CN111655869B - 检测乳腺癌 - Google Patents
检测乳腺癌 Download PDFInfo
- Publication number
- CN111655869B CN111655869B CN201880086996.9A CN201880086996A CN111655869B CN 111655869 B CN111655869 B CN 111655869B CN 201880086996 A CN201880086996 A CN 201880086996A CN 111655869 B CN111655869 B CN 111655869B
- Authority
- CN
- China
- Prior art keywords
- max
- methylation
- breast cancer
- sample
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410745727.6A CN118773309A (zh) | 2017-11-30 | 2018-11-28 | 用于表征生物样品的方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762592828P | 2017-11-30 | 2017-11-30 | |
| US62/592,828 | 2017-11-30 | ||
| PCT/US2018/062809 WO2019108626A1 (en) | 2017-11-30 | 2018-11-28 | Detecting breast cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410745727.6A Division CN118773309A (zh) | 2017-11-30 | 2018-11-28 | 用于表征生物样品的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111655869A CN111655869A (zh) | 2020-09-11 |
| CN111655869B true CN111655869B (zh) | 2024-06-28 |
Family
ID=66634445
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880086996.9A Active CN111655869B (zh) | 2017-11-30 | 2018-11-28 | 检测乳腺癌 |
| CN202410745727.6A Pending CN118773309A (zh) | 2017-11-30 | 2018-11-28 | 用于表征生物样品的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410745727.6A Pending CN118773309A (zh) | 2017-11-30 | 2018-11-28 | 用于表征生物样品的方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US10975443B2 (enExample) |
| EP (1) | EP3717644A4 (enExample) |
| JP (3) | JP7277460B2 (enExample) |
| KR (2) | KR20250117473A (enExample) |
| CN (2) | CN111655869B (enExample) |
| AU (2) | AU2018374176B2 (enExample) |
| CA (1) | CA3084584A1 (enExample) |
| WO (1) | WO2019108626A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| WO2015153284A1 (en) | 2014-03-31 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| WO2016160454A1 (en) | 2015-03-27 | 2016-10-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| WO2019108626A1 (en) | 2017-11-30 | 2019-06-06 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| WO2019178277A1 (en) | 2018-03-13 | 2019-09-19 | Grail, Inc. | Anomalous fragment detection and classification |
| US12203140B2 (en) * | 2018-05-08 | 2025-01-21 | EG BioMed Co., Ltd. | Methods for early prediction, treatment response, recurrence and prognosis monitoring of breast cancer |
| WO2020132572A1 (en) | 2018-12-21 | 2020-06-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free-dna samples |
| US11396679B2 (en) | 2019-05-31 | 2022-07-26 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| CA3154354A1 (en) | 2019-10-31 | 2021-05-06 | William R. Taylor | Detecting ovarian cancer |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| CN113122634A (zh) * | 2020-01-14 | 2021-07-16 | 上海鹍远生物技术有限公司 | 检测dna甲基化的试剂及用途 |
| KR102139313B1 (ko) * | 2020-02-27 | 2020-07-29 | 이화여자대학교 산학협력단 | 알츠하이머병 치매 조기 진단을 위한 후성 유전학적 진단 키트 개발 |
| JP7512664B2 (ja) * | 2020-05-08 | 2024-07-09 | コニカミノルタ株式会社 | 医療診断支援装置、医療診断支援プログラム、および医療診断支援方法 |
| US12467096B2 (en) | 2020-05-15 | 2025-11-11 | Universal Diagnostics, S.A. | Methods and systems for identifying methylation biomarkers |
| CN115997035A (zh) * | 2020-06-30 | 2023-04-21 | 通用诊断股份公司 | 用于检测多种癌症类型的系统和方法 |
| EP3945135A1 (en) * | 2020-07-27 | 2022-02-02 | Les Laboratoires Servier | Biomarkers for diagnosing and monitoring lung cancer |
| CN114432445B (zh) * | 2020-10-30 | 2024-09-06 | 复旦大学 | Itpripl1的调节剂在制备调节免疫反应或抗肿瘤的药物中的用途 |
