CN111566099B - 抗菌化合物 - Google Patents
抗菌化合物 Download PDFInfo
- Publication number
- CN111566099B CN111566099B CN201880085171.5A CN201880085171A CN111566099B CN 111566099 B CN111566099 B CN 111566099B CN 201880085171 A CN201880085171 A CN 201880085171A CN 111566099 B CN111566099 B CN 111566099B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- hydrogen
- group
- cycloalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Warehouses Or Storage Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1718285.8A GB201718285D0 (en) | 2017-11-03 | 2017-11-03 | Antibacterial Compounds |
| GB1718285.8 | 2017-11-03 | ||
| PCT/GB2018/053183 WO2019086890A1 (en) | 2017-11-03 | 2018-11-02 | Antibacterial compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111566099A CN111566099A (zh) | 2020-08-21 |
| CN111566099B true CN111566099B (zh) | 2023-06-02 |
Family
ID=60664899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880085171.5A Active CN111566099B (zh) | 2017-11-03 | 2018-11-02 | 抗菌化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11345694B2 (https=) |
| EP (2) | EP4606375A3 (https=) |
| JP (2) | JP7348897B2 (https=) |
| KR (1) | KR102470319B1 (https=) |
| CN (1) | CN111566099B (https=) |
| AU (1) | AU2018361828B2 (https=) |
| BR (1) | BR112020008531A2 (https=) |
| CA (1) | CA3081423A1 (https=) |
| CL (2) | CL2020001147A1 (https=) |
| CO (1) | CO2020005420A2 (https=) |
| EA (1) | EA202091118A1 (https=) |
| ES (1) | ES3005164T3 (https=) |
| GB (1) | GB201718285D0 (https=) |
| GE (2) | GEAP202315801A (https=) |
| IL (1) | IL274229B2 (https=) |
| MA (1) | MA50504A (https=) |
| MX (2) | MX2020004562A (https=) |
| PE (2) | PE20211390A1 (https=) |
| SG (1) | SG11202003717UA (https=) |
| UA (1) | UA128475C2 (https=) |
| WO (1) | WO2019086890A1 (https=) |
| ZA (1) | ZA202002093B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201718285D0 (en) * | 2017-11-03 | 2017-12-20 | Discuva Ltd | Antibacterial Compounds |
| CR20200553A (es) | 2018-04-18 | 2021-04-08 | Constellation Pharmaceuticals Inc | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos |
| CN120097995A (zh) | 2018-05-21 | 2025-06-06 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| WO2021016414A1 (en) | 2019-07-24 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide |
| CN111635372B (zh) * | 2020-06-28 | 2022-05-27 | 齐鲁工业大学 | 一种恶唑酮衍生物及其合成方法 |
| CN117597337A (zh) * | 2021-05-03 | 2024-02-23 | 迪斯库瓦有限公司 | 抗菌化合物的制备方法 |
| KR20240004494A (ko) * | 2021-05-03 | 2024-01-11 | 디스쿠바 엘티디. | 항균성 화합물 |
| JP7807529B2 (ja) | 2022-02-21 | 2026-01-27 | 三井化学株式会社 | 金属部材、金属樹脂接合体及び金属部材の製造方法 |
| CN118164937A (zh) * | 2024-03-13 | 2024-06-11 | 北京联本医药化学技术有限公司 | 一种铵盐离子液体催化制备5-乙酰基-2,3-苯丙二氢呋喃的方法 |
| CN120208965B (zh) * | 2025-05-28 | 2025-08-12 | 四川大学 | 靶向革兰氏阴性菌外膜组装关键蛋白质机器的4-(吡啶-4-基)-1h-咪唑-2-胺类衍生物、组合物 |
| CN121471219A (zh) * | 2026-01-09 | 2026-02-06 | 四川大学 | 用于革兰氏阴性菌特异性抗菌治疗的咪唑-2-胺类衍生物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015173788A1 (en) * | 2014-05-16 | 2015-11-19 | Westfaelische Wilhelms-Universitaet Muenster | Novel anti-infective strategy against influenza virus and s. aureus coinfections |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA869348B (en) | 1985-12-12 | 1987-10-28 | Smithkline Beckman Corp | Inhibition of the 5-lipoxygenase pathway |
| US4780470A (en) * | 1986-08-19 | 1988-10-25 | Smithkline Beckman Corporation | Inhibition of interleukin-1 by monocytes and/or macrophages |
| JP2808460B2 (ja) * | 1989-11-16 | 1998-10-08 | 大正製薬株式会社 | イミダゾール誘導体 |
| JPH09124640A (ja) | 1995-08-25 | 1997-05-13 | Nippon Soda Co Ltd | ピリジルイミダゾール化合物、製法および農園芸用殺菌剤 |
| US6207687B1 (en) | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
| AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| EP1532118A2 (en) * | 2002-07-05 | 2005-05-25 | Axxima Pharmaceuticals Aktiengesellschaft | Imidazole compounds for the treatment of hepatitis c virus infections |
| JP2004196678A (ja) | 2002-12-17 | 2004-07-15 | Dainippon Pharmaceut Co Ltd | ピラゾール系誘導体 |
| US8969372B2 (en) | 2003-11-14 | 2015-03-03 | Aptose Boisciences Inc. | Aryl imidazoles and their use as anti-cancer agents |
| NZ549003A (en) * | 2004-03-05 | 2009-07-31 | Taisho Pharmaceutical Co Ltd | Thiazole derivative as an ALK5 inhibitor |
| JP2007277230A (ja) * | 2006-03-15 | 2007-10-25 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
