CN111601606A - 用于活化的成纤维细胞与免疫细胞的相互作用及其用途 - Google Patents

用于活化的成纤维细胞与免疫细胞的相互作用及其用途 Download PDF

Info

Publication number
CN111601606A
CN111601606A CN201880086376.5A CN201880086376A CN111601606A CN 111601606 A CN111601606 A CN 111601606A CN 201880086376 A CN201880086376 A CN 201880086376A CN 111601606 A CN111601606 A CN 111601606A
Authority
CN
China
Prior art keywords
days
hours
cells
fibroblasts
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880086376.5A
Other languages
English (en)
Chinese (zh)
Inventor
P·奥希伦
T·伊奇姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Figene LLC
Original Assignee
Figene LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Figene LLC filed Critical Figene LLC
Publication of CN111601606A publication Critical patent/CN111601606A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33—Fibroblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1157—Monocytes, macrophages

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
CN201880086376.5A 2017-11-29 2018-11-29 用于活化的成纤维细胞与免疫细胞的相互作用及其用途 Pending CN111601606A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762591858P 2017-11-29 2017-11-29
US62/591,858 2017-11-29
PCT/US2018/063001 WO2019108756A1 (en) 2017-11-29 2018-11-29 Interaction of fibroblasts and immune cells for activation and uses thereof

Publications (1)

Publication Number Publication Date
CN111601606A true CN111601606A (zh) 2020-08-28

Family

ID=66665803

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880086376.5A Pending CN111601606A (zh) 2017-11-29 2018-11-29 用于活化的成纤维细胞与免疫细胞的相互作用及其用途

Country Status (7)

Country Link
US (2) US12233094B2 (https=)
EP (1) EP3716988A4 (https=)
JP (2) JP7387603B2 (https=)
CN (1) CN111601606A (https=)
AU (1) AU2018375151B2 (https=)
CA (1) CA3083354A1 (https=)
WO (1) WO2019108756A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109837250A (zh) * 2019-01-15 2019-06-04 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用
CN113584193A (zh) * 2021-07-06 2021-11-02 中南大学湘雅医院 毛螺菌属作为评估慢性自发性荨麻疹患者抗组胺药物疗效的标志物的应用
CN114213540A (zh) * 2022-02-22 2022-03-22 北京大学人民医院 一组用于髓系肿瘤免疫分型的抗体组合物及其应用
CN115590887A (zh) * 2022-10-17 2023-01-13 厦门大学（Cn） 诱导成纤维细胞呈现免疫抑制表型的方法
CN116831234A (zh) * 2023-09-01 2023-10-03 成都铁骑力士饲料有限公司 一种缓解保育猪热应激的营养功能包及其制备方法和应用
CN119386163A (zh) * 2025-01-03 2025-02-07 北京益华生物科技有限公司 一种提高细胞疗法再生的药物组合物及其应用
CN119592507A (zh) * 2024-12-03 2025-03-11 哈尔滨优莱福生物科技有限公司 一种人外周血调节性t细胞的体外扩增试剂盒及其使用方法和应用

