CN111615522B - 用于合成环糊精衍生物的方法 - Google Patents

用于合成环糊精衍生物的方法 Download PDF

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Publication number
CN111615522B
CN111615522B CN201880085655.XA CN201880085655A CN111615522B CN 111615522 B CN111615522 B CN 111615522B CN 201880085655 A CN201880085655 A CN 201880085655A CN 111615522 B CN111615522 B CN 111615522B
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chloride
sugammadex
formula
cyclodextrin
salt
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Chinese (zh)
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CN111615522A (zh
Inventor
J·帕格塞拉诺
J·博世伊利多
I·恩戈崔
E·杜兰佩兹
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880085655.XA 2017-11-27 2018-11-26 用于合成环糊精衍生物的方法 Active CN111615522B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382802 2017-11-27
EP17382802.1 2017-11-27
PCT/EP2018/082598 WO2019102009A1 (en) 2017-11-27 2018-11-26 Process for the synthesis of a cyclodextrin derivative

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CN111615522A CN111615522A (zh) 2020-09-01
CN111615522B true CN111615522B (zh) 2023-04-18

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CN201880085655.XA Active CN111615522B (zh) 2017-11-27 2018-11-26 用于合成环糊精衍生物的方法

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US (1) US11104746B2 (https=)
EP (1) EP3717521B1 (https=)
JP (1) JP7460521B2 (https=)
CN (1) CN111615522B (https=)
ES (1) ES2948930T3 (https=)
WO (1) WO2019102009A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021039084A1 (ja) * 2019-08-30 2021-03-04 テルモ株式会社 注射液製剤
JP2023515087A (ja) 2020-02-28 2023-04-12 メディチェム エセ．ア． スガマデクスを乾燥させるための方法
ES2949710T1 (es) * 2020-07-03 2023-10-02 Galenicum Health S L U Método para preparar composiciones farmacéuticas
CN115201171B (zh) * 2022-07-28 2025-03-18 中国农业大学 一种基于水溶性芘衍生物的罗库溴铵的快速可视化检测方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
JP2008203357A (ja) 2007-02-16 2008-09-04 Sanyo Chem Ind Ltd コンタクトレンズ用洗浄剤
PL2609120T3 (pl) 2010-08-25 2016-03-31 Davuluri Ramamohan Rao Ulepszony sposób wytwarzania sugammadeksu
WO2014125501A1 (en) * 2013-02-14 2014-08-21 Neuland Laboratories Limited An improved process for preparation of sugammadex sodium
CN105273095A (zh) * 2014-05-28 2016-01-27 四川海思科制药有限公司 一种舒更葡糖钠及其中间体的制备方法
WO2016194001A1 (en) 2015-05-29 2016-12-08 Alaparthi Lakshmi Prasad Processes for preparation of sugammadex and intermediates thereof
CN106749771A (zh) 2015-11-23 2017-05-31 成都渊源生物科技有限公司 一种高纯度的舒更葡糖钠制备方法
AU2016359420B2 (en) 2015-11-25 2020-10-01 Fresenius Kabi Ipsum S.R.L. An improved process for the preparation of sugammadex and its intermediates
EP3433285B1 (en) 2016-03-22 2020-06-03 Fresenius Kabi iPSUM S.r.l. An improved process for the preparation of sugammadex
US10894839B2 (en) 2016-06-23 2021-01-19 Synthon B.V. Process for making Sugammadex
US20180016359A1 (en) 2016-06-29 2018-01-18 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Sugammadex preparation and purification method
US10385142B2 (en) 2017-01-23 2019-08-20 Scinopharm Taiwan, Ltd. Method for preparing sugammadex sodium
WO2018185784A1 (en) 2017-04-06 2018-10-11 Neuland Pharma Research Private Limited Improved process for preparation of sugammadex sodium

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Publication number Publication date
EP3717521B1 (en) 2023-04-05
US11104746B2 (en) 2021-08-31
JP2021504505A (ja) 2021-02-15
CN111615522A (zh) 2020-09-01
ES2948930T3 (es) 2023-09-21
WO2019102009A1 (en) 2019-05-31
US20200377621A1 (en) 2020-12-03
JP7460521B2 (ja) 2024-04-02
EP3717521A1 (en) 2020-10-07

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