| KR20230100729A (ko) * | 2020-10-30 | 2023-07-05 | 푸단 유니버시티 | 면역반응 조절 또는 항종양 약물 제조에 있어 itpripl1 조절제의 용도 |
| CN116377071A (zh) * | 2020-12-30 | 2023-07-04 | 上海奕谱生物科技有限公司 | 一种位于10号染色体上的肿瘤标记物及其在检测肿瘤中的应用 |
| CN114908159A (zh) * | 2021-02-09 | 2022-08-16 | 复旦大学附属中山医院 | 结直肠进展期腺瘤的筛查、风险评估及预后方法和试剂盒 |
| CN113493863B (zh) * | 2021-06-23 | 2022-06-10 | 华中科技大学同济医学院附属同济医院 | 用于检测covid-19易感性的分子标记、试剂盒及应用 |
| CN114369661B (zh) * | 2022-01-13 | 2024-09-20 | 博尔诚(北京)科技有限公司 | 用于乳腺癌筛查的标志物、探针组合物及其应用 |
| CN115851959B (zh) * | 2022-12-30 | 2024-04-12 | 武汉艾米森生命科技有限公司 | 一种用于食管鳞状细胞癌及癌前病变的诊断或辅助诊断的试剂及检测试剂盒 |
| CN116148482A (zh) * | 2023-04-20 | 2023-05-23 | 天津云检医学检验所有限公司 | 用于乳腺癌患者鉴定的设备及其制备用途 |
| CN117210567A (zh) * | 2023-10-26 | 2023-12-12 | 中国人民解放军总医院第一医学中心 | 检测zscan23基因启动子区dna甲基化状态的引物对及试剂盒 |
Family Cites Families (170)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288609A (en) | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5541308A (en) | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5362623A (en) | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| US6677312B1 (en) | 1989-03-29 | 2004-01-13 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| US6800617B1 (en) | 1989-03-29 | 2004-10-05 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| US6872816B1 (en) | 1996-01-24 | 2005-03-29 | Third Wave Technologies, Inc. | Nucleic acid detection kits |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| US6235470B1 (en) | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| AU8102694A (en) | 1993-11-17 | 1995-06-06 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| WO1995015373A2 (en) | 1993-11-30 | 1995-06-08 | Mcgill University | Inhibition of dna methyltransferase |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| WO1995029251A1 (en) | 1994-04-25 | 1995-11-02 | Applied Technology Genetics Corporation | Detection of mutation by resolvase cleavage |
| WO1996020287A2 (en) | 1994-12-23 | 1996-07-04 | Behringwerke Aktiengesellschaft | Detection of nucleic acids by target-catalyzed product formation |
| US5882867A (en) | 1995-06-07 | 1999-03-16 | Dade Behring Marburg Gmbh | Detection of nucleic acids by formation of template-dependent product |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5670325A (en) | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| JP2001517925A (ja) | 1995-12-22 | 2001-10-09 | ベーリングウエルケ、アクティエンゲゼルシャフト | 核酸の均質増幅および検出 |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US5741650A (en) | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| US5891651A (en) | 1996-03-29 | 1999-04-06 | Mayo Foundation For Medical Education And Research | Methods of recovering colorectal epithelial cells or fragments thereof from stool |
| CA2252048C (en) | 1996-04-12 | 2008-03-11 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6020137A (en) | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US6251594B1 (en) | 1997-06-09 | 2001-06-26 | Usc/Norris Comprehensive Cancer Ctr. | Cancer diagnostic method based upon DNA methylation differences |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| ATE224458T1 (de) | 1998-02-04 | 2002-10-15 | Variagenics Inc | Techniken zu detektion von fehlpaarungen |
| US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US7700324B1 (en) | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| US6335193B1 (en) | 1999-04-15 | 2002-01-01 | Padmanabhan P Nair | Isolated colonocytes |
| ATE458831T1 (de) | 1999-12-07 | 2010-03-15 | Exact Sciences Corp | Verfahren zum nachweis von lungenneoplasmen in fäkalen proben |
| AU2001277521A1 (en) | 2000-06-30 | 2002-01-14 | Epigenomics Ag | Diagnosis of diseases associated with cell signalling |
| NZ524229A (en) | 2000-09-01 | 2006-01-27 | Epigenomics Ag | Method for simultaneous detection of many different methylation positions of specific cytosine residues in genomic DNA in the sequence context of 5'-CpG-3' |
| WO2003031932A2 (en) | 2001-10-05 | 2003-04-17 | Case Western Reserve University | Methods and compositions for detecting colon cancers |
| CN1650033A (zh) | 2002-03-07 | 2005-08-03 | 约翰霍普金斯大学医学院 | 针对与癌症相关的表观遗传学沉默基因的基因组筛选 |
| US20030186248A1 (en) * | 2002-03-29 | 2003-10-02 | Erlander Mark G. | Interpreting cytological specimens via molecular histological signatures |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| JP2007524369A (ja) | 2003-03-17 | 2007-08-30 | ザ ジョンズ ホプキンス ユニバーシティー | 膵癌における異常メチル化遺伝子 |
| EP2345745A1 (en) | 2003-06-23 | 2011-07-20 | Epigenomics AG | Methods and nucleic acids for analyses of colorectal cell proliferative disorders |
| CA2535910C (en) | 2003-08-14 | 2016-04-26 | Case Western Reserve University | Methods and compositions for detecting colon cancers |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| EP2354253A3 (en) | 2003-09-05 | 2011-11-16 | Trustees of Boston University | Method for non-invasive prenatal diagnosis |
| US20080039413A1 (en) | 2003-10-21 | 2008-02-14 | Morris David W | Novel compositions and methods in cancer |
| SI3296407T1 (sl) | 2004-03-02 | 2019-09-30 | The Johns Hopkins University | Mutacije gena PIK3CA pri rakih pri ljudeh |
| US8114587B2 (en) | 2005-06-23 | 2012-02-14 | Ambergen, Inc. | Methods for the detection of colorectal cancer |
| US7851154B2 (en) | 2005-07-22 | 2010-12-14 | Simon Daniel Spivack | GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra |
| US20070059753A1 (en) | 2005-09-15 | 2007-03-15 | Tatiana Vener | Detecting gene methylation |
| US7598052B2 (en) * | 2005-10-11 | 2009-10-06 | The Regents Of The University Of Michigan | Expression profile of thyroid cancer |
| SI2385143T1 (sl) | 2006-02-02 | 2016-11-30 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel | Neinvazivni genetski presejalni test ploda z digitalno analizo |
| JP4490382B2 (ja) | 2006-02-28 | 2010-06-23 | 富士フイルム株式会社 | 感熱転写受像シートおよびその製造方法 |
| WO2007116417A1 (en) | 2006-04-07 | 2007-10-18 | Silvia Sabbioni | Novel dna methylation markers useful for the diagnosis of neoplastic diseases |
| US20080081333A1 (en) | 2006-05-26 | 2008-04-03 | University Of Maryland, Baltimore | Methylated promoters as biomarkers of colon cancer |
| CN101622349A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-21调节的基因和途径 |
| WO2008079269A2 (en) * | 2006-12-19 | 2008-07-03 | Genego, Inc. | Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom |
| GB0700374D0 (en) | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| US20080213870A1 (en) | 2007-03-01 | 2008-09-04 | Sean Wuxiong Cao | Methods for obtaining modified DNA from a biological specimen |
| CN101353695B (zh) | 2007-07-23 | 2013-05-01 | 上海市肿瘤研究所 | 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒 |
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| MX2010010161A (es) | 2008-03-15 | 2011-03-21 | Hologic Inc Star | Composiciones y metodos para el analisis de moleculas de acido nucleico durante reacciones de amplificacion. |
