CN113332195A

CN113332195A - Acne mark removing composition and application thereof

Info

Publication number: CN113332195A
Application number: CN202110581598.8A
Authority: CN
Inventors: 林霁; 孙美娟; 郭文姣; 刘裕娇; 贺锐; 谢勇
Original assignee: Plant Doctor Guangdong Biotechnology Co ltd
Current assignee: Plant Doctor Guangdong Biotechnology Co ltd
Priority date: 2021-05-27
Filing date: 2021-05-27
Publication date: 2021-09-03

Abstract

The invention discloses an acne mark removing composition and application thereof, and belongs to the technical field of skin care products. The acne mark removing composition comprises the following components in parts by weight: 0.01-0.2 part of carnosine, 0.1-5 parts of nicotinamide, 0.1-3 parts of panthenol, 0.01-0.5 part of asiaticoside, 0.01-2 parts of gentian extract and 0.01-5 parts of cactus stem extract. The synergistic anti-inflammatory effect of the carnosine, the gentian root extract and the cactus stem extract can reduce the immune suppression of skin, promote the improvement of the anti-inflammatory capability of the skin, improve the dryness and peeling problems of pox muscles, further optimize the repair of the pox muscles and the metabolic elimination of pox marks, inhibit tyrosinase and hyaluronidase and promote the healing of the pox marks through the synergistic effect of panthenol and asiaticoside, thereby achieving the effect of reducing the pox marks, simultaneously enhancing the skin barrier and having a certain effect of whitening the skin.

Description

Acne mark removing composition and application thereof

Technical Field

The invention relates to the technical field of skin care products, and particularly relates to an acne mark removing composition and application thereof.

Background

Acne is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous gland ducts, and acne skin with long acne is dry and easy to peel off, and acne marks which can not be removed for a long time are easy to leave, so that the integral skin state and the face appearance are influenced. Carnosine is a crystalline solid composed of two amino acids, beta-alanine and L-histidine. The muscle and brain tissues contain high-concentration carnosine, the carnosine has an antioxidant property, is a natural antioxidant, has a remarkable inhibiting effect on lipid oxidation caused by free radicals and metal ions, protects structural proteins, resists glycosylation, increases collagen synthesis, and is widely applied to anti-aging products. Carnosine is also helpful for repairing the skin of the acne mark part, but the prior art does not disclose a carnosine product with good acne mark removing and acne muscle repairing effects.

CN108785122A discloses an acne-removing co-delivery nano composition, a preparation method and an application thereof, wherein the acne-removing co-delivery nano composition comprises the following components in percentage by weight: 0.1 to 10.0 percent of active substance for inhibiting grease secretion, 0.1 to 10.0 percent of active substance for inhibiting bacteria and diminishing inflammation, 0.1 to 5.0 percent of anti-allergic agent, 0.1 to 10.0 percent of active substance for lightening acne marks, 0.1 to 10.0 percent of active substance for peeling cutin, 5.0 to 40.0 percent of emulsifier, 5.0 to 30.0 percent of co-emulsifier, 5.0 to 30.0 percent of compound lipid, 0.1 to 5.0 percent of stabilizer and the balance of water. However, mainly aiming at solving the problems that the retention amount in vivo of effective components is not large enough and the retention time is not long enough, the multi-component multi-target delivery of the acne-removing active components is realized by loading a plurality of acne-removing active substances into the nano composition, the retention time at an acne-removing target position is long, the slow release and controlled release of the acne-removing active components are realized, the stability of the system and the antibacterial property of the composition are improved, and the problems of water shortage and peeling of acne muscles and the repair of acne marks are not solved.

Disclosure of Invention

The invention aims to solve the technical problems that the existing acne mark removing composition cannot well solve the problems of water shortage and peeling of acne marks and the defects and shortcomings of long-term unreliability of the acne marks, and provides an acne mark removing composition.