| EP2513064B1 (en) | 2009-12-17 | 2018-07-04 | Katholieke Universiteit Leuven K.U. Leuven R&D | Compounds, compositions and methods for controlling biofilms |
| GB201016261D0 (en) | 2010-09-28 | 2010-11-10 | Univ Leuven Kath | Compounds for controlling biofilms and process for their production |
| WO2012135016A2 (en) | 2011-03-25 | 2012-10-04 | North Carolina State University | Inhibition of bacterial biofilms and microbial growth with imidazole derivatives |
| DK2731949T3 (en) * | 2011-07-13 | 2018-06-14 | Tiumbio Co Ltd | 2-PYRIDYL-SUBSTITUTED IMIDAZOLS AS ALK5 AND / OR ALK4 INHIBITORS |
| US8840912B2 (en) | 2012-01-09 | 2014-09-23 | North Carolina State University | Imidazole derivatives useful for controlling microbial growth |
| ES2789331T3 (es) | 2015-03-02 | 2020-10-26 | Rigel Pharmaceuticals Inc | Inhibidores de TGF-beta |
| WO2016141381A2 (en) | 2015-03-05 | 2016-09-09 | University Of Notre Dame Du Lac | Potentiators of beta-lactam antibiotics |
| US10844051B2 (en) | 2015-07-22 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Substituted oxazoles for the treatment of cancer |
| GB201718285D0 (en) * | 2017-11-03 | 2017-12-20 | Discuva Ltd | Antibacterial Compounds |
-
2017
- 2017-11-03 GB GBGB1718285.8A patent/GB201718285D0/en not_active Ceased
-
2018
- 2018-11-02 AU AU2018361828A patent/AU2018361828B2/en active Active
- 2018-11-02 KR KR1020207015574A patent/KR102470319B1/ko active Active
- 2018-11-02 GE GEAP202315801A patent/GEAP202315801A/en unknown
- 2018-11-02 CN CN201880085171.5A patent/CN111566099B/zh active Active
- 2018-11-02 JP JP2020524275A patent/JP7348897B2/ja active Active
- 2018-11-02 EA EA202091118A patent/EA202091118A1/ru unknown
- 2018-11-02 MA MA050504A patent/MA50504A/fr unknown
- 2018-11-02 CA CA3081423A patent/CA3081423A1/en active Pending
- 2018-11-02 PE PE2020000454A patent/PE20211390A1/es unknown
- 2018-11-02 PE PE2022000118A patent/PE20221006A1/es unknown
- 2018-11-02 EP EP24200101.4A patent/EP4606375A3/en active Pending
- 2018-11-02 ES ES18800297T patent/ES3005164T3/es active Active
- 2018-11-02 UA UAA202003341A patent/UA128475C2/uk unknown
- 2018-11-02 MX MX2020004562A patent/MX2020004562A/es unknown
- 2018-11-02 GE GEAP201815801A patent/GEP20237522B/en unknown
- 2018-11-02 BR BR112020008531-6A patent/BR112020008531A2/pt active Search and Examination
- 2018-11-02 WO PCT/GB2018/053183 patent/WO2019086890A1/en not_active Ceased
- 2018-11-02 EP EP18800297.6A patent/EP3704105B9/en active Active
- 2018-11-02 US US16/761,016 patent/US11345694B2/en active Active
- 2018-11-02 SG SG11202003717UA patent/SG11202003717UA/en unknown
-
2020
- 2020-04-26 IL IL274229A patent/IL274229B2/en unknown
- 2020-04-30 CL CL2020001147A patent/CL2020001147A1/es unknown
- 2020-04-30 CO CONC2020/0005420A patent/CO2020005420A2/es unknown
- 2020-05-04 ZA ZA2020/02093A patent/ZA202002093B/en unknown
- 2020-07-13 MX MX2021010246A patent/MX2021010246A/es unknown
-
2021
- 2021-08-27 CL CL2021002263A patent/CL2021002263A1/es unknown
- 2021-11-01 JP JP2021178557A patent/JP2022025116A/ja not_active Withdrawn
-
2022
- 2022-04-25 US US17/728,335 patent/US20220372027A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015173788A1 (en) * | 2014-05-16 | 2015-11-19 | Westfaelische Wilhelms-Universitaet Muenster | Novel anti-infective strategy against influenza virus and s. aureus coinfections |
| CN107073123A (zh) * | 2014-05-16 | 2017-08-18 | 归属疗法有限公司 | 抗流感病毒和金黄色葡萄球菌合并感染的新型抗感染策略 |
Non-Patent Citations (2)
| Title |
|---|
| STN检索库中新颖性化合物;REGISTRY;《STN》;20090405;1-6页 * |
| Structure-activity relationship of 4(5)-aryl-2-amino-1H-imidazoles, N1-substituted 2-aminoimidazoles and imidazo[1,2-a]pyrimidinium salts as inhibitors of biofilm formation by Salmonella Typhimurium and Pseudomonas aeruginosa;Hans P. L.Steenackers;《Journal of Medicinal Chemistry》;20101120;第54卷(第2期);第475页table3，化合物11-17 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: oxford Applicant after: DISCUVA Ltd. Address before: Britain Camb Applicant before: DISCUVA Ltd. |
|
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: P. Mio Inventor after: M. N. Strauss Kahn Inventor after: Charrier Cedric Inventor before: P. Mio Inventor before: N. Kahn Inventor before: Charrier Cedric |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |