ATE224458T1 - Techniken zu detektion von fehlpaarungen - Google Patents

Techniken zu detektion von fehlpaarungen

Info

Publication number
ATE224458T1
ATE224458T1 AT99904427T AT99904427T ATE224458T1 AT E224458 T1 ATE224458 T1 AT E224458T1 AT 99904427 T AT99904427 T AT 99904427T AT 99904427 T AT99904427 T AT 99904427T AT E224458 T1 ATE224458 T1 AT E224458T1
Authority
AT
Austria
Prior art keywords
nucleic acid
duplex nucleic
mismatch
detection techniques
agent
Prior art date
Application number
AT99904427T
Other languages
English (en)
Inventor
Borries Kemper
Karin Var Birkenkamp-Demtroder
Stefan Golz
Original Assignee
Variagenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Variagenics Inc filed Critical Variagenics Inc
Application granted granted Critical
Publication of ATE224458T1 publication Critical patent/ATE224458T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
AT99904427T 1998-02-04 1999-01-29 Techniken zu detektion von fehlpaarungen ATE224458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7371698P 1998-02-04 1998-02-04
PCT/US1999/001936 WO1999040222A1 (en) 1998-02-04 1999-01-29 Mismatch detection techniques

Publications (1)

Publication Number Publication Date
ATE224458T1 true ATE224458T1 (de) 2002-10-15

Family

ID=22115362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904427T ATE224458T1 (de) 1998-02-04 1999-01-29 Techniken zu detektion von fehlpaarungen

Country Status (8)

Country Link
US (1) US6110684A (de)
EP (1) EP1053352B1 (de)
JP (1) JP2002502614A (de)
AT (1) ATE224458T1 (de)
AU (1) AU753273B2 (de)
CA (1) CA2319712A1 (de)
DE (1) DE69902996T2 (de)
WO (1) WO1999040222A1 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US6214552B1 (en) * 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
US6403309B1 (en) * 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
WO2001051668A1 (en) * 2000-01-13 2001-07-19 Immunivest Corporation Ferrofluid based arrays
GB0000995D0 (en) * 2000-01-18 2000-03-08 Zeneca Ltd Methods
GB0001005D0 (en) * 2000-01-18 2000-03-08 Zeneca Ltd Methods
GB0000992D0 (en) * 2000-01-18 2000-03-08 Astrazeneca Uk Ltd Methods
US6365355B1 (en) * 2000-03-28 2002-04-02 The Regents Of The University Of California Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches
US6340566B1 (en) * 2000-03-28 2002-01-22 The Regents Of The University Of California Detection and quantitation of single nucleotide polymorphisms, DNA sequence variations, DNA mutations, DNA damage and DNA mismatches
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
US6539102B1 (en) * 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
ATE421989T1 (de) * 2000-12-01 2009-02-15 Cornell Res Foundation Inc Nachweis von nukleinsäureunterschieden mit einer kombination aus endonukleasespaltungs- und ligationsreaktionen
DE60237509D1 (de) * 2001-01-06 2010-10-14 Gen Hospital Corp Gen zum nachweis von patienten mit familiärer dysautonomie
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
CA2448484A1 (en) * 2001-05-25 2002-12-05 Xenon Genetics, Inc. Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
AU2003254298A1 (en) * 2002-08-02 2004-02-23 Stratatech Corporation Species specific dna detection
US20050101640A1 (en) * 2002-10-16 2005-05-12 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
US20040147566A1 (en) * 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
WO2004057017A2 (en) 2002-12-18 2004-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7189512B2 (en) * 2003-02-20 2007-03-13 Noga Porat Methods for variation detection
WO2005017186A2 (en) * 2003-08-08 2005-02-24 Thomas Jefferson University Method for rapid identification of alternative splicing
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US20080199480A1 (en) * 2004-07-22 2008-08-21 Sequenom, Inc. Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
US20060110765A1 (en) * 2004-11-23 2006-05-25 Wang Xiao B Detection of nucleic acid variation by cleavage-amplification (CleavAmp) method
WO2007059348A2 (en) * 2005-11-17 2007-05-24 Third Wave Technologies, Inc. Compositions and methods for detecting an hcv-1 subtype
EP2602321B1 (de) 2006-05-31 2017-08-23 Sequenom, Inc. Verfahren und Zusammensetzungen zur Nukleinsäureextraktion und -verstärkung aus einer Probe
WO2007143097A1 (en) 2006-06-01 2007-12-13 Third Wave Technologies, Inc. Detection of nucleic acids
US8153369B2 (en) 2006-06-05 2012-04-10 Cancer Care Ontario Assessment of risk for colorectal cancer
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
WO2008084571A1 (ja) * 2007-01-12 2008-07-17 Japan Science And Technology Agency 核酸応答性ゲルおよびその製造方法ならびにその利用
WO2008098142A2 (en) 2007-02-08 2008-08-14 Sequenom, Inc. Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
US20110189663A1 (en) 2007-03-05 2011-08-04 Cancer Care Ontario Assessment of risk for colorectal cancer
AU2008230813B2 (en) 2007-03-26 2014-01-30 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
WO2008139902A1 (ja) * 2007-05-07 2008-11-20 Japan Science And Technology Agency 分子応答性ゲル微粒子およびその製造方法ならびにその利用
US7947446B2 (en) * 2007-05-29 2011-05-24 Ming-Sheng Lee High throughput mutation screening methods and kits using a universalized approach—differential sequence fill-in (DSF)-enabled sequential adapter ligation and amplification
GB0713183D0 (en) * 2007-07-06 2007-08-15 King S College London Method
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
CA2697411C (en) * 2007-09-07 2015-04-14 Third Wave Technologies, Inc. Methods and applications for target quantification
EP2271772B1 (de) 2008-03-11 2014-07-16 Sequenom, Inc. Tests auf nukleinsäurebasis zur pränatalen geschlechtsbestimmung
US8206926B2 (en) 2008-03-26 2012-06-26 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP3722810A3 (de) 2009-02-11 2021-01-13 Caris MPI, Inc. Molekulare profilierung von tumoren
CA2755615A1 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
EP2414545B1 (de) 2009-04-03 2017-01-11 Sequenom, Inc. Zusammensetzungen und verfahren für die herstellung von nukleinsäuren
US20110091931A1 (en) * 2009-04-24 2011-04-21 Colby Pharmaceutical Company Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
US8394589B2 (en) 2009-12-21 2013-03-12 Northwestern University Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4
WO2011087760A2 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
JP2014519310A (ja) 2011-02-02 2014-08-14 エクザクト サイエンシーズ コーポレイション Dnaメチル化のデジタル配列分析
WO2012117588A1 (ja) 2011-02-28 2012-09-07 独立行政法人科学技術振興機構 複数物質応答性ゲルおよびその製造方法並びにその利用
EP3378954B1 (de) 2011-04-29 2021-02-17 Sequenom, Inc. Quantifizierung einer minderheitsvariante einer nukleinsäure
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
ES2642683T3 (es) 2011-05-12 2017-11-17 Exact Sciences Corporation Aislamiento de ácidos nucleicos
BR112013033692A2 (pt) * 2011-06-27 2017-01-24 Flir Systems métodos e composições para segregar ácido nucleico alvo a partir de amostras de ácido nucleico mista
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
CA2924669C (en) 2013-09-20 2023-03-21 The Regents Of The University Of Michigan Compositions and methods for the analysis of radiosensitivity
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
WO2015095689A1 (en) 2013-12-19 2015-06-25 Exact Sciences Corporation Synthetic nucleic acid control molecules
EP3117011B1 (de) 2014-03-13 2020-05-06 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
US10465248B2 (en) 2014-12-12 2019-11-05 Exact Sciences Development Company, Llc Method of characterizing ZDHHC1 DNA
CN113897432A (zh) 2014-12-12 2022-01-07 精密科学公司 用于进行甲基化检测测定的组合物和方法
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
US10822638B2 (en) 2015-10-30 2020-11-03 Exact Sciences Development Company, Llc Isolation and detection of DNA from plasma
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
US10385406B2 (en) 2016-05-05 2019-08-20 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated DNA
EP3488004B1 (de) 2016-07-19 2021-10-06 Exact Sciences Development Company, LLC Methylierte kontroll-dna
AU2017300534B2 (en) 2016-07-19 2023-11-23 Exact Sciences Corporation Nucleic acid control molecules from non-human organisms
KR20240038151A (ko) 2016-09-02 2024-03-22 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 간세포 암종 검출
CN110736695A (zh) 2016-09-30 2020-01-31 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
US11118228B2 (en) 2017-01-27 2021-09-14 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated DNA
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CN112166199A (zh) 2018-04-02 2021-01-01 普罗格尼迪公司 用于对核酸分子进行计数的方法、系统和组合物
US11408030B2 (en) 2018-09-10 2022-08-09 Andy Madrid Test for detecting Alzheimer's disease
KR20210111254A (ko) 2018-11-30 2021-09-10 캐리스 엠피아이, 아이엔씨. 차세대 분자 프로파일링
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
WO2022040306A1 (en) 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Detecting non-hodgkin lymphoma
AU2021345359A1 (en) 2020-09-21 2023-05-11 Progenity, Inc. Compositions and methods for isolation of cell-free dna
EP4314286A1 (de) 2021-08-06 2024-02-07 Sansure Biotech Inc. Zusammensetzungen zur verflüssigung einer viskosen biologischen probe, kombinationsprodukte, verflüssigungsmittel und kits dafür sowie verfahren und anwendung davon

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217863A (en) * 1988-02-04 1993-06-08 Medical Research Council Detection of mutations in nucleic acids
WO1989009835A1 (en) * 1988-04-08 1989-10-19 The Salk Institute For Biological Studies Ligase-based amplification method
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
WO1993002216A1 (en) * 1991-07-19 1993-02-04 Upstate Biotechnology, Inc. Method for detection of mutations
AU3919293A (en) * 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
CA2188660C (en) * 1994-04-25 2005-01-18 Richard G. H. Cotton Detection of mutation by resolvase cleavage
EP0843736B1 (de) * 1995-05-11 1999-12-22 Ulf Landegren Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger
US5824471A (en) * 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
US5571676A (en) * 1995-06-07 1996-11-05 Ig Laboratories, Inc. Method for mismatch-directed in vitro DNA sequencing
AU6886296A (en) * 1995-09-08 1997-03-27 University Of Dundee, The Dna structure-specific nucleases
US6027898A (en) * 1997-08-18 2000-02-22 Transgenomic, Inc. Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals
DE19757144A1 (de) * 1997-12-20 1999-06-24 Boerries Prof Dr Rer Na Kemper Dualer enzymatischer Test zum Nachweis von Mutationen in DNA beliebiger Herkunft durch Endonuklease VII

Also Published As

Publication number Publication date
EP1053352B1 (de) 2002-09-18
DE69902996D1 (de) 2002-10-24
WO1999040222A1 (en) 1999-08-12
EP1053352A4 (de) 2001-03-21
EP1053352A1 (de) 2000-11-22
CA2319712A1 (en) 1999-08-12
AU2482899A (en) 1999-08-23
JP2002502614A (ja) 2002-01-29
DE69902996T2 (de) 2003-04-30
US6110684A (en) 2000-08-29
AU753273B2 (en) 2002-10-10

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