CN111787938A - 靶向bcma的嵌合抗原受体、靶向cd19的嵌合抗原受体及组合疗法 - Google Patents

靶向bcma的嵌合抗原受体、靶向cd19的嵌合抗原受体及组合疗法 Download PDF

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CN111787938A
CN111787938A CN201880086576.0A CN201880086576A CN111787938A CN 111787938 A CN111787938 A CN 111787938A CN 201880086576 A CN201880086576 A CN 201880086576A CN 111787938 A CN111787938 A CN 111787938A
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seq
car
cells
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cell therapy
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A·加法尔
A·D·科恩
M·C·米伦
G·普莱萨
E·A·斯塔德莫尔
C·H·琼
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Novartis AG
University of Pennsylvania Penn
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University of Pennsylvania Penn
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CN201880086576.0A 2017-11-15 2018-11-15 靶向bcma的嵌合抗原受体、靶向cd19的嵌合抗原受体及组合疗法 Pending CN111787938A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762586834P 2017-11-15 2017-11-15
US62/586,834 2017-11-15
US201762588836P 2017-11-20 2017-11-20
US62/588,836 2017-11-20
PCT/US2018/061239 WO2019099639A1 (en) 2017-11-15 2018-11-15 Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies

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CN111787938A true CN111787938A (zh) 2020-10-16

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US (1) US20200360431A1 (enExample)
EP (1) EP3710040A1 (enExample)
JP (1) JP2021502979A (enExample)
KR (1) KR20200089285A (enExample)
CN (1) CN111787938A (enExample)
AU (1) AU2018369883A1 (enExample)
BR (1) BR112020009336A2 (enExample)
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CN112409414A (zh) * 2020-12-01 2021-02-26 北京师范大学 锝-99m标记含异腈的FAPI衍生物及制备方法和应用
WO2022143870A1 (zh) * 2020-12-31 2022-07-07 北京艺妙神州医药科技有限公司 一种特异性结合bcma的抗体及其应用
CN118459604A (zh) * 2023-09-22 2024-08-09 江苏集萃崛创生物科技研究所有限公司 一种同时靶向bcma和cd19的car-t细胞及其应用
CN119120379A (zh) * 2024-09-04 2024-12-13 星奕昂(上海)生物科技有限公司 一种针对iPSC-NK细胞的嵌合抗原受体及其应用

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WO2010099205A1 (en) * 2009-02-24 2010-09-02 The Trustees Of The University Of Pennsylvania Methods for treating progressive multifocal leukoencephalopathy (pml)
WO2014130657A1 (en) 2013-02-20 2014-08-28 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
WO2016028896A1 (en) 2014-08-19 2016-02-25 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
PT3280729T (pt) 2015-04-08 2022-08-01 Novartis Ag Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19
CN108473957B (zh) 2015-04-17 2024-07-16 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法
AR105433A1 (es) 2015-07-21 2017-10-04 Novartis Ag Métodos para mejorar la eficacia y expansión de las células inmunes
US11667691B2 (en) 2015-08-07 2023-06-06 Novartis Ag Treatment of cancer using chimeric CD3 receptor proteins
EP3344996A2 (en) 2015-09-03 2018-07-11 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
US11549099B2 (en) 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
CN110225927B (zh) 2016-10-07 2024-01-12 诺华股份有限公司 用于治疗癌症的嵌合抗原受体
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
IL321733A (en) 2017-10-18 2025-08-01 Novartis Ag Compositions and methods for selective degradation of proteins
AU2019226101A1 (en) 2018-02-23 2020-09-17 H. Lee Moffitt Cancer Center And Research Institute Inc. CD83-binding chimeric antigen receptors
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