CN111743946B

CN111743946B - Inhalant composition capable of refreshing and resisting fatigue, inhalant and preparation method

Info

Publication number: CN111743946B
Application number: CN202010542999.8A
Authority: CN
Inventors: 徐雅意; 林涛; 滕晖; 蒋加拉
Original assignee: Qianjin Pharmaceutical Co ltd
Current assignee: Qianjin Pharmaceutical Co ltd
Priority date: 2020-06-15
Filing date: 2020-06-15
Publication date: 2022-11-04
Anticipated expiration: 2040-06-15
Also published as: CN111743946A

Abstract

The invention belongs to the technical field of daily necessities, and particularly relates to a refreshing and anti-fatigue inhalant composition, an inhalant and a preparation method. The inhalant composition is composed of turpentine, menthol, eucalyptus globulus oil, tiled gaultheria leaf oil, camphor, sweet orange oil and camphor leaf extract according to a certain proportion, and all the components have synergistic effect, so that the inhalant composition can have remarkable and lasting refreshing and anti-fatigue effects even if the inhalant is inhaled through the nose and does not directly contact with the skin, has strong penetrability and richer fragrance types, and is widely accepted and favored in human trial experiments.

Description

Inhalant composition capable of refreshing and resisting fatigue, inhalant and preparation method

Technical Field

The invention belongs to the technical field of daily necessities. More particularly, relates to an inhalant composition for refreshing and resisting fatigue, an inhalant and a preparation method thereof.

Background

With the rapid development of modern economy and the increasing acceleration of life rhythm, the influence of various factors such as study working pressure, social competition, environmental pollution, season change, dietary structure change, diseases, insomnia and the like is increased, the number of people suffering from various fatigue such as lassitude, weakness, fullness in head, amnesia and the like in people in recent years is increased day by day, and the people are especially long-distance bus drivers, employees working out at night, insomnia patients, students studying for a long time and the like. Therefore, there is an urgent need to improve the sub-health conditions of modern people, such as fatigue, drowsiness, feelings of loss, and inattention, caused by various stresses faced by the modern people in work, study, and life.

At present, most of people who improve fatigue state can refresh by drinking coffee, tea, functional beverage and the like, caffeine contained in the tea can achieve the effects of exciting central nerve, improving brain activity and eliminating fatigue, but the problems of continuously exciting people, penetrating physical energy and addiction exist, and various body discomfort or diseases can be induced after long-term eating. In addition to anti-fatigue beverages, people also commonly use essential oil products to help refreshing and anti-fatigue, for example, chinese patent application CN101879216a discloses a compound natural essential oil with refreshing function, which is prepared from lemon oil, sweet orange oil, rosemary oil, mint essential oil and other components, and has pleasant fragrance and remarkable refreshing effect when in use, but the essential oil products need to be smeared on the skin when in use, so that the skin of a user is easily greasy and heavy, and skin allergy can be caused; chinese patent application CN104815100A discloses a composition with refreshing effect, which is prepared from mint essential oil, lemon essential oil, cassia twig essential oil, wild chrysanthemum flower essential oil and grassleaf sweelflag rhizome essential oil, has good refreshing effect, is beneficial to relieving cachexia, can be prepared into aerosol, spray, nasal inhalant and the like, but when the composition is used as the nasal inhalant, active ingredients do not directly contact with skin, the composition is inhaled only through the nose, the penetrability is weak, the refreshing anti-fatigue effect is small, and the effect is short-lived.

Therefore, there is an urgent need to provide an inhalant composition having strong penetration, a remarkable refreshing and anti-fatigue effect, and a long-lasting effect.

Disclosure of Invention

The invention aims to solve the technical problems that the existing caffeine beverage is low in safety, smearing products are easy to generate discomfort and allergic symptoms, and inhalation products are weak in penetrability and short in effect, and provides an inhalation composition which is strong in penetrability, has remarkable refreshing and anti-fatigue effects and is long in effect.

The invention aims to provide an inhalant composition for refreshing and resisting fatigue.

