilong, 5 parts of glycerin, 10 parts of fruit vegetable oil, 40 parts of 40% ethanol solution parts, 40 parts of normal saline.

Preferably, in parts by weight, it includes 2 parts of Rehmannia glutinosa, 2 parts of Angelica sinensis, 1 part of Coptis chinensis, 1 part of Cortex Phellodendri, 1 part of Scutellaria baicalensis, 4 parts of Dilong, 5 parts of glycerin, 10 parts of fruit vegetable oil, 40 parts of 40% ethanol solution parts, 40 parts of normal saline.

Preferably, the fruit vegetable oil includes sesame oil, apple oil, citrus oil, coconut oil, etc. The use of vegetable oil can make the smell softer and not irritating.

A preparation method of a material for promoting wound healing, comprising the following steps:

Step 1: Put Rehmannia glutinosa, Angelica sinensis and Dilong in a container, stir and smash until completely mixed, then pour in physiological saline to cover the raw materials, stir for 5-10 minutes, then slowly add glycerin, stir again for 5 minutes, and then mix the mixed The solution is placed in an environment of about 15 degrees Celsius for 2 hours;

Step 2: Coptis chinensis, Cortex Phellodendri and Scutellaria baicalensis are poured into the vessel in the same proportion, then add physiological saline to pass the raw material, then stir and smash, and set aside for later use;

Step 3: Pour the 50% ethanol solution into another vessel, then add fruit vegetable oil while stirring, continue stirring for 1 hour, then place at room temperature for 2 hours and use molecular membranes to remove insoluble impurities in the solution;

Step 5: Heat the three mixtures in the above steps to about 40 degrees Celsius, then slowly pour the mixture in step 2 into the solution in step 1, stir for 30 minutes, then heat the completely mixed solution to about 60 degrees Celsius, then cool down to room temperature, then add the mixture in step 3, place it at 15-25 degrees Celsius for 3 hours, then use a molecular filtration membrane to filter the insoluble solids in the solution, and then store the filtered fixed raw materials separately from the solution;

Step 6: The separated solution is emulsified and stored, and then the separated solid raw materials are pulverized and stored.

The present invention has the following beneficial effects:

By using Chinese angelica, Dilong and other medicinal materials, the present invention has the effects of promoting blood circulation and removing blood stasis, promoting muscle and astringent, and is suitable for skin injuries such as scalds and cuts, and can greatly promote wound healing; , has the effect of clearing heat and detoxifying; the present invention uses fruit vegetable oil and ethanol solution, so that the medicine has the fragrance of fruit without irritation; and the present invention separates the solution and solid medicine of the finished product, stores it separately, and uses it separately, which improves the utilization rate. rate and avoid waste.

Of course, it is not necessary for any product embodying the present invention to simultaneously achieve all of the advantages described above.

Detailed ways

The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Example 1:

The present invention is a material for promoting wound healing, which comprises, in parts by weight, 2-4 parts of rehmannia glutinosa, 2-4 parts of angelica, 1-3 parts of rhizoma rhizoma, 1-3 parts of cortex phellodendri, 1-3 parts of scutellaria baicalensis, and earthworm 2-4 parts, 5 parts of glycerin, 10-20 parts of fruit vegetable oil, 40 parts of 50% ethanol solution, 40 parts of normal saline.

Wherein, in parts by weight, including 4 parts of Rehmannia glutinosa, 2 parts of Angelica sinensis, 1 part of Coptis chinensis, 1 part of Treat, 1 part of Scutellaria baicalensis, 2 parts of Dilong, 5 parts of glycerin, 10 parts of fruit vegetable oil, 40 parts of 40% ethanol solution , 40 parts of normal saline.

Wherein, in parts by weight, it includes 2 parts of Rehmannia glutinosa, 2 parts of Angelica sinensis, 1 part of Coptis chinensis, 1 part of Treats, 1 part of Scutellaria baicalensis, 4 parts of Dilong, 5 parts of glycerin, 10 parts of fruit vegetable oil, 40 parts of 40% ethanol solution , 40 parts of normal saline.

Wherein, the fruit vegetable oil includes sesame oil, apple oil, citrus oil and coconut oil, etc. The use of vegetable oil can make the smell softer and less irritating.

