CN107802511A - Whitening, spot additive used for cosmetic and its preparation method and application - Google Patents
Whitening, spot additive used for cosmetic and its preparation method and application Download PDFInfo
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- CN107802511A CN107802511A CN201711158617.6A CN201711158617A CN107802511A CN 107802511 A CN107802511 A CN 107802511A CN 201711158617 A CN201711158617 A CN 201711158617A CN 107802511 A CN107802511 A CN 107802511A
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- whitening
- alcohol
- skin
- calamine
- ursin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention proposes a kind of Whitening, spot additive used for cosmetic and its preparation method and application, is calculated according to percetage by weight, including following components：Alcohol 10~35%, calamine 14~65%, VCE 3~15%, ursin 1~15% and didextrose base gallate 1~10%.Preparation method：1) ursin, VCE and didextrose base gallate are dissolved in the alcohol of part and obtain solution A；2) calamine is dissolved in remaining alcohol and is dispersed with stirring to obtain solution B；3) solution A is well mixed with solution B.This can effectively suppress the activity of the tyrosinase in skin, block the formation of melanin, so as to carry out nti-freckle, white-skinned face function, securely and reliably.
Description
Technical field
The invention belongs to cosmetic technical field, and in particular to a kind of Whitening, spot additive used for cosmetic and its preparation
Methods and applications.
Background technology
The colour of skin of people is strongly dependent on the generation of melanin, divides a word with a hyphen at the end of a line and be distributed.Melanin is most important in skin
Pigment, it determines our colour of skin.Meanwhile melanin is also the natural defence system of human body skin, can resist ultraviolet pair
The injury of skin.Melanin uniform excess deposition in skin epidermis, the colour of skin will blackening, melanin part excess deposition,
It is to form freckle, the cardinal principle of chloasma.The reactions steps that melanin is formed：(1) it is free in oxygen by the tyrosinase of cupric
In the presence of base, catalysis oxidation tyrosine generation DOPA, this single step reaction proceeds by very slow but anti-after DOPA is formed
It should accelerate；(2) DOPA is changed into DOPA quinone under tyrosinase catalysis, and DOPA quinone has two kinds of Consumptions, and the first continues to change
For melanin, second with being changed into pheomelanin after cysteine interaction, pheomelanin is more of light color than melanin.
In the biosynthetic process of melanin, tyrosinase multiple reactions steps in play a crucial role.Therefore can
With by suppressing the carrying out to reduce the synthesis of melanin of tyrosinase activity or each blocking reaction in reaction chain, this
It is one of Basic Mechanism of current whitening and freckle-removing product formula design.From the point of view of the mechanism of action of known Melanin inhibitor
Two classes can be divided into：(1), to the cytotoxicity of melanocyte, the generation of melanin is suppressed；(2) black in melanocyte is hindered
The generation of element.
The effect of skin-lightening cosmetic adds in the market raw material mainly include hydroquinones, Qu acid, mercury compound,
One or more in the raw materials such as tartaric acid, vitamin C, hormone, but the defects of respective be present.Such as vitamin C, it is a kind of
Very strong reducing agent, itself has antioxidation, it is also assumed that being antioxidant, can reduce melanin, generally only L
Type vitamin C (i.e. L-vitamin C) just has whitening effect.However, vitamin C is extremely unstable, compare in dry air
It is stable, not pure and mild many natural prodcuts, it can be aoxidized by air and light, its aqueous solution is unstable, and it is anti-bad to be oxidized to dehydrogenation quickly
Hematic acid, especially it is oxidized quickly in neutral or alkaline solution.Meeting the metal ions such as light, heat, iron and copper can accelerated oxidation.
Plant extract relatively safety and gentle whitening composition, effect is played by suppressing the activity of tyraminase, generally a variety of
Together, long-term use does not have any burden to skin for collocation.It also has the function that antiallergic anti-inflammatory, but whitening effect produces
Speed can be very slow.The whitening principle of tartaric acid is to accelerate the metabolism of old cutin.Not enough, tartaric acid, which is excessively used, to be caused
The cuticula of skin easily departs from, and makes thinning of skin, becomes more sensitive.