The invention also aims to provide the application of the composition in preparing daily chemical products or medicines with the refreshing effect.

Another object of the present invention is to provide an inhalant for refreshing and resisting fatigue.

The above purpose of the invention is realized by the following technical scheme:

the inhalant composition for refreshing and resisting fatigue is prepared from the following raw materials in parts by weight: 40-50 parts of turpentine, 5-15 parts of menthol, 4-12 parts of eucalyptus globulus oil, 2-10 parts of spreading beautyberry leaf oil, 2-8 parts of camphor, 2-8 parts of sweet orange oil and 2-8 parts of camphor leaf extract.

In the invention, the turpentine is transparent colorless liquid with fragrance, the main component is terpene, the penetrability is strong, and the turpentine has the effects of promoting blood circulation, resisting bacteria, sterilizing, resisting bronchitis and the like; the menthol is colorless acicular or prismatic crystal or white crystalline powder, has special fragrance of herba Menthae, is cool after initial burning, and has effects of refreshing, relieving itching, diminishing inflammation, relieving pain, promoting blood circulation, etc.; the Eucalyptus globulus Labill oil is clear and transparent, has fresh and penetrating odor, has special woody fragrance of Camphora, contains eucalyptol, linalool, camphora, anethole terpene, and pomelo terpene as main ingredients, and has effects of refreshing, improving skin, and relieving pain; spreading folium Callicarpae Formosanae oil (also called wintergreen oil) which is colorless or yellowish transparent oily liquid, has folium Ilicis Purpureae fragrance, and has antibacterial, insecticidal and antioxidant effects; the camphor is white crystalline powder or colorless transparent hard blocks, has specific penetrating aroma, tastes spicy and cool, has the main component of the dextrocamphor, and has the advantages of cool stimulation, easy absorption and the like; the sweet orange oil is yellow, orange or yellowish-brown liquid, has special orange smell and mild aromatic taste, mainly contains d-limonene, decanal, hexanal, octanol, d-linalool, citral, undecanal, sweet orange aldehyde and the like, and can endow the product with unique fragrance; the folium Cinnamomi Camphorae extract is light yellow powder, and contains Camphora, 1,8-cineole, alpha-terpineol, pinene, geranial, alpha-phellandrene, camphene, neral, etc., and has antibacterial, analgesic, and refreshing effects.

Through a great deal of creative work, the inventor discovers that an inhalant composition which is composed of turpentine, menthol, eucalyptus globulus oil, flat-laid beautyberry leaf oil, camphor, sweet orange oil and camphor leaf extract according to a certain proportion can have remarkable and lasting refreshing and anti-fatigue effects through the synergistic effect of all natural plant components even if the inhalant is inhaled through nose and is not directly contacted with skin, has strong penetrability, can obviously improve the symptoms of fatigue, sleepiness, low mood, inattention and the like of fatigue crowds, enables brains to keep vitality and clear-headed, relieves mood and improves attention.

Preferably, the raw materials for preparing the inhalant composition comprise the following components in parts by weight: 42 to 46 parts of turpentine, 8 to 12 parts of menthol, 5 to 10 parts of eucalyptus globulus oil, 4 to 8 parts of spreading beautyberry leaf oil, 3 to 6 parts of camphor, 3 to 6 parts of sweet orange oil and 3 to 6 parts of camphor leaf extract.

More preferably, the raw materials for preparing the inhalant composition comprise the following components in parts by weight: 45 parts of turpentine, 10 parts of menthol, 7 parts of eucalyptus globulus oil, 6 parts of platyphylla leaf oil, 5 parts of camphor, 5 parts of sweet orange oil and 5 parts of camphor tree leaf extract.