The invention also aims to provide application of the acne mark removing composition in preparing an acne mark skin repair product.

Still another object of the present invention is to provide a acne mark skin repair product.

The invention also aims to provide a preparation method of the acne mark skin repair product.

The above purpose of the invention is realized by the following technical scheme:

the acne mark removing composition comprises the following components in parts by weight: 0.05-0.15 part of carnosine, 1-3 parts of nicotinamide, 1-3 parts of panthenol, 0.05-0.15 part of asiaticoside, 0.5-2 parts of gentian extract and 0.5-2 parts of cactus stem extract.

Wherein, it is required to be noted that:

carnosine: beta-alanyl-L-histidine, naturally occurring in the human body, is a white powder, soluble in water, is a globally approved cosmetic ingredient. Carnosine can promote the generation of collagen, chelate metal ions, prevent the glycosylation of protein and inhibit the generation of crosslinking, can reduce the skin aging induced by ultraviolet rays, and has the effect of protecting the skin. The acne muscle is more easily damaged by ultraviolet because the barrier is weaker, the epidermal flora is unbalanced, the acne mark is left, the self-repairing function of the skin is not good enough, the acne pit is difficult to eliminate, the molecular weight of the myopeptide is small (226.232Da), the myopeptide is easy to be absorbed by the skin, the damage of ultraviolet to cells is reduced, the generation of collagen is promoted, and the acne mark and the acne pit are eliminated more quickly.

Nicotinamide has anti-inflammatory effect, and can inhibit poly-ADP-ribose polymerase (PARP), and activation of PARP is an important mechanism of inflammatory reaction caused by endotoxin. Nicotinamide also inhibits a range of proinflammatory factors, such as interleukin-6 (interleukin-6, IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (interleukin-1 beta, IL-1 beta), interleukin-8 (interleukin-8, IL-8), and the like. Meanwhile, nicotinamide can also reduce the activity of desquamation enzyme, reduce the activity of tryptase and plasmin influencing inflammation, and reduce infiltration of monocytes and phagocytes. When the cells are irradiated by ultraviolet, the self-repairing function of the cells can be excited, a large amount of Adenosine Triphosphate (ATP) can be consumed in the process, nicotinamide can reduce the consumption of ATP in the cells and provide energy for cell repair, and meanwhile, nicotinamide is a component of coenzyme I (NAD) and coenzyme II (NADP) and can influence the normal respiration and metabolism of the cells, so that the immunosuppression of the skin can be reduced, the improvement of the anti-inflammatory capability of the skin is promoted, and the repair of the skin at the acne mark part and the elimination of the acne mark are facilitated.

Panthenol is a hydroxy homologue of pantothenic acid, used topically as a cream, lotion or solution, at a concentration of 2-5%, as an adjunct to the treatment of a variety of skin and mucosal lesions. The partial formula, sold in europe, typically has a D-panthenol concentration of 5%, and in the us, the food and drug administration allows the sale of a formulation with a D-panthenol concentration of 2% for local relief of itching or to aid in healing of various skin diseases. The main effects of the D-panthenol formula are promoting epithelization, granulation and relieving pruritus, and promoting scar treatment and repair.

The asiaticoside has effects of inhibiting tyrosinase, inhibiting hyaluronidase, and promoting wound healing. The asiaticoside can cause the obvious reduction of the expression of a metal matrix protease inhibitor, promote the degradation of type I collagen and relieve the effect of scar hyperplasia by reducing the expression of TGF-beta 1mRNA for promoting the scar hyperplasia and simultaneously increasing the expression of TGF-beta 3mRNA for inhibiting the scar hyperplasia; the pathological effect of TGF-beta can also be inhibited and the proliferation of fibroblasts can be prevented by increasing the expression of Smad7 which inhibits R-Smads transduction signals. Asiaticoside can affect the ultrastructure of fibroblast, make the proliferation of fibroblast inactive and reduce the activity of synthesized and secreted protein, so as to attain the effect of reducing acne mark and pockmark.

The gentiana scabra bunge extract has an inhibiting effect on rhizobia, escherichia coli, bacillus subtilis, staphylococcus aureus, pseudomonas aeruginosa and the like, and according to the research that a certain difference exists between skin flora susceptible to acne and normal skin, the gentiana scabra bunge extract has the effects of balancing skin flora and resisting inflammation when being applied to the acne mark removing composition. The gentiana scabra bunge extract used in the invention is a gentiana scabra bunge extract from the Yunnan Trijing area with the altitude of about 1700m, and has high altitude, strong sunshine and large temperature difference, so that the content of active substances of the extracted gentiana scabra bunge extract is higher.

The stem extract contains effective components such as flavone, polysaccharide, superoxide dismutase (SOD), vitamin E and vitamin C. The flavone content is higher, and mainly contains quercetin, rutin and other components, and the total content in dry matter is up to 0.65%, wherein the rutin content is a little lower than that of quercetin, and both of them have 3, 4-catechol structure, and the structure can enhance the antioxidant activity. The cactus flavone has strong antioxidant activity and shows quantitative effect relation on the restoration of acne marks.

Most of the usage amount of the niacinamide in the cosmetics is less than 5%, so that the intolerance reaction of sensitive skin to high-concentration niacinamide is avoided, and the discomfort reactions such as allergy or red swelling and stabbing pain are avoided. The asiaticoside, the gentian extract and the cactus stem extract are natural plant extracts, contain various antioxidant active ingredients, are not stable under the conditions of illumination and high temperature, and easily cause the problem of product discoloration in the product storage process when the addition amount is too large. Therefore, the synergistic compatibility content of each component of the acne mark removing composition needs to comprehensively consider the adaptability of the acne mark removing composition to users, particularly sensitive skin users, the repairing effect on the problems of lack of water and peeling of the whole acne skin, long-lasting acne marks and the like, the stability problem of the acne mark removing composition in the preparation process of a product needs to be considered, and the appropriate synergistic compatibility proportion is finally determined by comprehensively considering the complex influence of each factor from three dimensions.

In order to achieve better repairing effect of the vaccinia muscle problem, the composition preferably comprises the following components in parts by weight: 0.1 part of carnosine, 2-3 parts of nicotinamide, 1-2 parts of panthenol, 0.05-0.1 part of asiaticoside, 0.5-1 part of gentian extract and 0.5-1 part of cactus stem extract.

More preferably, the composition comprises the following components in parts by weight: 0.1 part of carnosine, 3 parts of nicotinamide, 2 parts of panthenol, 0.1 part of asiaticoside, 0.5 part of gentian extract and 0.5 part of cactus stem extract.

Preferably, the gentian extract comprises triterpenes, flavones, iridoid glycosides and secoiridoid glycosides.

Further preferably, the content of iridoid glycoside and secoiridoid glycoside in the radix gentianae extract is more than or equal to 4.5 mg/mL.

The gentiana extract disclosed by the invention has high content of active effective components, particularly iridoid glycoside and secoiridoid glycoside, can effectively balance special skin flora of acne skin, and has excellent anti-inflammatory effect.

Preferably, the cactus stem extract contains flavone, polysaccharide, superoxide dismutase, vitamin E and vitamin C.

Further preferably, the cactus stem extract is a cactus stem extract, wherein the polysaccharide content is more than or equal to 5.0 mg/mL.

The plant polysaccharide can effectively improve the immune function of skin, has beneficial antibacterial and anti-inflammatory effects, and the cactus stem extract with high polysaccharide content can be used for improving the repairing effect of pox muscles by being matched with other components.

The application of the acne mark removing composition in preparing the acne mark skin repair product is also within the protection scope of the invention.

The acne mark removing composition disclosed by the invention can improve acne marks from different action paths, wherein asiaticoside, carnosine and nicotinamide can effectively fade the acne marks and promote the elimination of generated acne marks, panthenol and cactus stem extracts can enhance skin barriers, and the carnosine, the nicotinamide and gentian extracts have certain skin whitening effects, can synergistically solve the problems of water shortage and peeling of the acne marks and can eliminate the acne marks.

Preferably, the acne mark skin repair product provided by the invention particularly reduces the percutaneous water loss rate of the acne mark skin, improves the whiteness of the acne mark skin, and reduces the redness and erythema indexes of the skin.

The invention also specifically provides a acne mark skin repair product which comprises the following components in parts by weight:

the component A comprises: 70-90 parts of water, 0.01-0.2 part of sodium hyaluronate, 0.5-10 parts of humectant, 0.01-0.1 part of chelating agent and 0.1-1 part of thickening agent;

and B component: 0.01-0.2 part of carnosine, 0.01-0.5 part of asiaticoside, 0.1-3 parts of panthenol, 0.1-5 parts of nicotinamide, 0.01-2 parts of gentian extract and 0.01-5 parts of cactus stem extract;

and C, component C: 0.1-1 part of preservative.

Among them, it should be noted that:

the humectant of the component A comprises one or more of but not limited to glycerin, propylene glycol, butanediol, pentanediol, trehalose, hydroxyethyl urea, glyceryl polyether-26 and the like;

chelating agents for component a include, but are not limited to, disodium EDTA;

the thickener of the component A comprises one or more of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, acrylic acid (ester) copolymer sodium, polyacrylate cross-linked polymer-6, acryloyl dimethyl taurate/VP copolymer, polyacrylic dimethyl taurate sodium, acrylic acid (ester) copolymer sodium and the like;

the preservative of the component C comprises one or more of phenoxyethanol, ethylhexyl glycerol, hexylene glycol, methylparaben, p-hydroxyacetophenone, glyceryl caprylate and the like.

The preparation method of the acne mark skin repair product can refer to the following steps:

s1, cleaning and disinfecting production equipment;

s2, adding the component A into a main pot, and stirring and dissolving completely;

s3, cooling the temperature of the main pot to 45-35 ℃, stirring and adding the component B, wherein the stirring speed is 15-20 r/min;

s4, adding the component C into the main pot, uniformly stirring, detecting the pH value to be 6.0-7.0, filtering and discharging to obtain the acne mark removing composition.

The pH value of a plurality of acne and acne mark removing skin care products sold in the market at present is low, a fruit acid component capable of promoting cutin renewal needs to be added, and the skin irritation is high.

Compared with the prior art, the invention has the beneficial effects that:

the invention provides an acne mark removing composition, which can reduce skin immunosuppression, promote the improvement of skin anti-inflammatory ability, resist the problems of pigmentation, dryness and easy peeling caused by acne and further optimize the repair of acne marks and the metabolic elimination of the acne marks through the synergistic anti-inflammatory action of carnosine, a radix gentianae extract and a cactus stem extract, and can inhibit tyrosinase, inhibit hyaluronidase and promote the healing of the acne marks through the synergistic action of panthenol, nicotinamide and asiaticoside, so that the effect of reducing the acne marks and acne marks is achieved, the skin barrier can be enhanced, and the skin whitening effect is achieved to a certain extent.

The pH value of the acne mark skin repair product is neutral to weak acidity, and the acne mark skin repair product is mild and non-irritant to skin, can be applied to the acne mark skin repair product, can effectively improve the skin barrier, can improve the 4W percutaneous water loss rate by about 30%, can improve the 4W skin whiteness value by more than 5%, can improve the 4W skin redness by 13%, can improve the 4W skin erythema index EI value by 11%, and has a good acne mark repair effect.

Drawings

Fig. 1 is a high-definition photograph of a subject's face taken by VISIA-CR.

Detailed Description

The present invention will be further described with reference to specific embodiments, but the present invention is not limited to the examples in any way. The starting reagents employed in the examples of the present invention are, unless otherwise specified, those that are conventionally purchased.

Example 1

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 1:

TABLE 1

Wherein the content of the first and second substances,

the humectant is as follows: butanediol, pentanediol and trehalose;

the chelating agent is: disodium EDTA;

the thickening agent is: acryloyl dimethyl ammonium taurate/VP copolymer;

the preservative is as follows: phenoxyethanol, ethylhexylglycerin;

the content of iridoid glycoside and secoiridoid glycoside in radix Gentianae extract is not less than 4.5 mg/ml.

The cactus stem extract is cactus stem extract, wherein the polysaccharide content is not less than 5.0 mg/mL.

The preparation method of the acne mark skin repair product comprises the following steps:

1) cleaning and disinfecting production equipment;

2) adding the component A into a main pot, stirring, and properly heating until the component A is completely dissolved;

3) cooling the temperature of the main pot to 40 ℃, adding the component B into the main pot, and stirring at the speed of 20 r/min.

4) Adding the component C into a main pot, uniformly stirring, detecting the pH value to be 6.0-7.0, filtering and discharging to obtain the acne mark removing composition.

Example 2

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 2:

TABLE 2

Wherein the content of the first and second substances,

the humectant is as follows: glycerol, pentanediol, trehalose;

the chelating agent is: disodium EDTA;

the thickening agent is: sodium polyacryloyl dimethyl taurate, ammonium acryloyl dimethyl taurate/VP copolymer;

the preservative is as follows: p-hydroxyacetophenone, ethylhexyl glycerol;

The preparation method of the acne mark skin repair product is the same as that of example 1.

Example 3

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 3:

TABLE 3

Wherein the content of the first and second substances,

the humectant is as follows: butanediol, pentanediol and trehalose;

the chelating agent is: disodium EDTA;

the thickening agent is: acryloyl dimethyl ammonium taurate/VP copolymer; acryloyl dimethyl ammonium taurate/VP copolymer;

the preservative is as follows: phenoxyethanol, ethylhexylglycerin;

Example 4

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 4:

TABLE 4

Wherein the content of the first and second substances,

the humectant is as follows: glycerin and butylene glycol;

the chelating agent is: disodium EDTA;

the thickening agent is: acryloyl dimethyl ammonium taurate/VP copolymer, polyacrylate cross-linked polymer-6;

the preservative is as follows: phenoxyethanol, ethylhexyl glycerol, glyceryl caprylate;

Example 5

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 5:

TABLE 5

Wherein the content of the first and second substances,

the humectant is as follows: propylene glycol, pentylene glycol, and trehalose;

the chelating agent is: disodium EDTA;

the thickening agent is: ammonium acryloyldimethyltaurate/VP copolymer, sodium acrylate copolymer;

the preservative is as follows: phenoxyethanol, hexylene glycol;

Comparative example 1

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 6:

TABLE 6

Wherein the content of the first and second substances,

the humectant is as follows: butanediol, pentanediol and trehalose;

the chelating agent is: disodium EDTA;

the thickening agent is: acryloyl dimethyl ammonium taurate/VP copolymer, carbomer;

the preservative is as follows: phenoxyethanol, hexylene glycol;

Comparative example 2

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 7:

TABLE 7

Wherein the content of the first and second substances,

the humectant is as follows: glycerol, butylene glycol, pentylene glycol, and trehalose;

the chelating agent is: disodium EDTA;

the thickening agent is: acryloyl dimethyl ammonium taurate/VP copolymer;

the preservative is as follows: phenoxyethanol, p-hydroxyacetophenone;

Comparative example 3

A acne mark skin repair product comprises a phase A, a phase B and a phase C, wherein the content of each phase is shown in the following table 8:

TABLE 8

Wherein the content of the first and second substances,

the humectant is as follows: glycerol, pentanediol and trehalose;

the chelating agent is: disodium EDTA;

the preservative is as follows: phenoxyethanol, hexylene glycol;

Result detection

The specific detection method comprises the following steps:

an objective instrument evaluation method is adopted, 15 persons in each group of volunteers are recruited, the test is carried out by a double-blind method, the test period is 4 weeks, the skin data acquisition times are 3 times, and the skin data acquisition times are 0W, 2W and 4W respectively. And (4) screening qualified subjects according to requirements, signing the volunteer informed consent with the qualified subjects when the volunteer visits for the first time, collecting 0-week data and issuing samples. The volunteers collected skin images and values of skin percutaneous water loss TEWL, skin whiteness L, skin erythema index EI and skin redness a at visits 2 and 3.

The test results were as follows:

(1) skin barrier moisture retention improving effect

TABLE 9 results of the measurement of the percutaneous Water loss

	0W	2W	4W	2W improvement (%)	4W improvementPercentage (%)
						Example 1	17.65	12.05	13.15	31.73	24.50
Example 2	21.7	14.9	15.0	31.34	30.88
						Example 3	20.26	13.19	13.67	34.87	32.53
Example 4	18.05	10.05	13.55	34.35	24.93
						Example 5	16.85	12.70	11.80	24.63	25.82
Comparative example 1	14.05	13.65	12.88	2.85	8.32
						Comparative example 2	16.23	14.52	15.21	10.54	6.28
Comparative example 3	15.69	13.82	14.65	11.92	6.63

The data in the table 1 show that the acne mark skin repair product has a percutaneous water loss rate improvement rate of about 35% after being used for 2W, can quickly take effect to repair the skin barrier of the acne mark skin, and has a percutaneous water loss rate improvement rate of about 33% after being used for a normal skin repair period of 4W. The data of the comparative example prove the synergistic effect of the components in the composition, and the improvement effect of the transdermal water loss rate is reduced due to the lack of any key functional component, so that the corresponding skin barrier repair effect cannot be achieved.

(2) Repairing effect of acne mark

The specific detection results are shown in the following table 10-12 under the three-dimensional conditions that the acne mark repairing result mainly passes through the skin whiteness L value, the skin redness a value and the skin erythema index EI value:

table 10 measurement results of whiteness L of skin

	0W	2W	4W	2W improvement rate%	4W improvement rate%
						Example 1	60.82	62.53	63.99	2.81	5.21
Example 2	62.24	62.63	66.93	0.63	7.54
						Example 3	63.19	68.44	69.01	8.31	9.21
Example 4	60.15	61.85	63.20	2.83	5.07
						Example 5	54.31	56.14	57.82	3.37	6.46
Comparative example 1	59.22	60.83	60.12	2.72	1.25
						Comparative example 2	62.37	63.15	61.85	1.25	-0.83
Comparative example 3	66.89	66.23	66.84	-0.99	-0.07

TABLE 11 results of skin redness a

	0W	2W	4W	2W improvement rate%	4W improvement rate%
						Example 1	9.00	8.33	8.29	7.44	7.89
Example 2	7.33	6.42	6.36	12.41	13.23
						Example 3	10.95	9.44	9.46	13.79	13.61
Example 4	8.78	8.35	8.17	4.90	6.95
						Example 5	10.75	10.09	9.47	6.14	11.91
Comparative example 1	9.13	9.01	9.65	1.31	-5.70
						Comparative example 2	12.40	12.49	11.97	-0.73	3.47
Comparative example 3	8.59	8.55	8.48	0.47	1.28

TABLE 12 detection results of skin erythema index EI values

	0W	2W	4W	2W improvement rate%	4W improvement rate%
						Example 1	296.83	293.00	272.00	1.29	8.37
Example 2	416.58	367.62	370.51	11.75	11.06
						Example 3	298.63	278.30	261.29	6.81	12.50
Example 4	440.58	433.29	394.57	1.65	10.44
						Example 5	447.25	418.00	399.33	6.54	10.71
Comparative example 1	386.83	389.23	383.26	-0.62	0.92
						Comparative example 2	379.18	364.17	375.00	3.96	1.10
Comparative example 3	450.50	439.44	504.13	2.46	-11.90

The data in tables 11-12 also show that the acne mark skin repair product disclosed by the invention has a good improvement effect on skin whiteness, redness and skin erythema index after being used for 2W, can quickly take effect, and can repair and eliminate acne marks, and meanwhile, after a normal skin repair period of 4W, the skin whiteness, redness and skin erythema index of a group using the acne mark skin repair product disclosed by the invention still have a good improvement effect. The data of the comparative example prove the synergistic effect of the components in the composition, and the lack of any key functional component can reduce the improvement effect and cannot achieve the corresponding acne mark removal and repair effect.

From the data, the water loss rate of the facial skin of the subject is reduced after the composition is used, which indicates that the skin barrier is improved, the whiteness of the skin at the acne mark part is improved, the redness is reduced, the skin erythema index is reduced, and the repairing condition of the acne mark on the face is represented to be good. Therefore, the composition has the effects of improving the skin barrier of the pox muscle, promoting the acne mark to disappear, increasing the skin whiteness and the like.

Fig. 1 is a high-definition photograph of the face of a subject taken by VISIA-CR, and it can be seen that the improvement of the skin of the face of the subject before the application of sample a (week 0) and after the application of sample 2 weeks and 4 weeks, the acne mark removing composition of the embodiment has the advantages of obvious improvement of the skin of the face of the subject, white and clean skin, obvious reduction of acne and improvement of the overall state of the skin.

It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. The acne mark removing composition is characterized by comprising the following components in parts by weight: 0.05-0.15 part of carnosine, 1-3 parts of nicotinamide, 1-3 parts of panthenol, 0.05-0.15 part of asiaticoside, 0.5-2 parts of gentian extract and 0.5-2 parts of cactus stem extract.

2. The acne mark removal composition according to claim 1, which comprises the following components in parts by weight: 0.1 part of carnosine, 2-3 parts of nicotinamide, 1-2 parts of panthenol, 0.05-0.1 part of asiaticoside, 0.5-1 part of gentian extract and 0.5-1 part of cactus stem extract.

3. The acne mark removal composition according to claim 1, which comprises the following components in parts by weight: 0.1 part of carnosine, 3 parts of nicotinamide, 2 parts of panthenol, 0.1 part of asiaticoside, 0.5 part of gentian extract and 0.5 part of cactus stem extract.

4. The composition for removing acne marks of claim 1, wherein the gentian extract comprises triterpenes, flavones, iridoid glycosides and secoiridoid glycosides.

5. The composition for removing acne marks according to claim 4, wherein the content of iridoid glycoside and secoiridoid glycoside in the gentian extract is not less than 4.5 mg/mL.

6. The composition for removing acne marks according to claim 1, wherein the cactus stem extract comprises flavones, polysaccharides, superoxide dismutase, vitamin E and vitamin C.

7. The composition for removing acne marks according to claim 6, wherein the cactus stem extract is opuntia ficus-indica stem extract, wherein the content of polysaccharide is not less than 5.0 mg/mL.

8. The application of the acne mark removing composition as described in any one of claims 1-7 in preparing an acne mark skin repair product.

9. The acne mark skin repair product is characterized by comprising the following components in parts by weight:

and B component: 0.05-0.15 part of carnosine, 1-3 parts of nicotinamide, 1-3 parts of panthenol, 0.05-0.15 part of asiaticoside, 0.5-2 parts of gentian extract and 0.5-2 parts of cactus stem extract;

and C, component C: 0.1-1 part of preservative.

10. A method for producing the acne mark skin repair product according to claim 9, which comprises the steps of:

s1, cleaning and disinfecting production equipment;