A preparation method of a material for promoting wound healing, comprising the following steps:

Step 1: Put Rehmannia glutinosa, Angelica sinensis and Dilong in a container, stir and smash until completely mixed, then pour in physiological saline to cover the raw materials, stir for 5-10 minutes, then slowly add glycerin, stir again for 5 minutes, and then mix the mixed The solution is placed in an environment of about 15 degrees Celsius for 2 hours;

Step 2: Coptis chinensis, Cortex Phellodendri and Scutellaria baicalensis are poured into the vessel in the same proportion, then add physiological saline to pass the raw material, then stir and smash, and set aside for later use;

Step 3: Pour the 50% ethanol solution into another vessel, then add fruit vegetable oil while stirring, continue stirring for 1 hour, then place at room temperature for 2 hours and use molecular membranes to remove insoluble impurities in the solution;

Step 5: Heat the three mixtures in the above steps to about 40 degrees Celsius, then slowly pour the mixture in step 2 into the solution in step 1, stir for 30 minutes, then heat the completely mixed solution to about 60 degrees Celsius, then cool down to room temperature, then add the mixture in step 3, place it at 15-25 degrees Celsius for 3 hours, then use a molecular filtration membrane to filter the insoluble solids in the solution, and then store the filtered fixed raw materials separately from the solution;

Step 6: The separated solution is emulsified and stored, and then the separated solid raw materials are pulverized and stored.

Embodiment 2:

The present invention is a material for promoting wound healing. By weight, it comprises 4 parts of Rehmannia glutinosa, 2 parts of Angelica sinensis, 2 parts of Rhizoma Coptidis, 2 parts of Cortex Phellodendri, 2 parts of Scutellaria baicalensis, 2 parts of Dilong, 5 parts of glycerin, and 10 parts of fruit vegetable oil. parts, 40 parts of 50% ethanol solution, and 40 parts of normal saline.

Embodiment three:

The present invention is a material for promoting wound healing. By weight, it comprises 4 parts of Rehmannia glutinosa, 2 parts of Angelica sinensis, 2 parts of Rhizoma Coptidis, 2 parts of Cortex Phellodendri, 2 parts of Scutellaria baicalensis, 2 parts of Dilong, 5 parts of glycerin, and 20 parts of fruit vegetable oil. parts, 40 parts of 50% ethanol solution, and 40 parts of normal saline.

Embodiment 4:

The present invention is a material for promoting wound healing, which comprises, by weight, 2 parts of Rehmannia glutinosa, 4 parts of Angelica sinensis, 1 part of Rhizoma Coptidis, 1 part of Cortex Phellodendri, 1 part of Scutellaria baicalensis, 2 parts of Dilong, 5 parts of glycerin, and 20 parts of fruit vegetable oil. parts, 40 parts of 50% ethanol solution, and 40 parts of normal saline.

Embodiment 5:

The present invention is a material for promoting wound healing, which comprises, by weight, 1 part of Rehmannia glutinosa, 1 part of Angelica sinensis, 1 part of Rhizoma Coptidis, 1 part of Cortex Phellodendri, 1 part of Scutellaria baicalensis, 1 part of Dilong, 5 parts of glycerin, and 20 parts of fruit vegetable oil. parts, 40 parts of 50% ethanol solution, and 40 parts of normal saline.

Embodiment 6:

The present invention is a material for promoting wound healing, which comprises, by weight, 6 parts of Rehmannia glutinosa, 6 parts of Angelica sinensis, 1 part of Rhizoma Coptidis, 1 part of Cortex Phellodendri, 1 part of Scutellaria baicalensis, 6 parts of Dilong, 5 parts of glycerin, and 20 parts of fruit vegetable oil. parts, 40 parts of 50% ethanol solution, and 40 parts of normal saline.

Embodiment 7:

It should be noted that in the present invention, Rehmannia glutinosa, Angelica sinensis and Dilong all have the effects of promoting blood circulation and removing blood stasis and promoting muscle astringency, so these three kinds of medicines are used as a variable in the comparative test, and Coptis chinensis, Scutellaria baicalensis and Cortex Phellodendri all have The effect of clearing heat and detoxification, so these three drugs are used as the second variable. Finally, the fruit-flavored vegetable oil combined with 50% ethanol solution is equivalent to the essence. As the third variable, this material is firstly prepared. After the preparation is completed, a comparative test is carried out on white mice. , to observe the preliminary effect, wherein 4 parts of Rehmannia glutinosa in Example 1, 2 parts of Angelica sinensis, 1 part of Coptis chinensis, 1 part of Treat, 1 part of Scutellaria baicalensis, 2 parts of Dilong, 5 parts of glycerin, 10 parts of fruit vegetable oil, 40 parts of 40 parts of ethanol solution, 40 parts of normal saline as control group 1, 2 parts of raw rehmannia, 2 parts of angelica, 1 part of coptis, 1 part of cortex phellodendri, 1 part of skullcap, 4 parts of earthworm, 5 parts of glycerin, 10 parts of fruit vegetable oil parts, 40 parts of 40% ethanol solution and 40 parts of physiological saline were used as control group II, and other examples were used as comparison groups, and their external environments were kept the same. The specific comparison conditions are shown in the following table:

