CN114642609A - Composition for improving stability of vitamin C and application of composition in cosmetics - Google Patents
Composition for improving stability of vitamin C and application of composition in cosmetics Download PDFInfo
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- CN114642609A CN114642609A CN202110462197.0A CN202110462197A CN114642609A CN 114642609 A CN114642609 A CN 114642609A CN 202110462197 A CN202110462197 A CN 202110462197A CN 114642609 A CN114642609 A CN 114642609A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention belongs to the technical field of materials for cosmetics, and relates to a composition for improving the stability of vitamin C and application thereof in cosmetics, wherein the composition comprises the following components in parts by weight: 3-7 parts of vitamin C derivative, 0.5-2 parts of humectant, 0.1-1 part of chelating agent, 2-4 parts of surfactant, 0.2-2 parts of phenol derivative and 84-95 parts of deionized water; the unique formula is adopted to reduce the influence of factors such as light, oxygen, heat and the like on the performance of the vitamin C, the mixed use method of the composition and the vitamin C powder is simple and easy to operate, and acne marks can be lightened and the skin color can be brightened after the composition and the vitamin C powder are used; the application value of the vitamin C in the cosmetics is improved by improving the stability of the vitamin C.
Description
Technical Field
The invention belongs to the technical field of materials for cosmetics, and relates to a composition for improving the stability of vitamin C and application thereof in cosmetics.
Background
Since the artificial synthesis of vitamin C (L-ascorbic acid) in 1933, vitamin C has been receiving attention from the chemical, medical and nutritional fields, and plays an important role in the industries of cosmetics, food additives, medicine and health care and the like.
The vitamin C has the effects of resisting wrinkles and whitening the skin, but is easily oxidized by oxygen dissolved in water due to unstable structure and is easily damaged by light and heat to lose the reducing capacity, the instability greatly reduces the effective utilization rate of the vitamin C, the method for improving the stability of the vitamin C can improve the application value of the vitamin C in cosmetics.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present invention provides a composition for improving the stability of vitamin C, comprising the following components in parts by weight: 3-7 parts of vitamin C derivative, 0.5-2 parts of humectant, 0.1-1 part of chelating agent, 2-4 parts of surfactant, 0.2-2 parts of phenol derivative and 84-95 parts of deionized water.
Preferably, the vitamin C derivative is selected from one or more of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, calcium ascorbyl phosphate, ascorbyl polypeptide, ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl glucoside, ethyl ascorbyl ether, ascorbyl stearate, and ascorbyl ethyl silanol pectate.
Further, the vitamin C derivative is ethyl ascorbic acid ether.
Still further, the ethyl ascorbic acid ether is 3-O-ethyl ascorbic acid ether; the 3-O-ethyl ascorbic acid ether is called vitamin C ethyl ether.
Preferably, the humectant is selected from vitamin C derivatives bearing an ester group.
Further, the vitamin C derivative with ester group is selected from one of vitamin C phosphate and vitamin C palmitate or the combination thereof.
Still further, the vitamin C derivative having an ester group is vitamin C palmitate.
Still further, the vitamin C palmitate is ascorbyl tetraisopalmitate.
Preferably, the chelating agent is a rutin derivative.
Further, the rutin derivative is a rutin derivative with a hydroxyl structure.
Further, the rutin derivative with a hydroxyl structure is 3',4', 7-tri [ O- (2-hydroxyethyl) ] rutin; the 3',4', 7-tri [ O- (2-hydroxyethyl) ] rutin is also called troxerutin.
Preferably, the surfactant is selected from one or more of anionic surfactant, nonionic surfactant, cationic surfactant.
Further, the surfactant is an anionic surfactant.
Still further, the anionic surfactant is a carboxylate; the carboxylate is a glycosyl carboxylate.
Still further, the glycosyl carboxylate is glycosyl benzoate.
Still further, the glycosylbenzoate is diglucosylgallic acid.
Preferably, the phenol derivative is an alkylresorcinol.
Still further, the alkylresorcinol is hexylresorcinol.
Preferably, the weight ratio of the chelating agent to the humectant to the vitamin C derivative is 1: (2-3): (8-14).
In a second aspect, the invention provides a composition for improving vitamin C stability, which is mixed with levorotatory vitamin C powder for use in cosmetics.
Advantageous effects
1. The unique formula is adopted to reduce the influence of factors such as light, oxygen, heat and the like on the performance of the vitamin C and improve the stability of the vitamin C.
2. The application value of the vitamin C in the cosmetics is improved by improving the stability of the vitamin C.
3. The mixing and using method of the composition and the vitamin C powder is simple and easy to operate.
4. After the acne cream is used, acne marks can be lightened, and the skin color can be brightened.
Drawings
Fig. 1 is a recorded facial skin image of subject No. 8 on day0 before the product was obtained by mixing the composition prepared in example 1 with levovitamin C powder.
Fig. 2 is a facial skin image recorded for 14 days for the product obtained by mixing the composition prepared in example 1 with levovitamin C powder for subject No. 8.
Fig. 3 is a facial skin image recorded for 28 days of product obtained by mixing the composition prepared in example 1 with levovitamin C powder for subject No. 8.
Fig. 4 is a recorded facial skin image of subject 16 on day0 prior to the product, after mixing the composition prepared in example 1 with levovitamin C powder.
Fig. 5 is a facial skin image recorded 14 days after the product was obtained by mixing the composition prepared in example 1 with levovitamin C powder for subject 16.
Fig. 6 is a facial skin image recorded for 28 days of product obtained after the 16 th subject mixed levovitamin C powder with the composition prepared in example 1.
Fig. 7 is a recorded facial skin image of subject # 27 on day0 prior to the product, after mixing the composition prepared in example 1 with levovitamin C powder.
Fig. 8 is a facial skin image recorded 14 days after the product was obtained by mixing the composition prepared in example 1 with levovitamin C powder for subject No. 27.
Fig. 9 is a facial skin image recorded for 28 days of product obtained after trial 27 had mixed levovitamin C powder with the composition prepared in example 1.
Detailed Description
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.
The words "preferred", "more preferred", and the like, in the present invention refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention.
When a range of values is disclosed herein, the range is considered to be continuous and includes both the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range-describing features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to encompass any and all subranges subsumed therein. For example, a stated range from "1 to 10" should be considered to include any and all subranges between the minimum value of 1 and the maximum value of 10. Exemplary subranges of the range 1 to 10 include, but are not limited to, 1 to 6.1, 3.5 to 7.8, 5.5 to 10, and the like.
The invention provides a composition for improving the stability of vitamin C, which comprises the following components in parts by weight: 3-7 parts of vitamin C derivative, 0.5-2 parts of humectant, 0.1-1 part of chelating agent, 2-4 parts of surfactant, 0.2-2 parts of phenol derivative and 84-95 parts of deionized water.
In a preferred embodiment, the vitamin C derivative is selected from one or more of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, calcium ascorbyl phosphate, ascorbyl polypeptide, ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl glucoside, ethyl ascorbyl ether, ascorbyl stearate, and ascorbyl ethyl silanol pectate.
In a more preferred embodiment, the vitamin C derivative is ethyl ascorbyl ether.
In a more preferred embodiment, the ethyl ascorbate ether is 3-O-ethyl ascorbate ether; the 3-O-ethyl ascorbic acid ether is called vitamin C ethyl ether.
In a preferred embodiment, the vitamin C ethyl ether purchase is made by Shandong Teng chemical company, Inc. model 101.
In a preferred embodiment, the humectant is selected from vitamin C derivatives bearing an ester group.
In a preferred embodiment, the vitamin C derivative with ester group is selected from one of vitamin C phosphate and vitamin C palmitate or their combination.
In a preferred embodiment, the vitamin C derivative having an ester group is vitamin C palmitate.
In a more preferred embodiment, the ascorbyl palmitate is ascorbyl tetraisopalmitate.
In a preferred embodiment, the ascorbyl tetraisopalmitate supplier is Wuhan Haishan technologies Inc. at a mass content of 95%.
In a preferred embodiment, the chelating agent is a derivative of rutin.
Chelating agent: reacting a metal atom or ion with a ligand containing two or more coordinating atoms to form a complex having a cyclic structure, which is called a chelate; such ligand substances capable of forming chelates are called chelating agents, also known as complexing agents.
