CN111840158A

CN111840158A - Compound plant prickly heat-removing and itching-relieving liquid

Info

Publication number: CN111840158A
Application number: CN202010735932.6A
Authority: CN
Inventors: 田贵丰; 李文锋
Original assignee: Guangzhou Baoyan Biotech Co ltd
Current assignee: Guangzhou Baoyan Biotech Co ltd
Priority date: 2020-07-28
Filing date: 2020-07-28
Publication date: 2020-10-30

Abstract

The invention relates to a compound plant miliaria-removing and itching-relieving liquid, which comprises the following components in percentage by mass: menthol: 0.02-0.3%; wild chrysanthemum flower extract: 1 to 7 percent; golden yellow chamomile extract: 1 to 5 percent; camellia seed extract: 0.5-4%; and (3) liquorice extract: 0.5-3%; sweet clover extract: 0.1-4%; honeysuckle flower extract: 0.1-4%; extract of rheum palmatum root: 0.1-3%; extract of kuh-seng root: 0.1-3%; humectant: 3 to 17 percent; auxiliary components: 0.5-1%; water: and (4) the balance. The compound plant miliaria-removing and itching-relieving liquid disclosed by the application is formed by combining a plurality of plant extracts and synergistically exerts the optimal effect. Compared with the common toilet water in the market, the product is free of alcohol and essence, free of irritation and more suitable for delicate skin of infants.

Description

Compound plant prickly heat-removing and itching-relieving liquid

Technical Field

The invention relates to the technical field of daily chemical products, in particular to a compound plant miliaria-removing and itching-relieving liquid.

Background

The temperature is higher in summer, the infant can move outside for a long time, and because the skin is contacted with sunlight for a long time and is wrapped in clothes, especially the body function of the infant is not completely developed and is in a period of vigorous metabolism, miliaria is easy to grow on the skin, and the problems of itching and the like are caused; and can also make the mood of people impatient.

Aiming at the situation, the toilet water commonly used on the market at present achieves the effects of preventing mosquitoes and removing miliaria, but the toilet water often contains a large amount of alcohol, and although the toilet water has cool experience feeling in the using process, the toilet water also has certain irritation to the skin, and certain potential safety hazards exist for infants.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the compound plant miliaria-removing and itching-relieving liquid, which is prepared by combining a plurality of plant extracts and synergistically exerting the optimal effect. Compared with the common toilet water in the market, the product is free of alcohol and essence, free of irritation and more suitable for delicate skin of infants.

The technical purpose of the invention is realized by the following technical scheme: the composite material comprises the following components in percentage by mass:

menthol: 0.02-0.3%;

wild chrysanthemum flower extract: 1 to 7 percent;

golden yellow chamomile extract: 1 to 5 percent;

camellia seed extract: 0.5-4%;

and (3) liquorice extract: 0.5-3%;

sweet clover extract: 0.1-4%;

honeysuckle flower extract: 0.1-4%;

extract of rheum palmatum root: 0.1-3%;

extract of kuh-seng root: 0.1-3%;

humectant: 3 to 17 percent;

auxiliary components: 0.5-1%;

water: and (4) the balance.

Further, the auxiliary ingredient comprises at least one of a preservative, a solubilizer, a thickener, an auxiliary skin conditioner.

Further, the humectant comprises the following components: glycerol: 1 to 5 percent; propylene glycol: 1 to 6 percent; and (3) butanediol: 1 to 6 percent.

As a preferred scheme of the invention, the compound plant miliaria-removing and itching-relieving liquid comprises the following components in percentage by mass:

menthol: 0.1 percent;

glycerol: 2 percent;

propylene glycol: 3 percent;

butanediol: 3 percent;

wild chrysanthemum flower extract: 6 percent;

golden yellow chamomile extract: 4 percent;

camellia seed extract: 3 percent;

and (3) liquorice extract: 2.5 percent;

sweet clover extract: 1.5 percent;

honeysuckle flower extract: 1.8 percent;

extract of rheum palmatum root: 0.4 percent;

extract of kuh-seng root: 0.8 percent;

auxiliary components: 0.5-1%;

water: and (4) the balance.

