LU501530B1 - A method for preparing and implanting collagen - Google Patents
A method for preparing and implanting collagen Download PDFInfo
- Publication number
- LU501530B1 LU501530B1 LU501530A LU501530A LU501530B1 LU 501530 B1 LU501530 B1 LU 501530B1 LU 501530 A LU501530 A LU 501530A LU 501530 A LU501530 A LU 501530A LU 501530 B1 LU501530 B1 LU 501530B1
- Authority
- LU
- Luxembourg
- Prior art keywords
- collagen
- implantation
- preparing
- implanting
- nutrient solution
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract description 47
- 108010035532 Collagen Proteins 0.000 title claims abstract description 47
- 229920001436 collagen Polymers 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 25
- 238000002513 implantation Methods 0.000 claims abstract description 19
- 239000000501 collagen implant Substances 0.000 claims abstract description 15
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 13
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 13
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 13
- 235000015097 nutrients Nutrition 0.000 claims abstract description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 8
- 230000001815 facial effect Effects 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims abstract description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 6
- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 208000006735 Periostitis Diseases 0.000 claims description 3
- 210000004207 dermis Anatomy 0.000 claims description 3
- 210000003195 fascia Anatomy 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 206010033675 panniculitis Diseases 0.000 claims description 3
- 210000003460 periosteum Anatomy 0.000 claims description 3
- 210000002950 fibroblast Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 238000002676 facial rejuvenation Methods 0.000 abstract description 2
- 230000006698 induction Effects 0.000 abstract description 2
- 230000008719 thickening Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 8
- 230000032683 aging Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010024604 Lipoatrophy Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Abstract
The invention discloses the method for preparing and implanting collagen, comprising the steps of preparing the collagen implants, sodium hyaluronate complex solutions and normal saline injections by mixed in a particular proportion, then implanting the prepared collagen complex nutrient solution into the face by layers for the facial implantation; and 40 days after the collagen implantation, reimplanting the collagen complex nutrient solution according to the facial condition. The invention provides the method for implanting collagen by adopting the layering implantation and reimplantation approach to carry out collagen implantation at all skin layers effectively. A large number of fibroblasts will attach to the implanted collagen and grow accordingly under the environment where collagen is directly replenished to the skin; which can activate the activity of fibroblasts and thus realizes the regeneration induction of high-quality collagen effectively, to achieve a significant effect of collagen regeneration and tissue thickening. There remains new collagen when the collagen is degraded to effectively accomplish the aim of facial rejuvenation.
Description
BL-5436
A METHOD FOR PREPARING AND IMPLANTING COLLAGEN 1001000
The invention relates to the technical fields of beauty, in particular to a method for preparing and implanting collagen.
Collagen is the major component of the body's connective tissue and is widely distributed throughout the body, mainly playing the roles of moisturizing, whitening, anti-wrinkle and anti- aging. However, the increasing ages result in the decreases of the synthetic ability of fibroblasts.
Furthermore, the collagen fibers tend to cross-link and be solidified when the skin lacks sufficient collagen, which reduces intercellular polysaccharides, leading to the aging skin losing luster, softness, and elasticity. Aging skin will cause fiber breakage, lipoatrophy, the hyposecretion of sweat gland and sebaceous gland, wrinkles, age spots, cutis laxa and other aging problems.
Therefore, based on the above background, the invention provides a method for preparing and implanting collagen, by means of layering implantation and reimplantation of collagen implants, to slow the rate of collagen loss in the skin, improve the aging cells of the skin, promote the increase and growth of collagen production and reduce the appearance of necrotic tissue, realizing the youthful-looking skin.
To achieve the above objects, the technical solution provided by the invention is as follows:
A method for preparing and implanting collagen, comprising the following steps: (1) preparing the collagen implants; (2) preparing the sodium hyaluronate complex solutions; (3) homogeneously mixing the collagen implant, the sodium hyaluronate complex solutions 1
BL-5436
LU501530 and the 0.9% normal saline injections with a disposable sterile cock to prepare the collagen complex nutrient solution; (4) implanting the prepared collagen complex nutrient solution in step (3) into the face by layers for the facial implantation; (5) 40 days after the collagen implantation according to the step (4), following the step (4) to reimplant the collagen complex nutrient solution according to the facial condition.
Further, the collagen implants, sodium hyaluronate complex solution and normal saline in step (3) are prepared in a volume ratio of 0.5:2.5:10.
Further, the amount of collagen implant in step (3) is 0.5 ml, the amount of sodium hyaluronate complex solutions in step (3) is 2.5 ml and the amount of normal saline in step (3) is ml.
Further, the step (3) provides the 1 ml disposable sterile insulin syringe as the implantation tool, and the layers of implantation are the upper layer of the periosteum, the deep fascia layer, the superficial fascia layer, the subcutaneous tissue and the dermis respectively.
The invention has the following advantages: the invention provides the method for implanting collagen by adopting the layering implantation and reimplantation approach to carry out collagen implantation effectively at all layers of the skin. A large number of fibroblasts will attach to the implanted collagen and grow accordingly under the environment where collagen is directly replenished to the skin; which is able to activate the activity of fibroblasts and thus realizes the regeneration induction of high- quality collagen effectively, to achieve a significant effect of collagen regeneration and tissue thickening. When the collagen is degraded, there remains new collagen to accomplish the aim of facial rejuvenation effectively. 2
BL-5436
Description of Embodiments 100108
To better understand the invention, a further description of the invention is given below in combination with the specific embodiments.
Embodiment 1: A method for preparing and implanting collagen, wherein comprises the steps of: (1) prepare 0.5ml collagen implants. The chosen collagen implant can be the collagen implants (Fu Li Mei-Sunmax Collagen Implant I-Plus) produced by the Sunmax Biotechnology
CO.,LTD. and its specification is 1 ml/piece; or the medical collagen filler (FILLDERM) produced by Changchun Botai Pharmaceutical Biotechnology Co., Ltd, and its specification is 0.5 ml/piece. (2) prepare 2.5ml sodium hyaluronate complex solutions. The chosen sodium hyaluronate complex solutions can be sodium hyaluronate solution (Hearty) produced by the Imeik
Technology Development Co.,ltd., and its specification is 2.5 ml/piece. (3) homogeneously mix the collagen implants in step (2), the sodium hyaluronate complex solutions in step (3) and 0.9% normal saline injections with a disposable sterile cock to prepare the collagen complex nutrient solution. (4) implant the prepared collagen complex nutrient solution in step (3) into the face by layers for the facial implantation by using the 1 ml disposable sterile insulin syringe as the implantation tool, and the layers of implantation are the upper layer of periosteum, the deep fascia layer, the superficial fascia layer, the subcutaneous tissue and the dermis respectively. (5) 40 days after the collagen implantation according to the step (3), follow the step (3) to reimplant the collagen complex nutrient solution according to the facial condition.
The invention and the embodiments thereof are described hereinabove, and this description is not restrictive. What is shown in the drawings is only one of the embodiments of the invention, and the actual structure is not limited thereto. It is not intended to be exhaustive or to limit the 3
BL-5436
LU501530 invention to the precise form disclosed, and the invention can be modified and substituted in many ways according to the above instructions and descriptions. The object of selecting and describing the above exemplary embodiment 1s to explain certain principles of the invention and practical application thereof, to help the ordinary technicians in the art can achieve and utilize different embodiments of the invention with various modifications and substitutions. Therefore, the protection scope of the invention should be subject to the protection scope defined by the claims and equivalents thereof. 4
Claims (4)
1. A method for preparing and implanting collagen, wherein comprises the steps of (1) preparing the collagen implants; (2) preparing the sodium hyaluronate complex solutions; (3) homogeneously mixing the collagen implants, the sodium hyaluronate complex solutions and the 0.9% normal saline injections with a disposable sterile cock to prepare the collagen complex nutrient solution; (4) implanting the prepared collagen complex nutrient solution in step (3) into the face by layers for the facial implantation; (5) 40 days after the collagen implantation according to the step (4), following the step (4) to reimplant the collagen complex nutrient solution according to the facial condition.
2. A method for preparing and implanting collagen according to claim 1, wherein the collagen implants, sodium hyaluronate complex solutions and normal saline in step (3) are prepared in a volume ratio of 0.5:2.5:10.
3. A method for preparing and implanting collagen according to claim 2, wherein the amount of collagen implant in step (3) is 0.5 ml, the amount of sodium hyaluronate complex solutions in step (3) is 2.5 ml and the amount of normal saline in step (3) is 10 ml.
4. A method for preparing and implanting collagen according to claim 1, wherein the step (3) provides the 1 ml disposable sterile insulin syringe as the implantation tool, and the layers of implantation are the upper layer of the periosteum, the deep fascia layer, the superficial fascia layer, the subcutaneous tissue and the dermis respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU501530A LU501530B1 (en) | 2022-02-21 | 2022-02-21 | A method for preparing and implanting collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU501530A LU501530B1 (en) | 2022-02-21 | 2022-02-21 | A method for preparing and implanting collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU501530B1 true LU501530B1 (en) | 2023-08-21 |
Family
ID=80448336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU501530A LU501530B1 (en) | 2022-02-21 | 2022-02-21 | A method for preparing and implanting collagen |
Country Status (1)
| Country | Link |
|---|---|
| LU (1) | LU501530B1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015579A2 (en) * | 2011-07-26 | 2013-01-31 | (주)차바이오앤디오스텍 | Medical composite organic material including collagen and hyaluronic acid derivatives |
| CN107213028A (en) * | 2017-05-26 | 2017-09-29 | 陕西慧康生物科技有限责任公司 | A kind of collagen implant and preparation method thereof |
| CN112089642A (en) * | 2020-09-23 | 2020-12-18 | 李举 | Collagen cultivation method |
-
2022
- 2022-02-21 LU LU501530A patent/LU501530B1/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015579A2 (en) * | 2011-07-26 | 2013-01-31 | (주)차바이오앤디오스텍 | Medical composite organic material including collagen and hyaluronic acid derivatives |
| CN107213028A (en) * | 2017-05-26 | 2017-09-29 | 陕西慧康生物科技有限责任公司 | A kind of collagen implant and preparation method thereof |
| CN112089642A (en) * | 2020-09-23 | 2020-12-18 | 李举 | Collagen cultivation method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Effective date: 20230821 |