In a more preferred embodiment, the rutin derivative is a rutin derivative having a hydroxyl structure.
In a most preferred embodiment, the derivative of rutin having a hydroxyl structure is 3',4', 7-tris [ O- (2-hydroxyethyl) ] rutin; the 3',4', 7-tri [ O- (2-hydroxyethyl) ] rutin is also called troxerutin.
In a preferred embodiment, the troxerutin purchaser is Saian Green Biotechnology, Inc. under CAS number 7085-55-4 and model number PMM 0401.
In a preferred embodiment, the surfactant is selected from one or more of an anionic surfactant, a nonionic surfactant, and a cationic surfactant.
Anionic surfactant: anionic surfactants are classified according to the structure of their hydrophilic groups: sulfonates and sulfate salts are currently the major class of anionic surfactants. The various functions of surfactants are mainly manifested in changing the properties of the surface, liquid-liquid interface and liquid-solid interface of a liquid, of which the surface (interfacial) properties of the liquid are most important.
Cationic surfactant: the cationic surfactant is mainly a nitrogenous organic amine derivative, and because a nitrogen atom in a molecule of the cationic surfactant contains lone pair electrons, the cationic surfactant can be combined with hydrogen in an acid molecule by a hydrogen bond to enable an amino group to carry positive charges; therefore, they have good surface activity in acidic media; and is easy to precipitate in an alkaline medium to lose surface activity; besides the nitrogen-containing cationic surfactant, a small part of cationic surfactant containing elements such as sulfur, phosphorus, arsenic and the like is also available.
Nonionic surfactant: the nonionic surfactant is a surfactant which contains an ether group which is not dissociated in an aqueous solution as a main hydrophilic group in a molecule, and the surface activity of the surfactant is represented by neutral molecules; the nonionic surfactant has high surface activity, good solubilization, washing, antistatic, calcium soap dispersion and other performances, small irritation, and excellent wetting and washing functions. The pH value range of the surfactant can be wider than that of a common ionic surfactant, and the surfactant can also be used together with other ionic surfactants, and the surfactant of the system can be improved by adding a small amount of nonionic surfactant into the ionic surfactant; nonionic surfactants can be classified into polyoxyethylene type, polyhydric alcohol type, alkanolamide type, polyether type, amine oxide type, and the like according to the structure of the hydrophilic group.
In a preferred embodiment, the surfactant is an anionic surfactant.
In a preferred embodiment, the anionic surfactant is a carboxylate; the carboxylate is a glycosyl carboxylate.
In a more preferred embodiment, the glycosyl carboxylate is glycosyl benzoate.
In a most preferred embodiment, the glycosylbenzoate is diglucosylgallic acid.
In a preferred embodiment, the diglucosylgallic acid is purchased from GmbH, Biglucosylgallic acid with a mass content of 98%.
In a preferred embodiment, the phenol derivative is an alkylresorcinol.
In a preferred embodiment, the alkylresorcinol is hexylresorcinol.
In a preferred embodiment, the purchased resorcinol is 99% by weight from Guangzhou Xinlang Biochemical Co.
In a preferred embodiment, the weight ratio of the chelating agent, the humectant and the vitamin C derivative is 1: (2-3): (8-14).
During the experiment, the weight ratios of troxerutin, ascorbyl tetraisopalmitate and vitamin C ethyl ether are found as follows: 1: (2-3): (8-14), preferably 1: 2.5: 12.5, the influence of factors such as light, oxygen, heat and the like on the performance of the vitamin C can be reduced, and the stability of the vitamin C can be improved; the hexylresorcinol and the ascorbyl tetraisopalmitate are matched with each other to form an isolation layer in the application process, so that the service time of the biotin C is prolonged; through the coordination effect of a system formed among the components in each composition, the effects of lightening acne marks, brightening skin and whitening skin color can be achieved;
the preparation method comprises the following steps: weighing 3-7 parts of vitamin C derivative, 0.5-2 parts of humectant, 0.1-1 part of chelating agent, 2-4 parts of surfactant, 0.2-2 parts of phenol derivative and 84-95 parts of deionized water by weight, heating to 30-40 ℃, homogenizing and stirring for 2-10min, cooling to obtain the composition, bottling the composition, sealing and storing.