The standard Chinese name of the menthol crystal in the invention is as follows: menthol, which is mainly a terpenoid substance, has fresh smell, can calm the skin, brings cool and comfortable feeling, is commonly used as an aromatizing agent of toothpaste, perfume, beverage, candy and the like, can be used for the skin or mucous membrane, has the effects of cooling and relieving itching, and has the unique fragrance of cooling and relieving itching and the effect of dispelling mosquitoes.

Propylene glycol in the invention, standard chinese name: the propylene glycol not only has the moisture-preserving capability, but also can help the active ingredients to permeate, and simultaneously has the antiseptic capability, so that the shelf life of the product can be further prolonged.

Glycerol in the present invention, standard chinese name: glycerin, in addition to having moisturizing ability in the present invention, helps the skin to heal, reduces the occurrence of related dermatitis, and restores the normal barrier function of the skin.

The butanediol of the invention, standard Chinese name: as a moisturizing agent, it can retain water in the stratum corneum to form a film on the skin surface. Butanediol also has effect in destroying bacteria living environment, and can inhibit bacteria growth after long-term use.

The wild chrysanthemum extract of the invention has the standard Chinese name: flos Chrysanthemi Indici (Chrysanthemum INDICUM) flower extract has bitter, pungent and slightly cold properties, and belongs to lung and liver channels, contains CHRYSANTHEMUM lactone, bitter essence, volatile oil, vitamin A and vitamin B1, and has strong inhibitory effect on Staphylococcus aureus and Bacillus diphtheriae. Also has the effects of clearing away heat and toxic materials, removing miliaria, relieving itching, resisting inflammation, relieving pain, etc.

The golden yellow chamomile extract disclosed by the invention has the following standard Chinese name: flos Chrysanthemi (CHRYSANTHELLUMINDIUM) extract, also called Roman flos Matricariae Chamomillae, has slightly bitter and sweet taste, and has effects of improving eyesight, clearing liver fire, and treating insomnia. Contains more flavonoid active ingredients, mainly apigenin and luteolin, and has antioxidant, antibacterial and antiinflammatory effects. Can also relieve skin, calm and tranquilize, and is especially suitable for fragile and sensitive skin.

The camellia seed extract of the invention has standard Chinese name: extract of seed of Camellia JAPONICA (Camellia JAPONICA) belonging to genus Camellia, family Theaceae, for cooling blood and stopping bleeding; dissipating blood stasis; eliminating swelling and blood stasis. Is mainly extracted from flowers, leaves and seeds, contains various unsaturated fatty acids, has good skin compatibility, contains tea polyphenol, camellia glossy ganoderma, tea saponin and other components, and has extremely high vitamin E content.

The licorice extract of the invention, standard Chinese name: glycyrrhrizae radix (Glycyrrhiza URALENSIS) extract has effects of promoting proliferation of muscle cell and vascular endothelial cell, promoting collagen-4 type generation, inhibiting NO generation, and promoting skin growth of infants and children.

The standard Chinese name of the sweet clover extract in the invention is: melilotus OFFICINALIS (Melilotus OFFICINALIS) extract contains luteolin, and is a natural flavonoid substance for relieving cough, eliminating phlegm, relieving inflammation and relieving pain.

The standard Chinese name of the honeysuckle flower extract of the invention is: lonicera JAPONICA (Lonicera JAPONICA) flower extract, also called honeysuckle flower, is a plant of the genus Lonicera of the family Caprifoliaceae. Honeysuckle flower is white at first bloom and then turns yellow, so that the honeysuckle flower is named. Honeysuckle flower is a commonly used heat-clearing and toxicity-removing medicine, and has obvious effects on skin sore and ulcer pyogenic infections by oral administration and external use.

The standard Chinese name of the rhubarb root extract in the invention is: radix et rhizoma Rhei Palmatum (Rheum PALMATUM) root extract containing emodin and chrysophanol. Can promote skin blood circulation, improve skin permeability, promote absorption of effective components, inhibit bacteria, remove acne, and astringe skin.

The standard Chinese name of the extract of the kushen root in the invention is as follows: radix Sophorae Flavescentis (Sophora FLAVESCENS) root extract is a plant of Leguminosae, and has effects of clearing heat and eliminating dampness. Contains various alkaloids, and its main ingredients are kushenin and oxymatrine; in addition, it also contains matrine, matrinol, methyl indiine, and fetuinine. Has effects in resisting pathogenic microorganism, and can kill various anaerobic bacteria including Propionibacterium acnes. It also has anti-inflammatory and antiallergic effects, and can promote leukocyte increase and relieve itching. Can be used for treating eczema, skin pruritus, etc.