According to the comparative situation, the scheme adopted in Example 2 and Example 3 is effective and has no irritation to the skin, and the user can choose to use it according to the sensitivity of its odor.

In the description of this specification, description with reference to the terms "one embodiment," "example," "specific example," etc. means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one aspect of the present invention. in one embodiment or example. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The above-disclosed preferred embodiments of the present invention are provided only to help illustrate the present invention. PREFERRED EMBODIMENTS All details are not exhaustive and the invention is not intended to be a mere embodiment of the invention. Obviously, many modifications and variations are possible in light of the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principle and practical application of the present invention, so that those skilled in the art can well understand and utilize the present invention. The present invention is to be limited only by the claims and their full scope and equivalents.

Claims (5)

1. A material for promoting wound healing, characterized by: the traditional Chinese medicine composition comprises, by weight, 2-4 parts of radix rehmanniae recen, 2-4 parts of angelica sinensis, 1-3 parts of coptis chinensis, 1-3 parts of phellodendron amurense, 1-3 parts of scutellaria baicalensis, 2-4 parts of lumbricus, 5 parts of glycerol, 10-20 parts of fruit vegetable oil, 40 parts of 50% ethanol solution and 40 parts of normal saline.

2. The material for promoting wound healing according to claim 1, comprising, by weight, 4 parts of radix rehmanniae recen, 2 parts of angelica sinensis, 1 part of coptis chinensis, 1 part of phellodendron amurense, 1 part of scutellaria baicalensis, 2 parts of lumbricus, 5 parts of glycerol, 10 parts of fruit vegetable oil, 40 parts of 40% ethanol solution and 40 parts of normal saline.

3. The material for promoting wound healing according to claim 1, comprising 2 parts by weight of radix rehmanniae recen, 2 parts by weight of angelica sinensis, 1 part by weight of coptis chinensis, 1 part by weight of phellodendron amurense, 1 part by weight of scutellaria baicalensis, 4 parts by weight of earthworm, 5 parts by weight of glycerol, 10 parts by weight of fruit vegetable oil, 40 parts by weight of 40% ethanol solution and 40 parts by weight of normal saline.

4. The wound healing promoting material of claim 1, wherein the vegetable oil comprises sesame oil, apple oil, citrus oil, coconut oil, and the like.

5. A method of preparing a material for promoting wound healing as claimed in any one of claims 1 to 4, comprising the steps of:

the method comprises the following steps: placing radix rehmanniae, radix Angelicae sinensis and Lumbricus in a vessel, stirring and mashing to mix completely, then pouring physiological saline water to submerge the raw materials, stirring for 5-10min, then slowly adding glycerol, stirring for 5min again, and then placing the mixed solution at 15 deg.C for 2 h;

step two: pouring the coptis chinensis, the golden cypress and the scutellaria baicalensis into a vessel according to the same proportion, then adding normal saline to submerge the raw materials, stirring and mashing the raw materials, and standing aside for later use;

step three: pouring 50% ethanol solution into another vessel, adding fruit vegetable oil while stirring, continuing stirring for 1h, standing at room temperature for 2h, and removing water-insoluble impurities in the solution by using molecular membrane;

step five: respectively heating the three mixtures in the step to about 40 ℃, slowly pouring the mixture in the step two into the solution in the step one, stirring for 30min, heating the completely mixed solution to about 60 ℃, cooling to normal temperature, adding the mixture in the step three, standing for 3h in an environment of 15-25 ℃, filtering the insoluble solid in the solution by using a molecular filtration membrane, and separately storing the filtered fixed raw material and the solution;

step six: emulsifying the separated solution, storing, pulverizing the separated solid raw material, and storing.