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11034934B2 (en) 2017-01-11 2021-06-15 Spinalcyte, Llc Methods of enhancing fibroblast therapeutic activity
CN110520140A (zh) 2017-04-19 2019-11-29 菲格内有限责任公司 成纤维细胞衍生的外泌体刺激血管生成
JP7386162B2 (ja) * 2017-12-20 2023-11-24 フィジーン、エルエルシー 線維芽細胞の再生活性の増強
WO2020046910A1 (en) * 2018-08-27 2020-03-05 Figene, Llc Chimeric antigen receptor fibroblast cells for treatment of cancer
EP3873540A4 (en) 2018-10-31 2022-07-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
WO2020092839A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
JP2022506683A (ja) 2018-11-04 2022-01-17 フィジーン、エルエルシー 膵臓移植のファシリテーターとして繊維芽細胞を用いる１型糖尿病の治療方法および組成物
CA3286605A1 (en) 2018-11-04 2025-11-29 Fibrobiologics, Inc. Treatment of cachexia using fibroblast cells and products thereof
AU2020208472B2 (en) * 2019-01-17 2025-03-27 Fibrobiologics, Inc. Fibroblasts and microvesicles thereof for reduction of toxicity associated with cancer immunotherapy
AU2020284114B2 (en) * 2019-05-31 2025-06-26 Fibrobiologics, Inc. Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis
US20220235326A1 (en) * 2019-06-12 2022-07-28 Figene, Llc Enhancement of fibroblast therapeutic activity by rna
AU2020302908A1 (en) * 2019-06-28 2022-02-24 Figene, Llc Administration of fibroblasts and derivatives thereof for treatment of type 2 diabetes
EP4045065A4 (en) * 2019-10-15 2023-08-30 Figene, LLC Fibroblast-based immunotherapy of graves disease
EP4051689A4 (en) * 2019-11-01 2023-11-29 Figene, LLC FIBROBLAST THERAPY TO TREAT SCLEROSING CHOLANGITIS
JP7817159B2 (ja) * 2019-11-08 2026-02-18 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 炎症状態及び変性疾患を処置するために操作された間葉系幹細胞を使用する方法及び材料
EP4058045A4 (en) * 2019-11-15 2023-11-01 Figene, LLC FIBROBLAST THERAPY AGAINST INFLAMMATORY BOWEL DISEASE
US12576112B2 (en) 2019-12-26 2026-03-17 Spinalcyte Llc Inhibition of TNF-alpha by fibroblasts and fibroblast exosomes
WO2021133793A1 (en) * 2019-12-26 2021-07-01 Figene, Llc Suppression of interleukin-17 production and inhibition of th17 cell generation by fibroblasts and products thereof
WO2021133790A1 (en) * 2019-12-26 2021-07-01 Figene, Llc Prevention and treatment of kidney failure by administration of fibroblasts and products thereof
RU2727751C1 (ru) * 2020-01-09 2020-07-23 Сергей Николаевич Лепетунов Способ продления безрецидивного периода интерстициального цистита
US20230117738A1 (en) * 2020-03-13 2023-04-20 Figene, Llc Generation of autoimmune inhibitory t cells by fibroblast mediated education
WO2021202031A1 (en) * 2020-03-30 2021-10-07 Figene, Llc Peptides and adjuvants for augmentation of fibroblast therapy for coronavirus
EP4142751A4 (en) * 2020-04-01 2025-01-08 Figene, LLC Fibroblast mediated expansion and augmentation of immune regulatory cells for treatment of acute respiratory distress syndrome (ards)
BR112022021104A2 (pt) 2020-04-20 2022-11-29 Duogenic Stemcells Corp Macrófagos modificados, suas composições e seus usos
JP2023524679A (ja) * 2020-04-30 2023-06-13 フィジーン、エルエルシー 癌線維芽細胞を標的化するための免疫療法の方法および組成物
US20230248777A1 (en) * 2020-05-29 2023-08-10 Figene, Llc Augmentation of fibroblast cell therapy efficacy by microbiome manipulation
CN111643526A (zh) * 2020-07-14 2020-09-11 贵州金元泰生物科技有限公司 一种用于延缓卵巢衰老及防治老年痴呆和抑郁的间充质干细胞制剂
US20230340416A1 (en) * 2020-07-14 2023-10-26 Figene, Llc Augmentation of fibroblast therapeutic activity by complement blockade and/or inhibition
CN116761606A (zh) * 2020-11-25 2023-09-15 上海君赛生物科技有限公司 增强细胞杀伤的药物组合物及其用途
US20240000854A1 (en) * 2020-12-04 2024-01-04 PRIMORIS THERAPEUTICS Co., Ltd. Method for preparing high-concentration stem cell exosomes with enhanced anti-inflammatory and regenerative functions using lipopolysaccharide and lipoteichoic acid
CN112553155A (zh) * 2020-12-28 2021-03-26 山东省齐鲁干细胞工程有限公司 一种脐带血间充质干细胞培养方法
WO2022182763A1 (en) * 2021-02-23 2022-09-01 KSQ Therapeutics, Inc. Methods for expanding regulatory t cells
CN113203781B (zh) * 2021-05-13 2022-05-31 桂林电子科技大学 一种非诊断目的基于RGO-CS-Hemin@Pt NPs纳米材料和适配体检测GPC3的方法
CN113519459B (zh) * 2021-06-11 2022-03-25 中国科学院合肥物质科学研究院 一种采用调节肝细胞ros水平的磁场发生装置在调节人/鼠肝细胞氧化应激中的应用
US20250092366A1 (en) * 2021-07-20 2025-03-20 Efm Biotech Inc. Proteolytic Enzymes for Cell Culture Media
CN113736737B (zh) * 2021-09-18 2023-09-08 四川大学华西医院 一种原代胶质瘤相关成纤维细胞培养方法
WO2023075623A1 (en) * 2021-10-26 2023-05-04 Ineb (Instituto Nacional De Engenharia Biomédica) Macrophage phenoypes for use in the treatment of intravertebral discs
US20230158080A1 (en) * 2021-11-22 2023-05-25 Spinalcyte, Llc Hormonal manipulation of fibroblast therapeutic activity
KR20230099677A (ko) * 2021-12-27 2023-07-04 주식회사 진켐 신규한 메토트렉세이트 결합체와 이의 용도
AU2024288194A1 (en) * 2023-07-11 2026-02-05 Fibrobiologics, Inc. Therapeutic use of fibroblasts for the treatment of psoriasis
KR20250023295A (ko) * 2023-08-08 2025-02-18 주식회사 현대메디텍 N-아세틸시스테인(nac)을 이용한 편도 유래 중간엽 줄기세포의 배양방법
CN117147817B (zh) * 2023-08-25 2025-11-18 上海艾棵颂生物科技有限公司 多能干细胞来源小细胞外囊泡的特征性标志物组合及其应用
CN118165932A (zh) * 2023-10-18 2024-06-11 北京细胞治疗集团有限公司 一种car-t细胞的制备方法
WO2025151923A1 (en) * 2024-01-17 2025-07-24 Newsouth Innovations Pty Limited Apparatus for production of engineered cells
WO2025207662A1 (en) * 2024-03-25 2025-10-02 Fibrobiologics, Inc. Therapeutic use of fibroblasts for the treatment of systemic lupus erythematosus
CN118045104A (zh) * 2024-04-03 2024-05-17 椎元医学技术(上海)有限公司 一种成纤维细胞制剂及其在制备预防增生性脊柱炎的药物中的应用
US20250312383A1 (en) * 2024-04-05 2025-10-09 Stemcyte, Inc. Human umbilical cord blood for use in alleviating fatigue
CN118655199B (zh) * 2024-08-19 2024-12-24 四川菊乐食品股份有限公司 一种细胞印迹电化学传感器的制备方法及利用其快速定量检测乳制品中乳酸菌的方法
CN119638837B (zh) * 2025-01-21 2025-12-30 广东拓普灵生物医药科技有限公司 一种人脐带间充质干细胞扩增培养基及培养方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596223A (zh) * 2009-08-22 2012-07-18 查尔斯·肯尼萨维奇 杀肿瘤的、杀菌的、或杀病毒的巨噬细胞的激活
WO2014139883A1 (en) * 2013-03-14 2014-09-18 Galapagos Nv Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases
CN106659743A (zh) * 2014-06-10 2017-05-10 迈索布拉斯特国际有限公司 免疫病症的治疗

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
CN1234417A (zh) 1998-11-05 1999-11-10 褚炎明 一种彩色发光塑料
WO2000029001A1 (en) 1998-11-13 2000-05-25 Osiris Therapeutics, Inc. Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation
AU7743100A (en) * 1999-09-30 2001-04-30 Corixa Corporation Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
JP2005524601A (ja) * 2000-09-15 2005-08-18 ザ スクリップス リサーチ インスティテュート 抗体による過酸化水素およびスーパーオキシド生成に関する方法および組成物
US7011965B2 (en) 2001-03-09 2006-03-14 Regents Of The University Of Minnesota Compositions and methods for stimulating wound healing and fibroblast proliferation
US20030216315A1 (en) * 2002-02-13 2003-11-20 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
WO2005094353A2 (en) * 2004-03-29 2005-10-13 Cytomatrix, Llc Methods for production of regulatory t cells and uses thereof
AU2005279934A1 (en) * 2004-08-30 2006-03-09 Theregen, Inc. Compositions and methods of promoting hair growth
US20070059824A1 (en) * 2005-09-12 2007-03-15 Yong Zhao Human umbilical cord blood-derived pluripotent fibroblast-like-macrophages
CA2663749A1 (en) 2005-09-21 2007-03-29 Dask Technologies, Llc Methods and compositions for organ and tissue functionality
FI20065514A0 (fi) * 2006-08-16 2006-08-16 Licentia Oy Aktivoidut fibroblastit kudosvaurioiden hoitamiseksi
EP1944361A1 (en) 2007-01-11 2008-07-16 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for expanding monocytes
KR100995340B1 (ko) 2007-11-19 2010-11-19 재단법인서울대학교산학협력재단 자연 살해 ｔ 세포의 리간드와 항원을 적재한 단핵구 또는미분화 골수성 세포를 포함하는 백신
GB0918615D0 (en) 2009-10-23 2009-12-09 Cellerix Sa Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
US20140314869A1 (en) * 2011-08-29 2014-10-23 Arnold I. Caplan Isolating and therapeutic use of perivascular medicinal cells
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
EP3936137A1 (en) * 2013-02-07 2022-01-12 The General Hospital Corporation Methods for expansion or depletion of t-regulatory cells
BR112015030237A2 (pt) * 2013-06-04 2017-10-03 Selecta Biosciences Inc Imunoterapêutico antígeno-específico, composição, método de fabricação e seu uso
WO2016068217A1 (ja) 2014-10-29 2016-05-06 国立大学法人山口大学 末梢血単核球又は末梢血単核球より分泌される因子を伴う線維芽細胞を含む細胞シート
US20170196951A1 (en) 2015-01-09 2017-07-13 Batu Biologics, Inc. Polyvalent anti-tumor fibroblast vaccine
CN107208055B (zh) * 2015-01-17 2021-06-15 浙江大学 引起免疫原性反应降低的被修饰细胞
US11473059B2 (en) * 2015-10-22 2022-10-18 Lucas Bio Co. Ltd. Method for enrichment and expansion of virus antigen-specific T cells
TWI612057B (zh) * 2015-10-28 2018-01-21 大江生醫股份有限公司 可促進傷口癒合、膠原蛋白增生、血管新生、活化免疫細胞並降低傷口感染之胜肽及其應用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596223A (zh) * 2009-08-22 2012-07-18 查尔斯·肯尼萨维奇 杀肿瘤的、杀菌的、或杀病毒的巨噬细胞的激活
WO2014139883A1 (en) * 2013-03-14 2014-09-18 Galapagos Nv Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases
CN106659743A (zh) * 2014-06-10 2017-05-10 迈索布拉斯特国际有限公司 免疫病症的治疗

