LU501530B1 - A method for preparing and implanting collagen - Google Patents
A method for preparing and implanting collagen Download PDFInfo
- Publication number
- LU501530B1 LU501530B1 LU501530A LU501530A LU501530B1 LU 501530 B1 LU501530 B1 LU 501530B1 LU 501530 A LU501530 A LU 501530A LU 501530 A LU501530 A LU 501530A LU 501530 B1 LU501530 B1 LU 501530B1
- Authority
- LU
- Luxembourg
- Prior art keywords
- collagen
- implantation
- preparing
- implanting
- nutrient solution
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract description 47
- 108010035532 Collagen Proteins 0.000 title claims abstract description 47
- 229920001436 collagen Polymers 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 25
- 238000002513 implantation Methods 0.000 claims abstract description 19
- 239000000501 collagen implant Substances 0.000 claims abstract description 15
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 13
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 13
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 13
- 235000015097 nutrients Nutrition 0.000 claims abstract description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 8
- 230000001815 facial effect Effects 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims abstract description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 6
- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 208000006735 Periostitis Diseases 0.000 claims description 3
- 210000004207 dermis Anatomy 0.000 claims description 3
- 210000003195 fascia Anatomy 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 206010033675 panniculitis Diseases 0.000 claims description 3
- 210000003460 periosteum Anatomy 0.000 claims description 3
- 210000002950 fibroblast Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 238000002676 facial rejuvenation Methods 0.000 abstract description 2
- 230000006698 induction Effects 0.000 abstract description 2
- 230000008719 thickening Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 8
- 230000032683 aging Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010024604 Lipoatrophy Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Claims (4)
1. Verfahren zur Kollagenkultivierung, dadurch gekennzeichnet, dass es die folgenden Schritte umfasst: (1) Vorbereitung eines Kollagenimplantats; (2) Vorbereitung einer Natriumhyaluronat-Komplexlosung; (3) Mischen des Kollagenimplantats, der Natriumhyaluronat-Komplexlésung und einer 0,9%-ige Kochsalzlôsung mit einem sterilen Einweghahn, um eine Kollagenkomplex-Nährlôsung zu bilden; (4) Implantation der Kollagenkomplex-Nährlôsung aus Schritt (3) auf verschiedenen Schichten des Gesichts; (5) nach 40 Tagen der Kollagenimplantation gemäß Schritt (4) wird die Kollagenkomplex-Nährlôsung entsprechend dem Zustand des Gesichts gemäß Schritt (4) erneut implantiert und überlagert.
2. Verfahren zur Kollagenkultivierung nach Anspruch 1, dadurch gekennzeichnet, dass das Kollagenimplantat, die Natriumhyaluronat-Komplexlôësung und die Kochsalzlôsung in Schritt (3) in einem Volumenverhältnis von 0,5:2,5:10 formuliert werden.
3. Verfahren zur Kollagenkultivierung nach Anspruch 2, dadurch gekennzeichnet, dass die Menge des Kollagenimplantats in Schritt (3) 0,5 ml, die Menge der Natriumhyaluronat-Komplexlôsung 2,5 ml und die Menge der Kochsalzlôsung 10 ml beträgt.
4. Verfahren zur Kollagenkultivierung nach Anspruch 1, dadurch gekennzeichnet, dass das in Schritt (3) verwendete Implantationswerkzeug eine sterile 1-ml-Insulinspritze zur einmaligen Verwendung ist und dass die Schichten der Implantation die supraperiostale Schicht, die tiefe Faszienschicht, die oberflächliche Faszienschicht, das subkutane Gewebe und die Dermis sind.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU501530A LU501530B1 (en) | 2022-02-21 | 2022-02-21 | A method for preparing and implanting collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU501530A LU501530B1 (en) | 2022-02-21 | 2022-02-21 | A method for preparing and implanting collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU501530B1 true LU501530B1 (en) | 2023-08-21 |
Family
ID=80448336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU501530A LU501530B1 (en) | 2022-02-21 | 2022-02-21 | A method for preparing and implanting collagen |
Country Status (1)
| Country | Link |
|---|---|
| LU (1) | LU501530B1 (de) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015579A2 (ko) * | 2011-07-26 | 2013-01-31 | (주)차바이오앤디오스텍 | 콜라겐 및 히알루론산 유도체를 포함하는 의료용 복합 생체 소재 |
| CN107213028A (zh) * | 2017-05-26 | 2017-09-29 | 陕西慧康生物科技有限责任公司 | 一种胶原蛋白植入剂及其制备方法 |
| CN112089642A (zh) * | 2020-09-23 | 2020-12-18 | 李举 | 一种胶原培植的方法 |
-
2022
- 2022-02-21 LU LU501530A patent/LU501530B1/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015579A2 (ko) * | 2011-07-26 | 2013-01-31 | (주)차바이오앤디오스텍 | 콜라겐 및 히알루론산 유도체를 포함하는 의료용 복합 생체 소재 |
| CN107213028A (zh) * | 2017-05-26 | 2017-09-29 | 陕西慧康生物科技有限责任公司 | 一种胶原蛋白植入剂及其制备方法 |
| CN112089642A (zh) * | 2020-09-23 | 2020-12-18 | 李举 | 一种胶原培植的方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1734894B2 (de) | Teilchen für den weichteilgewebeaufbau | |
| WO2008072229A2 (en) | Methods for dermal filling using microneedles | |
| Ali et al. | Perioral rejuvenation and lip augmentation | |
| KR20120089433A (ko) | 충전제와 섬유아세포 성장 배지를 조합한 주사용 조성물 | |
| JP2019010089A (ja) | 人工皮膚製造方法および人工皮膚 | |
| CN102229705A (zh) | 一种胶原蛋白温敏型水凝胶及其制备方法 | |
| CN110787319A (zh) | 用于面部美容提拉的植入物及其应用 | |
| CN110279888A (zh) | 一种注射用琼脂糖凝胶剂及其制备方法 | |
| Rhee et al. | Injectable tissue-engineered soft tissue for tissue augmentation | |
| LU501530B1 (en) | A method for preparing and implanting collagen | |
| RU2135122C1 (ru) | Способ омолаживания кожи | |
| CN112089642A (zh) | 一种胶原培植的方法 | |
| CN111773379A (zh) | 一种可注射的美白去皱制剂、制备方法及其应用 | |
| CN110292655A (zh) | 一种含羟基磷灰石的注射填充制剂及其制备方法 | |
| Goodwin | Collagen stimulation with a range of polycaprolactone dermal fillers | |
| CN113456806A (zh) | 一种i型胶原蛋白混悬药剂及其制备方法 | |
| CN114588069A (zh) | 一种复合营养液及其应用 | |
| Sattler et al. | Tower technique of filler injection | |
| Robertson et al. | The use of fillers in the aging patient | |
| CN112545967A (zh) | 一种肌肤全层抗衰组分的配方 | |
| Sadick | Filler Biologic Properties and Techniques | |
| Sadick | Introduction to Structural Volumetric Rejuvenation | |
| CN108478865A (zh) | 一种用于注射美容整形的填充材料及制备方法 | |
| Wu et al. | Novel administration technique for large-particle stabilized hyaluronic acid-based gel of nonanimal origin in facial tissue augmentation | |
| Chaima et al. | Idiopathic hemifacial atrophy successfully treated with hyaluronic acid filler: About two new cases. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Effective date: 20230821 |