In conclusion, the invention has the following beneficial effects:

1. the compound plant miliaria-removing and itching-relieving liquid is prepared by perfectly matching menthol, glycerol, propylene glycol, butanediol, a wild chrysanthemum extract, a golden yellow chamomile extract, a camellia seed extract, a liquorice extract, a sweet clover extract, a honeysuckle extract, a rheum palmatum root extract and a sophora flavescens root extract. The wild chrysanthemum flower extract, the golden yellow chamomile extract, the rheum palmatum root extract, the honeysuckle flower extract and the sophora flavescens root extract are compounded, so that the compound preparation has a strong inhibiting effect on staphylococcus aureus, diphtheria bacillus, propionibacterium acnes and other strains, can relieve skin, calm and soothe nerves, and is particularly suitable for fragile and sensitive skin; meanwhile, the skin blood circulation can be promoted, the skin permeability can be improved, the absorption of the skin on effective components can be promoted, and the effective time of the product can be shortened; by compounding the menthol, the camellia seed extract, the humectant and the liquorice extract, the strain can be inhibited, rich nutrient substances can be provided for skin, the proliferation of muscle cells and vascular endothelial cells can be promoted, the collagen-4 type generation can be positively promoted, the generation of NO can be inhibited, and the skin growth of infants is facilitated.

2. The compound plant prickly heat removing and itching relieving liquid integrates three effects of removing prickly heat, relieving itching and preventing mosquitoes, can be used by infants and adults, and is free of greasiness and irritation. The product combines the ideas of 'holism, dialectical treatment and synthesis' of the traditional Chinese medicine, is compatible, perfectly integrates various plant extracts together, and exerts the optimal effect.

3. The propylene glycol provided by the invention not only has the moisturizing capability, but also can help active ingredients to permeate, and can accelerate the effective time of the product; the propylene glycol also has the antiseptic capability, and the shelf life of the product can be further prolonged.

4. The compound plant prickly heat removing and itching relieving liquid does not contain alcohol and essence, and the prepared product has no irritation, does not irritate the skin of a human body in the using process, and is more suitable for delicate skin of infants.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.

Example 1: a compound plant prickly heat-removing and itching-relieving liquid comprises the following components (by weight percent):

menthol: 0.05 percent;

glycerol: 2 percent;

propylene glycol: 3 percent;

butanediol: 3 percent;

wild chrysanthemum flower extract: 4 percent;

golden yellow chamomile extract: 2 percent;

camellia seed extract: 1.5 percent;

and (3) liquorice extract: 1 percent;

sweet clover extract: 0.8 percent;

honeysuckle flower extract: 0.5 percent;

extract of rheum palmatum root: 0.2 percent;

extract of kuh-seng root: 0.2 percent;

preservatives and solubilizers: 0.75 percent;

water: and (4) the balance.

The preparation method comprises the following steps:

the method comprises the following steps:

1. mixing menthol and a solubilizer, stirring and dissolving uniformly, then sequentially adding water, glycerol, propylene glycol, butanediol, a wild chrysanthemum extract, a golden yellow chamomile extract, a camellia seed extract, a liquorice extract, a sweet clover extract, a honeysuckle extract, a rheum palmatum root extract and a sophora flavescens root extract, and stirring uniformly to obtain a mixture;

2. adding the preservative into the mixture, and stirring for about 10 minutes until the mixture is uniform, thus obtaining the compound plant miliaria-removing and itching-relieving liquid of the embodiment 1, which is marked as a product 1.

The using method comprises the following steps: pouring the prepared compound plant miliaria-removing and itching-relieving liquid into a common nozzle bottle, aligning to a part to be used, extruding a proper amount of the liquid onto a body, and slightly smearing and massaging the liquid until the liquid is absorbed.

Example 2 to example 4:

the method of example 1 is repeated according to the contents of menthol, glycerin, propylene glycol, butylene glycol, wild chrysanthemum extract, golden chamomile extract, camellia seed extract, licorice extract, sweet clover extract, honeysuckle extract, rhubarb palmate root extract and bitter ginseng root extract specified in the following table 1 to obtain the compound plant miliaria-removing and itching-relieving liquid products of examples 2 to 4 respectively, and as the auxiliary components such as the preservative have almost no influence on the efficacy of the products, no example is given in the formula:

table 1:

clinical experiments are carried out on the compound plant miliaria-removing and itching-relieving liquid of the products 1 to 4.

