CN111818925A - Cdk4/6抑制剂与egfr抑制剂联合在制备治疗肿瘤疾病的药物中的用途 - Google Patents

Cdk4/6抑制剂与egfr抑制剂联合在制备治疗肿瘤疾病的药物中的用途 Download PDF

Info

Publication number
CN111818925A
CN111818925A CN201980017473.3A CN201980017473A CN111818925A CN 111818925 A CN111818925 A CN 111818925A CN 201980017473 A CN201980017473 A CN 201980017473A CN 111818925 A CN111818925 A CN 111818925A
Authority
CN
China
Prior art keywords
inhibitor
cancer
cdk4
tumor
egfr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980017473.3A
Other languages
English (en)
Other versions
CN111818925B (zh
Inventor
张蕾
杨昌永
廖成
张连山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN111818925A publication Critical patent/CN111818925A/zh
Application granted granted Critical
Publication of CN111818925B publication Critical patent/CN111818925B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明提供了CDK4/6抑制剂与EGFR抑制剂联合在制备治疗肿瘤疾病的药物中的用途。具体而言,本发明提供一种细胞周期蛋白依赖性激酶4和6抑制剂(CDK4/6i)与人表皮生长因子受体抑制剂(EGFRi)联合在制备预防或治疗肿瘤疾病的药物中的用途。

Description

PCT国内申请,说明书已公开。

Claims (14)

  1. PCT国内申请,权利要求书已公开。
CN201980017473.3A 2018-05-23 2019-05-22 Cdk4/6抑制剂与egfr抑制剂联合在制备治疗肿瘤疾病的药物中的用途 Active CN111818925B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2018104995962 2018-05-23
CN201810499596 2018-05-23
CN201811086544 2018-09-18
CN2018110865449 2018-09-18
CN201811182296 2018-10-11
CN2018111822968 2018-10-11
PCT/CN2019/087945 WO2019223716A1 (zh) 2018-05-23 2019-05-22 Cdk4/6抑制剂与egfr抑制剂联合在制备治疗肿瘤疾病的药物中的用途

Publications (2)

Publication Number Publication Date
CN111818925A true CN111818925A (zh) 2020-10-23
CN111818925B CN111818925B (zh) 2023-12-12

Family

ID=68616085

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980017473.3A Active CN111818925B (zh) 2018-05-23 2019-05-22 Cdk4/6抑制剂与egfr抑制剂联合在制备治疗肿瘤疾病的药物中的用途

Country Status (9)

Country Link
US (1) US20210196719A1 (zh)
EP (1) EP3811946A4 (zh)
JP (1) JP2021525244A (zh)
KR (1) KR20210013155A (zh)
CN (1) CN111818925B (zh)
CA (1) CA3100867A1 (zh)
MX (1) MX2020012540A (zh)
TW (1) TWI762784B (zh)
WO (1) WO2019223716A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202211923A (zh) * 2020-07-27 2022-04-01 美商光譜製藥公司 波奇替尼(poziotinib)於非小細胞肺癌之治療
CN112168828A (zh) * 2020-11-10 2021-01-05 南京医科大学 一种egfr与cdk4/6小分子靶向药组合物及其应用
CN114748479B (zh) * 2021-01-08 2023-10-20 轩竹生物科技股份有限公司 一种预防和/或治疗癌症的药物组合物
TWI804333B (zh) * 2021-06-04 2023-06-01 中國醫藥大學 醫藥組合物治療肺癌之用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014183520A1 (zh) * 2013-05-17 2014-11-20 上海恒瑞医药有限公司 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2017161937A1 (zh) * 2016-03-22 2017-09-28 江苏豪森药业集团有限公司 Egfr抑制剂游离碱或其酸式盐的多晶型、其制备方法和应用
CN107652284A (zh) * 2017-09-30 2018-02-02 武汉中钰钰民医药科技有限公司 用于治疗增殖性疾病的cdk抑制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0706633D0 (en) * 2007-04-04 2007-05-16 Cyclacel Ltd Combination
WO2012123889A1 (en) * 2011-03-14 2012-09-20 Piramal Healthcare Limited A synergistic pharmaceutical combination for the treatment of pancreatic cancer
US9321749B1 (en) * 2012-07-25 2016-04-26 Globavir Biosciences, Inc. Heterocyclic compounds and uses thereof
LT3205650T (lt) * 2014-10-11 2021-09-10 Shanghai Hansoh Biomedical Co., Ltd. Egfr inhibitorius ir jo gavimas bei taikymas
RS59782B1 (sr) 2015-02-03 2020-02-28 Jiangsu hengrui medicine co ltd Hidroksietil sulfonat od ciklina zavisnog inhibitora kinaze proteina, njegov kristalni oblik, i postupak za njegovo dobijanje
WO2017037576A1 (en) * 2015-08-28 2017-03-09 Novartis Ag Pharmaceutical combinations comprising (a) the cyclin dependent kinase 4/6 (cdk4/6) inhibitor lee011 (=ribociclib), and (b) the epidermal growth factor receptor (egfr) inhibitor erlotinib, for the treatment or prevention of cancer
WO2017160568A1 (en) * 2016-03-16 2017-09-21 Eli Lilly And Company Combination therapy comprising the cdk4/6 inhibitor necitumumab and the egfr inhibitor abemaciclib for use in treating cancer
WO2017193141A1 (en) * 2016-05-06 2017-11-09 Siyuan Zhang Prognosis biomarkers and anti-tumor compositions of targeted therapeutic treatments for triple negative breast cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014183520A1 (zh) * 2013-05-17 2014-11-20 上海恒瑞医药有限公司 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2017161937A1 (zh) * 2016-03-22 2017-09-28 江苏豪森药业集团有限公司 Egfr抑制剂游离碱或其酸式盐的多晶型、其制备方法和应用
CN107652284A (zh) * 2017-09-30 2018-02-02 武汉中钰钰民医药科技有限公司 用于治疗增殖性疾病的cdk抑制剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOHN E. BISI等: "Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors", 《ONCOTARGET》 *
MINGHUI LIU等: "PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors", 《ONCOTARGET》 *
张百红等: "肿瘤的细胞周期治疗", 《中国肿瘤临床》 *

