CN111773379A - Injectable whitening wrinkle-removing preparation, preparation method and application thereof - Google Patents
Injectable whitening wrinkle-removing preparation, preparation method and application thereof Download PDFInfo
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- CN111773379A CN111773379A CN201910264513.6A CN201910264513A CN111773379A CN 111773379 A CN111773379 A CN 111773379A CN 201910264513 A CN201910264513 A CN 201910264513A CN 111773379 A CN111773379 A CN 111773379A
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- skin
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 34
- 230000000694 effects Effects 0.000 claims abstract description 20
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- 108010035532 Collagen Proteins 0.000 claims abstract description 17
- 229920001436 collagen Polymers 0.000 claims abstract description 17
- 230000037303 wrinkles Effects 0.000 claims abstract description 16
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims abstract description 13
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims abstract description 13
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- 229940116978 human epidermal growth factor Drugs 0.000 claims abstract description 13
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- 238000002347 injection Methods 0.000 claims description 19
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- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 1
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses an injectable whitening wrinkle-removing preparation, a preparation method and application thereof, wherein the preparation comprises the following raw materials in percentage by weight: 5-9% of collagen, 0.01-0.02% of recombinant human epidermal growth factor, 2.1-3.5% of mannose, 0.2-0.3% of grape seed extract, 0.3-0.5% of lidocaine hydrochloride and the balance of phosphate buffer solution. The skin care product integrates various components, can supplement skin nutrient components, promote metabolism of cells, activate cells, keep nutrition and metabolism balance of subcutaneous cells, achieves the effects of whitening and removing wrinkles by self regulation of skin, has long-term effects of whitening, antioxidation and anti-aging, enables the skin to be full and elastic, improves the skin quality, and achieves the effects of tendering, whitening and removing wrinkles.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an injectable whitening wrinkle-removing preparation, and a preparation method and application thereof.
Background
With the aging, wrinkles are the initial signs of skin aging, the wrinkles are mainly caused by loss of skin collagen, subcutaneous lipoatrophy, decreased cell water locking function, change of facial contour from parabola to jagged line, wrinkle, collapse and prolapse, and phenomena of gully and rugosity, the wrinkles are mainly concentrated on the parts exposed in the air for a long time, such as face, neck, hands, etc., and the collagen fiber bundles are straightened and the elasticity is deteriorated due to the irradiation of ultraviolet rays in the sun, which leads to the rupture of fibers of the dermis, lipoatrophy, and the secretion of sweat glands and sebaceous glands is reduced. The economic development and the living standard of modern society are improved, people pay more and more attention to aging resistance, beauty treatment and youth keeping, the current mode of removing wrinkles mainly adopts cosmetics or beauty treatment operations, the cosmetics have the characteristics of various types, different effects, long service cycle and unobvious effect, and cosmetic medicaments mostly have the side effect of chemical reagents and are not beneficial to skin health; the skin is improved by adopting an injection medicament in the cosmetic surgery, the activity and the metabolism of the skin are enhanced by the medicament, the effect is fast, and the long-acting whitening and wrinkle-removing reagent is in the mainstream demand.
The present invention has been made in view of this situation.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the defects of the prior art, and provide an injectable whitening wrinkle-removing preparation, a preparation method and application thereof, in order to solve the technical problems, the invention adopts the basic concept of the technical scheme that:
an injectable whitening wrinkle-removing preparation comprises the following raw materials in percentage by weight: 5-9% of collagen, 0.01-0.02% of recombinant human epidermal growth factor, 2.1-3.5% of mannose, 0.2-0.3% of grape seed extract, 0.3-0.5% of lidocaine hydrochloride and the balance of phosphate buffer solution.
Further, the composite material comprises the following raw materials in percentage by weight: 7.2% of collagen, 0.016% of recombinant human epidermal growth factor, 2.43% of mannose, 0.24% of grape seed extract, 0.37% of lidocaine hydrochloride and the balance of phosphate buffer solution.
A preparation method of an injectable whitening wrinkle-removing preparation comprises the following steps:
s1, taking the components according to the proportion, adding the recombinant human epidermal growth factor into phosphate buffer solution, and mixing;
s2, adding mannose, collagen and grape seed extract, and dispersing completely;
s3, adding lidocaine hydrochloride, mixing, and homogenizing to obtain the target preparation.
An injectable preparation for whitening and removing wrinkles is used for whitening and removing wrinkles of skin.
A method for using an injectable whitening and wrinkle-removing preparation comprises the following steps:
s1, cleaning the skin to be whitened and wrinkle-removed, and disinfecting the skin for 2-3 times by medical alcohol;
s2, marking out the points to be injected by using an operation pen, wherein the marked points form a net-shaped surface area;
s3, injecting the preparation into skin at the marked point, injecting the preparation into the fascia layer along with the periosteum during injection, and separating the fascia layer by virtue of the soft stripping effect of liquid water power;
and S4, after the injection of the marked points is finished, the skin can be washed by clear water after 2-4h of absorption.
The collagen can be high-purity bovine dermal collagen, contains a large amount of polar groups, is a moisturizing factor, has the effect of preventing tyrosine in the skin from being converted into melanin, and has the effects of purely natural moisturizing, whitening, wrinkle resistance and freckle removal; the recombinant human epidermal growth factor has strong mitogenic action on various histiocytes, can stimulate various cells originated from ectoderm and endoderm, proliferate and migrate the cells, accelerate metabolism, promote the biosynthesis of DNA, RNA and functional protein, increase the water content of the skin, promote the active transport of cell nutrients from the outside of the cells to the inside of the cells, increase the nutrition in the cells, thereby achieving the effects of tendering the skin, increasing the elasticity of the skin and moistening the skin; mannose has the effects of regulating immune system, increasing wound healing, avoiding certain bacterial infection and the like, and is beneficial to the absorption and recovery of skin after injection; the grape seed extract can be procyanidin with high purity, and has strong oxidation resistance, skin resistance enhancing, and skin whitening and wrinkle removing long-acting effects.
After the technical scheme is adopted, compared with the prior art, the invention has the following beneficial effects.
The skin care product integrates various components, can supplement skin nutrient components, promote metabolism of cells, activate cells, keep nutrition and metabolism balance of subcutaneous cells, achieves the effects of whitening and removing wrinkles by self regulation of skin, has long-term effects of whitening, antioxidation and anti-aging, enables the skin to be full and elastic, improves the skin quality, and achieves the effects of tendering, whitening and removing wrinkles. When the medicament is used, facial area repair is formed by combining injection points, and scar hyperplasia capacity of the injection points, a plurality of loose, sunken and collapse parts with incomplete congenital development are plump, the skin quality is improved from the development of skin cells, and the purpose of beautifying the skin is achieved.
The invention has reasonable structure, simple and convenient operation and strong practicability and is suitable for popularization and application.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the following embodiments are used for illustrating the present invention, but are not intended to limit the scope of the present invention.
Example 1
An injectable whitening wrinkle-removing preparation comprises the following raw materials in percentage by weight: 5% of collagen, 0.01% of recombinant human epidermal growth factor, 2.1% of mannose, 0.2% of grape seed extract, 0.3% of lidocaine hydrochloride and the balance of phosphate buffer solution.
Example 2
An injectable whitening wrinkle-removing preparation comprises the following raw materials in percentage by weight: 7.2% of collagen, 0.016% of recombinant human epidermal growth factor, 2.43% of mannose, 0.24% of grape seed extract, 0.37% of lidocaine hydrochloride and the balance of phosphate buffer solution.
Example 3
An injectable whitening wrinkle-removing preparation comprises the following raw materials in percentage by weight: 9% of collagen, 0.02% of recombinant human epidermal growth factor, 3.5% of mannose, 0.3% of grape seed extract, 0.5% of lidocaine hydrochloride and the balance of phosphate buffer solution.
The skin care product integrates various components, can supplement skin nutrient components, promote metabolism of cells, activate cells, keep nutrition and metabolism balance of subcutaneous cells, achieves the effects of whitening and removing wrinkles by self regulation of skin, has long-term effects of whitening, antioxidation and anti-aging, enables the skin to be full and elastic, improves the skin quality, and achieves the effects of tendering, whitening and removing wrinkles.
Example 4
A method for preparing an injectable whitening wrinkle-removing preparation comprises the following steps:
s1, proportionally taking collagen, recombinant human epidermal growth factor, mannose, grape seed extract, lidocaine hydrochloride and phosphate buffer solution, adding the recombinant human epidermal growth factor into the phosphate buffer solution, and uniformly mixing;
s2, adding mannose, collagen and grape seed extract, dispersing fully, and controlling to operate at room temperature;
s3, adding lidocaine hydrochloride, mixing, and homogenizing to obtain the target preparation. Can be filled into injection according to the dosage as required.
Example 5
A method of using an injectable whitening wrinkle-removing preparation, comprising:
s1, cleaning the skin to be whitened and wrinkle-removed, and disinfecting the skin for 2-3 times by medical alcohol. The skin position of injection is face, neck, arm etc. generally, and the washing degree is controlled to different positions, avoids bacterium, filth pollution injection environment.
And S2, marking the injection points with the operation pen, wherein the marked points form a mesh surface area. Marking points are selected according to the injection position, such as the face, according to different aging degrees of the face, the marking points form a net shape in the forehead, the temporal hairline, the ear side, the back and other more hidden places,
s3, injecting the preparation into skin at the marked point, injecting into fascia layer along periosteum during injection, and separating fascia layer by liquid hydrodynamic soft stripping effect. The preparation can be directly injected into the skin by using the current medical science and technology equipment, such as an injector integrating a needle head and a needle handle, particularly, when the preparation is injected into the face, the preparation is injected into a fascia layer by adhering to a periosteum, the fascia layer is separated by virtue of the hydrodynamic soft stripping effect of liquid, and attention is required to be paid to avoiding subcutaneous blood vessels and nerves during injection. The skin tissue can heal after encountering the wound, scars can be generated in the healing process, a large amount of scar fibers can be generated by the scar hyperplasia capability, and the skin can be tightened from all directions by the contracture capability. Therefore, the skin forms a collagen fiber net with a point surface, and a large amount of HN-fibronectin is generated by combining the self-repairing and regenerating capacity of cells, so that the thickness of subcutaneous tissues is increased, the compact and full contour of the skin is remolded, the elasticity, the whitening and the smoothness of the skin are kept, the contracture net of scars can prolong the aging period of the skin, and the long-acting property of improving the skin quality is improved.
And S4, after the injection of the marked points is finished, the skin can be washed by clear water after 2-4h of absorption. After injection, the skin can be fully absorbed, the skin can be washed by clear water after 2-4 hours, the skin is initially washed by the clear water, the skin is not different from the normal skin after one week, and the skin can be normally washed and protected.
When the medicament is used, facial area repair is formed by combining injection points, and scar hyperplasia capacity of the injection points, a plurality of loose, sunken and collapse parts with incomplete congenital development are plump, the skin quality is improved from the development of skin cells, and the purpose of beautifying the skin is achieved.
Although the present invention has been described with reference to a preferred embodiment, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (5)
1. An injectable whitening wrinkle-removing preparation is characterized by comprising the following raw materials in percentage by weight: 5-9% of collagen, 0.01-0.02% of recombinant human epidermal growth factor, 2.1-3.5% of mannose, 0.2-0.3% of grape seed extract, 0.3-0.5% of lidocaine hydrochloride and the balance of phosphate buffer solution.
2. The injectable whitening and wrinkle-removing preparation according to claim 1, which comprises the following raw materials in percentage by weight: 7.2% of collagen, 0.016% of recombinant human epidermal growth factor, 2.43% of mannose, 0.24% of grape seed extract, 0.37% of lidocaine hydrochloride and the balance of phosphate buffer solution.
3. The method for preparing an injectable whitening and wrinkle-removing preparation according to claim 1 or 2, comprising the steps of:
s1, taking the components according to the proportion, adding the recombinant human epidermal growth factor into phosphate buffer solution, and mixing;
s2, adding mannose, collagen and grape seed extract, and dispersing completely;
s3, adding lidocaine hydrochloride, mixing, and homogenizing to obtain the target preparation.
4. Use of an injectable whitening wrinkle-removing preparation according to claim 1 or 2 for whitening and removing wrinkles of the skin.
5. The use of the injectable whitening and wrinkle-removing preparation according to claim 1 or 2, characterized by comprising the steps of:
s1, cleaning the skin to be whitened and wrinkle-removed, and disinfecting the skin for 2-3 times by medical alcohol;
s2, marking out the points to be injected by using an operation pen, wherein the marked points form a net-shaped surface area;
s3, injecting the preparation into skin at the marked point, injecting the preparation into the fascia layer along with the periosteum during injection, and separating the fascia layer by virtue of the soft stripping effect of liquid water power;
and S4, after the injection of the marked points is finished, the skin can be washed by clear water after 2-4h of absorption.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113520976A (en) * | 2021-08-05 | 2021-10-22 | 安丽维(广州)医疗美容门诊部有限责任公司 | Autologous collagen release anti-aging technology |
| CN113877002A (en) * | 2021-11-09 | 2022-01-04 | 孙守义 | Self-repairing small needle liquid medicine and using method thereof |
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| WO2018159983A1 (en) * | 2017-02-28 | 2018-09-07 | (주)시지바이오 | Composition for injection into skin |
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