In a second aspect, the present invention provides a cosmetic use of a composition for improving the stability of vitamin C, comprising the steps of:
(1) adding levo-vitamin C powder into the composition for bottling and sealing;
(2) shaking up and down to be fully mixed;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any inventive step based on the embodiments of the present invention, belong to the scope of protection of the present invention, and the present invention is described below by way of specific embodiments, but is not limited to the specific embodiments given below.
Examples
Example 1
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 0.4 part of troxerutin, 3 parts of diglucosylgallic acid, 1 part of hexyl resorcinol and 89.6 parts of deionized water.
The preparation method comprises the following steps: weighing 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 0.4 part of troxerutin, 3 parts of diglucosylgallic acid, 1 part of hexylresorcinol and 89.6 parts of deionized water by weight, slightly heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, and sealing for preservation.
A composition for improving the stability of vitamin C is applied to cosmetics, and the application method comprises the following steps:
(1) adding 2g of levorotary vitamin C powder into a bottle containing 20ml of composition;
(2) shaking up and down to be fully mixed;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The troxerutin purchasing manufacturer is Xian Lutian biotechnology limited company, the CAS number is 7085-55-4, and the model is PMM 0401.
The described diglucosylgallic acid purchasing manufacturer is a scientific and scientific biotechnology limited company of Wuhan Hua, and the quality content of diglucosylgallic acid is 98%.
The vitamin C ethyl ether purchasing manufacturer is Shandong TengWang chemical industry Co., Ltd, and the model is 101.
The supplier of the ascorbic acid tetraisopalmitate is Wuhan Haishan science and technology Limited company, and the mass content is 95 percent.
The hexyl resorcinol purchasing manufacturer is Guangzhou Xinlang biochemical engineering limited company, and the mass content is 99%.
Example 2
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 7 parts of vitamin C ethyl ether, 2 parts of ascorbyl tetraisopalmitate, 0.8 part of troxerutin, 4 parts of diglucosylgallic acid, 2 parts of hexyl resorcinol and 84.2 parts of deionized water.
The preparation method comprises the following steps: weighing 7 parts of vitamin C ethyl ether, 2 parts of ascorbyl tetraisopalmitate, 0.8 part of troxerutin, 4 parts of diglucosylgallic acid, 2 parts of hexyl resorcinol and 84.2 parts of deionized water by weight, slightly heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, and sealing for preservation.
The application of a composition for improving the stability of vitamin C in cosmetics comprises the following steps:
(1) adding 2g of levo-vitamin C powder into a bottle containing 20ml of the composition;
(2) shaking up and down to be fully mixed;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The troxerutin purchasing manufacturer is Xian Lutian biotechnology limited company, the CAS number is 7085-55-4, and the model is PMM 0401.
The described diglucosylgallic acid purchasing manufacturer is a scientific and scientific biotechnology limited company of Wuhan Hua, and the quality content of diglucosylgallic acid is 98%.
The vitamin C ethyl ether purchasing manufacturer is Shandong TengWang chemical industry Co., Ltd, and the model is 101.
The supplier of the ascorbic acid tetraisopalmitate is Wuhan Haishan science and technology Limited company, and the mass content is 95 percent.
The purchase manufacturer of the hexyl resorcinol is Guangzhou Xinlang biochemical engineering limited company, and the mass content is 99 percent.
Example 3
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 3 parts of vitamin C ethyl ether, 0.8 part of ascorbyl tetraisopalmitate, 0.3 part of troxerutin, 2 parts of diglucosylgallic acid, 0.2 part of hexyl resorcinol and 93.7 parts of deionized water.
The preparation method comprises the following steps: weighing 3 parts of vitamin C ethyl ether, 0.8 part of ascorbyl tetraisopalmitate, 0.3 part of troxerutin, 2 parts of diglucosylgallate, 0.2 part of hexylresorcinol and 93.7 parts of deionized water according to the weight, heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, sealing and storing.
A composition for improving the stability of vitamin C is applied to cosmetics, and the application method comprises the following steps:
(1) adding 2g of levo-vitamin C powder into a bottle containing 20ml of the composition;
(2) shaking up and down to mix fully;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The troxerutin purchasing manufacturer is Xian Lutian biotechnology limited company, the CAS number is 7085-55-4, and the model is PMM 0401.
The described diglucosylgallic acid purchasing manufacturer is a scientific and scientific biotechnology limited company of Wuhan Hua, and the quality content of diglucosylgallic acid is 98%.
The vitamin C ethyl ether purchasing manufacturer is Shandong TengWang chemical industry Co., Ltd, and the model is 101.
The supplier of the ascorbic acid tetraisopalmitate is Wuhan Haishan science and technology Limited company, and the mass content is 95 percent.
The purchase manufacturer of the hexyl resorcinol is Guangzhou Xinlang biochemical engineering limited company, and the mass content is 99 percent.
Example 4
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 5 parts of vitamin C ethyl ether, 0.4 part of troxerutin, 3 parts of diglucosylgallic acid, 1 part of hexyl resorcinol and 90.6 parts of deionized water.
The preparation method comprises the following steps: weighing 5 parts of vitamin C ethyl ether, 0.4 part of troxerutin, 3 parts of diglucosylgallic acid, 1 part of hexylresorcinol and 90.6 parts of deionized water by weight, slightly heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, and sealing for storage.
A composition for improving the stability of vitamin C is applied to cosmetics, and the application method comprises the following steps:
(1) adding 2g of levo-vitamin C powder into a bottle containing 20ml of the composition;
(2) shaking up and down to mix fully;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The troxerutin purchasing manufacturer is Xian Lutian biotechnology limited company, the CAS number is 7085-55-4, and the model is PMM 0401.
The described diglucosylgallic acid purchasing manufacturer is a scientific and scientific biotechnology limited company of Wuhan Hua, and the quality content of diglucosylgallic acid is 98%.
The vitamin C ethyl ether purchasing manufacturer is Shandong TengWang chemical industry Co., Ltd, and the model is 101.
The purchase manufacturer of the hexyl resorcinol is Guangzhou Xinlang biochemical engineering limited company, and the mass content is 99 percent.
Example 5
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 3 parts of diglucosylgallic acid, 1 part of hexyl resorcinol and 90 parts of deionized water.
The preparation method comprises the following steps: weighing 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 3 parts of diglucosylgallic acid, 1 part of hexylresorcinol and 90 parts of deionized water by weight, heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, and sealing for storage.
A composition for improving the stability of vitamin C is applied to cosmetics, and the application method comprises the following steps:
(1) adding 2g of levo-vitamin C powder into a bottle containing 20ml of the composition;
(2) shaking up and down to mix fully;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The described diglucosylgallic acid purchasing manufacturer is a scientific and scientific biotechnology limited company of Wuhan Hua, and the quality content of diglucosylgallic acid is 98%.
The vitamin C ethyl ether purchasing manufacturer is Shandong Tengwang chemical industry Co., Ltd, and the model is 101.
The supplier of the ascorbic acid tetraisopalmitate is Wuhan Haishan science and technology Limited company, and the mass content is 95 percent.
The purchase manufacturer of the hexyl resorcinol is Guangzhou Xinlang biochemical engineering limited company, and the mass content is 99 percent.
Example 6
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 0.4 part of troxerutin, 1 part of hexyl resorcinol and 92.6 parts of deionized water.
The preparation method comprises the following steps: weighing 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 0.4 part of troxerutin, 1 part of hexylresorcinol and 92.6 parts of deionized water according to the weight, heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, and sealing for storage.
A composition for improving the stability of vitamin C is applied to cosmetics, and the application method comprises the following steps:
(1) adding 2g of levo-vitamin C powder into a bottle containing 20ml of the composition;
(2) shaking up and down to be fully mixed;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The troxerutin purchasing manufacturer is a Sigan Lutian biotechnology limited company, the CAS number is 7085-55-4, and the model is PMM 0401.
The vitamin C ethyl ether purchasing manufacturer is Shandong TengWang chemical industry Co., Ltd, and the model is 101.
The manufacturer of the ascorbyl tetraisopalmitate is Wuhan Haishan science and technology Limited company, and the mass content is 95 percent.
The purchase manufacturer of the hexyl resorcinol is Guangzhou Xinlang biochemical engineering limited company, and the mass content is 99 percent.
Example 7
The composition for improving the stability of vitamin C comprises the following components in parts by weight: 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 0.4 part of troxerutin, 3 parts of diglucosylgallic acid and 90.6 parts of deionized water.
The preparation method comprises the following steps: weighing 5 parts of vitamin C ethyl ether, 1 part of ascorbyl tetraisopalmitate, 0.4 part of troxerutin, 3 parts of diglucosylgallic acid and 90.6 parts of deionized water according to the weight, heating to 35 ℃, homogenizing and stirring for 5min, cooling to obtain the composition, bottling the composition, and sealing for storage.
A composition for improving the stability of vitamin C is applied to cosmetics, and the application method comprises the following steps:
(1) adding 2g of levo-vitamin C powder into a bottle containing 20ml of the composition;
(2) shaking up and down to be fully mixed;
(3) the bottle cap is replaced by a dropper cap, and the bottle cap is used by being sucked by a dropper.
The L-vitamin C purchasing manufacturer is Siemens Qianye grass biotechnology limited, the CAS number is 50-81-7, and the mass content is more than 99%.
The troxerutin purchasing manufacturer is Xian Lutian biotechnology limited company, the CAS number is 7085-55-4, and the model is PMM 0401.
The diglucosylgallate purchasing manufacturer is a full and complete biotechnology limited company of Wuhan Hua, and the diglucosylgallate mass content is 98%.
The vitamin C ethyl ether purchasing manufacturer is Shandong TengWang chemical industry Co., Ltd, and the model is 101.
The supplier of the ascorbic acid tetraisopalmitate is Wuhan Haishan science and technology Limited company, and the mass content is 95 percent.
Test of
1. The compositions prepared in examples 1 to 7 were mixed with levovitamin C powder and then stored for 15 days, and the stability of the mixture was observed, and the results are shown in Table 1.
TABLE 1
| Examples | Stability of |
| Example 1 | Uniformly dispersed without sedimentation |
| Example 2 | Uniformly dispersed without sedimentation |
| Example 3 | Uniformly dispersed without sedimentation |
| Example 4 | With settling |
| Example 5 | With settling |
| Example 6 | With settling |
| Example 7 | With settling |
2. The composition prepared in example 1 was mixed with levo-vitamin C powder and tested for its effects of lightening acne marks, lightening skin and whitening skin.
The using method comprises the following steps:
the using part: a face.
Frequency of use and period of use: is used once a day in the evening and is continuously used 28.
The using method comprises the following steps: the levorotatory VC powder was poured into an erlenmeyer flask, mixed with the composition prepared in example 1, capped with a drip cap and shaken for about 15 seconds to allow the VC to dissolve sufficiently. After mixing, it is recommended to use within 15 days. The formula adopts a water-oil separation system, the essential oil can float after standing, and the essential oil is shaken for 2-3 times before use every time, so that the water and the oil are mixed again. After application to water, before cream.
The following requirements are imposed on the tester:
(1) age of subject: 18-35 years old;
(2) subject status: a healthy female;
(3) subject facial skin: acne marks and dark skin color exist on normal skin and facial skin;
(4) requirements during testing: the regularity of life can be maintained during the test period; prohibiting the use of other skin care products and products affecting the test at the test site; and reduce the outdoor intense solarization activity, forbid the tourism vacation; cosmetics, medicines and health care products which have an influence on the results are not used, and medical treatment, massage, nursing in beauty parlors and the like are prohibited; the tester may not use the base skin care products and cosmetics within 12 hours prior to the test site;
the testing process comprises the following steps:
Day0：
(1) cleaning the face
The subject cleanses the face with the cleansing product, and wipes the skin dry with dry facial tissue, sitting still for 30min in a laboratory at a temperature of 21 + -1 deg.C and 50 + -5% RH;
(2) testing subject skin basis
Testing a skin color basic value, a skin melanin basic value and a skin glossiness basic value of a acne mark position of a subject by a laboratory technician, and carrying out image acquisition by using Visia-CR;
(3) the laboratory technician instructs the subject on the product usage requirements and site of use and provides written test precautions and product instructions;
(4) the subject received the sample and left the laboratory.
Day14
(1) Subjects revisit, clean the face and wait
Cleaning face with the face cleaning product, wiping skin with dry facial tissue, and sitting in laboratory at 21 + -1 deg.C and 50 + -5% RH for 30 min;
(2) testing subject skin data values
Testing a cheek skin color data value, a skin melanin data value and a skin glossiness data value of a subject by a laboratory technician, and carrying out image acquisition by using Visia-CR;
(3) the subjects filled out a questionnaire.
Day28
(1) Subjects visited back, cleaned the face and waited for
Cleaning face with the face cleaning product, wiping skin with dry facial tissue, and sitting in laboratory at 21 + -1 deg.C and 50 + -5% RH for 30 min;
(2) testing subject skin data values
Laboratory technicians test cheek skin color data values, skin melanin data values, skin gloss data values for subjects, image acquisition using Visia-CR, instrumentation and numerical specifications are shown in table 2 below.
TABLE 2
The test method comprises the following steps:
(1) 33 subjects are selected from each group, 0.020ml of the mixture prepared in the example 1 and the levorotatory vitamin C powder are mixed and added into a spot tester 1, the spot tester 1 and a spot tester 2 with negative control are respectively pasted on the forearm curved side of the subjects, the spot tester is removed after 24h, the skin reactions of the subjects 30min, 24h and 48h after the spot tester is removed are respectively recorded, the scoring standard is shown in a table 3, and the test result is shown in a table 4.
TABLE 3
TABLE 4
(2) Facial skin basic values of the subjects were collected 0 days before the subjects used the product, 14 days after the use of the product, 28 days after the use of the product, and 3 subjects were randomly selected and subjected to skin image recording, and the test results are shown in tables 5 to 10 and fig. 1 to 9.
TABLE 5
Note: the p value of the normality test is larger than 0.050, which shows that the data obeys normal distribution, and a pairing t test is adopted, or a non-parametric wilcoxon test is adopted if the data does not obey the normal distribution.
② significance p value <0.050, which shows significant difference compared with Day0 before using the sample. The significance p value is more than or equal to 0.050, which shows that compared with Day0 before using the sample, the significance p value is not different.
TABLE 6
TABLE 7
TABLE 8
TABLE 9
Watch 10
Claims (10)
1. The composition for improving the stability of vitamin C is characterized by comprising the following components in parts by weight: 3-7 parts of vitamin C derivative, 0.5-2 parts of humectant, 0.1-1 part of chelating agent, 2-4 parts of surfactant, 0.2-2 parts of phenol derivative and 84-95 parts of deionized water.
2. A composition for improving vitamin C stability according to claim 1, wherein the vitamin C derivative is selected from one or more of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, calcium ascorbyl phosphate, ascorbyl polypeptide, ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl glucoside, ethyl ascorbyl ether, ascorbyl stearate, and ascorbyl ethyl silanol pectate.
3. A composition for improving vitamin C stability according to claim 1, wherein the humectant is selected from vitamin C derivatives having an ester group.
4. A composition for improving vitamin C stability according to claim 3, wherein the vitamin C derivative having an ester group is selected from one or a combination of vitamin C phosphate and vitamin C palmitate.
5. A composition for improving vitamin C stability according to claim 1, wherein said chelating agent is a rutin derivative.
6. A composition for improving vitamin C stability according to claim 5, wherein said rutin derivative is a rutin derivative having a hydroxyl structure.
7. A composition for improving vitamin C stability according to claim 1, wherein the surfactant is selected from one or more of anionic surfactant, nonionic surfactant and cationic surfactant.
8. A composition for improving vitamin C stability according to claim 1, wherein the phenol derivative is alkylresorcinol.
9. A composition for improving vitamin C stability according to claim 1, wherein the weight ratio of the chelating agent, humectant and vitamin C derivative is 1: (2-3): (8-14).
10. Use of a composition for improving vitamin C stability according to any one of claims 1 to 9 in cosmetics, wherein the composition is mixed with levovitamin C powder for use.
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| DE10013156A1 (en) * | 2000-03-17 | 2001-09-20 | Volkhard Jenning | Water-containing vehicle for cosmetic or dermatological compositions, in which active agents or auxiliaries are stabilized by combination of ascorbic acid or derivative, polyphenol and buffer |
| CN102046141A (en) * | 2008-05-29 | 2011-05-04 | 株式会社资生堂 | External preparation for skin |
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