Also Published As

Publication number Publication date
TWI762784B (zh) 2022-05-01
JP2021525244A (ja) 2021-09-24
US20210196719A1 (en) 2021-07-01
CN111818925B (zh) 2023-12-12
EP3811946A4 (en) 2022-02-09
MX2020012540A (es) 2021-02-16
WO2019223716A1 (zh) 2019-11-28
TW202002964A (zh) 2020-01-16
EP3811946A1 (en) 2021-04-28
CA3100867A1 (en) 2019-11-28
KR20210013155A (ko) 2021-02-03

Similar Documents

Publication Publication Date Title
CN111818925B (zh) Cdk4/6抑制剂与egfr抑制剂联合在制备治疗肿瘤疾病的药物中的用途
US20210100813A1 (en) Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
TW202038957A (zh) 抗體-藥物結合物與激酶抑制劑之組合
JP6911019B2 (ja) Egfr−tki耐性を獲得した肺癌の治療薬
JP2021512101A (ja) 肥満細胞症の治療のための併用療法
TWI685341B (zh) 阿帕替尼和c-Met抑制劑聯合在製備治療腫瘤的藥物中的用途
TW202019421A (zh) Bcl-2/Bcl-xL抑制劑與化療藥物的組合及其應用
KR20120096053A (ko) 아르테미시닌계 약물 및 다른 화학요법제의 항암 조합물
JP2023500906A (ja) キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
KR20110089402A (ko) 종양의 치료를 위한 화학요법제와 병용된 알카노일 엘 카르니틴의 용도
CN111184863B (zh) 酪氨酸激酶抑制剂、cdk4/6抑制剂、serd联合在制备治疗肿瘤的药物中的用途
CN110840892A (zh) 酪氨酸激酶抑制剂与cdk4/6抑制剂联合在制备预防或治疗肿瘤疾病的药物中的用途
CN113301895B (zh) 多靶点酪氨酸激酶抑制剂与egfr抑制剂联合在制备治疗肿瘤的药物中的用途
CN113840608B (zh) Cdk4/6抑制剂与vegfr抑制剂联合在制备治疗肿瘤的药物中的用途
CN113939297A (zh) 用于治疗Notch活化的乳腺癌的双氟烷基-1,4-苯并二氮杂卓酮化合物
TWI777321B (zh) 藥物組合及其用途
CN115768416A (zh) 图卡替尼联合曲妥珠单抗和基于奥沙利铂的化学疗法治疗her2阳性癌症的方法
WO2023051606A1 (zh) Shp2抑制剂联合egfr-tki治疗和预防肿瘤疾病的医药用途
CN115006397A (zh) 一种预防或治疗肿瘤疾病的药物用途
CN114191558A (zh) Egfr抑制剂与抗血管新生药物在治疗肿瘤疾病的药物中的用途
CN118019537A (zh) Shp2抑制剂联合egfr-tki治疗和预防肿瘤疾病的医药用途
CN113797342A (zh) 用于预防或治疗肿瘤疾病的治疗剂组合
CN114569619A (zh) Pi3k抑制剂单用或联合egfr抑制剂在制备治疗头颈癌或胃癌的药物中的用途
CN115040519A (zh) Egfr抑制剂用于治疗非常见或非经典突变的用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant