CN111728891A - Acne mark removing composition and application thereof - Google Patents
Acne mark removing composition and application thereof Download PDFInfo
- Publication number
- CN111728891A CN111728891A CN202010608723.5A CN202010608723A CN111728891A CN 111728891 A CN111728891 A CN 111728891A CN 202010608723 A CN202010608723 A CN 202010608723A CN 111728891 A CN111728891 A CN 111728891A
- Authority
- CN
- China
- Prior art keywords
- parts
- acne
- cosmetic
- collagen
- madecassoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 63
- 206010000496 acne Diseases 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000002537 cosmetic Substances 0.000 claims abstract description 20
- 102000008186 Collagen Human genes 0.000 claims abstract description 16
- 108010035532 Collagen Proteins 0.000 claims abstract description 16
- 229920001436 collagen Polymers 0.000 claims abstract description 16
- 239000006071 cream Substances 0.000 claims abstract description 16
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims abstract description 15
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims abstract description 15
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229940090813 madecassoside Drugs 0.000 claims abstract description 15
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 14
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 14
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 14
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 14
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 14
- 239000011570 nicotinamide Substances 0.000 claims abstract description 14
- 229940101267 panthenol Drugs 0.000 claims abstract description 14
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 14
- 239000011619 pantothenol Substances 0.000 claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 12
- WQZGKKKJIJFFOK-UHFFFAOYSA-N hexopyranose Chemical compound OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 14
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 14
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 13
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical group [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 7
- 229960000458 allantoin Drugs 0.000 claims description 7
- 229960001631 carbomer Drugs 0.000 claims description 7
- 229960000541 cetyl alcohol Drugs 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 7
- 229940031575 hydroxyethyl urea Drugs 0.000 claims description 7
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 7
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 7
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 7
- 229940032094 squalane Drugs 0.000 claims description 7
- 229960001295 tocopherol Drugs 0.000 claims description 7
- 229930003799 tocopherol Natural products 0.000 claims description 7
- 235000010384 tocopherol Nutrition 0.000 claims description 7
- 239000011732 tocopherol Substances 0.000 claims description 7
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 7
- 229920002307 Dextran Polymers 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 5
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 4
- 229940075529 glyceryl stearate Drugs 0.000 claims description 4
- 229940073669 ceteareth 20 Drugs 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- -1 cyclopentadecyl Chemical group 0.000 claims description 2
- 229940008099 dimethicone Drugs 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 2
- 229940074391 gallic acid Drugs 0.000 claims description 2
- 235000004515 gallic acid Nutrition 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 25
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 230000003467 diminishing effect Effects 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 14
- 235000013601 eggs Nutrition 0.000 description 9
- 230000007794 irritation Effects 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000013077 scoring method Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- IHCCLXNEEPMSIO-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 IHCCLXNEEPMSIO-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- DFGKGUXTPFWHIX-UHFFFAOYSA-N 6-[2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]acetyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)C1=CC2=C(NC(O2)=O)C=C1 DFGKGUXTPFWHIX-UHFFFAOYSA-N 0.000 description 1
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The invention discloses an acne mark removing composition which comprises the following components in parts by weight: 0.5 to 5 parts of panthenol, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.01 to 0.2 part of carboxymethyl glucan, 0.05 to 0.5 part of madecassoside, 1 to 5 parts of collagen, 1 to 3 parts of diglucosylgallic acid and 0.5 to 2 parts of nicotinamide. The acne mark removing composition disclosed by the invention has the three effects of diminishing inflammation, repairing and removing melanin, has a good effect of removing black acne marks and red acne marks, has a certain repairing effect on pit acne marks, enables the skin to be in a healthy state, and is mild and safe for the skin. The composition for removing acne mark can be added into cosmetics to prepare into lotion or cream, and is convenient for patients to use.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an acne mark removing composition and application thereof.
Background
Acne marks are marks left by whelks and are often formed by inflammation due to infection or by external force extrusion. The acne mark is a repair reaction generated by organism to tissue injury, when the skin injury is deep and the dermis or a large area of epidermis is damaged, the epidermis of the part can not be regenerated, and the skin can be replaced by dermal fiber cells, collagen and proliferated blood vessels, so that the acne mark is generated. The acne marks are divided into a plurality of types, and generally comprise black acne marks, red acne marks and pit acne marks. Among them, the black pox mark is a pigmentation caused by inflammation of pox, which makes the local skin dark after growing red pox. The red pox mark is the vasodilation caused by the inflammation of skin cells at the position of a long pox, but the pox is removed and the blood vessel is not immediately contracted, so that the red pox mark is formed. The pockmark is caused by the fact that pockmarks are too severely inflamed and damage collagen of dermis, so that the dermis is collapsed to leave a pit.
The acne marks not only affect the beauty, but also even affect the mental health of some patients. Therefore, it is crucial to find a new therapeutic method with fast effect, good effect and slight adverse reaction. The cosmetics become necessities in daily life, and the acne-removing functional components added in the cosmetics bring more convenience to patients.
Disclosure of Invention
Based on the above, in order to solve the disadvantages and shortcomings of the prior art, the present invention aims to provide an acne mark removing composition and application thereof. The acne mark removing composition disclosed by the invention has a good effect of removing black acne marks and red acne marks, is quick in effect, mild and safe to skin, and has a certain effect of removing pockmarks.
In order to realize the purpose, the technical scheme adopted by the invention is as follows:
the acne mark removing composition comprises the following components in parts by weight: 0.5 to 5 parts of panthenol, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.01 to 0.2 part of carboxymethyl glucan, 0.05 to 0.5 part of madecassoside, 1 to 5 parts of collagen, 1 to 3 parts of diglucosylgallic acid and 0.5 to 2 parts of nicotinamide.
In the above formulation, the addition of panthenol, dipotassium glycyrrhizinate and madecassoside enhances the anti-inflammatory effect of the composition, the addition of methyl dextran, madecassoside and collagen enhances the repairing effect of the composition, and the addition of diglucosylgallic acid and nicotinamide enhances the depigmenting effect of the composition. The inventor finds that the composition with the formula can play three roles of diminishing inflammation, repairing and removing melanin, has a good effect of removing black acne marks and red acne marks, and has a certain repairing effect on pit acne marks.
Preferably, the acne mark removing composition comprises the following components in parts by weight: 1-3 parts of panthenol, 0.2-1 part of dipotassium glycyrrhizinate, 0.05-0.2 part of carboxymethyl glucan, 0.3-0.5 part of madecassoside, 1-3 parts of collagen, 1-3 parts of diglucosylgallic acid and 0.5-2 parts of nicotinamide.
Preferably, the acne mark removing composition comprises the following components in parts by weight: 2 parts of panthenol, 0.5 part of dipotassium glycyrrhizinate, 0.1 part of carboxymethyl glucan, 0.3 part of madecassoside, 2 parts of collagen, 2.5 parts of diglucosylgallic acid and 1 part of nicotinamide. Tests show that the composition of the formula has good effect of removing black acne marks and red acne marks, and has reasonable cost.
The invention also provides an application of the acne mark removing composition, in particular to an application in cosmetics.
The invention also provides a cosmetic containing the acne mark removing composition.
Preferably, the cosmetic is in the form of a lotion or cream.
Preferably, the cosmetic also comprises the following components in parts by weight: 1-10 parts of butanediol, 0.1-2 parts of hydroxyethyl urea, 0.1-1 part of carbomer, 0.01-0.1 part of sodium hyaluronate, 0.05-0.5 part of allantoin, 1-5 parts of cetearyl alcohol, 200.1-2 parts of ceteareth-200.5-3 parts of glyceryl stearate, 1-5 parts of cyclopentadimethylsiloxane, 0.1-2 parts of cetyl alcohol, 0.1-1 part of tocopherol and 0.5-3 parts of squalane.
Preferably, the cosmetic comprises the following components in percentage by weight: panthenol 2%, dipotassium glycyrrhizinate 0.5%, carboxymethyl dextran 0.1%, madecassoside 0.3%, collagen 2%, diglucosyl gallic acid 2.5%, niacinamide 1%, butylene glycol 5%, hydroxyethyl urea 1%, carbomer 0.5%, sodium hyaluronate 0.05%, allantoin 0.15%, cetostearyl alcohol 3%, ceteth-201%, glyceryl stearate 1.5%, cyclopentadecyl dimethicone 3%, cetyl alcohol 1%, tocopherol 0.5%, squalane 1%, preservative 0.5% -2%, pH regulator 0.01% -0.1%, and deionized water in balance.