At present also without a kind of generally acknowledged safely and effectively spot-removing function additive in China market.Almost all of nti-freckle
The freckle effect of cosmetics is little, and some nti-freckle products add heavy dose of quinhydrones or amino for nti-freckle or light spot purpose
The harmful substances such as mercury chloride, some consumers are caused the event of disfeaturing such as severe allergy or irreversible mercury spot (mercury poisoning) occur.With
The progress of modern science and technology, the research to safe and effective whitening spot-removing functional additive is always beauty and make-up industry emphasis
The problem of concern.People begin to use milder, effective Skin whitening care cosmeticses to cause the white temporary effect of skin to reach.By suppressing junket
The activity of propylhomoserin enzyme, the generation of melanin is reduced, so as to prevent new pigementation, improve and made because of Exposure to Sunlight or endocrinopathy
Into skin it is dark and gloomy, the bright and clean degree of the increase colour of skin and well-balanced degree, and gradually desalinate blackspot.
The content of the invention
The present invention proposes a kind of Whitening, spot additive used for cosmetic, and this can effectively suppress the tyrosinase in skin
Activity, block the formation of melanin, so as to carry out nti-freckle, white-skinned face function, securely and reliably.
The technical proposal of the invention is realized in this way：
A kind of Whitening, spot additive used for cosmetic, is calculated according to percetage by weight, including following components：
Alcohol 10~35%, calamine 14~65%, VCE 3~15%, ursin 1~15% and didextrose
Base gallate 1~10%.
Preferably, calculated according to percetage by weight, including following components：
Alcohol 10~25%, calamine 14~55%, VCE 3~15%, ursin 1~15% and didextrose
Base gallate 5~10%.
Preferably, the alcohol is butanediol.
Preferably, the ursin is alpha-arbutin.
It is a further object to provide a kind of preparation method of Whitening, spot additive used for cosmetic, including with
Lower step：
1) to weigh alcohol, calamine, VCE, ursin and didextrose base gallate according to proportioning standby；
2) ursin, VCE and didextrose base gallate are dissolved in the alcohol of part and obtain solution A；
3) calamine is dissolved in remaining alcohol and is dispersed with stirring to obtain solution B；
4) solution A is well mixed with solution B.
It is also another object of the present invention to provide a kind of application of Whitening, spot additive used for cosmetic, by the cosmetic
Product by the use of Whitening, spot additive be added to as component in the cosmetics.
Beneficial effects of the present invention：
Its dominant mechanism of Whitening, spot additive used for cosmetic of the present invention be by itself and junket ammonia enzyme directly in conjunction with
And the oxidation of tyrosinase and DOPA is blocked, accelerate the decomposition and excretion of melanin, effectively can suppress in skin
The activity of tyrosinase, the formation of melanin is blocked, so as to carry out nti-freckle, white-skinned face function.
Embodiment
Technical scheme is described in detail below：
A kind of Whitening, spot additive used for cosmetic, is calculated according to percetage by weight, including following components：
Alcohol 10~35%, calamine 14~65%, VCE 3~15%, ursin 1~15% and didextrose
Base gallate 1~10%.
Component VCE in the Whitening, spot additive of the present invention, it is the amphiprotic substance of hydrophilic and oleophilic, is dimension
Raw plain C derivative best so far, it is not only stable in chemical constitution, and is non-discolouring dimension life truly
Plain C derivative, this amphiprotic substance can be quickly through cuticula and reaches corium, so as to play biological effectiveness, it
Into after skin, metabolic pathway is identical in vivo with vitamin C, so as to play more preferable ascorbic effect.By acting on
Cu in tyrosinase structure2+, block melanin to be formed, whitening effect and nti-freckle.It is intensely dark that it can improve skin, makes band
The skin of blackspot and obscure skin become bright, while repair cell activity, accelerate collagen synthesis, assign skin elasticity.
