CN111655869B - 检测乳腺癌 - Google Patents

检测乳腺癌 Download PDF

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Publication number
CN111655869B
CN111655869B CN201880086996.9A CN201880086996A CN111655869B CN 111655869 B CN111655869 B CN 111655869B CN 201880086996 A CN201880086996 A CN 201880086996A CN 111655869 B CN111655869 B CN 111655869B
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methylation
breast cancer
sample
dna
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CN111655869A (zh
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大卫·A·阿尔奎斯特
威廉·R·泰勒
道格拉斯·W·马奥尼
特蕾西·C·亚卜
约翰·B·基谢尔
哈特姆·T·阿拉维
格雷厄姆·P·利德加德
迈克尔·W·凯泽
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Exact Sciences Corp
Mayo Clinic in Florida
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Exact Sciences Corp
Exact Sciences Development Co LLC
Mayo Clinic in Florida
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CN201880086996.9A 2017-11-30 2018-11-28 检测乳腺癌 Active CN111655869B (zh)

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US201762592828P 2017-11-30 2017-11-30
US62/592,828 2017-11-30
PCT/US2018/062809 WO2019108626A1 (en) 2017-11-30 2018-11-28 Detecting breast cancer

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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2255198A4 (en) 2008-02-15 2011-05-25 Mayo Foundation DETECTION OF NEOPLASM
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
WO2015153284A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
WO2019108626A1 (en) 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
WO2019178277A1 (en) 2018-03-13 2019-09-19 Grail, Inc. Anomalous fragment detection and classification
US12203140B2 (en) * 2018-05-08 2025-01-21 EG BioMed Co., Ltd. Methods for early prediction, treatment response, recurrence and prognosis monitoring of breast cancer
WO2020132572A1 (en) 2018-12-21 2020-06-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN113122634A (zh) * 2020-01-14 2021-07-16 上海鹍远生物技术有限公司 检测dna甲基化的试剂及用途
KR102139313B1 (ko) * 2020-02-27 2020-07-29 이화여자대학교 산학협력단 알츠하이머병 치매 조기 진단을 위한 후성 유전학적 진단 키트 개발
JP7512664B2 (ja) * 2020-05-08 2024-07-09 コニカミノルタ株式会社 医療診断支援装置、医療診断支援プログラム、および医療診断支援方法
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
CN115997035A (zh) * 2020-06-30 2023-04-21 通用诊断股份公司 用于检测多种癌症类型的系统和方法
EP3945135A1 (en) * 2020-07-27 2022-02-02 Les Laboratoires Servier Biomarkers for diagnosing and monitoring lung cancer
CN114432445B (zh) * 2020-10-30 2024-09-06 复旦大学 Itpripl1的调节剂在制备调节免疫反应或抗肿瘤的药物中的用途
KR20230100729A (ko) * 2020-10-30 2023-07-05 푸단 유니버시티 면역반응 조절 또는 항종양 약물 제조에 있어 itpripl1 조절제의 용도
CN116377071A (zh) * 2020-12-30 2023-07-04 上海奕谱生物科技有限公司 一种位于10号染色体上的肿瘤标记物及其在检测肿瘤中的应用
CN114908159A (zh) * 2021-02-09 2022-08-16 复旦大学附属中山医院 结直肠进展期腺瘤的筛查、风险评估及预后方法和试剂盒
CN113493863B (zh) * 2021-06-23 2022-06-10 华中科技大学同济医学院附属同济医院 用于检测covid-19易感性的分子标记、试剂盒及应用
CN114369661B (zh) * 2022-01-13 2024-09-20 博尔诚(北京)科技有限公司 用于乳腺癌筛查的标志物、探针组合物及其应用
CN115851959B (zh) * 2022-12-30 2024-04-12 武汉艾米森生命科技有限公司 一种用于食管鳞状细胞癌及癌前病变的诊断或辅助诊断的试剂及检测试剂盒
CN116148482A (zh) * 2023-04-20 2023-05-23 天津云检医学检验所有限公司 用于乳腺癌患者鉴定的设备及其制备用途
CN117210567A (zh) * 2023-10-26 2023-12-12 中国人民解放军总医院第一医学中心 检测zscan23基因启动子区dna甲基化状态的引物对及试剂盒

Family Cites Families (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
WO1995015373A2 (en) 1993-11-30 1995-06-08 Mcgill University Inhibition of dna methyltransferase
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
WO1995029251A1 (en) 1994-04-25 1995-11-02 Applied Technology Genetics Corporation Detection of mutation by resolvase cleavage
WO1996020287A2 (en) 1994-12-23 1996-07-04 Behringwerke Aktiengesellschaft Detection of nucleic acids by target-catalyzed product formation
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
JP2001517925A (ja) 1995-12-22 2001-10-09 ベーリングウエルケ、アクティエンゲゼルシャフト 核酸の均質増幅および検出
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
CA2252048C (en) 1996-04-12 2008-03-11 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6251594B1 (en) 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
ATE224458T1 (de) 1998-02-04 2002-10-15 Variagenics Inc Techniken zu detektion von fehlpaarungen
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
ATE458831T1 (de) 1999-12-07 2010-03-15 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
AU2001277521A1 (en) 2000-06-30 2002-01-14 Epigenomics Ag Diagnosis of diseases associated with cell signalling
NZ524229A (en) 2000-09-01 2006-01-27 Epigenomics Ag Method for simultaneous detection of many different methylation positions of specific cytosine residues in genomic DNA in the sequence context of 5'-CpG-3'
WO2003031932A2 (en) 2001-10-05 2003-04-17 Case Western Reserve University Methods and compositions for detecting colon cancers
CN1650033A (zh) 2002-03-07 2005-08-03 约翰霍普金斯大学医学院 针对与癌症相关的表观遗传学沉默基因的基因组筛选
US20030186248A1 (en) * 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
JP2007524369A (ja) 2003-03-17 2007-08-30 ザ ジョンズ ホプキンス ユニバーシティー 膵癌における異常メチル化遺伝子
EP2345745A1 (en) 2003-06-23 2011-07-20 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
CA2535910C (en) 2003-08-14 2016-04-26 Case Western Reserve University Methods and compositions for detecting colon cancers
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
EP2354253A3 (en) 2003-09-05 2011-11-16 Trustees of Boston University Method for non-invasive prenatal diagnosis
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
SI3296407T1 (sl) 2004-03-02 2019-09-30 The Johns Hopkins University Mutacije gena PIK3CA pri rakih pri ljudeh
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
US20070059753A1 (en) 2005-09-15 2007-03-15 Tatiana Vener Detecting gene methylation
US7598052B2 (en) * 2005-10-11 2009-10-06 The Regents Of The University Of Michigan Expression profile of thyroid cancer
SI2385143T1 (sl) 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
US20080081333A1 (en) 2006-05-26 2008-04-03 University Of Maryland, Baltimore Methylated promoters as biomarkers of colon cancer
CN101622349A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-21调节的基因和途径
WO2008079269A2 (en) * 2006-12-19 2008-07-03 Genego, Inc. Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
EP2255198A4 (en) 2008-02-15 2011-05-25 Mayo Foundation DETECTION OF NEOPLASM
MX2010010161A (es) 2008-03-15 2011-03-21 Hologic Inc Star Composiciones y metodos para el analisis de moleculas de acido nucleico durante reacciones de amplificacion.
WO2010062914A1 (en) 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk
WO2010074924A1 (en) 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
US20120164238A1 (en) 2009-02-03 2012-06-28 Mdxhealth Sa Methods of detecting colorectal cancer
CN102292458A (zh) 2009-04-03 2011-12-21 A&T株式会社 大肠肿瘤的检测方法
EP2480686A2 (en) * 2009-09-22 2012-08-01 Koninklijke Philips Electronics N.V. Method and compositions for assisting in diagnosing and/or monitoring breast cancer progression
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
AU2011230633B2 (en) 2010-03-26 2015-01-22 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
WO2011126768A2 (en) 2010-03-29 2011-10-13 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
US9957570B2 (en) 2010-10-04 2018-05-01 The Johns Hopkins University DNA hypermethylation diagnostic biomarkers for colorectal cancer
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US20140113286A1 (en) 2010-12-21 2014-04-24 Sloan-Kettering Institute For Cancer Research Epigenomic Markers of Cancer Metastasis
JP2014519310A (ja) 2011-02-02 2014-08-14 エクザクト サイエンシーズ コーポレイション Dnaメチル化のデジタル配列分析
US20140057262A1 (en) 2011-03-14 2014-02-27 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US9000146B2 (en) 2011-05-12 2015-04-07 Exact Sciences Corporation Isolation of nucleic acids
WO2012167145A2 (en) 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
JP6085603B2 (ja) 2011-08-25 2017-02-22 クリニカル ゲノミクス プロプライエタリー リミテッド 結腸直腸がん及び乳がん診断法におけるdnaメチル化
WO2013081188A1 (ja) 2011-11-30 2013-06-06 独立行政法人国立がん研究センター 誘導悪性幹細胞
JP2015503356A (ja) 2012-01-06 2015-02-02 バイオミクス, インコーポレイテッドViomics, Inc. 末梢血中で、がんによって変化したrnaを検出するシステムおよび方法
CA3111723A1 (en) 2012-01-30 2013-08-08 Exact Sciences Development Company, Llc Sulfonated small dna compositions and methods for sulfonating and desulfonating small dnas
WO2013130880A1 (en) 2012-02-28 2013-09-06 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
CA2865087A1 (en) 2012-03-15 2013-09-19 Mayo Foundation For Medical Education And Research Methods and materials for noninvasive detection of colorectal neoplasia associated with inflammatory bowel disease