The test items include:

irritation:

1) according to analysis of results of multiple skin irritation tests of different types of cosmetics recorded in 2016, 10, 30, 5, of toxicological journal, irritation tests are carried out on the compound plant miliaria-removing and itching-relieving liquid products of examples 1 to 4, and the test results comprise no irritation, light irritation and moderate irritation;

2) taking 0.5g of the compound plant miliaria-removing and itching-relieving liquid products in the embodiments 1 to 4 respectively, uniformly smearing the liquid products on the back of the ear of a volunteer, and observing whether redness, eruption and blistering occur after 30 minutes.

The test results are shown in tables 2 and 3:

table 2: product 1-product 4 and allergy test results

Test items	Product 1	Product 2	Product 3	Product 4
					Irritation property	Has no irritation	Has no irritation	Has no irritation	Has no irritation
Allergic phenomenon	Is free of	Is free of	Is free of	Is free of

The test results in table 2 show that the compound plant miliaria-removing and itching-relieving liquid of the products 1 to 4 does not stimulate the skin of a human body in the using process, and is more suitable for delicate skin of infants.

Bacteriostatic experiments:

1. experimental strains: staphylococcus aureus, corynebacterium diphtheriae, and propionibacterium acnes;

2. experimental samples: the compound plant prickly heat removing and itching relieving liquid of the products 1 to 4;

3. judging the bacteriostatic action: the diameter of the bacteriostatic circle is more than 7mm, namely the bacteriostatic action is achieved; if the diameter of the inhibition zone is less than or equal to 7mm, the inhibition is not effective.

Table 3: product 1-product 4 bacteriostatic action (mm)

Test items	Product 1	Product 2	Product 3	Product 4
					Staphylococcus aureus	11.2	13.5	19.5	20.6
Diphtheria bacillus	9.8	11.2	17.0	18.6
					Propionibacterium acnes	9.6	12.6	15.2	17.5

According to the test results in table 3, the compound plant miliaria-removing and itching-relieving liquid of the products 1 to 4 has significant bacteriostatic action on staphylococcus aureus, diphtheria bacillus and propionibacterium acnes, and the bacteriostatic action is significantly improved along with the increase of the content of the wild chrysanthemum extract, the chamomile extract, the camellia seed extract, the licorice extract, the sweet clover extract, the honeysuckle flower extract, the rheum palmatum root extract and the sophora flavescens root extract in the mixture ratio range of the application. When the content of each component in the formula is the wild chrysanthemum extract: 6 percent; golden yellow chamomile extract: 4 percent; camellia seed extract: 3 percent; and (3) liquorice extract: 2.5 percent; sweet clover extract: 1.5 percent; honeysuckle flower extract: 1.8 percent; extract of rheum palmatum root: 0.4 percent; extract of kuh-seng root: when the concentration is 0.8%, the bacteriostatic effect is most obvious.

Clinical experiments are as follows:

the experimental conditions are as follows: in summer, the temperature is between 28 and 35 ℃;

subject: because the miliaria phenomenon is frequently occurred in children, 80 volunteers with miliaria between 1-8 years old are randomly divided into 4 groups of 20 persons, and the compound plant miliaria-removing and itching-relieving liquid product corresponding to each group of volunteers;

the using method comprises the following steps: the preparation is administered 2-3 times daily for four weeks.

And (3) testing items: miliaria-removing, redness-removing and itching-relieving effects;

the results of the clinical trial tests are shown in table 4:

table 4:

test items	Product 1	Product 2	Product 3	Product 4
					Miliaria-removing effect	Good taste	Good taste	Superior food	Superior food
Fading effect of red	In general	In general	Good taste	Good taste
					Antipruritic effect	Good wine	Good wine	Good taste	Good taste