| WO2010062914A1 (en) | 2008-11-26 | 2010-06-03 | The Johns Hopkins University | Methods for identifying cancer risk |
| WO2010074924A1 (en) | 2008-12-23 | 2010-07-01 | University Of Utah Research Foundation | Identification and regulation of a novel dna demethylase system |
| EP2233590A1 (en) | 2009-01-28 | 2010-09-29 | AIT Austrian Institute of Technology GmbH | Methylation assay |
| US20120164238A1 (en) | 2009-02-03 | 2012-06-28 | Mdxhealth Sa | Methods of detecting colorectal cancer |
| CN102292458A (zh) | 2009-04-03 | 2011-12-21 | A&T株式会社 | 大肠肿瘤的检测方法 |
| EP2480686A2 (en) * | 2009-09-22 | 2012-08-01 | Koninklijke Philips Electronics N.V. | Method and compositions for assisting in diagnosing and/or monitoring breast cancer progression |
| US20120164110A1 (en) | 2009-10-14 | 2012-06-28 | Feinberg Andrew P | Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof |
| US8709736B2 (en) | 2010-07-09 | 2014-04-29 | Medical Research Council | Biomarker for Barrett's Oesophagus |
| AU2011230633B2 (en) | 2010-03-26 | 2015-01-22 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal neoplasm |
| WO2011126768A2 (en) | 2010-03-29 | 2011-10-13 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal cancer and adenoma |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| US9957570B2 (en) | 2010-10-04 | 2018-05-01 | The Johns Hopkins University | DNA hypermethylation diagnostic biomarkers for colorectal cancer |
| US8715937B2 (en) | 2010-11-15 | 2014-05-06 | Exact Sciences Corporation | Mutation detection assay |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| US20140113286A1 (en) | 2010-12-21 | 2014-04-24 | Sloan-Kettering Institute For Cancer Research | Epigenomic Markers of Cancer Metastasis |
| JP2014519310A (ja) | 2011-02-02 | 2014-08-14 | エクザクト サイエンシーズ コーポレイション | Dnaメチル化のデジタル配列分析 |
| US20140057262A1 (en) | 2011-03-14 | 2014-02-27 | Mayo Foundation For Medical Education And Research | Methods and materials for using the contents of phagocytes to detect neoplasms |
| US8980107B2 (en) | 2011-05-12 | 2015-03-17 | Exact Sciences Corporation | Spin filter |
| US8993341B2 (en) | 2011-05-12 | 2015-03-31 | Exact Sciences Corporation | Removal of PCR inhibitors |
| US8808990B2 (en) | 2011-05-12 | 2014-08-19 | Exact Sciences Corporation | Serial isolation of multiple DNA targets from stool |
| US9000146B2 (en) | 2011-05-12 | 2015-04-07 | Exact Sciences Corporation | Isolation of nucleic acids |
| WO2012167145A2 (en) | 2011-06-01 | 2012-12-06 | University Of Southern California | Genome-scale analysis of aberrant dna methylation in colorectal cancer |
| US20130022974A1 (en) | 2011-06-17 | 2013-01-24 | The Regents Of The University Of Michigan | Dna methylation profiles in cancer |
| WO2012175562A2 (en) | 2011-06-21 | 2012-12-27 | University Of Tartu | Methylation and microrna markers of early-stage non-small cell lung cancer |
| JP6085603B2 (ja) | 2011-08-25 | 2017-02-22 | クリニカル ゲノミクス プロプライエタリー リミテッド | 結腸直腸がん及び乳がん診断法におけるdnaメチル化 |
| WO2013081188A1 (ja) | 2011-11-30 | 2013-06-06 | 独立行政法人国立がん研究センター | 誘導悪性幹細胞 |
| JP2015503356A (ja) | 2012-01-06 | 2015-02-02 | バイオミクス, インコーポレイテッドViomics, Inc. | 末梢血中で、がんによって変化したrnaを検出するシステムおよび方法 |
| CA3111723A1 (en) | 2012-01-30 | 2013-08-08 | Exact Sciences Development Company, Llc | Sulfonated small dna compositions and methods for sulfonating and desulfonating small dnas |
| WO2013130880A1 (en) | 2012-02-28 | 2013-09-06 | The Johns Hopkins University | Hypermethylated gene markers for head and neck cancer |
| CA2865087A1 (en) | 2012-03-15 | 2013-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for noninvasive detection of colorectal neoplasia associated with inflammatory bowel disease |
| WO2013142545A1 (en) | 2012-03-20 | 2013-09-26 | Exact Sciences Corporation | Marker panel for detecting cancer |
| US9212392B2 (en) | 2012-09-25 | 2015-12-15 | Exact Sciences Corporation | Normalization of polymerase activity |
| WO2014052855A1 (en) | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
| EP2971179B1 (en) | 2013-03-14 | 2019-01-09 | Mayo Foundation for Medical Education and Research | Detecting neoplasm |
| US20140322243A1 (en) | 2013-04-26 | 2014-10-30 | The Translational Genomics Research Institute | Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers |
| JP6369857B2 (ja) | 2013-05-29 | 2018-08-08 | シスメックス株式会社 | 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット |
| WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
| US10138524B2 (en) | 2013-12-19 | 2018-11-27 | Exact Sciences Development Company, Llc | Synthetic nucleic acid control molecules |
| WO2015153284A1 (en) * | 2014-03-31 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasm |
| US20160010081A1 (en) | 2014-07-11 | 2016-01-14 | Exact Sciences Corporation | Systems, methods and kits for extracting nucleic acid from digestive fluid |
| AU2015318823A1 (en) * | 2014-09-15 | 2016-03-24 | Garvan Institute Of Medical Research | Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10465248B2 (en) | 2014-12-12 | 2019-11-05 | Exact Sciences Development Company, Llc | Method of characterizing ZDHHC1 DNA |
| EP3230476B1 (en) | 2014-12-12 | 2020-02-05 | Exact Sciences Development Company, LLC | Zdhhc1 for normalizing methylation detection assays |
| EP3034624A1 (en) | 2014-12-18 | 2016-06-22 | Hospital Clínic de Barcelona | Method for the prognosis of hepatocellular carcinoma |
| US20190136325A1 (en) | 2014-12-31 | 2019-05-09 | Case Western Reserve University | Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus |
| US10030272B2 (en) | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
| WO2016160454A1 (en) | 2015-03-27 | 2016-10-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| WO2016170348A2 (en) * | 2015-04-22 | 2016-10-27 | Mina Therapeutics Limited | Sarna compositions and methods of use |
| GB201511152D0 (en) | 2015-06-24 | 2015-08-05 | Ucl Business Plc | Method of diagnosing bladder cancer |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| CA3002196C (en) | 2015-10-30 | 2024-05-14 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay and isolation and detection of dna from plasma |
| WO2017119510A1 (ja) | 2016-01-08 | 2017-07-13 | 国立大学法人京都大学 | 乳がんの診断のための検査方法、遺伝子マーカー、および検査薬 |
| EP3443089A4 (en) * | 2016-04-14 | 2020-04-22 | Mayo Foundation for Medical Education and Research | DETECTION OF HIGH-GRADE PANCREATIC DYSPLASIA |
| US10370726B2 (en) | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
| CN107326065B (zh) * | 2016-04-29 | 2022-07-29 | 博尔诚(北京)科技有限公司 | 一种基因标识物的筛选方法及其应用 |
| US12300356B2 (en) * | 2016-05-04 | 2025-05-13 | Queen's University At Kingston | Cell-free detection of methylated tumour DNA |
| US10385406B2 (en) * | 2016-05-05 | 2019-08-20 | Exact Sciences Development Company, Llc | Detection of lung neoplasia by analysis of methylated DNA |
