CN109260255A - A kind of woody compound sunstroke prevention essential oil and preparation method thereof - Google Patents
A kind of woody compound sunstroke prevention essential oil and preparation method thereof Download PDFInfo
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- CN109260255A CN109260255A CN201811400764.4A CN201811400764A CN109260255A CN 109260255 A CN109260255 A CN 109260255A CN 201811400764 A CN201811400764 A CN 201811400764A CN 109260255 A CN109260255 A CN 109260255A
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- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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Abstract
The invention discloses a kind of woody compound sunstroke prevention essential oils, including walnut peel extract and walnut leaf extracts, preparation method includes: by the raw material cleaning including green peel of walnut and Walnut Leaves, it is broken, it is successively extracted respectively with ether and ethyl alcohol, after gained extracting solution removes solvent, is dissolved and mixed with ethyl alcohol.Using the bioactive substance extracted in green peel of walnut and Walnut Leaves as sunstroke prevention component, the appearance of heatstroke sign can be inhibited, reach excellent anti-heatstroke and relieving summer-heat effect, while irritation is small, be easy to be received and absorbed by human body.
Description
Technical field
The present invention relates to the separation and Extraction field of natural products more particularly to a kind of woody compound sunstroke prevention essential oil and its preparations
Method.
Background technique
Body heat regulation dysfunction is easily caused under high temperature environment, the diseases such as profuse sweating, thirsty, out of strength, dizzy, uncomfortable in chest occurs
Shape, as heatstroke tendency.Rise sharply in temperature and when extreme temperatures, easily further cause fever, skin burns, Nausea and vomiting,
The heatstrokes symptoms such as blood pressure decline, especially for puerpera, the elderly and weak crowd.
As handled not in time after there is heatstroke, human body can be caused greatly to injure, serious person even can jeopardize people
Life.Therefore, as can inhibiting the generation of heatstroke symptom from source, the quantity of heatstroke patient will be greatly reduced, avoids heatstroke to strong
Health generates damage.This method is inconvenient for use, is easy to interfere patient's rest, increases nursing work load.To overcome this defect, one
Kind effective method be using can effective sunstroke prevention drug, the generation of heatstroke symptom is reduced from source.Patent application publication is said
Bright book CN103565927A discloses a kind of Heatstroke-preventiomasking masking liquid formula, including camphor 0.2-1.2%, peppermint oil 1.2-1.7%, eucalyptus
Leaf oil 1.1-1.6%, cassia bark 0.4-0.9%, edible ethanol 72.4-75.3%, remaining as pure water.Though having certain sunstroke prevention
Effect, but camphor smell is stronger, and has certain irritation, easily causes discomfort after use.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of woody compound sunstroke prevention essential oils, using green peel of walnut and core
The collocation of peach leaf extract, can be realized the effect of refreshing the mind and maintain body eubolism in hot weather, reaches anti-heatstroke
Purpose.The preparation method of the woody compound sunstroke prevention essential oil is also provided.
To achieve the above object, Ben Fa the technical solution adopted is that:
A kind of woody compound sunstroke prevention essential oil, including walnut peel extract and walnut leaf extracts.
Green peel of walnut is a thick layer pericarp outside walnut, at present isolated many validations from green peel of walnut
Substance such as juglone, phenolic acid class, polysaccharide and Diarylheptanoids etc. is learned, is not only had good antitumor, antibacterial etc. living
Property, and there are also very strong insecticidal activity, pesticide, chemical fertilizer, drug, cosmetics, in terms of have potential application
Prospect.In addition to above-mentioned application, inventors have found that walnut peel extract also has the effect of preferable sunstroke prevention, such as wherein
Quinones substance there is nervous centralis sedation well, additionally containing the steroid for playing regulation and control to vital movement
Body class compound, advantageously reduces sendible temperature, maintains normal organism metabolism function.
Walnut Leaves are same containing effective containing bioactive substances such as kernel feature space, walnut glucoside, tannin, flavonoids, phytosterols
Anti- heatstroke active component, arrange in pairs or groups with the active principle in green peel of walnut, can obviously inhibit the appearance of heatstroke sign, realize in anti-
Heat purpose.
Preferably, the weight ratio of the walnut peel extract and walnut leaf extracts is 0.1~20:0.1~20.
It preferably, further include mint extract, Anoectochilus, chrysanthemum extract.
Most preferably, the walnut peel extract, walnut leaf extracts, mint extract, Anoectochilus, chrysanthemum
The mass ratio of extract is 0.1~10:0.1~10:0.1~10:0.1~10:0.1~10.
Preferably, further include ethyl alcohol, play dilution walnut peel extract and walnut leaf extracts and Physical temperature-lowering
Effect.It is highly preferred that the mass percent concentration of the ethyl alcohol is 60-80%.
A kind of preparation method of woody compound sunstroke prevention essential oil, comprising steps of
Raw material cleaning, is crushed, is successively extracted respectively with ether and ethyl alcohol, after gained extracting solution removes solvent, respectively
The ether extract and ethanol extract of each raw material are obtained, the ether extract of all raw materials and ethanol extract ethyl alcohol is molten
Solution mixes, and obtains the woody compound sunstroke prevention essential oil；The raw material includes green peel of walnut and Walnut Leaves.
Preferably, the raw material further includes peppermint, roxburgh anoectochilus terminal bud and chrysanthemum.
It is furthermore preferred that the extracted by ether of the ether extract of the ether extract of the green peel of walnut, Walnut Leaves, peppermint
The ethyl alcohol extraction of object, the ether extract of roxburgh anoectochilus terminal bud, the ether extract of chrysanthemum, the ethanol extract of green peel of walnut, Walnut Leaves
Object, the ethanol extract of peppermint, the ethanol extract of roxburgh anoectochilus terminal bud, chrysanthemum ethanol extract be in mass ratio 0.1~5:0.1~
5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5 is compounded.
Preferably, 20~40 DEG C of the Extracting temperature of the ether, extraction time are 1~3 hour, the extraction temperature of the ethyl alcohol
60~90 DEG C of degree, extraction time are 2~4 hours.
Preferably, the extracting solution removes solvent at vacuum degree 0.01-0.99MPa, 1~40 DEG C of temperature.
Preferably, the mass percent concentration of the ethyl alcohol is 60-80%.
The beneficial effects of the present invention are:
The present invention is creatively using the bioactive substance extracted in green peel of walnut and Walnut Leaves as sunstroke prevention component, energy
The appearance for inhibiting heatstroke sign, reaches excellent anti-heatstroke and relieving summer-heat effect, while irritation is small, is easy to be received and inhaled by human body
It receives.It further arranges in pairs or groups, can further improve with mint extract, Anoectochilus and chrysanthemum extract with relieving summer-heat effect
Sunstroke prevention effect, and can assign product unique faint scent.
Specific embodiment
The present invention will be described in detail With reference to embodiment.It should be understood that described herein
Specific embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
Embodiment 1
(1) prepared by coarse fodder: acquiring fresh walnut Chinese olive, walnut leaf, peppermint, roxburgh anoectochilus terminal bud, chrysanthemum respectively, cleaning is dry
Only, by walnut Chinese olive peeling, green peel of walnut is obtained, then respectively by green peel of walnut, walnut leaf, peppermint, roxburgh anoectochilus terminal bud, chrysanthemum powder
It is broken, obtain green peel of walnut coarse fodder, walnut leaf coarse fodder, peppermint coarse fodder, roxburgh anoectochilus terminal bud coarse fodder, chrysanthemum coarse fodder.
(2) prepared by extract: first using ether respectively to green peel of walnut coarse fodder, walnut leaf coarse fodder, peppermint coarse fodder, gold thread
Lotus coarse fodder, chrysanthemum coarse fodder extract, and 1 hour extraction time, 40 DEG C of Extracting temperature, obtain corresponding ether extracted liquid, then divide
It is other that ethyl alcohol extraction is carried out to material, 4 hours extraction times, 60 DEG C of Extracting temperature, corresponding ethanol extract is obtained, by every kind of original
The ether extracted liquid and ethanol extract of material remove solvent at vacuum degree 0.01MPa, 20 DEG C of temperature, respectively obtain walnut blueness
Skin ether extract, walnut leaf ether extract, peppermint ether extract, roxburgh anoectochilus terminal bud ether extract, chrysanthemum extracted by ether
Object, green peel of walnut ethanol extract, walnut leaf ethanol extract, peppermint ethanol extract, roxburgh anoectochilus terminal bud ethanol extract, chrysanthemum
Ethanol extract.
(3) prepared by essential oil: by the green peel of walnut ether extract, walnut leaf ether extract, peppermint extracted by ether
Object, roxburgh anoectochilus terminal bud ether extract, chrysanthemum ether extract, green peel of walnut ethanol extract, walnut leaf ethanol extract, peppermint
Ethanol extract, roxburgh anoectochilus terminal bud ethanol extract, chrysanthemum ethanol extract weight ratio be 0.6:0.2:2:1:0.5:0.4:0.3:
1:0.5:0.1, then dissolved with ethyl alcohol, make the mass percent concentration concentration 80% of ethyl alcohol.
Embodiment 2
With embodiment 1, the difference is that, in step (2), the time of extracted by ether is 2 hours, 30 DEG C of Extracting temperature.
Embodiment 3
With embodiment 1, the difference is that, in step (2), the time that ethyl alcohol extracts is 2 hours, 90 DEG C of Extracting temperature.
Embodiment 4
With embodiment 1, the difference is that, the green peel of walnut ether extract, walnut leaf ether extract, peppermint ether
Extract, roxburgh anoectochilus terminal bud ether extract, chrysanthemum ether extract, green peel of walnut ethanol extract, walnut leaf ethanol extract,
Peppermint ethanol extract, roxburgh anoectochilus terminal bud ethanol extract, chrysanthemum ethanol extract weight ratio be 10:1:4:3:1:0.5:6:8:1:
2。
Embodiment 5
With embodiment 1, the difference is that, save raw material peppermint, roxburgh anoectochilus terminal bud and chrysanthemum.
Embodiment 6
With embodiment 1, the difference is that, save ethanol extraction step.
Comparative example 1
Referring to embodiment 1, raw material green peel of walnut is saved.
Comparative example 2
Referring to embodiment 1, raw material walnut leaf is saved.
Test case 1
For testing sunstroke prevention effect of the present invention, 18~45 years old age and body heat, easy heatstroke personage 80 are chosen, is divided into 8
Group respectively tries out essential oil made from 1-6 of the embodiment of the present invention and comparative example 1 and 2.Time on probation is summer, experimental day
Mean temperature be higher than 35 DEG C.This product is applied to heating position in body heat daily, such as temple, forehead, neck, thigh and calf
Inside etc., dosage are voluntarily determined according to the weight of symptom.It is scored by trier according to the alleviation situation of heating paresthesia, it is whole
Evaluation result is as shown in table 1:
Table 1 (unit: number)
It can be seen from the above result that can effectively prevent going out for heatstroke sign using green peel of walnut and walnut leaf extracts collocation
It is existing, two-stage extraction especially is carried out with ethyl alcohol and ether, and increase better effect after raw material peppermint, roxburgh anoectochilus terminal bud and chrysanthemum.
Odor Evaluations, evaluation mark successively are carried out to essential oil made from embodiment 1-5 and comparative example 1 and 2 as all experimenters
Standard is divided into faint scent, general, acceptable, unpleasant level Four, and as a result as follows: 85% or so experimenter thinks embodiment 1-4 and comparison
The essential oil of example 1-2 has faint scent, and 80% or so experimenter thinks that the essential oil of embodiment 6 has faint scent, and 65% is left
Right experimenter thinks that the essential oil smell of embodiment 5 is general.As it can be seen that peppermint, roxburgh anoectochilus terminal bud and chrysanthemum can improve the fragrance of essential oil, make
It is easier to be accepted.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
Claims (10)
1. a kind of woody compound sunstroke prevention essential oil, which is characterized in that including walnut peel extract and walnut leaf extracts.
2. woody compound sunstroke prevention essential oil according to claim 1, which is characterized in that the walnut peel extract and walnut
The weight ratio of leaf extract is 0.1~20:0.1~20.
3. woody compound sunstroke prevention essential oil according to claim 1 or 2, which is characterized in that further include mint extract, gold thread
Lotus extract, chrysanthemum extract.
4. woody compound sunstroke prevention essential oil according to claim 3, which is characterized in that the walnut peel extract, walnut
Leaf extract, mint extract, Anoectochilus, chrysanthemum extract mass ratio be 0.1~10:0.1~10:0.1~10:
0.1~10:0.1~10.
5. woody compound sunstroke prevention essential oil according to claim 1 or 2, which is characterized in that it further include ethyl alcohol, the ethyl alcohol
Mass percent concentration is 60-80%.
6. a kind of preparation method of woody compound sunstroke prevention essential oil, which is characterized in that comprising steps of
Raw material cleaning, is crushed, is successively extracted respectively with ether and ethyl alcohol, after gained extracting solution removes solvent, respectively obtains
The ether extract and ethanol extract of each raw material dissolve the ether extract of all raw materials and ethanol extract ethyl alcohol mixed
It is even, obtain the woody compound sunstroke prevention essential oil；The raw material includes green peel of walnut and Walnut Leaves.
7. preparation method according to claim 6, which is characterized in that the raw material further includes peppermint, roxburgh anoectochilus terminal bud and chrysanthemum.
8. preparation method according to claim 7, which is characterized in that the second of the ether extract of green peel of walnut, Walnut Leaves
Ether extract, the ether extract of peppermint, the ether extract of roxburgh anoectochilus terminal bud, the ether extract of chrysanthemum, green peel of walnut ethyl alcohol
The ethyl alcohol extraction of extract, the ethanol extract of Walnut Leaves, the ethanol extract of peppermint, the ethanol extract of roxburgh anoectochilus terminal bud, chrysanthemum
Object is 0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5:0.1~5 in mass ratio:
0.1~5 compounding.
9. according to the described in any item preparation methods of claim 6-8, which is characterized in that the Extracting temperature 20~40 of the ether
DEG C, extraction time is 1~3 hour, 60~90 DEG C of the Extracting temperature of the ethyl alcohol, and extraction time is 2~4 hours.
10. according to the described in any item preparation methods of claim 6-8, which is characterized in that gained extracting solution is in vacuum degree 0.01-
0.99MPa, solvent is removed at 1~40 DEG C of temperature.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811400764.4A CN109260255A (en) | 2018-11-22 | 2018-11-22 | A kind of woody compound sunstroke prevention essential oil and preparation method thereof |
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| CN201811400764.4A CN109260255A (en) | 2018-11-22 | 2018-11-22 | A kind of woody compound sunstroke prevention essential oil and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184764A (en) * | 2020-01-14 | 2020-05-22 | 河南农业大学 | Walnut leaf-based essential balm, preparation method thereof and mosquito-repellent incense |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224027A (en) * | 2008-01-24 | 2008-07-23 | 杨同喜 | Chinese traditional medicine drink |
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2018
- 2018-11-22 CN CN201811400764.4A patent/CN109260255A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224027A (en) * | 2008-01-24 | 2008-07-23 | 杨同喜 | Chinese traditional medicine drink |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184764A (en) * | 2020-01-14 | 2020-05-22 | 河南农业大学 | Walnut leaf-based essential balm, preparation method thereof and mosquito-repellent incense |
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Application publication date: 20190125 |