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
RUBEN A. FERRER等: "Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 137, no. 4, pages 942 *
何为民等: "IFN-γ、IL-6对眼眶成纤维细胞ICAM-1表达的影响", 眼科研究, vol. 24, no. 2, pages 1 - 3 *
刘贤忠等: "肿瘤相关巨噬细胞在血管生成和淋巴管生成中的研究进展", 细胞与分子免疫学杂志, vol. 32, no. 2, pages 280 - 283 *
尹学红;庞春燕;白力;张颖;耿立霞;: "脂肪间充质干细胞促进M1型巨噬细胞向M2型巨噬细胞转化", 细胞与分子免疫学杂志, vol. 32, no. 3, pages 332 - 338 *
崔文柱等: "细胞因子在伤口愈合中的作用", 河北医药, vol. 18, no. 2, pages 89 - 90 *
张颖等: "巨噬细胞极化相关机制的研究进展", 细胞与分子免疫学杂志, vol. 32, no. 11, pages 1570 - 1573 *
缪明远等: "巨噬细胞活化与创面愈合", 上海交通大学学报(医学版), vol. 31, no. 8, pages 1189 - 1193 *
聂小蒙等: "成纤维细胞在炎症反应中具有"岗哨细胞"的作用", 中国病理生理杂志, vol. 16, no. 4, pages 368 - 370 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109837250A (zh) * 2019-01-15 2019-06-04 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用
CN109837250B (zh) * 2019-01-15 2021-10-12 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用
CN113584193A (zh) * 2021-07-06 2021-11-02 中南大学湘雅医院 毛螺菌属作为评估慢性自发性荨麻疹患者抗组胺药物疗效的标志物的应用
CN114213540A (zh) * 2022-02-22 2022-03-22 北京大学人民医院 一组用于髓系肿瘤免疫分型的抗体组合物及其应用
CN114213540B (zh) * 2022-02-22 2022-07-01 北京大学人民医院 一组用于髓系肿瘤免疫分型的抗体组合物及其应用
CN115590887A (zh) * 2022-10-17 2023-01-13 厦门大学（Cn） 诱导成纤维细胞呈现免疫抑制表型的方法
CN115590887B (zh) * 2022-10-17 2026-04-03 厦门大学 诱导成纤维细胞呈现免疫抑制表型的方法
CN116831234A (zh) * 2023-09-01 2023-10-03 成都铁骑力士饲料有限公司 一种缓解保育猪热应激的营养功能包及其制备方法和应用
CN119592507A (zh) * 2024-12-03 2025-03-11 哈尔滨优莱福生物科技有限公司 一种人外周血调节性t细胞的体外扩增试剂盒及其使用方法和应用
CN119386163A (zh) * 2025-01-03 2025-02-07 北京益华生物科技有限公司 一种提高细胞疗法再生的药物组合物及其应用
CN119386163B (zh) * 2025-01-03 2025-03-07 北京益华生物科技有限公司 一种提高细胞疗法再生的药物组合物及其应用