Preferably, the pH adjuster is potassium hydroxide.
Preferably, the preparation method of the cosmetic comprises the following steps:
(1) putting deionized water, carbomer, butanediol, hydroxyethyl urea, sodium hyaluronate and allantoin into a water phase pot, stirring for dissolving, heating to 80-85 ℃, and homogenizing to obtain a water phase material;
(2) adding ceteareth-20, cetearyl alcohol, glycerol stearate, cyclopentadimethylsiloxane, cetyl alcohol, tocopherol and squalane into an oil phase pot, uniformly stirring, and heating to 80-85 ℃ to obtain an oil phase material;
(3) mixing the water phase material and the oil phase material, homogenizing at 80-85 ℃, preserving heat for 15-20 min, and adjusting the pH to 5.5-6.5 by using a pH regulator;
(4) cooling to below 45 deg.C, adding panthenol, dipotassium glycyrrhizinate, carboxymethyl dextran, madecassoside, collagen, diglucosylgallic acid, nicotinamide and antiseptic, stirring, cooling to below 30 deg.C, and discharging to obtain the final product.
Has the advantages that: the acne mark removing composition disclosed by the invention has the three effects of diminishing inflammation, repairing and removing melanin, has a good effect of removing black acne marks and red acne marks, has a certain repairing effect on pit acne marks, enables the skin to be in a healthy state, and is mild and safe for the skin. The composition for removing acne mark can be added into cosmetics to prepare into lotion or cream, and is convenient for patients to use.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention is further illustrated by the following examples. It is apparent that the following examples are only a part of the embodiments of the present invention, and not all of them. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention. The starting materials used in the examples of the present invention are all commercially available.
Examples 1 to 5:
embodiments 1 to 5 provide acne mark removing facial cream, which respectively comprises the following components in percentage by weight:
the preparation method of the acne mark removing cream of the embodiment 1-5 comprises the following steps:
(1) putting deionized water, carbomer, butanediol, hydroxyethyl urea, sodium hyaluronate and allantoin into a water phase pot, stirring for dissolving, heating to 80 deg.C (80-85 deg.C), and homogenizing at 30Hz for 5min to obtain water phase material;
(2) adding ceteareth-20, cetearyl alcohol, glycerol stearate, cyclopentadimethylsiloxane, cetyl alcohol, tocopherol and squalane into an oil phase pot, uniformly stirring, and heating to 80 ℃ (80-85 ℃) to obtain an oil phase material;
(3) mixing the water phase material and the oil phase material, homogenizing at 80 ℃ (80-85 ℃) for 5min at 40HZ speed, then preserving heat at 80 ℃ for 15min (80-85 ℃) for 15-20 min), and adding potassium hydroxide to adjust the pH to 5.5-6.5;
(4) cooling to below 45 deg.C under stirring at a speed of 10r/min, adding panthenol, dipotassium glycyrrhizinate, carboxymethyl dextran, madecassoside, collagen, diglucosylgallic acid, nicotinamide and phenoxyethanol, stirring, cooling to below 30 deg.C, and discharging to obtain the final product.
Comparative examples 1 to 2:
comparative examples 1 to 2 provide acne mark removing face creams, which are composed of the components in the weight percentage shown in the table, and the preparation method refers to the preparation methods of examples 1 to 5.
And (3) testing:
first, stability investigation
The creams prepared in examples 1 to 5 were bottled and placed in 3 cold-heat circulation boxes at 50 ℃, 45 ℃, 40 ℃, 25 ℃, 4 ℃, -18 ℃, and-18 ℃ under TL84 light for stability examination for 1 month. After the room temperature is recovered, the creams of the examples 1 to 5 have no oil-water separation phenomenon, which shows that the creams prepared in the examples 1 to 5 have better stability.
Second, mild safety test
Main test materials: SPF eggs, Teflon rings.
The test substance: cream prepared in examples 1 to 5
The test method comprises the following steps:
CAM preparation: eggs of age 0d are purchased and incubated to age 9d, and defective eggs are inspected and discarded. Marking the position of an air chamber on the surface of the shell of a normal egg, and stripping off the shell part to expose a white egg membrane; the intima is carefully removed with forceps to ensure that the vascular membrane is not damaged.
2 formal experiment
2.1 stimulation scoring method: at least 6 eggs in each group are respectively taken from a test object, 3mL of the test object is diluted into a sample solution with the mass fraction of 50%, the sample solution is dripped on the surface of the CAM, the CAM reaction condition is observed, the time of each toxic effect within 5min of action is recorded, the time is accurate to second, the reactions comprise 3 reactions of bleeding, blood coagulation and vessel fusion, and the degree of the reactions is recorded.
2.2 endpoint scoring: and (3) directly dripping 0.3mL of prepared sample liquid on the surface of the CAM for observing the CAM reaction condition, slightly washing with normal saline after 3min of action to remove the test object, and observing 3 reactions and degrees of bleeding, blood coagulation and vessel thawing within about 30s after washing. If observations indicate that at least 1 response scored moderately above (total score ≧ 12) for all 6 eggs, the test should be repeated once.
3. Endpoint Scoring (ES): score per egg-the sum of the extent of bleeding, clotting and vascular thawing observed per egg; end point score (ES) is the sum of the number of 6 eggs scored.
End point scoring method result evaluation table
| Irritation classification | Non/light irritability | Moderate irritation | Strong irritation/corrosion |
| Endpoint scoring | ES≤12 | 12<ES<16 | ES≥16 |
The results of the tests are given in the following table:
| test article | ES | Irritation property |
| Example 1 | 2 | Has no irritation |
| Example 2 | 2 | Has no irritation |
| Example 3 | 3 | Has no irritation |
| Example 4 | 3 | Has no irritation |
| Example 5 | 3 | Has no irritation |
Third, acne mark removing effect test
Testing the population: 84 patients who had an eliminated whelk but had a distinct black whelk mark and a distinct red whelk mark on their faces were randomized into 7 groups of 12 people each, of which male and female halves aged from 17 to 30 years. The acne mark removing face creams of examples 1-5 and comparative examples 1-2 are tried on 7 groups of patients respectively.
The test method comprises the following steps: respectively and uniformly coating a proper amount of corresponding acne mark removing cream on acne marks of patients twice a day (once in the morning and at night), and 15 days is a treatment course. The acne mark removing effect is observed after two treatment courses.
The judgment standard of the curative effect is as follows:
and (3) curing: the black acne marks and the red acne marks completely disappear;
the method has the following advantages: the black pox mark and the red pox mark are reduced but not completely disappeared;
and (4) invalidation: the black and red acne marks were not reduced or even increased.
The test results are given in the table below.
| Group of | The number of people cured | Number of effective persons | Number of invalid persons |
| Example 1 | 5 | 6 | 1 |
| Example 2 | 5 | 7 | 0 |
| Example 3 | 9 | 3 | 0 |
| Example 4 | 9 | 2 | 1 |
| Example 5 | 9 | 3 | 0 |
| Comparative example 1 | 3 | 8 | 1 |
| Comparative example 2 | 3 | 9 | 0 |
As can be seen from the test results in the table above, the removal effect of the creams of examples 1 to 5 on black and red acne marks is significantly better than that of the creams of comparative examples 1 to 2, which shows that the composition for removing acne marks simultaneously contains the components of panthenol, dipotassium glycyrrhizinate, carboxymethyl glucan, madecassoside, diglucosylgallic acid, nicotinamide and collagen, and thus the composition for removing acne marks can exert a better effect of removing acne marks. Secondly, as can be seen from the comparative analysis of the component contents of the examples 1 to 5, the component contents of the acne mark removing composition gradually increase from the examples 1 to 5, but the trend of the acne mark removing effect of the acne mark removing composition significantly increases from the examples 1 and 2 to the examples 3, and then the acne mark removing composition tends to be stable from the examples 3 and 4 to the examples 5, the effect is not obviously improved, and the cost is considered, so that the invention takes the example 3 as an optimal formula.
According to the feedback of the subjects, the cream in example 3 also has a certain repairing effect on the pit pox.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The acne mark removing composition is characterized by comprising the following components in parts by weight: 0.5 to 5 parts of panthenol, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.01 to 0.2 part of carboxymethyl glucan, 0.05 to 0.5 part of madecassoside, 1 to 5 parts of collagen, 1 to 3 parts of diglucosylgallic acid and 0.5 to 2 parts of nicotinamide.
2. The acne mark removal composition of claim 1, wherein the acne mark removal composition comprises the following components in parts by weight: 1-3 parts of panthenol, 0.2-1 part of dipotassium glycyrrhizinate, 0.05-0.2 part of carboxymethyl glucan, 0.3-0.5 part of madecassoside, 1-3 parts of collagen, 1-3 parts of diglucosylgallic acid and 0.5-2 parts of nicotinamide.
3. The acne mark removal composition of claim 1, wherein the acne mark removal composition comprises the following components in parts by weight: 2 parts of panthenol, 0.5 part of dipotassium glycyrrhizinate, 0.1 part of carboxymethyl glucan, 0.3 part of madecassoside, 2 parts of collagen, 2.5 parts of diglucosylgallic acid and 1 part of nicotinamide.
4. Use of the composition for removing acne marks according to any of claims 1 to 3 in cosmetics.
5. A cosmetic comprising the composition for removing acne marks according to any one of claims 1 to 3.
6. The cosmetic of claim 5, wherein the cosmetic is in the form of an emulsion or a cream.
7. The cosmetic according to claim 5, further comprising the following components in parts by weight: 1-10 parts of butanediol, 0.1-2 parts of hydroxyethyl urea, 0.1-1 part of carbomer, 0.01-0.1 part of sodium hyaluronate, 0.05-0.5 part of allantoin, 1-5 parts of cetearyl alcohol, 200.1-2 parts of ceteareth-200.5-3 parts of glyceryl stearate, 1-5 parts of cyclopentadimethylsiloxane, 0.1-2 parts of cetyl alcohol, 0.1-1 part of tocopherol and 0.5-3 parts of squalane.
8. The cosmetic of claim 5, wherein the cosmetic comprises the following components in percentage by weight: panthenol 2%, dipotassium glycyrrhizinate 0.5%, carboxymethyl dextran 0.1%, madecassoside 0.3%, collagen 2%, diglucosyl gallic acid 2.5%, niacinamide 1%, butylene glycol 5%, hydroxyethyl urea 1%, carbomer 0.5%, sodium hyaluronate 0.05%, allantoin 0.15%, cetostearyl alcohol 3%, ceteth-201%, glyceryl stearate 1.5%, cyclopentadecyl dimethicone 3%, cetyl alcohol 1%, tocopherol 0.5%, squalane 1%, preservative 0.5% -2%, pH regulator 0.01% -0.1%, and deionized water in balance.
9. The cosmetic of claim 8, wherein the pH adjusting agent is potassium hydroxide.
10. The method for preparing a cosmetic according to claim 8, comprising the steps of:
(1) putting deionized water, carbomer, butanediol, hydroxyethyl urea, sodium hyaluronate and allantoin into a water phase pot, stirring for dissolving, heating to 80-85 ℃, and homogenizing to obtain a water phase material;
(2) adding ceteareth-20, cetearyl alcohol, glycerol stearate, cyclopentadimethylsiloxane, cetyl alcohol, tocopherol and squalane into an oil phase pot, uniformly stirring, and heating to 80-85 ℃ to obtain an oil phase material;
(3) mixing the water phase material and the oil phase material, homogenizing at 80-85 ℃, preserving heat for 15-20 min, and adjusting the pH to 5.5-6.5 by using a pH regulator;
(4) cooling to below 45 deg.C, adding panthenol, dipotassium glycyrrhizinate, carboxymethyl dextran, madecassoside, collagen, diglucosylgallic acid, nicotinamide and antiseptic, stirring, cooling to below 30 deg.C, and discharging to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010608723.5A CN111728891A (en) | 2020-06-29 | 2020-06-29 | Acne mark removing composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010608723.5A CN111728891A (en) | 2020-06-29 | 2020-06-29 | Acne mark removing composition and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111728891A true CN111728891A (en) | 2020-10-02 |
Family
ID=72653521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010608723.5A Pending CN111728891A (en) | 2020-06-29 | 2020-06-29 | Acne mark removing composition and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111728891A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332195A (en) * | 2021-05-27 | 2021-09-03 | 植物医生(广东)生物科技有限公司 | Acne mark removing composition and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802511A (en) * | 2017-11-20 | 2018-03-16 | 广州市梦采生物科技有限公司 | Whitening, spot additive used for cosmetic and its preparation method and application |
| CN108158931A (en) * | 2018-03-26 | 2018-06-15 | 广东盛美化妆品有限公司 | A kind of moisturizing whitening cream of the extract containing Flos micheliae Albae and preparation method thereof |
| CN109010245A (en) * | 2018-09-13 | 2018-12-18 | 广东丸美生物技术股份有限公司 | Anti-acne preparations |
| CN110237018A (en) * | 2019-07-31 | 2019-09-17 | 东晟源研究院(广州)有限公司 | The Recipe and preparation method of various dimensions speckle removing, acne removing print and even skin tone |
-
2020
- 2020-06-29 CN CN202010608723.5A patent/CN111728891A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802511A (en) * | 2017-11-20 | 2018-03-16 | 广州市梦采生物科技有限公司 | Whitening, spot additive used for cosmetic and its preparation method and application |
| CN108158931A (en) * | 2018-03-26 | 2018-06-15 | 广东盛美化妆品有限公司 | A kind of moisturizing whitening cream of the extract containing Flos micheliae Albae and preparation method thereof |
| CN109010245A (en) * | 2018-09-13 | 2018-12-18 | 广东丸美生物技术股份有限公司 | Anti-acne preparations |
| CN110237018A (en) * | 2019-07-31 | 2019-09-17 | 东晟源研究院(广州)有限公司 | The Recipe and preparation method of various dimensions speckle removing, acne removing print and even skin tone |
Non-Patent Citations (4)
| Title |
|---|
| 刘德培编著: "《中华医学百科全书 公共卫生学 环境卫生学》", 31 March 2017, 中国协和医科大学出版社 * |
| 彭冠杰，郭清泉主编: "《美白化妆品科学与技术》", 30 June 2019, 中国轻工业出版社 * |
| 徐璐敏等: "复方积雪草苷乳膏的制备与应用", 《中国药师》 * |
| 王庆华等: "羧甲基酵母葡聚糖在护肤品中的应用研究", 《广东化工》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332195A (en) * | 2021-05-27 | 2021-09-03 | 植物医生(广东)生物科技有限公司 | Acne mark removing composition and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110731923B (en) | Enhanced moisturizing cosmetic compositions | |
| CN105902461A (en) | Essence containing snail mucus extracts and preparation method thereof | |
| CN111658590A (en) | Acne-removing composition and application thereof | |
| CN109010100A (en) | A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition | |
| CN112516044A (en) | Traditional Chinese medicine acne-removing and oil-controlling essence and preparation method thereof | |
| JP4067073B2 (en) | Skin cosmetics | |
| CN113041172B (en) | Sebum membrane bionic composition for skin barrier repair, application thereof and cosmetics | |
| CN111728891A (en) | Acne mark removing composition and application thereof | |
| CN113332160A (en) | Cosmetic composition for conditioning peritrichotic skin | |
| CN108354891B (en) | Soothing cream and preparation method thereof | |
| CN111743826A (en) | Freckle-removing, wrinkle-resisting and moisturizing emulsion | |
| CN115737451A (en) | Alpha-gel composition, cosmetic and preparation method thereof | |
| CN114042010A (en) | Enzyme preparation cutin removing cream and preparation method thereof | |
| CN115444773A (en) | Anti-inflammatory repairing composition containing glycol salicylate, preparation method and application | |
| CN112353728A (en) | Repairing composition and application thereof, cosmetics, essence and preparation method thereof | |
| JP5855949B2 (en) | Keratin production promoter, hair dye and nail polish | |
| JPH03167113A (en) | Hair regenerating agent | |
| JP2002363038A (en) | Cosmetic | |
| CN110237012A (en) | A kind of bletilla striata hand lotion and preparation method thereof for preventing and treating chapped skin | |
| CN107929226A (en) | A kind of whitening containing sweet osmanthus stem cell extract, acne-removing composition and preparation method thereof | |
| CN113893199B (en) | A facial cream composition with effect of increasing skin thickness and its preparation method | |
| CN115531256B (en) | Essential oil and preparation process thereof | |
| KR101499168B1 (en) | Composition for improving Hair Damage containing Propolis extract and Method Of Composition for improving Hair Damage | |
| JPH0930927A (en) | Skin preparation for external use | |
| JPH0217113A (en) | Externally applying agent for skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201002 |