WO2013142545A1 (en) 2012-03-20 2013-09-26 Exact Sciences Corporation Marker panel for detecting cancer
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
EP2971179B1 (en) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
US20140322243A1 (en) 2013-04-26 2014-10-30 The Translational Genomics Research Institute Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
WO2015066695A1 (en) 2013-11-04 2015-05-07 Exact Sciences Corporation Multiple-control calibrators for dna quantitation
US10138524B2 (en) 2013-12-19 2018-11-27 Exact Sciences Development Company, Llc Synthetic nucleic acid control molecules
WO2015153284A1 (en) * 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US20160010081A1 (en) 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
AU2015318823A1 (en) * 2014-09-15 2016-03-24 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10465248B2 (en) 2014-12-12 2019-11-05 Exact Sciences Development Company, Llc Method of characterizing ZDHHC1 DNA
EP3230476B1 (en) 2014-12-12 2020-02-05 Exact Sciences Development Company, LLC Zdhhc1 for normalizing methylation detection assays
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
US20190136325A1 (en) 2014-12-31 2019-05-09 Case Western Reserve University Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
WO2016170348A2 (en) * 2015-04-22 2016-10-27 Mina Therapeutics Limited Sarna compositions and methods of use
GB201511152D0 (en) 2015-06-24 2015-08-05 Ucl Business Plc Method of diagnosing bladder cancer
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
WO2017119510A1 (ja) 2016-01-08 2017-07-13 国立大学法人京都大学 乳がんの診断のための検査方法、遺伝子マーカー、および検査薬
EP3443089A4 (en) * 2016-04-14 2020-04-22 Mayo Foundation for Medical Education and Research DETECTION OF HIGH-GRADE PANCREATIC DYSPLASIA
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CN107326065B (zh) * 2016-04-29 2022-07-29 博尔诚(北京)科技有限公司 一种基因标识物的筛选方法及其应用
US12300356B2 (en) * 2016-05-04 2025-05-13 Queen's University At Kingston Cell-free detection of methylated tumour DNA
US10385406B2 (en) * 2016-05-05 2019-08-20 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated DNA
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
US11208679B2 (en) 2016-05-31 2021-12-28 The Translational Genomics Research Institute Method for validating assays of biological samples
WO2018017740A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Methylated control dna
US20180066320A1 (en) 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
CA3054836A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
WO2019068082A1 (en) 2017-09-29 2019-04-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Dna methylation biomarkers for cancer diagnosing
WO2019108626A1 (en) 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
CN118685516A (zh) 2018-11-04 2024-09-24 Pfs基因组学公司 用于乳腺癌的预后和预测来自辅助放射疗法的益处的方法和基因组分类器
BR112021009795A2 (pt) 2018-11-27 2021-08-17 Exact Sciences Development Company, Llc métodos de caracterização e para caracterizar uma amostra, kit e composição
US20220033912A1 (en) 2018-12-08 2022-02-03 Pfs Genomics Inc Transcriptomic profiling for prognosis of breast cancer to identify subjects who may be spared adjuvant systemic therapy
US20220106644A1 (en) 2019-01-24 2022-04-07 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
CN113811622B (zh) 2019-04-03 2024-09-17 梅约医学教育与研究基金会 在血浆中检测胰腺导管腺癌
US11345967B2 (en) 2019-05-23 2022-05-31 Paradigm Diagnostics Tissue preparation using nuclease
WO2020264220A1 (en) 2019-06-25 2020-12-30 The Translational Genomics Research Institute Detection and treatment of residual disease using circulating tumor dna analysis
US20220403471A1 (en) 2019-08-27 2022-12-22 Exact Sciences Corporation Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
CN115038968A (zh) 2019-10-18 2022-09-09 精密科学公司 多种分析物粪便抗原测试
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
CA3174354A1 (en) 2020-04-17 2021-10-21 Robert F. Eisele Ingestible sampling device
CN115867566A (zh) 2020-05-04 2023-03-28 梅约医学教育与研究基金会 检测黑素瘤
AU2021268631A1 (en) 2020-05-04 2023-01-05 Mayo Foundation For Medical Education And Research Detecting pancreatic neuroendocrine tumors
CN116157519A (zh) 2020-07-29 2023-05-23 精密科学公司 经磺化dna的纯化
AU2021329899A1 (en) 2020-08-19 2023-03-09 Exact Sciences Corporation Detecting non-hodgkin lymphoma
WO2022165247A1 (en) 2021-01-29 2022-08-04 Mayo Foundation For Medical Education And Research Detecting the presence or absence of multiple types of cancer
EP4301867A1 (en) 2021-03-01 2024-01-10 PFS Genomics, Inc. Methods and genomic classifiers for prognosis of breast cancer and identifying subjects not likely to benefit from radiotherapy
WO2022187695A1 (en) 2021-03-05 2022-09-09 Mayo Foundation For Medical Education And Research Detecting cervical cancer
US20220349009A1 (en) 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
CA3236697A1 (en) 2021-11-05 2023-05-11 William R. Taylor Compositions and methods for detecting oropharyngeal cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Plasma assay of methylated DNA markers(MDM) detects patients with metastatic breast cancer(MBC) compared to healthy controls and treated breast cancer patients with no evidence of disease;Karthik V. Girdhar et al.;《Cancer research》;20230331;第83卷(第5期);Abstract P2-11-06 *

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