Component ursin in the Whitening, spot additive of the present invention, extracts the leaf from black bearberry, is derived from green plants
Natural active matter, collection " green plants, safe and reliable " and " efficient decolorizing " three conjunction is humorous is unified in integral depigmentation of skin
Component, it can rapidly permeate into skin, while cell propagation concentration is not influenceed, by itself and junket ammonia enzyme directly in conjunction with and
The oxidation of tyrosinase and DOPA is blocked, accelerates the decomposition and excretion of melanin, can effectively suppress the junket ammonia in skin
The activity of sour enzyme, the formation of melanin is blocked, so as to reduce Skin pigmentation, dispelling stain and freckle, whitening function is quick
Effectively, and to melanocyte the side effects such as toxic, excitant, sensitization are not produced, while also have sterilization, the work of anti-inflammatory
With.The middle ursin that is preferable to carry out of the present invention is alpha-arbutin, because alpha-arbutin is β-ursin in terms of whitening effect
More than 15 times.
Component didextrose base gallate in the Whitening, spot additive of the present invention, there is very strong oxidation resistance, antioxygen
Change effect than 4 times of VC, quickly remove free radical, avoid clogging of pores；Splendid DNA protects effect, prevents DNA damage；Suppression
The activity of TYR enzyme processed, suppress the transfer and melanin accumulation of melanin, the content of melanin in basalis is reduced, lifting
Skin lightness, skin-whitening degree is lifted, reduce sunburn and even skin tone, reduce the general red phenomenon of skin, effect is than kojic acid 60
Times, moreover it is possible to significantly reduce pore.
The present invention also fills reinforcing agent with alcohol from calamine as solvent, and alcohol selects fourth two in preferable technical scheme
Alcohol.Calamine main component is zinc carbonate, still calcium containing small amounts 0.27%, magnesia 0.45%, iron oxide 0.58%, oxidation
Manganese 0.01%.Zinc in this stone, often substituted by a small amount of iron (divalence).In addition, some calamine kinds still containing it is a small amount of bore,
Copper, cadmium, the germanium and indium of lead and denier.Calamine is not of uniform size in irregular block, circular or oblateness.It is superficial white, light
Red or yellowish-brown, it is uneven, it is porous like cellular.The aobvious mealiness of body lightweight pine, frangible, section white or pale red, in
It is granular and have fine pore, there is hygroscopicity.It is odorless, taste micro-puckery.So that body is light, matter is loose, block is big, and Se Bai or light red persons are good.It is widely used in skin
Skin section, as the anti-corrosion of moderate, convergence, protective agent treatment scytitis or surface injury.Typically (washed with 5-10% aqueous suspensions
Agent), also useful ointment person.External application can partially absorb wound extract, there is convergence, protective effect；Local staphylococcus can be suppressed
Growth.
Each independent function was having relevant report to each component before in technical scheme, but will be above-mentioned
Component, which is combined, to be reported without such.Particularly using calamine as promotion active matter skin penetrant and vitamin
C ethylethers, which are used together, not to be reported, calamine, which promotes said components and penetrated into the skin corium of skin, plays its whitening
Effect.
In terms of preparation method, calamine is dissolved in alcohol by the application, and other components are mixed after being dissolved in alcohol
Conjunction is handled, and is more easy to give play to respective whitening effect than being re-dissolved in alcohol after each mixing.
In some currently preferred embodiments of the present invention, a kind of Whitening, spot additive used for cosmetic, according to percetage by weight
Calculate, including following components：
Butanediol 10~25%, calamine 14~55%, VCE 3~15%, ursin 1~15% and two
Glucityl gallate 5~10%.
The cosmetics of the present invention, can be skin type, cleaning class etc., preferably skin type or cleaning class emulsifying or foaming
Type product, described skin type is such as skin lotion, facial mask, and described cleaning class is such as hand cleanser, mildy wash or bath oil.
In different types of cosmetics, the addition of Whitening, spot additive of the invention can be with different.
Embodiment 1
A kind of Whitening, spot additive used for cosmetic, is calculated according to percetage by weight, including following components：
Butanediol 25%, calamine 55%, VCE 3%, ursin 12% and didextrose base gallate 5%.
Preparation method：
1) to weigh alcohol, calamine, VCE, ursin and didextrose base gallate according to proportioning standby；
2) ursin, VCE and didextrose base gallate are dissolved in the alcohol of part and obtain solution A；
3) calamine is dissolved in remaining alcohol and is dispersed with stirring to obtain solution B；
4) solution A is well mixed with solution B
Embodiment 2
A kind of Whitening, spot additive used for cosmetic, is calculated according to percetage by weight, including following components：
Butanediol 10%, calamine 50%, VCE 15%, ursin 15% and didextrose base gallate 10%.
Preparation method is substantially the same manner as Example 1, and difference is the content of each component.
Embodiment 3
A kind of Whitening, spot additive used for cosmetic, is calculated according to percetage by weight, including following components：
Butanediol 35%, calamine 25%, VCE 15%, alpha-arbutin 15%, didextrose base gallate
10%.
Preparation method is substantially the same manner as Example 1, and difference is the content of each component.
Embodiment 4
A kind of Whitening, spot additive used for cosmetic, is calculated according to percetage by weight, including following components：
Butanediol 15%, calamine 65%, VCE 10%, alpha-arbutin 9%, didextrose base gallate 1%.
Preparation method is substantially the same manner as Example 1, and difference is the content of each component.
Application Example
The Whitening, spot additive of the present invention is expanded on further by the following examples in face mask for eliminating macula and whitening skin Essence
The application of (being applied to paper film or non-woven fabrics facial mask), wherein Whitening, spot additive of the invention in following formula is with generation
Code：Mix White are represented.
The component and content of the face mask for eliminating macula and whitening skin Essence of table 1
The production method of face mask for eliminating macula and whitening skin Essence：A and B are dissolved by heating respectively, mixing, after cooling under agitation successively
C and D is added, is stirred.
40 women triers are selected, the experiment crowd as the present invention.4 groups of experiment point, every group of 10 people, every group uses one
The semi-finished product of individual scheme, and by using the contrast of peace group is consoled, service life is 1 month.
The Whitening, spot additive of table 2 application effect in face mask for eliminating macula and whitening skin Essence
Whitening, spot positive effect refers to continue to use once all interior effective.
Whitening, spot effect is effective within preferably persistently using more than one week, one month.
Below the functions and effects of calamine in inventive formulation component and didextrose base gallate are made with following experiment to carry out
Checking：
The formula scheme of embodiment 1 is chosen by examples detailed above result, removes calamine in Mix White constituent
New composition Mix White-1 are formed with didextrose base gallate, by selecting 15 triers, respectively in left and right arm and upper
The facial mask liquid for stating embodiment 1 carries out contrast test, persistently using feeding back using effect after two weeks.As a result 11 people are fed back to feel to contain
Mix White whitening effect is better than White-1 containing Mix, and 4 people think that both differences are little, and 0 people feels to contain Mix
White-1 effect is more preferable.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection with principle.
Claims (6)
- A kind of 1. Whitening, spot additive used for cosmetic, it is characterised in that calculated according to percetage by weight, including with the following group Point：Alcohol 10~35%, calamine 14~65%, VCE 3~15%, ursin 1~15% and didextrose base Gallate Acid 1~10%.
- 2. Whitening, spot additive according to claim 1, it is characterised in that calculated according to percetage by weight, including with Lower component：Alcohol 10~25%, calamine 14~55%, VCE 3~15%, ursin 1~15% and didextrose base Gallate Acid 5~10%.
- 3. Whitening, spot additive according to claim 1 or 2, it is characterised in that the alcohol is butanediol.
- 4. Whitening, spot additive according to claim 1 or 2, it is characterised in that the ursin is alpha-arbutin.
- 5. the preparation method of Whitening, spot additive used for cosmetic as claimed in claim 1, it is characterised in that including following Step：1) to weigh alcohol, calamine, VCE, ursin and didextrose base gallate according to proportioning standby；2) ursin, VCE and didextrose base gallate are dissolved in the alcohol of part and obtain solution A；3) calamine is dissolved in remaining alcohol and is dispersed with stirring to obtain solution B；4) solution A is well mixed with solution B.
- 6. the application of Whitening, spot additive used for cosmetic as claimed in claim 1, it is characterised in that by the cosmetics By the use of Whitening, spot additive be added to as component in the cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711158617.6A CN107802511A (en) | 2017-11-20 | 2017-11-20 | Whitening, spot additive used for cosmetic and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711158617.6A CN107802511A (en) | 2017-11-20 | 2017-11-20 | Whitening, spot additive used for cosmetic and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
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| CN107802511A true CN107802511A (en) | 2018-03-16 |
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ID=61580217
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711158617.6A Pending CN107802511A (en) | 2017-11-20 | 2017-11-20 | Whitening, spot additive used for cosmetic and its preparation method and application |
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| CN (1) | CN107802511A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721104A (en) * | 2019-10-31 | 2020-01-24 | 泉后(广州)生物科技研究院有限公司 | Whitening cream and preparation method thereof |
| CN111728891A (en) * | 2020-06-29 | 2020-10-02 | 泉后(广州)生物科技研究院有限公司 | Acne mark removing composition and application thereof |
| CN112569132A (en) * | 2020-11-30 | 2021-03-30 | 彭氏(惠州)实业发展有限公司 | Bath cream and preparation method thereof |
| CN114642609A (en) * | 2021-04-27 | 2022-06-21 | 上海科黛生物科技有限公司 | Composition for improving stability of vitamin C and application of composition in cosmetics |
| CN116531275A (en) * | 2023-07-04 | 2023-08-04 | 北京青颜博识健康管理有限公司 | Microcapsule for relieving high-concentration vitamin C ethyl ether stimulation and preparation method and application thereof |
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| CN106074203A (en) * | 2016-08-29 | 2016-11-09 | 李金华 | A kind of light speckles, beautification and white frost and preparation method thereof |
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| CN106074203A (en) * | 2016-08-29 | 2016-11-09 | 李金华 | A kind of light speckles, beautification and white frost and preparation method thereof |
| CN107213084A (en) * | 2017-05-27 | 2017-09-29 | 广州市千邦化妆品有限公司 | A kind of whitening spot-eliminating composition and cosmetics |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721104A (en) * | 2019-10-31 | 2020-01-24 | 泉后(广州)生物科技研究院有限公司 | Whitening cream and preparation method thereof |
| CN110721104B (en) * | 2019-10-31 | 2020-10-27 | 泉后(广州)生物科技研究院有限公司 | Whitening cream and preparation method thereof |
| CN111728891A (en) * | 2020-06-29 | 2020-10-02 | 泉后(广州)生物科技研究院有限公司 | Acne mark removing composition and application thereof |
| CN112569132A (en) * | 2020-11-30 | 2021-03-30 | 彭氏(惠州)实业发展有限公司 | Bath cream and preparation method thereof |
| CN114642609A (en) * | 2021-04-27 | 2022-06-21 | 上海科黛生物科技有限公司 | Composition for improving stability of vitamin C and application of composition in cosmetics |
| CN116531275A (en) * | 2023-07-04 | 2023-08-04 | 北京青颜博识健康管理有限公司 | Microcapsule for relieving high-concentration vitamin C ethyl ether stimulation and preparation method and application thereof |
| CN116531275B (en) * | 2023-07-04 | 2023-10-13 | 北京青颜博识健康管理有限公司 | Microcapsule for relieving high-concentration vitamin C ethyl ether stimulation and preparation method and application thereof |
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