According to the test results in table 4, the compound plant miliaria-removing and itching-relieving liquid of the product 1 and the product 2 has no significant effect on miliaria-removing effect, red fading effect and itching-relieving effect when the content of the wild chrysanthemum flower extract, the golden yellow chamomile extract, the camellia seed extract, the liquorice extract, the sweet clover extract, the honeysuckle flower extract, the rheum palmatum root extract and the sophora flavescens root extract is low; with the higher percentage content of each functional component, the compound plant miliaria-removing and itching-relieving liquid of the product 3 and the product 4 has obvious miliaria-removing effect, red fading effect and itching-relieving effect. When the content of each component is the wild chrysanthemum extract: 6 percent; golden yellow chamomile extract: 4 percent; camellia seed extract: 3 percent; and (3) liquorice extract: 2.5 percent; sweet clover extract: 1.5 percent; honeysuckle flower extract: 1.8 percent; extract of rheum palmatum root: 0.4 percent; the extract of the root of kushen: when the content of the red face powder is 0.8%, the prickly heat removing effect, the red fading effect and the itching relieving effect of the product are optimal.

In conclusion, the compound plant miliaria-removing and itching-relieving liquid disclosed by the invention is prepared by perfectly matching menthol, glycerol, propylene glycol, butanediol, a wild chrysanthemum flower extract, a golden yellow chamomile extract, a camellia seed extract, a liquorice root extract, a sweet clover extract, a honeysuckle flower extract, a rheum palmatum root extract and a sophora flavescens root extract. The wild chrysanthemum extract, the golden yellow chamomile extract, the rheum palmatum root extract, the honeysuckle extract and the sophora flavescens root extract are compounded, so that the compound preparation has a strong inhibiting effect on staphylococcus aureus, diphtheria bacillus, propionibacterium acnes and other strains, can relieve the skin, calms the nerves and is particularly suitable for fragile and sensitive skin; meanwhile, the skin blood circulation can be promoted, the skin permeability can be improved, the absorption of the skin on effective components can be promoted, and the effective time of the product can be shortened; by compounding the menthol, the camellia seed extract, the humectant and the liquorice extract, rich nutrient substances can be provided for skin while inhibiting strains, proliferation of muscle cells and vascular endothelial cells can be promoted, positive promotion effect on collagen-4 generation can be achieved, generation of NO can be inhibited, and skin growth of infants is facilitated.

The compound plant prickly heat removing and itching relieving liquid integrates three effects of removing prickly heat, relieving itching and preventing mosquitoes, can be used by infants and adults, and is free of greasiness and irritation. The product combines the ideas of 'integration, syndrome differentiation and synthesis' of the traditional Chinese medicine, is compatible, perfectly integrates various plant extracts together, and plays the optimal effect.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to those skilled in the art may occur to persons skilled in the art without departing from the spirit and scope of the present invention.

Claims

1. The compound plant miliaria-removing and itching-relieving liquid is characterized by comprising the following components in percentage by mass:

menthol: 0.02-0.3%;

wild chrysanthemum flower extract: 1 to 7 percent;

golden yellow chamomile extract: 1 to 5 percent;

camellia seed extract: 0.5-4%;

and (3) liquorice extract: 0.5-3%;

sweet clover extract: 0.1-4%;

honeysuckle flower extract: 0.1-4%;

extract of rheum palmatum root: 0.1-3%;

extract of kuh-seng root: 0.1-3%;

humectant: 3 to 17 percent;

auxiliary components: 0.5-1%;

water: and (4) the balance.

2. The compound plant miliaria-removing and itching-relieving liquid as claimed in claim 1, wherein the auxiliary components comprise at least one of a preservative, a solubilizer, a thickener and an auxiliary skin conditioner.

3. The compound plant miliaria-removing and itching-relieving liquid as claimed in claim 1, wherein the moisturizing agent comprises the following components: glycerol: 1 to 5 percent; propylene glycol: 1 to 6 percent; butanediol: 1 to 6 percent.

4. The compound plant miliaria-removing and itching-relieving liquid as claimed in any one of claims 1 to 3, which is characterized by comprising the following components in percentage by mass:

menthol: 0.1 percent;

glycerol: 2 percent;

propylene glycol: 3 percent;

butanediol: 3 percent;

wild chrysanthemum flower extract: 6 percent;

golden yellow chamomile extract: 4 percent;

camellia seed extract: 3 percent;

and (3) liquorice extract: 2.5 percent;

sweet clover extract: 1.5 percent;

honeysuckle flower extract: 1.8 percent;

extract of rheum palmatum root: 0.4 percent;

extract of kuh-seng root: 0.8 percent;

auxiliary components: 0.5-1%;

water: and (4) the balance.