Further, the preparation raw materials of the inhalant composition also comprise the following components in parts by weight: 1 to 6 parts of cassia oil, 1 to 5 parts of patchouli oil, 1 to 5 parts of citrus peel extract, 0.2 to 2 parts of rosemary leaf oil, 0.2 to 2 parts of lemon peel oil, 0.2 to 2 parts of citral, 0.2 to 2 parts of citronellol, 0.2 to 2 parts of litsea cubeba oil, 0.2 to 2 parts of clove oil, 0.2 to 2 parts of lysimachia foenum-graecum extract, 0.2 to 2 parts of artificial musk, 0.2 to 2 parts of amyl acetate and 0.2 to 2 parts of ethyl acetate.

In practice, the inhalant composition is found to be added with the components such as cassia oil, patchouli oil, citrus peel extract and the like, so that the fragrance of each component can be fused and coordinated with each other, the traditional single fragrance type inhalant composition is richer in fragrance, and the inhalant composition is widely accepted and favored in human trial experiments.

Preferably, the raw materials for preparing the inhalant composition also comprise the following components in parts by weight: 1 to 4 parts of cassia oil, 1 to 3 parts of patchouli oil, 1 to 3 parts of citrus peel extract, 0.5 to 2 parts of rosemary leaf oil, 0.5 to 2 parts of lemon peel oil, 0.5 to 2 parts of citral, 0.5 to 2 parts of citronellol, 0.5 to 2 parts of litsea cubeba oil, 0.5 to 2 parts of clove oil, 0.5 to 2 parts of lysimachia foenum-graecum extract, 0.5 to 2 parts of artificial musk, 0.2 to 1 part of amyl acetate and 0.2 to 1 part of ethyl acetate.

More preferably, the raw materials for preparing the inhalant composition also comprise the following components in parts by weight: 3 parts of cassia oil, 2 parts of patchouli oil, 2 parts of citrus peel extract, 1 part of rosemary leaf oil, 1 part of lemon peel oil, 1 part of citral, 1 part of citronellol, 1 part of litsea cubeba oil, 1 part of clove oil, 1 part of lysimachia foenum-graecum extract, 1 part of artificial musk, 1 part of amyl acetate and 1 part of ethyl acetate.

The application of the composition in preparing daily chemical products or medicines with the effects of refreshing and restoring consciousness also falls into the protection scope of the invention. Meanwhile, different types of daily chemical product auxiliary materials or medicine auxiliary materials can be added to prepare various products. Such as inhalants, etc.

In addition, the invention also provides a refreshing and anti-fatigue inhalant which takes the composition as a main active ingredient.

Further, the inhalant also comprises auxiliary materials which are allowed to be added in the pharmaceutical or cosmetic field.

Still further, the adjuvants include a solvent, a solubilizer, a penetration enhancer and an antioxidant.

Further, the preparation method of the inhalant comprises the following steps:

mixing the raw materials, stirring, filtering, adsorbing on fiber rod, assembling, inspecting, and packaging.

Further, the fiber rod is polyethylene terephthalate resin or low density polyethylene.

The invention has the following beneficial effects:

the refreshing and anti-fatigue inhalant composition is composed of turpentine, menthol, eucalyptus globulus oil, tiled gaultheria oil, camphor, sweet orange oil and camphor tree leaf extract according to a certain proportion, all the components have synergistic effect, even if the composition is inhaled through nose and does not directly contact skin, the refreshing and anti-fatigue inhalant composition can also have remarkable and lasting refreshing and anti-fatigue effects, has strong penetrability and richer fragrance, and is widely accepted and favored in human trial experiments.

Detailed Description

The present invention will be further described with reference to the following specific examples, which are not intended to limit the invention in any manner. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.

Unless otherwise indicated, reagents and materials used in the following examples are commercially available.

Example 1 an inhalant for refreshing and relieving fatigue

The inhalant for refreshing and resisting fatigue is prepared from the following components in parts by weight:

45 parts of turpentine, 10 parts of menthol, 7 parts of eucalyptus globulus oil, 6 parts of phyllanthus urinaria leaf oil, 5 parts of camphor, 5 parts of sweet orange oil, 5 parts of camphor leaf extract, 3 parts of cinnamon oil, 2 parts of patchouli oil, 2 parts of citrus peel extract, 1 part of rosemary leaf oil, 1 part of lemon peel oil, 1 part of citral, 1 part of citronellol, 1 part of litsea cubeba oil, 1 part of clove oil, 1 part of lysimachia foenum-graecum extract, 1 part of artificial musk, 1 part of amyl acetate and 1 part of ethyl acetate.

The preparation method comprises the following steps:

Example 2 an inhalant for refreshing and relieving fatigue

40 parts of turpentine, 15 parts of menthol, 12 parts of eucalyptus globulus oil, 10 parts of phyllanthus urinaria leaf oil, 2 parts of camphor, 2 parts of sweet orange oil, 8 parts of camphor leaf extract, 6 parts of cinnamon oil, 1 part of patchouli oil, 5 parts of citrus peel extract, 2 parts of rosemary leaf oil, 2 parts of lemon peel oil, 2 parts of citral, 0.2 part of citronellol, 0.2 part of litsea cubeba oil, 0.2 part of clove oil, 0.2 part of lysimachia foenum-graecum hance extract, 2 parts of artificial musk, 0.2 part of amyl acetate and 2 parts of ethyl acetate.

The preparation process is referred to example 1.

Example 3 an inhalant for refreshing and relieving fatigue

50 parts of turpentine oil, 5 parts of menthol, 4 parts of eucalyptus globulus oil, 2 parts of bigelia leaf oil, 8 parts of camphor, 8 parts of sweet orange oil, 2 parts of camphor leaf extract, 1 part of cinnamon oil, 5 parts of patchouli oil, 1 part of citrus peel extract, 0.2 part of rosemary leaf oil, 0.2 part of lemon peel oil, 0.2 part of citral, 2 parts of citronellol, 2 parts of litsea cubeba oil, 2 parts of clove oil, 0.2 part of lysimachia foenum-graecum extract, 0.2 part of artificial musk, 2 parts of amyl acetate and 0.2 part of lysimachia foenum-graecum oil

And (3) ethyl acetate.

The preparation method refers to example 1.

Comparative example 1 an inhalant

Comparative example 1 is different from example 1 in that the addition of turpentine is not performed, menthol is increased to 55 parts, and other parameters and operations are referred to example 1.

Comparative example 2 an inhalant

Comparative example 2 is different from example 1 in that menthol was not added, turpentine was added to 55 parts, and other parameters and operations were referred to example 1.

Comparative example 3 an inhalant

Comparative example 3 is different from example 1 in that eucalyptus globulus oil is not added and turpentine is added to 52 parts, and other parameters and operations refer to example 1.

Comparative example 4 an inhalant

Comparative example 4 differs from example 1 in that the addition of Callicarpa kolomikta leaf oil was omitted and turpentine was increased to 51 parts, and other parameters and operations were referred to example 1.

Comparative example 5 an inhalant

Comparative example 5 is different from example 1 in that camphor is not added, turpentine is increased to 50 parts, and other parameters and operations are referred to example 1.

Comparative example 6 an inhalant

Comparative example 6 is different from example 1 in that sweet orange oil is not added and turpentine is added to 50 parts, and other parameters and operations are referred to example 1.

Comparative example 7 an inhalant

Comparative example 7 is different from example 1 in that the camphor tree leaf extract is not added, the turpentine is added to 50 parts, and other parameters and operations refer to example 1.

Test example 1 Effect of inhalant on hypnosis of mice by diphenhydramine

1. Experimental materials: inhalants prepared in examples 1 to 3 and comparative examples 1 to 7.

2. Subject: 110 SPF mice, 20. + -.2 g, male and female halves.

3. The experimental method comprises the following steps:

randomly dividing mice into a model group, examples 1-3 groups and comparative examples 1-7 groups, wherein each group comprises 10 mice, and immediately carrying out inhalation on each group of mice with a corresponding inhalant after each mouse is injected with 0.1mg/kg diphenhydramine subcutaneously, wherein the inhalation amount is 5 mu l, and the model group is given distilled water with the same amount as the inhalation amount; the number of mice that did not fall asleep within 30min and the latency of the mice that fell asleep (time from the injection of diphenhydramine to the falling asleep) were recorded, and the rate of insomnia was calculated.

