CN109010094A - A kind of resveratrol beautifying face and moistering lotion cosmetics and preparation method - Google Patents
A kind of resveratrol beautifying face and moistering lotion cosmetics and preparation method Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The present invention provides a kind of resveratrol beautifying face and moistering lotion cosmetics and preparation methods.Resveratrol, monoglyceride dispersing agent are added in ethyl alcohol, obtain resveratrol dispersion, homogenization after being mixed with water, spray drying obtains nanoscale resveratrol, the ethanol solution of perillaldehyde is sprayed on surface, and after rapid draing, modified nanoscale resveratrol is made, it is finally mixed with lecithin, vitamin E, hyaluronic acid, oxide powder and zinc, glutathione peroxidase, collagen, deionized water to get a kind of resveratrol beautifying face and moistering lotion cosmetics.This method is by being dispersed in resveratrol nano-particle surface for perillaldehyde, utilize the osmosis of perillaldehyde, resveratrol has been effectively facilitated in the infiltration and absorption of skin, improve bioavilability, the activity of resveratrol is given full play to, cosmetics safety obtained and stability are good, have excellent anti-aging, anti-oxidant, ultra-violet radiation resisting, skin whitening, moisturizing and other effects.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to the preparation of resveratrol cosmetics, more particularly to a kind of white Chenopodiaceae
Reed alcohol beautifying face and moistering lotion cosmetics and preparation method.
Background technique
Skin is the largest organ for being covered on human body surface, due to directly being contacted with external environment, aoxidized, dried,
Ultraviolet light etc. is highly susceptible to injure.Especially in winter, the entire metabolism of human body all becomes more slowly, skin
Be metabolized also become especially slowly, the cutin of skin epidermis can not eubolism, cutin is deposited in skin surface, leads to epidermis bottom
The cell of layer is oppressed, and skin can not absorb nutrition, and metabolic toxicities are accumulated in skin, various skin problems be generated, to people
Normal life generates inconvenient.Existing cosmetics in order to extend service life and attract consumer, be added to a large amount of preservatives and
Essence etc. produces damage to consumer skin.In order to achieve the purpose that fast onset, it also added chemical article, cause to make
The skin allergy of user has carried out more bad influence for the health of skin.Therefore, the face nourishing skin care products for developing health are very heavy
It wants.
Resveratrol is the primary raw material in terms of medicine, chemical industry, food, cosmetics.It is found that it has a variety of pharmacology
Activity, including antioxidant activity, platelet aggregation-against, antiatherosclerosis, anti-inflammatory, estrogenic activity, growth inhibition are living
Property, immunological regulation and elemental abundances etc..Application resveratrol molecule structure of the resveratrol on cosmetics, which has, catches
Free radical, characteristic that is anti-oxidant, absorbing ultraviolet light are obtained, brilliant effect is shown in terms of cosmetics, is a kind of good day
Right antioxidant.In general, antioxidant, which is used in cosmetics, mainly plays the part of the anti-oxidant role of skin, skin is made to delay to decline
Always.In addition, resveratrol can also be effectively facilitated blood vessel dilatation, there is anti-inflammatory, sterilization and moisture-keeping function, be suitble to dispel skin
Acne, packet rash, wrinkle etc. can be used for moisturizing, late frost, moisturizing class cosmetics.
Chinese invention patent application number 201710185754.2 discloses a kind of cosmetic composition containing nanometer platinum,
The composition includes nanometer platinum colloid and resveratrol.Studies have shown that nanometer platinum colloid is used in combination with resveratrol,
The dosage of nanometer platinum can be reduced, meanwhile, have the function that 1+1 > 2.
Chinese invention patent application number 201611161052.2 discloses a kind of whitening and moisturizing facial mask mud containing resveratrol
And the preparation method and application thereof, belong to daily chemical products field.Comprising following components, resveratrol, procyanidine, hydroxytyrosol,
Rosa Damascana, rose slag, bentonite, glycerol, UV- filtering agent, preservative and deionized water.
Chinese invention patent application number 201610709647.0 discloses and a kind of cosmetic combinations with white-skinned face function
Object, formula include the raw material components of following parts by weight: in 0.1 ~ 2 part of glucityl rutin, 0.05 ~ 1 part of oxidized resveratrol, hundred
0.1 ~ 2 part of fragrant extract, 0.1 ~ 3 part of ethylascorbyl, 0.1 ~ 5 part of evodia rutaecarpa berry extract, Bacillus acidi lactici/pomegranate fruit fermentation
0.1 ~ 10 part of product extract.
Chinese invention patent application number 201410269596.5 discloses a kind of natural anti-oxidation modularization cosmetic and its system
Preparation Method is grouped as by the group of following parts by weight: 3.1 ~ 10.1 parts of natural anti-oxidation component, 10.1 ~ 30.1 parts of oil phase components, and water
Phase component surplus, 0.06 ~ 0.12 part of oxygen sodium oxide molybdena, 0.15 ~ 1.0 part of auxiliary agent component, the sum of percentage of above-mentioned each phase is 100
Part.Natural anti-oxidation component therein is by haematococcus pluvialis extract, resveratrol, grape seed extract, Punica granatum L. extract group
At.
According to above-mentioned, in existing scheme for the resveratrol of cosmetics poorly water-soluble, bioavilability is low, is being used for
When cosmetics, activity is difficult to be used effectively, therefore promotes resveratrol dissolution and absorb, to being pushed further into resveratrol
In cosmetics using particularly important.In consideration of it, the invention proposes a kind of resveratrol beautifying face and moistering lotion cosmetics and preparation sides
Method can effectively solve above-mentioned technical problem.
Summary of the invention
When being applied to cosmetics for the wider resveratrol of current application, there are solution absorption rate is low, bioavilability
Low, activity is difficult to the defect effectively played, and the present invention proposes a kind of resveratrol beautifying face and moistering lotion cosmetics and preparation method, thus
Resveratrol is effectively increased in the infiltration and absorption of skin, cosmetics safety stability obtained is good, has fabulous beauty
Moistening face.
Specific technical solution of the present invention is as follows:
A kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics, comprising the following steps:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic.
Resveratrol, which has, is dissolved in ethyl alcohol, insoluble in water in characteristic, the present invention by resveratrol dissolve in ethanol,
Under the dispersion of monoglyceride, homogenization is carried out in aqueous systems, and be spray-dried, so that resveratrol dispersion is grown to nanoscale micro-
Grain.And perillaldehyde has good osmosis, the present invention creatively uses perillaldehyde to be dispersed in resveratrol nanoparticle
Surface, to promote the infiltration and absorption of resveratrol in skin, to solve resveratrol poorly water-soluble, biological utilisation
Spend it is low, in cosmetics activity be difficult to the defect being used effectively.
Preferably, in step (1) the resveratrol dispersion, 4 ~ 8 parts by weight of resveratrol, 90 ~ 95 parts by weight of ethyl alcohol,
1 ~ 2 parts by weight of monoglyceride dispersing agent.
Preferably, step (1) heating temperature is 70 ~ 90 DEG C, and jitter time is 2 ~ 4h.
Preferably, in step (2) described mixture, 20 ~ 30 parts by weight of resveratrol dispersion, 70 ~ 80 parts by weight of water.
Preferably, the pressure of step (2) described homogenization be 30 ~ 50MPa, temperature be 70 ~ 90 DEG C, the time be 15 ~
20h。
Preferably, the pressure of step (2) described spray drying is 3 ~ 5bar, and drying time is 1 ~ 1.5s, and spray orifice aperture is 1
~3mm。
Preferably, in the nanoscale resveratrol of step (3) described modification, 5 ~ 15 parts by weight of perillaldehyde, the white Chenopodiaceae of nanoscale
85 ~ 95 parts by weight of reed alcohol.
Preferably, step (3) the quick-drying temperature is 300 ~ 500 DEG C, and the time is 10 ~ 20min.
Preferably, in step (4) the beautifying face and moistering lotion cosmetics, modified 12 ~ 16 parts by weight of nanoscale resveratrol, ovum
Phosphatidase 6 ~ 10 parts by weight, 0.5 ~ 1 parts by weight of vitamin E, 2 ~ 4 parts by weight of hyaluronic acid, 3 ~ 5 parts by weight of oxide powder and zinc, gluathione
0.5 ~ 1 parts by weight of peptide peroxidase, 15 ~ 20 parts by weight of collagen, 43 ~ 61 parts by weight of deionized water.
The present invention also provides a kind of resveratrol beautifying face and moistering lotion cosmetics that above-mentioned preparation method is prepared.By white black false hellebore
Alcohol dissolves in ethanol, and monoglyceride dispersing agent is then added, and heating is uniformly dispersed to obtain resveratrol dispersion；Further with water
Homogenizer homogenization is added, spray drying obtains nanoscale resveratrol；Perillaldehyde is dissolved in ethyl alcohol and is configured to liquid, is sprayed
It is sprinkled upon nanoscale resveratrol surface, and rapid draing removes ethyl alcohol, and perillaldehyde is made to be dispersed in nanoscale resveratrol
Surface obtains modified nanoscale resveratrol；By modified nanoscale resveratrol and lecithin, vitamin E, hyalomitome
Acid, oxide powder and zinc, glutathione peroxidase, collagen, deionized water are uniformly dispersed, and obtain product.
The present invention provides a kind of resveratrol beautifying face and moistering lotion cosmetics and preparation methods, compared with prior art, dash forward
Out the characteristics of and excellent effect are:
1, it proposes perillaldehyde and is dispersed in the method that resveratrol nano-particle surface prepares resveratrol beautifying face and moistering lotion cosmetics.
2, by the way that perillaldehyde is dispersed in resveratrol nano-particle surface, using the osmosis of perillaldehyde, effectively promote
Into resveratrol in the infiltration and absorption of skin, bioavilability is improved, has given full play to the activity of resveratrol.
3, the resveratrol of high osmosis is cooperated lecithin, vitamin E, hyaluronic acid, glutathione peroxide by the present invention
The cosmetics that compound enzyme, collagen obtain, active skull cap components have safety and stability good a little, while having excellent
Different anti-aging, anti-oxidant, ultra-violet radiation resisting, skin whitening, moisturizing and other effects.
Specific embodiment
In the following, the present invention will be further described in detail by way of specific embodiments, but this should not be interpreted as to the present invention
Range be only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill
The various replacements or change that knowledge and customary means are made, should be included in the scope of the present invention.
Embodiment 1
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 6 parts by weight of resveratrol, 93 parts by weight of ethyl alcohol, 1 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 79 DEG C, jitter time 3h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 24 parts by weight of resveratrol dispersion, 76 parts by weight of water；Homogeneous
The pressure of processing is 39MPa, and temperature is 78 DEG C, time 17h；The pressure of spray drying is 4bar, drying time 1s, spray orifice
Aperture is 2mm；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；In modified nanoscale resveratrol, 9 parts by weight of perillaldehyde, 91 parts by weight of nanoscale resveratrol；Quick-drying temperature
It is 380 DEG C, time 14min；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic；Hold in beauty treatment cosmetics, modified 14 parts by weight of nanoscale resveratrol, 7 parts by weight of lecithin, 0.5 weight of vitamin E
Measure part, 3 parts by weight of hyaluronic acid, 4 parts by weight of oxide powder and zinc, 0.5 parts by weight of glutathione peroxidase, 16 weight of collagen
Measure part, 55 parts by weight of deionized water.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from embodiment 1 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from embodiment 1,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the embodiment 1 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Embodiment 2
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 5 parts by weight of resveratrol, 94 parts by weight of ethyl alcohol, 1 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 72 DEG C, jitter time 4h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 22 parts by weight of resveratrol dispersion, 78 parts by weight of water；Homogeneous
The pressure of processing is 35MPa, and temperature is 75 DEG C, time 19h；The pressure of spray drying be 3.5bar, drying time 1.5s,
Spray orifice aperture is 1mm；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；In modified nanoscale resveratrol, 8 parts by weight of perillaldehyde, 92 parts by weight of nanoscale resveratrol；Quick-drying temperature
It is 360 DEG C, time 18min；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic；Hold in beauty treatment cosmetics, modified 13 parts by weight of nanoscale resveratrol, 7 parts by weight of lecithin, 0.5 weight of vitamin E
Measure part, 2 parts by weight of hyaluronic acid, 4 parts by weight of oxide powder and zinc, 0.5 parts by weight of glutathione peroxidase, 16 weight of collagen
Measure part, 57 parts by weight of deionized water.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from embodiment 2 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from embodiment 2,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the embodiment 2 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Embodiment 3
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 7 parts by weight of resveratrol, 91 parts by weight of ethyl alcohol, 2 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 85 DEG C, jitter time 2.5h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 27 parts by weight of resveratrol dispersion, 73 parts by weight of water；Homogeneous
The pressure of processing is 45MPa, and temperature is 85 DEG C, time 16h；The pressure of spray drying is 5bar, drying time 1.5s, spray
Hole aperture is 3mm；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；In modified nanoscale resveratrol, 12 parts by weight of perillaldehyde, 88 parts by weight of nanoscale resveratrol；Quick-drying temperature
Degree is 450 DEG C, time 12min；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic；Hold in beauty treatment cosmetics, modified 15 parts by weight of nanoscale resveratrol, 9 parts by weight of lecithin, vitamin e1 weight
Part, 3 parts by weight of hyaluronic acid, 5 parts by weight of oxide powder and zinc, 1 parts by weight of glutathione peroxidase, 19 weight of collagen
Part, 47 parts by weight of deionized water.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from embodiment 3 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from embodiment 3,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the embodiment 3 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Embodiment 4
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 8 parts by weight of resveratrol, 90 parts by weight of ethyl alcohol, 2 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 90 DEG C, jitter time 2h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 30 parts by weight of resveratrol dispersion, 70 parts by weight of water；Homogeneous
The pressure of processing is 50MPa, and temperature is 90 DEG C, time 15h；The pressure of spray drying is 5bar, drying time 1.5s, spray
Hole aperture is 3mm；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；In modified nanoscale resveratrol, 15 parts by weight of perillaldehyde, 85 parts by weight of nanoscale resveratrol；Quick-drying temperature
Degree is 500 DEG C, time 10min；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic；Hold in beauty treatment cosmetics, modified 16 parts by weight of nanoscale resveratrol, 10 parts by weight of lecithin, vitamin e1 weight
Part, 4 parts by weight of hyaluronic acid, 5 parts by weight of oxide powder and zinc, 1 parts by weight of glutathione peroxidase, 20 weight of collagen
Part, 43 parts by weight of deionized water.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from embodiment 4 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from embodiment 4,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the embodiment 4 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Embodiment 5
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 4 parts by weight of resveratrol, alcohol 95 parts by weight, 1 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 70 DEG C, jitter time 4h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 20 parts by weight of resveratrol dispersion, 80 parts by weight of water；Homogeneous
The pressure of processing is 30MPa, and temperature is 90 DEG C, time 15h；The pressure of spray drying is 5bar, drying time 1.5s, spray
Hole aperture is 3mm；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；In modified nanoscale resveratrol, 5 parts by weight of perillaldehyde, 95 parts by weight of nanoscale resveratrol；Quick-drying temperature
It is 500 DEG C, time 10min；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic；Hold in beauty treatment cosmetics, modified 12 parts by weight of nanoscale resveratrol, 6 parts by weight of lecithin, 0.5 weight of vitamin E
Measure part, 2 parts by weight of hyaluronic acid, 3 parts by weight of oxide powder and zinc, 0.5 parts by weight of glutathione peroxidase, 15 weight of collagen
Measure part, 61 parts by weight of deionized water.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from embodiment 5 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from embodiment 5,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the embodiment 5 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Embodiment 6
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 6 parts by weight of resveratrol, 92 parts by weight of ethyl alcohol, 2 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 80 DEG C, jitter time 3h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 25 parts by weight of resveratrol dispersion, 75 parts by weight of water；Homogeneous
The pressure of processing is 40MPa, and temperature is 80 DEG C, time 18h；The pressure of spray drying is 4bar, drying time 1s, spray orifice
Aperture is 2mm；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；In modified nanoscale resveratrol, 10 parts by weight of perillaldehyde, 90 parts by weight of nanoscale resveratrol；Quick-drying temperature
Degree is 400 DEG C, time 15min；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic；Hold in beauty treatment cosmetics, modified 14 parts by weight of nanoscale resveratrol, 8 parts by weight of lecithin, 1 weight of vitamin E
Part, 3 parts by weight of hyaluronic acid, 4 parts by weight of oxide powder and zinc, 1 parts by weight of glutathione peroxidase, 18 weight of collagen
Part, 51 parts by weight of deionized water.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from embodiment 6 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from embodiment 6,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the embodiment 6 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Comparative example 1
Preparation process are as follows:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；In resveratrol dispersion, 6 parts by weight of resveratrol, 92 parts by weight of ethyl alcohol, 2 parts by weight of monoglyceride dispersing agent；Add
Hot temperature is 80 DEG C, jitter time 3h；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；In mixture, 25 parts by weight of resveratrol dispersion, 75 parts by weight of water；Homogeneous
The pressure of processing is 40MPa, and temperature is 80 DEG C, time 18h；The pressure of spray drying is 4bar, drying time 1s, spray orifice
Aperture is 2mm；
(3) by nanoscale resveratrol made from step (2) and lecithin, vitamin E, hyaluronic acid, oxide powder and zinc, gluathione
Peptide peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion cosmetics are made；Hold
In beauty treatment cosmetics, 14 parts by weight of nanoscale resveratrol, 8 parts by weight of lecithin, 1 parts by weight of vitamin E, 3 weight of hyaluronic acid
Measure part, 4 parts by weight of oxide powder and zinc, 1 parts by weight of glutathione peroxidase, 18 parts by weight of collagen, 51 weight of deionized water
Measure part.
Test method are as follows:
In vitro transdermal test: after taking the healthy sucking pig of 15 ~ 20kg, anesthesia to put to death, abdomen pig hair is shaved off, skin is removed, rejects skin
Lower fat deposit and connective tissue are cleaned with physiological saline, after filter paper blots surface moisture, are tested as sample；By skin
Sample is fixed on improved Franz diffusing cells method, and 30% PEG400 physiological saline is added towards supply pool, receiving chamber in cuticula, will
Cosmetics made from comparative example 1 are uniformly applied on skin, and in 37 DEG C of waters bath with thermostatic control, magnetic stirring speed 200r/min divides
Receiving liquid is taken when not in 6h, 12h, 18h and for 24 hours, HPLC analysis is carried out after 0.45 μm of membrane filtration, measures the dense of resveratrol
Degree, according to formulaIt calculates resveratrol and adds up infiltration capacity, in formula, CnAnd CiFor n-th and i-th
The mass concentration of a time point receiving liquid sample, A are effective infiltrating area, and C is liquor capacity in receiving chamber, ViFor every sub-sampling
Volume；
Cosmetic result investigation statistics: testing laggard pedestrian group investigation on probation in biocompatibility for skin care item made from comparative example 1,
It is dim, volunteer 100 aging to be distributed to skin, each half of men and women, the age is 20 ~ 50 years old.After 1 month, questionnaire tune is carried out
It looks into, calculates significant effective, effective and invalid ratio
The in vitro transdermal test of the cosmetics of the comparative example 1 measured by the above method adds up infiltration capacity and result on trial investigates ratio
Such as shown in table 1.
Table 1:
Claims (10)
1. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics, which comprises the following steps:
(1) in ethanol by resveratrol dissolution, it is subsequently added into monoglyceride dispersing agent, heats and is uniformly dispersed, white black false hellebore is made
Alcohol dispersion；
(2) resveratrol dispersion made from step (1) is mixed with water, be added homogenizer in carry out homogenization, then into
Row spray drying, is made nanoscale resveratrol；
(3) perillaldehyde is dissolved in ethyl alcohol and solution is made, be sprayed at the surface of nanoscale resveratrol made from step (2), fastly
Speed dries and removes ethyl alcohol, and perillaldehyde is made to be dispersed in the surface of nanoscale resveratrol, and the modified white black false hellebore of nanoscale is made
Alcohol；
(4) by nanoscale resveratrol and lecithin modified made from step (3), vitamin E, hyaluronic acid, oxide powder and zinc,
Glutathione peroxidase, collagen, deionized water mixing, are uniformly dispersed, a kind of resveratrol beautifying face and moistering lotion are made
Cosmetic.
2. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(1) in the resveratrol dispersion, 4 ~ 8 parts by weight of resveratrol, 90 ~ 95 parts by weight of ethyl alcohol, 1 ~ 2 weight of monoglyceride dispersing agent
Part.
3. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(1) heating temperature is 70 ~ 90 DEG C, and jitter time is 2 ~ 4h.
4. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(2) in the mixture, 20 ~ 30 parts by weight of resveratrol dispersion, 70 ~ 80 parts by weight of water.
5. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(2) pressure of the homogenization is 30 ~ 50MPa, and temperature is 70 ~ 90 DEG C, and the time is 15 ~ 20h.
6. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(2) pressure of the spray drying is 3 ~ 5bar, and drying time is 1 ~ 1.5s, and spray orifice aperture is 1 ~ 3mm.
7. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(3) in the nanoscale resveratrol of the modification, 5 ~ 15 parts by weight of perillaldehyde, 85 ~ 95 parts by weight of nanoscale resveratrol.
8. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(3) the quick-drying temperature is 300 ~ 500 DEG C, and the time is 10 ~ 20min.
9. a kind of preparation method of resveratrol beautifying face and moistering lotion cosmetics according to claim 1, it is characterised in that: step
(4) in the beautifying face and moistering lotion cosmetics, modified 12 ~ 16 parts by weight of nanoscale resveratrol, 6 ~ 10 parts by weight of lecithin, dimension life
Plain 0.5 ~ 1 parts by weight of E, 2 ~ 4 parts by weight of hyaluronic acid, 3 ~ 5 parts by weight of oxide powder and zinc, 0.5 ~ 1 weight of glutathione peroxidase
Measure part, 15 ~ 20 parts by weight of collagen, 43 ~ 61 parts by weight of deionized water.
10. a kind of resveratrol beautifying face and moistering lotion cosmetics that any one of claim 1 ~ 9 preparation method is prepared.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115803004A (en) * | 2020-08-25 | 2023-03-14 | 莱雅公司 | Stable composition comprising polydatin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115803004A (en) * | 2020-08-25 | 2023-03-14 | 莱雅公司 | Stable composition comprising polydatin |
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Application publication date: 20181218 |