CN110787319A

CN110787319A - Implant for facial cosmetic lifting and application thereof

Info

Publication number: CN110787319A
Application number: CN201911144841.9A
Authority: CN
Inventors: 林光明; 陈向东; 李禹辰; 江春阳; 杨欢
Original assignee: Shanghai Moyang Biotechnology Co Ltd
Current assignee: Shanghai Moyang Biotechnology Co Ltd
Priority date: 2019-11-19
Filing date: 2019-11-19
Publication date: 2020-02-14

Abstract

The invention provides an implant for lifting facial beauty and an application thereof, the implant is a microsphere filler, and a material system of the microsphere filler is prepared from the following raw materials in parts by mass: 10-40 parts of microsphere material solid; 5-20 parts of a suspension stabilizer; 2-10 parts of a lubricant; 65-90 parts of a mobile phase; and 90-360 parts of a diluting component. The invention is applied to skin beauty, can maximize the skin beauty improving effect and simultaneously stimulate the regeneration of facial collagen. The invention aims at the unique facial characteristics and aesthetic requirements of Chinese people to realize the requirements of beauty-seeking people on full, natural and young states, and the technology is specially named as magic face lifting operation.

Description

Implant for facial cosmetic lifting and application thereof

Technical Field

The invention relates to the technical field of cosmetic reshaping, in particular to an implant for lifting and lifting facial cosmetics and application thereof.

Background

Along with the continuous progress of society and the improvement of living standard, the demand of people on beauty is also continuously improved. According to the reckoning report of orthopedics in 2018 of the american society for orthopedics, soft tissue augmentation is the second most common minimally invasive procedure, having been performed 267 ten thousand times, and consistently maintaining the same 3% growth rate. Since the beginning of the century, the soft tissue augmentation procedure increased 294%, while the cosmetic surgery decreased 12% overall. With the explosion of the soft tissue augmentation industry, patients and physicians in the united states are faced with an increasing choice of available products. The soft tissue augmentation material may be produced from natural sources or synthetically. Currently, there are dozens of known dermal fillers for dermal augmentation, including autograft materials, xenogeneic products and synthetically derived products. Dermal filler materials that may be used include biodegradable natural substances (e.g., collagen, gelatin, hyaluronic acid, dextran, and dried acellular microparticulate dermal matrices), biodegradable synthetic polymers (e.g., poly-L-lactic acid, polyethylene oxide, and carboxymethyl cellulose), non-biodegradable synthetic polymers (e.g., polymethyl methacrylate), polyacrylamides, polyalkylamides, and silicones), and combinations thereof. Volume substitution filling is mainly achieved by using hyaluronic acid and collagen. Typical microsphere products such as calcium hydroxyapatite (CaHA), polymethyl methacrylate (PMMA), poly L-lactic acid (PLLA), and calcium caseinate (Ca & Casein) have an additional biostimulation effect in addition to providing initial volume replacement, which stimulates autologous fibroblasts to produce collagen.

Polymethylmethacrylate (PMMA) was originally used in neurosurgery, orthopaedics and otorhinolaryngology as a biocompatible cement. Artemil (Suneva Medical, San Diego, CA) is the only FDAA approved injectable filler in the united states. It was first approved in 2007 as Artefill as a dermal filler for the nasolabial sulcus. Artemifill consists of 30 to 50um smooth round PMMA microspheres suspended in 3.5% bovine collagen. The collagen carrier is adsorbed 1-3 months after injection. The remaining non-biodegradable microspheres served as guarantee for new collagen formation within 3 months. Due to the presence of bovine collagen, artemifill required an allergic skin injection test 4 weeks prior to treatment.

Poly-L-lactic acid (PLLA) has been clinically used for over 20 years and in 2004, has been approved by the FDA as an injectable implant for repairing or correcting signs of facial fat loss in HIV patients with facial atrophy.PLLA has been approved for the treatment of the nasolabial folds and other wrinkle sites in 2009 PLLA is a non-toxic absorbable polymer (about 40-50 kDa) consisting of the α -hydroxy acid family that must be injected with sterile water at least 2 hours prior to use.

Calcium hydroxyapatite (CaHA) was first approved by the U.S. food and drug administration in 2001 as a soft tissue radiographic marker, after which its indications, including vocal cord dilation, oromaxillofacial defect repair and soft tissue dilation, for stress urinary incontinence, were rapidly expanded. Radiesse (merz ametheses, roche, north carolina) was approved by the FDA for the enhancement of moderate to severe nasolabial sulcus and human immunodeficiency virus-associated facial lipoatrophy. The CaHA microspheres of Radiesse, which are between 25 and 45um in diameter, are dispersed in 70% hydrogel. Within weeks after injection, the carrier gel was absorbed by the nascent collagen and volume displaced. Because no immune response is elicited, no skin test is required. CaHA degrades to calcium and phosphate ions over time and is slowly excreted from the body, creating a sustained capacity for an average of 12 to 18 months. CaHA has become an increasingly popular filler choice due to its unique chemical composition, safety and enhanced properties. Its versatility extends to the use of the marionette, anterior mandibular sulcus and posterior mandible. It has also been reported that the injection was effective in the temple and in the zygomatic/submandibular region. Practitioners today have steadily expanded the depth of injection into the deep dermis, structurally lifting and contouring.

The other novel materials comprise a polycaprolactone microsphere system and a human casein calcium microsphere system, and the microsphere products can perform volume amplification except for the initial stage and can also stimulate the regeneration of collagen to achieve a long-term expansion effect through the microsphere characteristics. To address this property, PMMA was approved in 2014 for the treatment of moderately severe, atrophic, facial acne scars on the cheeks of patients over 21 years old, CaHA was approved in 2015 for hand rejuvenation, and recent studies have shown that diluted CaHA is capable of rejuvenation treatment to improve facial laxity.

Facial aging is a result of a combination of factors including intrinsic changes in the skin, the effects of gravity, the movement of facial muscles leading to the formation of kinetic lines, skin exfoliation or displacement, bone loss, loss of tissue elasticity, and exposure to harsh environmental conditions, particularly sun or ultraviolet radiation and pollutants. As the epidermis begins to thin, the skin ages, resulting in a flattening of the junction with the dermis. With age, collagen decreases and the bundles of collagen that cause the skin to swell become loose and lose strength. When the skin loses elasticity, it cannot resist stretching. In addition to gravity, muscle pull and tissue changes, the skin begins to wrinkle and lose water. To date, treatments for facial rejuvenation have been performed primarily by thread techniques. The thread technology is also called as thread-embedding beauty technology or thread-embedding lifting technology, and refers to a beauty surgery technology which can achieve a series of aesthetic effects such as lifting and tightening of sagging tissues, filling of sunken tissues, skin quality improvement, body surface contour shaping and the like by embedding wires in different layers of body surface tissues. The line technology with more clinical and literature reports and higher popularity at present comprises the comprehensive treatment of facial rejuvenation, such as the improvement of loose and drooping skin of the face, the smoothing of wrinkles such as raised lines, eyebrow lines, crow's feet, puppet lines and the like, the improvement of pouches and lacrimal canals, the line technology hump nose and the like. In recent years, the medicine is rapidly popularized in clinic due to simple operation, small wound and quick recovery. However, the number of the pull lines is large, the materials are different, and the existing clinical research evidence is few, so that the effect and the safety of the pull lines are greatly disputed. Once serious complications occur, it becomes extremely difficult to remove the non-absorbable thread. The FDA was also disqualified in 2007 for serious complications of pullout. Later researches mainly focus on how to ensure the treatment effect and reduce the complications, and then the absorbable lifting line is gradually popularized to clinic. With the application of a series of absorbable wires, such as PCL, PGLA, PPDO, etc., the wire-burying promotion has again received much attention. In 2015 for 4 months, the FDA approved absorbable threads for suspension lifting of mid-facial soft tissue. Theoretically, absorbable lines have fewer complications than non-absorbable lines, and even if serious complications occur and the lines cannot be taken out, the absorbable lines can be waited for natural hydrolysis and absorption, so that the absorbable lines are safer in a long term. However, the characteristics of thread technology also lead to complications that are unique, mainly including facial asymmetry in the short term, and line displacement, breakage, exposure, scarring, etc. in the intermediate and long term. Even if it can be absorbed, the longer cycle is a nuisance. In view of the short panels of the current thread lifting technique, we propose a new injection technique combining plastic filling and facial rejuvenation to provide a precisely controlled facial lifting effect, and are named "magic face lift".

Disclosure of Invention

The invention provides an implant for facial beauty lifting and an application thereof, which can stimulate facial collagen regeneration while maximizing the skin beauty improvement effect.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the implant for facial cosmetology lifting is a microsphere filler, and a material system of the microsphere filler is prepared from the following raw materials in parts by mass: 10-40 parts of microsphere material solid; 5-20 parts of a suspension stabilizer; 2-10 parts of a lubricant; 65-90 parts of a mobile phase; and 90-360 parts of a diluting component.

Further, the microsphere material solid is selected from at least one of the following materials: the collagen-based facial tissue repair material is characterized by comprising hydroxyapatite calcium microspheres (CaHA), poly-L-lactic acid microspheres (PLLA), polycaprolactone microspheres (PCL), Polymethyl Methacrylate Microspheres (PMMA), human Casein calcium microspheres (Ca & Casein) and polylactic acid-glycolic acid copolymer microspheres (PLGA), wherein the diameters of the microspheres are within the range of 5um to 75um, and the generation of human facial collagen is stimulated through the specific biological characteristics of the material.

Further, the suspension stabilizer is sodium alginate, sodium carboxymethylcellulose or sodium hydroxypropyl cellulose, and the materials can generate a high-viscoelasticity gel material for suspending the stable microsphere material when dissolved in a mobile phase.

Further, the lubricant is at least one of the following materials: mannitol, glycerol and a lubricating microsphere system formula are adopted, so that the injection thrust is reduced.

Further, the mobile phase is water for injection, (pig, cattle, fish, human-like gene recombination type I, type III) collagen, sodium hyaluronate, and the materials are matched with a suspension stabilizer for bearing and uniformly dispersing microsphere materials.

The microsphere filler system has the characteristic of high viscosity, is easy to shape when being vertically injected into the area above a periosteum, and can continuously play roles in filling volume and stimulating collagen regeneration after the medium-slow degradation or non-degradation (PMMA) of the microsphere filler system is absorbed by a human body.

Furthermore, the dilution component is injection water or normal saline containing low-concentration sodium hyaluronate and 2% lidocaine, is used for diluting the high-concentration microsphere filler, is used for being paved below facial dermis by reducing the concentration, and does not generate nodules.

Further, the method for diluting the microsphere filler comprises the following steps: mixing and diluting the microsphere filler with normal saline or 2% lidocaine at a dilution ratio of 1:1 to 1: 4.

Use of an implant for cosmetic lifting of the face as mentioned hereinbefore for cosmetic application to the skin for non-therapeutic purposes.

The method for performing facial shaping on the microsphere filler comprises the following steps:

dividing the specific area of the face to form the following specific points: the injection filling device comprises points E, T, Z, A and N, wherein the point E is located in a bony depression region on the outer side of the tail of the eyebrow, the point T is located in a temple region, the point Z is located in a zygomatic crest region below the tail of the eye, the area A is an anterior inner cheek region below an orbit, and the area N is a nasal fundus region.

Further, the specific steps of injecting and filling the point E are as follows: the microsphere filler is injected by a sharp needle perpendicular to the outer side of the brow tail, and the dosage of one side is 0.2-1.6 ml, so that the promotion of the brow tip and the tail of the eye is realized.

Further, the specific steps of injecting and filling the T point are as follows: the microsphere filler is injected by a sharp needle perpendicular to the temple, and the dosage of one side of the microsphere filler is 0.3-3.0 ml, so that the depression of the area is improved, and the plumpness and outline fullness of the temple are realized.

Further, the specific steps of injecting and filling the Z point are as follows: the microsphere filler is injected by a sharp needle perpendicular to the zygomatic junction below the tail of the eye, and one side of the microsphere filler is 0.5-3.0 ml for improving the front contour line and plumping the apple muscle.

Further, the specific steps of injecting and filling the point A are as follows: the microsphere filler is injected by a sharp needle perpendicular to the anterior-medial area of the infraorbital cheek, and one side of the microsphere filler is 0.3-3.0 ml for improving the dark eye circles and realizing the natural transition of the cheek.

Further, the specific steps of injecting and filling the N points are as follows: the microsphere filler is injected by a sharp needle perpendicular to the nasal fundus, and one side of the microsphere filler is measured to be 0.5-5.0 ml, so that the microsphere filler is used for improving the grain caused by aging of the eyes.

A novel injection method matched with the use of microsphere injection filling agents comprises the following steps:

dividing the specific area of the face to form the following specific points: the nasal cavity injection device comprises an M area, a P area and a C area, wherein the M area is positioned in a lower jaw angle area on the side, the P area is positioned in an area where the outer edge of a nostril is vertical to the lower jaw anterior sulcus, the C area is positioned in a side cheek area below a zygomatic crest, and the M area, the P area and the C area are respectively used as injection points to be diluted and spread.

In a novel injection method matched with the use of microsphere injection filling agents, the specific steps of injecting and tiling an M area are as follows: the opening was made at point M using a 23G sharp needle, then entered through the opening using a 25G blunt needle, and was tiled backwards in a fan-like fashion using 0.5ml to 6ml for skin laxity and wrinkle improvement in the mandibular angle region.

In a novel injection method matched with the use of microsphere injection filling agents, the concrete steps of injecting and tiling a P area are as follows: opening at a point P by using a 23G sharp needle, then entering through the opening by using a 25G blunt needle, and reversely tiling in a fan-shaped manner, wherein the tiling usage amount is 1-6 ml, and the method is used for improving the corner lines.

In a novel injection method matched with the use of microsphere injection filling agents, the concrete steps of injecting and tiling a region C are as follows: and (3) opening the point C by using a 23G sharp needle, then entering the point C through the opening by using a 25G blunt needle, and reversely tiling in a fan-shaped mode, wherein the usage amount of tiling is 0.5-6 ml on each side, so that the cheek skin is pulled and tightened, the natural transition from the cheekbone to the nasal base is realized, and the sharp feeling of the cheekbone high point is reduced.

The invention is helpful to promote the contour line and stimulate the regeneration of facial collagen, realize the facial rejuvenation and better solve the problems of the relaxation and the wrinkles of the upper middle part of the face.

The invention is beneficial to improving the contour lines of the zygomatic process and the mandibular angle, simultaneously, stimulating the regeneration of facial collagen, and improving the problems of facial lines, statutory lines, facial laxity and the like caused by facial aging.

Drawings

Fig. 1 is a schematic diagram of a facial injection filling method according to an embodiment of the present invention.

Fig. 2 is a schematic diagram of a face injection tiling method according to an embodiment of the present invention.

Fig. 3 is a view showing a facial effect before the implant for facial cosmetic lifting provided by the present invention is used.

Fig. 4 is a diagram of facial effects after using the implant for facial cosmetic lifting provided by the present invention.

Fig. 5 is a graph showing effects 1 week after using the implant for facial cosmetic lifting provided by the present invention.

Detailed Description

The technical solution adopted by the present invention will be further explained with reference to the schematic drawings.

Example 1: the implant for facial cosmetology lifting is a microsphere filler, and a material system of the microsphere filler is prepared from the following raw materials in parts by mass: 10 parts of microsphere material solid; 5 parts of a suspension stabilizer; 2 parts of a lubricant; 65 parts of a mobile phase; and 90 parts of a diluting component.

The microsphere material solid is hydroxyapatite calcium microsphere.

The suspension stabilizer is sodium alginate.

The lubricant is mannitol.

The mobile phase is sodium hyaluronate.

The diluent component contains low-concentration sodium hyaluronate.

Example 2: the implant for facial cosmetology lifting is a microsphere filler, and a material system of the microsphere filler is prepared from the following raw materials in parts by mass: 13 parts of microsphere material solid; 8 parts of a suspension stabilizer; 5 parts of a lubricant; 68 parts of a mobile phase; and 93 parts of a diluent component.

The microsphere material solid is a poly-L-lactic acid microsphere.

The suspension stabilizer is sodium carboxymethyl cellulose.

The lubricant is glycerol.

The mobile phase is water for injection.

The dilution component is 2% lidocaine in water for injection.

Example 3: the implant for facial cosmetology lifting is a microsphere filler, and a material system of the microsphere filler is prepared from the following raw materials in parts by mass: 18 parts of microsphere material solid; 13 parts of a suspension stabilizer; 10 parts of a lubricant; 73 parts of a mobile phase; 98 portions of diluted components.

The microsphere material solid is polycaprolactone microsphere.

The suspension stabilizer is sodium hydroxypropyl cellulose.

The lubricant is mannitol.

The dilution composition is physiological saline.

Example 4: the material system of the microsphere filler is prepared from the following raw materials in parts by mass: 35 parts of microsphere material solid; 20 parts of a suspension stabilizer; 9 parts of a lubricant; 80 parts of a mobile phase; 100 parts of diluted components.

The microsphere material solid is polymethyl methacrylate microsphere, and can also be human casein calcium microsphere or polylactic acid-glycolic acid copolymer microsphere.

The suspension stabilizer is sodium carboxymethyl cellulose.

The lubricant is glycerol.

The mobile phase is (pig, cattle, fish, human gene recombination type I, type III) collagen.

The dilution component is 2% lidocaine in water for injection.

Example 5: for the case of moderate to mild mid-upper facial laxity, we provide mainly 5 areas of periorbital sites, including 4 fixed-point filling sites and 1 dilution tiled area, see fig. 1, respectively:

e, point: injecting and filling the glabellar tail part and the upper part of a periosteum vertically, wherein the filling agent is a hydroxyapatite calcium microsphere hydrogel system or a human casein calcium microsphere hydrogel system, the injection needle head is a 27G sharp needle, and the volume of one side of the injection needle head is 0.2-0.6 ml, so that the eyebrow tip can be lifted.

And point T: the temple position and the deep layer of the temporalis are vertically injected and filled, the filling agent is a hydroxyapatite calcium microsphere hydrogel system or a human casein calcium microsphere hydrogel system, the injection needle head is a 27G sharp needle, and one side of the injection needle head is 0.3-1.0 ml, so that the injection needle is used for filling the temple to ensure that the outline is fuller.

Point Z: the zygomatic process part and the upper part of periosteum are injected and filled vertically, the filling agent is a hydroxyapatite calcium microsphere hydrogel system or a human casein calcium microsphere hydrogel system, an injection needle head is a 27G sharp needle, and one side of the injection needle head is 0.5-1.5 ml, so that the injection needle is used for improving the front contour line and plumping apple muscles.

And (B) point A: the filling agent is a hydroxyapatite calcium microsphere hydrogel system or a human casein calcium microsphere hydrogel system, the injection needle head is a 27G sharp needle, and the volume of one side of the injection needle is 0.3-0.8 ml.

And a C region: in the cheek area, 2ml of a hydroxyapatite calcium microsphere hydrogel system or a human casein calcium microsphere hydrogel system is fully mixed with 2% lidocaine or normal saline for dilution, a 23G sharp needle is used for opening at a point M, then a 25G blunt needle is used for entering through the opening, the mixture is reversely tiled at the corium layer and below the corium layer in a fan-shaped mode according to the direction shown in figure 2, the tiling usage amount is 1.5 ml-3 ml per side, the cheek area is used for lifting and tightening cheek skin, natural transition from cheeks to nasal bases is achieved, and the sharp feeling of high points of the cheekbones is reduced.

The scheme of injection filling and dilution tiling of the middle and upper face provided by the embodiment is beneficial to stimulating the regeneration of facial collagen while lifting the contour line, realizing facial rejuvenation and better solving the problems of looseness and wrinkles of the middle and upper face.

Example 6: for the mild to moderate cases of mid-lower laxity, we provide mainly 6 regions of the cheek region, including 3 site-specific filling sites and 3 dilution tiling regions, respectively:

point Z: the zygomatic process part and the upper part of periosteum are injected and filled vertically, the filling agent is a polycaprolactone microsphere hyaluronic acid system or a polymethyl methacrylate microsphere collagen system, the injection needle head is a 27G sharp needle, and one side of the injection needle head is 0.5-1.5 ml, so that the injection needle is used for improving the front contour line and plumping the apple muscle.

And (B) point A: the inner side area before cheek and above periosteum are injected and filled vertically, the filling agent is a polycaprolactone microsphere hyaluronic acid system or a polymethyl methacrylate microsphere collagen system, the injection needle head is a 27G sharp needle, one side of the injection needle head is 0.3-0.8 ml, and the filling at the position can improve the black eye ring and realize the natural transition from the nose to the zygomatic process.

And N point: the nasal base and the upper part of the periosteum are vertically injected and filled, the filling agent is a polycaprolactone microsphere hyaluronic acid system or a polymethyl methacrylate microsphere collagen system, the injection needle head is a 27G sharp needle, and the dosage of one side of the injection needle head is 0.5-1.5 ml, so that the nasal spray is used for improving the statute lines caused by aging of the face.

Before dilution, spreading and injection, the polycaprolactone microsphere hyaluronic acid system or the polymethyl methacrylate microsphere collagen system and the low-concentration sodium hyaluronate are fully mixed and diluted according to the proportion of 1:3

And a C region: and in the cheek area on the side, a sharp needle of 23G is used for opening at a point C, then a blunt needle of 25G is used for entering through the opening, and the cheek area and the lower part of the cheek area are reversely and flatly paved in a fan-shaped mode according to the direction of the figure 2, wherein the flatly paved usage amount is 1.5-3 ml on each side, and the cheek area is used for lifting and tightening cheek skin, so that the natural transition from a cheek projection to the base of a nose is realized, and the sharp feeling of the high point of the cheek bone is reduced.

And an M region: in the mandibular angle region, the opening was made at point M using a 23G sharp needle, then accessed through the opening using a 25G blunt needle, and the skin was tiled back up in the dermis and below in a fan-like fashion in the direction of figure 2 using 1.5ml to 3ml per side for laxity and wrinkle improvement in the mandibular angle region.

And a P region: in the anterior sulcus area of the lower jaw of the mouth corner, a 23G sharp needle is used for opening at a point P, then a 25G blunt needle is used for entering through the opening, and the mouth corner is reversely paved in a fan-shaped mode according to the direction of the graph 2, wherein the paving usage amount is 1 ml-2 ml on each side, and the mouth corner wrinkle improvement and the skin tightening are realized.

The scheme of injection filling and dilution tiling of the middle and lower faces provided by the embodiment is beneficial to lifting the contour lines of the zygomatic process and the mandibular angle, and simultaneously, the scheme stimulates the regeneration of facial collagen and solves the problems of facial lines, statute lines, facial looseness and the like caused by facial aging.

In view of the above embodiments, the present invention provides specific embodiments of a specific lifting operation, as shown in fig. 3, 4, and 5, which are photographs taken before, after, and after 1 week respectively.

The above description is only a preferred embodiment of the present invention, and does not limit the present invention in any way. It will be understood by those skilled in the art that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. The implant for face beauty treatment lifting is characterized in that the implant is a microsphere filler, and a material system of the microsphere filler is prepared from the following raw materials in parts by mass:

2. the implant for facial cosmetic lift as claimed in claim 1, wherein the microsphere material solid is selected from at least one of the following materials: hydroxyapatite calcium microspheres, poly-L-lactic acid microspheres, polycaprolactone microspheres, polymethyl methacrylate microspheres, calcium-like casein microspheres and polylactic acid-glycolic acid copolymer microspheres.

3. An implant for facial cosmetic lift as claimed in claim 1, wherein the suspension stabilizer is sodium alginate, sodium carboxymethyl cellulose or sodium hydroxypropyl cellulose.

4. An implant for facial cosmetic lift according to claim 1, characterized in that said lubricant is at least one of the following materials: mannitol, glycerol.

5. Implant for facial cosmetic lift, according to claim 1, characterized by the fact that the mobile phase is porcine, bovine, fish, human-like gene recombination type I, type iii collagen or water for injection, sodium hyaluronate.

6. The implant for facial cosmetic lift as set forth in claim 1, wherein the diluting component is water for injection or physiological saline containing sodium hyaluronate at a low concentration, 2% lidocaine.

7. The implant for facial cosmetic lifting as set forth in claim 1, wherein the microsphere-based filler is diluted by a method comprising: mixing and diluting the microsphere filler with normal saline or 2% lidocaine at a dilution ratio of 1:1 to 1: 4.

8. Use of an implant according to any one of claims 1 to 7 for the cosmetic treatment of skin for non-therapeutic purposes.

9. The method for performing facial shaping on the microsphere filler is characterized by comprising the following steps of:

10. The method of claim 9, wherein the step of filling the injection site with E comprises the steps of: the microsphere filler is injected by a sharp needle perpendicular to the outer side of the brow tail, and the dosage of one side is 0.2-1.6 ml, so that the promotion of the brow tip and the tail of the eye is realized.

11. The method according to claim 9, wherein the injection filling of the T-point comprises the following specific steps: the microsphere filler is injected by a sharp needle perpendicular to the temple, and the dosage of one side of the microsphere filler is 0.3-3.0 ml, so that the depression of the area is improved, and the plumpness and outline fullness of the temple are realized.

12. The method of claim 9, wherein the step of filling the Z-site by injection comprises the steps of: the microsphere filler is injected by a sharp needle perpendicular to the zygomatic junction below the tail of the eye, and one side of the microsphere filler is 0.5-3.0 ml for improving the front contour line and plumping the apple muscle.

13. The method of claim 9, wherein the injection filling of point a comprises the following specific steps: the microsphere filler is injected by a sharp needle perpendicular to the anterior-medial area of the infraorbital cheek, and one side of the microsphere filler is 0.3-3.0 ml for improving the dark eye circles and realizing the natural transition of the cheek.

14. The method according to claim 9, wherein the specific steps of injecting and filling the N points are as follows: the microsphere filler is injected by a sharp needle perpendicular to the nasal fundus, and one side of the microsphere filler is measured to be 0.5-5.0 ml, so that the microsphere filler is used for improving the grain caused by aging of the eyes.

15. A novel injection method matched with microsphere injection filling agents is characterized by comprising the following steps:

16. The method of claim 15, wherein the step of injection tiling the M-zone comprises: the opening was made at point M using a 23G sharp needle, then entered through the opening using a 25G blunt needle, and was tiled backwards in a fan-like fashion using 0.5ml to 6ml for skin laxity and wrinkle improvement in the mandibular angle region.

17. The method of claim 15, wherein the step of injection tiling the P-zones comprises: opening at a point P by using a 23G sharp needle, then entering through the opening by using a 25G blunt needle, and reversely tiling in a fan-shaped manner, wherein the tiling usage amount is 1-6 ml, and the method is used for improving the corner lines.

18. The method of claim 15, wherein the step of injection tiling zone C comprises: and (3) opening the point C by using a 23G sharp needle, then entering the point C through the opening by using a 25G blunt needle, and reversely tiling in a fan-shaped mode, wherein the usage amount of tiling is 0.5-6 ml on each side, so that the cheek skin is pulled and tightened, the natural transition from the cheekbone to the nasal base is realized, and the sharp feeling of the cheekbone high point is reduced.