Also Published As

Publication number Publication date
US20250144151A1 (en) 2025-05-08
JP7387603B2 (ja) 2023-11-28
AU2018375151A1 (en) 2020-06-11
US20210393700A1 (en) 2021-12-23
JP2021503923A (ja) 2021-02-15
JP2023159370A (ja) 2023-10-31
WO2019108756A1 (en) 2019-06-06
US12233094B2 (en) 2025-02-25
EP3716988A1 (en) 2020-10-07
EP3716988A4 (en) 2021-12-15
CA3083354A1 (en) 2019-06-06
AU2018375151B2 (en) 2025-06-26

Similar Documents

Publication Publication Date Title
US20250144151A1 (en) Interaction of fibroblasts and immune cells for activation and uses thereof
US12465621B2 (en) Mesenchymal stromal cells and uses related thereto
TWI698242B (zh) 利用血管母細胞產生間葉基質細胞之方法
ES2769778T3 (es) Composiciones inmunomoduladoras
US20230226119A1 (en) Umbilical cord derived regenerative and immune modulatory stem cell populations
US20230014637A1 (en) Therapeutic Monocytic Lineage Cells
AU2020284114B2 (en) Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis
US20230295569A1 (en) Therapeutic regenerative cells
US20250375520A1 (en) Production of immune cells
US20230149523A1 (en) Treatment of autoimmunity and transplant rejection through establishment and/or promotion of tolerogenic processes by fibroblast-mediated reprogramming of antigen presenting cells
HK40031603A (en) Interaction of fibroblasts and immune cells for activation and uses thereof
US20230057356A1 (en) Enhancement of umbilical cord mesenchymal stem cell therapeutic activity by stimulators of t regulatory cells and/or cells expressing cd73
WO2025125443A1 (en) Production of immune cells
TWI921638B (zh) 包含經由血管母細胞產生之間葉基質細胞之醫藥組合物
US20210353685A1 (en) Augmentation of Cell Therapy Efficacy by Inhibition of Complement Activation Pathways
Blood Non-hematopoietic Stem and Progenitor Cells
Atoui Marrow stromal cells as" universal donor cells" for myocardial regenerative therapy

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40031603

Country of ref document: HK