4. The experimental results are as follows: see table 1.

TABLE 1 Effect of inhalants on hypnosis in mice by diphenhydramine

Group of	Mice not falling asleep (Only)	Rate of non-sleep (%)	Latency (min)
				Model set	0	0	4.12±0.98
Example 1	4	40	17.33±3.64 ^**
				Example 2	3	30	16.95±3.87 ^**
Example 3	4	40	17.06±3.71 ^**
				Comparative example 1	1	10	8.18±3.05 ^*
Comparative example 2	2	20	10.07±2.93 ^*
				Comparative example 3	1	10	8.74±3.36 ^*
Comparative example 4	2	20	9.76±3.17 ^*
				Comparative example 5	1	10	9.41±3.28 ^*
Comparative example 6	2	20	9.87±3.66 ^*
				Comparative example 7	1	10	9.23±2.85 ^*

Note: in comparison with the set of models, ^* P<0.05， ^** P<0.01。

as can be seen from table 1, the inhalant prepared in the embodiments 1 to 3 of the present invention can significantly prolong the time for mice to sleep after injecting diphenhydramine, and even 30 to 40% of mice can not fall asleep, so that the mouse hypnotic effect caused by diphenhydramine can be effectively weakened, the refreshing effect is significant, and the effect is durable; the inhalants prepared in comparative examples 1 to 7 (without turpentine, menthol, eucalyptus globulus oil, kombu leaf oil, camphor, sweet orange oil and camphor leaf extract respectively) have remarkably shortened latency and remarkably reduced insomnia rate.

Test example 2 Effect of inhalant on mouse endurance

2. Subjects: 110 SPF mice, 20. + -.2 g, male and female halves.

3. The experimental method comprises the following steps:

randomly dividing mice into a model group, example 1-3 groups and comparative example 1-7 groups, wherein each group comprises 10 mice, each group of mice smells corresponding inhalants respectively, and the amount of the inhalants is 5 mu l, wherein the model group is provided with distilled water with the same amount of the inhalants; immediately after sniffing, the mice were placed on a rotary rod fatigue tester at a rotation speed of 20r/min, and the time of the mice's movement on the rod (from putting on the rotary rod to falling due to fatigue) was observed and recorded to evaluate the endurance of the mice.

4. The experimental results are as follows: see table 2.

TABLE 2 Effect of inhalants on mouse endurance

Group of	Time of activity on stick (min)
		Model set	2.61±0.58
Example 1	8.22±1.27 ^**
		Example 2	7.89±1.18 ^**
Example 3	8.05±1.42 ^**
		Comparative example 1	4.64±1.05 ^*
Comparative example 2	5.62±1.13 ^*
		Comparative example 3	4.87±1.59 ^*
Comparative example 4	5.11±1.36 ^*
		Comparative example 5	5.05±1.47 ^*
Comparative example 6	5.34±1.21 ^*
		Comparative example 7	4.96±1.65 ^*

Note: in comparison with the set of models, ^* P<0.05， ^** P<0.01。

as can be seen from Table 1, the inhalant prepared in the embodiments 1 to 3 of the present invention can significantly prolong the time of the mouse moving on the rod rotating fatigue apparatus, improve the rod rotating endurance of the mouse, and has a good anti-fatigue effect and a long lasting effect; the mice of the inhalants prepared in comparative examples 1 to 7 (respectively without turpentine, menthol, eucalyptus globulus oil, kombu leaf oil, camphor, sweet orange oil and camphor leaf extract) have remarkably shortened activity time on a rotating rod fatigue tester and weakened anti-fatigue effect.

Test example 3 inhalant stability measurement

After the inhalants in examples 1 to 3 were placed in an incubator with a relative humidity of 75% at 37. + -.1 ℃ for 90 days, whether the sensory properties such as flavor of the inhalant were changed or not was observed, and the influence of the inhalant on the hypnosis of mice by diphenhydramine was measured with reference to example 1, and the experimental results are shown in Table 3.

TABLE 3 Effect of inhalants on hypnosis in mice induced by diphenhydramine after 90 days of storage

Note: in comparison with the set of models, ^* P<0.05， ^** P<0.01。

as can be seen from table 3, the inhalant prepared in the embodiment of the present invention has almost the same refreshing effect after being placed for 90 days, and has good stability, and the sensory properties such as flavor and the like are not significantly different from those of the inhalant when being placed for 0 day.

Test example 4 inhalant fragrance retention test measurement

100 testers were randomly arranged by using a sensory evaluation method, and the inhalants prepared in examples 1 to 3 and comparative examples 1 to 7 were scored; the evaluation method is that the liquid in the inhalant is dipped on the fragrance smelling strip, and each inhalant is tested for three times according to the standard that the fragrance retention time is more than or equal to 0 and less than 1h and 0 minute, the fragrance retention time is more than or equal to 1h and less than 1h and 1-3 minutes, the fragrance retention time is more than or equal to 1h and less than 4h and less than 7h and 4-6 minutes, the fragrance retention time is more than or equal to 7h and less than 10h and 9 minutes, and the fragrance retention time is more than or equal to 10 hours and 10 minutes, and the average value of the three times is taken as the final score, and the adjacent two times are separated by one day. The fragrance retention time test results are shown in table 4.

Table 4 inhalant fragrance retention test assay

Group of	For the first time	For the second time	The third time	Average score
					Example 1	10	10	10	10
Example 2	10	9	10	9.6
					Example 3	9	10	10	9.6
Comparative example 1	9	8	9	8.7
					Comparative example 2	9	8	8	8.3
Comparative example 3	9	9	8	8.7
					Comparative example 4	8	9	8	8.3
Comparative example 5	9	9	10	9.3
					Comparative example 6	9	9	9	9.0
Comparative example 7	10	9	8	9.0

The inhalants prepared in the examples 1 to 3 of the present invention have fused and coordinated flavors, and have a long fragrance-retaining time and a long lasting fragrance, while the inhalants prepared in the comparative examples 1 to 7 have a short fragrance-retaining time.

Test example 5 measurement of indicators of microorganisms and toxic substances in inhalant

The inhalants prepared in examples 1 to 3 were subjected to microbiological and toxic substance index measurement, and the detection indexes are shown in table 5.

TABLE 5 determination of inhalant microorganism and toxic substance indexes

Experimental results show that the inhalants prepared in the embodiments 1-3 completely meet the standard requirements.

Test example 6 trial effect of inhalant on population

1. Test materials: inhalants prepared in examples 1 to 3 and comparative examples 1 to 7 were commercially available inhalants (hydrangea macrophylla, thailand).

2. Test subjects: the volunteers between 20 and 45 years old have symptoms of fatigue, drowsiness, low mood, inattention and the like.

3. The test method comprises the following steps:

the volunteers used the inhalants prepared in examples 1 to 3 and comparative examples 1 to 7 and commercially available inhalants in the case of fatigue, drowsiness, and inattention, and scored from the fragrance, cooling sensation, refreshing effect, duration, and comprehensive experience of the products, respectively, for 1 to 5 points.

4. The experimental results are as follows: see table 6.

TABLE 6 trial Effect for inhalant population

Group of	Fragrance	Feeling of coolness	Refreshing effect	Durability of	Comprehensive experience	Total score
							Example 1	4.8	4.7	4.8	4.6	4.7	23.6
Example 2	4.6	4.5	4.6	4.4	4.5	22.6
							Example 3	4.7	4.6	4.7	4.5	4.6	23.1
Comparative example 1	4.2	4.2	2.8	2.7	3.1	17.0
							Comparative example 2	3.9	3.9	3.6	3.8	3.8	19.0
Comparative example 3	3.6	4.2	3.1	3.3	3.6	17.8
							Comparative example 4	3.7	4.1	3.5	3.7	3.7	18.7
Comparative example 5	4.2	3.8	3.3	3.5	3.7	18.5
							Comparative example 6	3.4	4.2	3.8	3.9	3.6	18.9
Comparative example 7	4.1	3.9	3.4	3.4	3.5	18.3
							Commercially available inhalant	4.2	4.1	3.3	2.5	3.5	17.6

As can be seen from table 6, the inhalants prepared in examples 1 to 3 of the present invention have high scores in the aspects of flavor, cooling feeling, refreshing effect, durability, etc., the total score is over 22 points, and compared with the inhalant sold on the market, the total score is higher, and part of the inhalants react with the test subjects, and the inhalants in examples 1 to 3 also have significant effects of preventing dizziness, carsickness, etc., and are favored by the majority of the test subjects; the inhalants prepared in comparative examples 1 to 7 (without turpentine, menthol, eucalyptus globulus oil, cacumen gaultheriae Galli oil, camphor, sweet orange oil, camphor leaf extract, respectively) had poor effects in fragrance, refreshing effect, persistence, etc., and had low scores.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such modifications are intended to be included in the scope of the present invention.

Claims

1. The inhalant composition for refreshing and resisting fatigue is characterized by being prepared from the following raw materials in parts by weight: 40 to 50 parts of turpentine, 5 to 15 parts of menthol, 4 to 12 parts of eucalyptus globulus oil, 2 to 10 parts of spreading beautyberry leaf oil, 2~8 parts of camphor, 2~8 parts of sweet orange oil, 2~8 parts of camphor leaf extract, 1~6 parts of cinnamon oil, 1~5 parts of patchouli oil, 1~5 parts of citrus peel extract, 0.2 to 2 parts of rosemary leaf oil, 0.2 to 2 parts of lemon peel oil, 0.2 to 2 parts of citral, 0.2 to 2 parts of citronellol, 0.2 to 2 parts of litsea cubeba oil, 0.2 to 2 parts of clove oil, 0.2 to 2 parts of lysimachia foenum-graecum extract, 0.2 to 2 parts of artificial musk, 0.2 to 2 parts of amyl acetate and 0.2 to 2 parts of ethyl acetate.

2. The inhalant composition according to claim 1, wherein the inhalant composition is prepared from the following components in parts by weight: 42 to 46 parts of turpentine, 8 to 12 parts of menthol, 5 to 10 parts of eucalyptus globulus oil, 4~8 parts of beautyberry leaf oil, 3~6 parts of camphor, 3~6 parts of sweet orange oil, 3~6 parts of camphor leaf extract, 1~4 parts of cinnamon oil, 1~3 parts of patchouli oil, 1~3 parts of orange peel extract, 0.5 to 2 parts of rosemary leaf oil, 0.5 to 2 parts of lemon peel oil, 0.5 to 2 parts of citral, 0.5 to 2 parts of citronellol, 0.5 to 2 parts of litsea cubeba oil, 0.5 to 2 parts of clove oil, 0.5 to 2 parts of vanilla extract, 0.5 to 2 parts of artificial musk, 0.2 to 1 part of amyl acetate and 0.2 to 1 part of ethyl acetate.

3. Use of the composition of claim 1 or 2 for the preparation of a daily chemical product or a pharmaceutical product having a refreshing and anti-fatigue effect.

4. An inhalant for refreshing and relieving fatigue, which comprises the composition according to claim 1 or 2 as an active ingredient.

5. The inhalant as claimed in claim 4, wherein the inhalant further comprises excipients which are pharmaceutically or cosmetically acceptable for addition.

6. The inhalant as claimed in claim 4 or 5, wherein the inhalant is prepared by a method comprising the steps of:

7. The inhalant as claimed in claim 6, wherein the fiber rod is polyethylene terephthalate resin or low density polyethylene.