| US20170321286A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Corporation | Detection of lung neoplasia by amplification of rna sequences |
| US11208679B2 (en) | 2016-05-31 | 2021-12-28 | The Translational Genomics Research Institute | Method for validating assays of biological samples |
| WO2018017740A1 (en) | 2016-07-19 | 2018-01-25 | Exact Sciences Development Company, Llc | Methylated control dna |
| US20180066320A1 (en) | 2016-09-02 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Detecting hepatocellular carcinoma |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| CA3054836A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Detecting prostate cancer |
| WO2019068082A1 (en) | 2017-09-29 | 2019-04-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Dna methylation biomarkers for cancer diagnosing |
| WO2019108626A1 (en) | 2017-11-30 | 2019-06-06 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| CN118685516A (zh) | 2018-11-04 | 2024-09-24 | Pfs基因组学公司 | 用于乳腺癌的预后和预测来自辅助放射疗法的益处的方法和基因组分类器 |
| BR112021009795A2 (pt) | 2018-11-27 | 2021-08-17 | Exact Sciences Development Company, Llc | métodos de caracterização e para caracterizar uma amostra, kit e composição |
| US20220033912A1 (en) | 2018-12-08 | 2022-02-03 | Pfs Genomics Inc | Transcriptomic profiling for prognosis of breast cancer to identify subjects who may be spared adjuvant systemic therapy |
| US20220106644A1 (en) | 2019-01-24 | 2022-04-07 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
| CN113811622B (zh) | 2019-04-03 | 2024-09-17 | 梅约医学教育与研究基金会 | 在血浆中检测胰腺导管腺癌 |
| US11345967B2 (en) | 2019-05-23 | 2022-05-31 | Paradigm Diagnostics | Tissue preparation using nuclease |
| WO2020264220A1 (en) | 2019-06-25 | 2020-12-30 | The Translational Genomics Research Institute | Detection and treatment of residual disease using circulating tumor dna analysis |
| US20220403471A1 (en) | 2019-08-27 | 2022-12-22 | Exact Sciences Corporation | Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia |
| CN115038968A (zh) | 2019-10-18 | 2022-09-09 | 精密科学公司 | 多种分析物粪便抗原测试 |
| CA3154354A1 (en) | 2019-10-31 | 2021-05-06 | William R. Taylor | Detecting ovarian cancer |
| CA3174354A1 (en) | 2020-04-17 | 2021-10-21 | Robert F. Eisele | Ingestible sampling device |
| CN115867566A (zh) | 2020-05-04 | 2023-03-28 | 梅约医学教育与研究基金会 | 检测黑素瘤 |
| AU2021268631A1 (en) | 2020-05-04 | 2023-01-05 | Mayo Foundation For Medical Education And Research | Detecting pancreatic neuroendocrine tumors |
| CN116157519A (zh) | 2020-07-29 | 2023-05-23 | 精密科学公司 | 经磺化dna的纯化 |
| AU2021329899A1 (en) | 2020-08-19 | 2023-03-09 | Exact Sciences Corporation | Detecting non-hodgkin lymphoma |
| WO2022165247A1 (en) | 2021-01-29 | 2022-08-04 | Mayo Foundation For Medical Education And Research | Detecting the presence or absence of multiple types of cancer |
| EP4301867A1 (en) | 2021-03-01 | 2024-01-10 | PFS Genomics, Inc. | Methods and genomic classifiers for prognosis of breast cancer and identifying subjects not likely to benefit from radiotherapy |
| WO2022187695A1 (en) | 2021-03-05 | 2022-09-09 | Mayo Foundation For Medical Education And Research | Detecting cervical cancer |
| US20220349009A1 (en) | 2021-04-23 | 2022-11-03 | Mayo Foundation For Medical Education And Research | Detecting esophageal disorders |
| CA3236697A1 (en) | 2021-11-05 | 2023-05-11 | William R. Taylor | Compositions and methods for detecting oropharyngeal cancer |
-
2018
- 2018-11-28 WO PCT/US2018/062809 patent/WO2019108626A1/en not_active Ceased
- 2018-11-28 AU AU2018374176A patent/AU2018374176B2/en active Active
- 2018-11-28 KR KR1020257024869A patent/KR20250117473A/ko active Pending
- 2018-11-28 JP JP2020529764A patent/JP7277460B2/ja active Active
- 2018-11-28 EP EP18882634.1A patent/EP3717644A4/en active Pending
- 2018-11-28 KR KR1020207018721A patent/KR102839621B1/ko active Active
- 2018-11-28 CN CN201880086996.9A patent/CN111655869B/zh active Active
- 2018-11-28 US US16/202,935 patent/US10975443B2/en active Active
- 2018-11-28 US US16/202,944 patent/US10934594B2/en not_active Ceased
- 2018-11-28 CA CA3084584A patent/CA3084584A1/en active Pending
- 2018-11-28 CN CN202410745727.6A patent/CN118773309A/zh active Pending
-
2021
- 2021-02-17 US US17/178,110 patent/US20210172027A1/en active Pending
- 2021-03-18 US US17/205,796 patent/US12325878B2/en active Active
-
2022
- 2022-05-03 US US17/735,477 patent/USRE50621E1/en active Active
-
2023
- 2023-05-08 JP JP2023076625A patent/JP7757338B2/ja active Active
-
2025
- 2025-03-12 AU AU2025201794A patent/AU2025201794A1/en active Pending
- 2025-04-09 JP JP2025064241A patent/JP2025106467A/ja active Pending
- 2025-05-06 US US19/199,792 patent/US20250327134A1/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| Plasma assay of methylated DNA markers(MDM) detects patients with metastatic breast cancer(MBC) compared to healthy controls and treated breast cancer patients with no evidence of disease;Karthik V. Girdhar et al.;《Cancer research》;20230331;第83卷(第5期);Abstract P2-11-06 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US12325878B2 (en) | 2025-06-10 |
| AU2018374176B2 (en) | 2024-12-12 |
| CN111655869A (zh) | 2020-09-11 |
| US20210172027A1 (en) | 2021-06-10 |
| US10934594B2 (en) | 2021-03-02 |
| JP7277460B2 (ja) | 2023-05-19 |
| JP2023100848A (ja) | 2023-07-19 |
| US10975443B2 (en) | 2021-04-13 |
| EP3717644A1 (en) | 2020-10-07 |
| US20190161805A1 (en) | 2019-05-30 |
| KR102839621B1 (ko) | 2025-07-30 |
| KR20200105661A (ko) | 2020-09-08 |
| CA3084584A1 (en) | 2019-06-06 |
| WO2019108626A1 (en) | 2019-06-06 |
| KR20250117473A (ko) | 2025-08-04 |
| JP2021503943A (ja) | 2021-02-15 |
| AU2025201794A1 (en) | 2025-04-03 |
| US20190161806A1 (en) | 2019-05-30 |
| JP2025106467A (ja) | 2025-07-15 |
| USRE50621E1 (en) | 2025-10-07 |
| AU2018374176A1 (en) | 2020-06-11 |
| JP7757338B2 (ja) | 2025-10-21 |
| CN118773309A (zh) | 2024-10-15 |
| US20210207224A1 (en) | 2021-07-08 |
| US20250327134A1 (en) | 2025-10-23 |
| EP3717644A4 (en) | 2021-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111655869B (zh) | 检测乳腺癌 | |
| AU2022291502B2 (en) | Detecting hepatocellular carcinoma | |
| CN113557308B (zh) | 检测子宫内膜癌 | |
| US11697853B2 (en) | Detecting prostate cancer | |
| CN114729399A (zh) | 检测卵巢癌 | |
| KR20180081042A (ko) | 위 신생물 검출 방법 | |
| EP3948292A1 (en) | Detecting pancreatic ductal adenocarcinoma in plasma | |
| HK40103516A (en) | Detecting hepatocellular carcinoma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20221207 Address after: Minn Applicant after: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Applicant after: EXACT SCIENCES Corp. Address before: Minn Applicant before: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Applicant before: EXACT SCIENCES DEVELOPMENT CO.,LLC |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |