CN111557449A - Composition with function of improving immunity and preparation method thereof - Google Patents

Composition with function of improving immunity and preparation method thereof Download PDF

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CN111557449A
CN111557449A CN202010434828.3A CN202010434828A CN111557449A CN 111557449 A CN111557449 A CN 111557449A CN 202010434828 A CN202010434828 A CN 202010434828A CN 111557449 A CN111557449 A CN 111557449A
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parts
peptide
composition
function
powder
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邹坚
李桂珠
刘婕
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Beijing Meixin Hi Tech Co ltd
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Beijing Meixin Hi Tech Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention relates to a composition with the function of improving immunity and a preparation method thereof, wherein the composition comprises the following active ingredients: ginseng oligopeptide, bovine bone collagen peptide, erythritol, elderberry juice powder and acerola cherry powder; the active ingredients of the feed also comprise sea cucumber peptide, Antarctic krill peptide, Cordyceps militaris concentrate or spine date seed powder, theanine, gamma-aminobutyric acid, walnut peptide and soybean polypeptide. Processing the above active ingredients and/or pharmaceutically acceptable adjuvants to make into various oral preparations; the preparation is convenient to take, and experiments prove that the preparation can effectively improve the immunity.

Description

Composition with function of improving immunity and preparation method thereof
Technical Field
The invention relates to the technical field of compositions, in particular to a composition with an immunity improving function and a preparation method thereof.
Background
Immunity is the body's own defense mechanism, and whether the body can protect against the attack of diseases depends on the strength of the immune system. The low immunity is easy to cause the infection of bacteria, viruses, fungi and the like, and the most direct expression is that the disease is easy to occur; secondly, the spirit cannot be raised, the working efficiency is not high, and the expression of inattention often appears. Although it can be relaxed after rest, after several days, fatigue can occur, with dizziness, which is cachectic and malaise throughout the day. It is clear that the body is very tired, but the user can not sleep at all when sleeping, insomnia often occurs, and the user can be easily awakened even if the user sleeps, and then the user cannot fall asleep again easily.
People with low immunity are easily infected by virus, infected by cold or other diseases, sometimes slightly cold and blow, are also easily ill, and are more easily infected than normal people.
The immunity of the human body is not constant but is in constant change. The immunity of people is very weak when the people are born, so that the health problem is easy to occur in the young. The immunity can be slowly enhanced later, the peak is reached after adolescence, then the user slowly walks down the slope, and the immunity is rapidly reduced in the middle-aged and the elderly.
Studies have shown that certain oligopeptides and polypeptides can enhance cell viability, effectively modulate the function of a subset of lymphoid T cells, enhance humoral and cellular immune functions. Therefore, the method can improve the immunity of the human body and is an effective method for treating and preventing various pathological changes.
The effect of peptides on the human body can be summarized in eight words: inhibiting, activating, promoting and repairing. Inhibition: inhibiting cell degeneration, and nutritionally intervening in the immunity of the organism; activating: activating the activity of cells, and effectively eliminating free radicals which are very harmful to human bodies; promoting: promoting and maintaining normal metabolism of cells; repairing: repairing damaged cells, and maintaining normal cell structure and function. Biologists refer to peptides as "amino acid chains" and small molecule active peptides as "bioactive peptides".
The small molecule active biological peptide composition is derived from pollution-free polar region oceans, near-land oceans, plateaus, mountain forests and polar regions. The micromolecule active peptide is obtained by combining ginseng of 'the king of grass', sea cucumber and antarctic krill which are pollution-free and are sourced from oceans, and grassland yak bones, walnuts and soybeans through a compound biological enzyme cutting method: ginseng oligopeptide, sea cucumber peptide, Antarctic krill peptide, bovine bone collagen peptide, walnut peptide and soybean peptide; the herbal plant cordyceps militaris concentrate, elderberry juice powder, acerola cherry powder, wild jujube kernel powder and tea theanine which are homologous in medicine and food are supplemented; in addition, the gel is prepared by specially combining a nerve transfer substance gamma-aminobutyric acid and erythritol which has zero heat and can replace sucrose. The product of the invention provides diversified micromolecule bioactive peptides, improves the immune effect of each single nutrient component, and has more prominent immune effect through synergistic intervention; the enzyme digestion micromolecule technology and the ultrafiltration purification technology are more precise and easier to absorb.
Disclosure of Invention
The invention aims to provide a composition with the function of improving immunity and a preparation method thereof.
The invention is realized by the following technical scheme:
a composition with the function of improving immunity comprises the following active ingredients: ginseng oligopeptide, bovine bone collagen peptide, erythritol, elderberry juice powder and acerola cherry powder. The active ingredients for preparing the composition are as follows according to the parts by weight: 1-35 parts of ginseng oligopeptide, 5-35 parts of bovine bone collagen peptide, 4-30 parts of erythritol, 0.5-5 parts of elderberry juice powder and 0.5-5 parts of acerola cherry powder. Preferably, the composition is prepared from the following active ingredients in parts by weight: 5-30 parts of ginseng oligopeptide, 10-30 parts of bovine bone collagen peptide, 4-10 parts of erythritol, 1-2.5 parts of elderberry juice powder and 1-2.5 parts of acerola cherry powder.
A composition with the function of improving immunity comprises the following active components: sea cucumber peptide, Antarctic krill peptide and Cordyceps militaris concentrate. 5-30 parts of sea cucumber peptide, 5-15 parts of Antarctic krill peptide and 1-5 parts of cordyceps militaris concentrate.
Preferably, the composition is prepared from the following active ingredients in parts by weight: 31.25 parts of ginseng oligopeptide, 31.25 parts of bovine bone collagen peptide, 12.5 parts of sea cucumber peptide, 5 parts of erythritol, 1.5625 parts of elderberry juice powder, 1.5625 parts of acerola cherry powder, 12.5 parts of antarctic scale shrimp peptide and 2.5 parts of cordyceps militaris concentrate.
A composition with the function of improving immunity comprises the following active components: spine date seed powder, tea theanine, gamma-aminobutyric acid, walnut peptide and soybean polypeptide.
Preferably, the wild jujube seed powder comprises, by weight, 10-50 parts of wild jujube seed powder, 1-10 parts of tea theanine, 2-15 parts of gamma-aminobutyric acid, 1-10 parts of walnut peptide and 1-10 parts of soybean polypeptide.
More preferably, the composition is prepared from the following active ingredients in parts by weight: 7.1875 parts of bovine bone collagen peptide, 1.875 parts of ginseng peptide, 6.25 parts of erythritol, 1.25 parts of elderberry juice powder, 1.25 parts of acerola cherry powder, 12.5 parts of wild jujube kernel powder, 1.875 parts of soybean polypeptide, 3.125 parts of gamma-aminobutyric acid, 2.1875 parts of tea theanine and 1.875 parts of walnut peptide.
The composition with the function of improving immunity is an oral preparation; the method comprises the following steps: granule, powder, solid beverage, tablet, milk tablet, yogurt tablet, colostrum tablet, chewable tablet, bagged tea, decocted tea, beverage, sugar, medicated wine, confection, etc.
The composition with the function of improving immunity comprises an active ingredient and auxiliary materials; the auxiliary materials comprise citric acid, stevioside, edible essence, natural menthol and strawberry essence. The active ingredients account for 40-90 parts by weight, and the auxiliary materials account for 10-60 parts by weight.
A composition with the function of improving immunity is prepared by a process comprising the following steps: taking the active ingredients with the prescription amount, sieving, mixing, adding auxiliary materials, crushing, sieving, uniformly mixing, and preparing the required oral preparation according to the conventional process.
The composition with the function of improving immunity is prepared by the following steps: taking the active ingredients according to the prescription amount, sieving, mixing, adding the auxiliary materials according to the prescription amount, crushing, sieving, uniformly mixing and packaging to obtain the solid beverage.
The efficacy of each active ingredient of the invention is as follows:
the ginseng oligopeptide is easy to be absorbed by human body, has low viscosity, good taste and high utilization rate. Can enhance the immunity by enhancing the cellular immunity function, the humoral immunity function, the phagocytic ability of the mononuclear-macrophage and the activity of NK cells.
The bovine bone collagen peptide is high-quality active bone collagen peptide extracted from natural raised yak bones with the altitude of more than 3000 m. The average molecular weight is 800 daltons, and the collagen peptide is a small molecule collagen peptide which is very easy to be absorbed by a human body. Strengthening body constitution, supplementing calcium and nourishing bone. According to the latest bone-nourishing theory, calcium is supplemented, and collagen is necessary. Effective ossein extracted from yak bones and natural and fresh microelements such as bone calcium supplement and bone nourishing are all managed, thereby promoting bone fracture healing, preventing osteoporosis, arthralgia and bone ache, and having more remarkable effect.
The protein content in the body wall of the sea cucumber is up to 90 percent, the sea cucumber is mainly collagen, and the sea cucumber contains extremely high glycine, proline and hydroxylysine, and can be compared favorably with donkey-hide gelatin, tortoise-plastron glue, turtle shell glue and antler glue of the traditional Chinese medicine glue. Sea cucumber is widely favored as an important medicinal resource. The sea cucumber peptide adopted by the invention enables macromolecular protein to be changed into small peptide, the biological activity is greatly enhanced, and the sea cucumber peptide has no antigenicity and can not generate anaphylactic reaction; the solubility, the stability and the low viscosity are greatly improved, and the processing characteristics are improved; the small molecular peptide has faster absorption and higher efficiency than amino acid, has the auxiliary conveying function which is not possessed by the amino acid, and can be used as a carrier to convey various nutrient components, so that the efficacy of the product is exerted to the maximum extent.
Krill is a class of marine invertebrates that are widely distributed throughout the world's oceans. The storage amount of the antarctic krill is 6.5-10 hundred million tons, and the antarctic krill is a huge protein treasure house for human beings. The protein content of the dry krill is about 65-75%, the amino acid composition is reasonable, and the essential amino acid content is high. The method for preparing the low-molecular-weight krill peptide by hydrolyzing the antarctic krill with the protease is one of effective ways for high-value utilization of krill protein.
The cordyceps militaris concentrate is a new resource raw material, is similar to cordyceps sinensis, is a known immunity component, and is highly concentrated.
Elderberry is called his "kit" by the father of western medicine, hippo-glas, and has been proven from ancient times to be the best choice for natural antiviral natural phytotherapy, which is rich in the anthocyanin components cyanidin-3-glucoside, cyanidin-3, 5-diglucoside, and flavonoid components quercetin, rutinoside. The elderberry has nutrition intervention immunity function on diseases caused by low immunity and other viral infectious diseases, can increase the generation of specific cell factors to activate macrophages, and promotes the activity of the cells on inflamed tissues. Japanese raspberry was used to treat cold, flu, arthritis, constipation, and other ailments. Has been praised as the best medicine for treating cold and fever all the time, and is popular all over the world gradually.
The acerola cherry is famous for being rich in natural vitamin C, also contains a large amount of oxidation resistant components such as bioflavonoids, procyanidine and the like, and cooperates with active small molecular peptides, cordyceps militaris and elderberry to intervene immunity and keep health.
The soybean oligopeptide as an important nutrient substance influences the immune function of animals and is a direct participant for maintaining and regulating the immune function of animals. The soybean peptide not only can provide protein and other nutrient substances for human bodies, but also can directly participate in body metabolism to meet the material basis of the immune function of the human bodies. The soybean oligopeptide has the immunonutrition characteristic of preventing nutrition deficiency, can stimulate immune cells in a specific mode, enhances the immune response of an organism, and relieves excessive inflammatory reaction by regulating and controlling the generation and release of cytokines. Compared with soybean protein, the soybean oligopeptide can better play a role in supporting immunonutrition due to the characteristics of quick absorption, high utilization rate, good amino acid balance and the like.
Erythritol, also known as Erythritol and its english name erythtol, is a natural, zero-calorie, bulk sweetener that can replace sucrose. Has similar clear sweet taste to sucrose, and can be widely used in natural animals and plants such as Sargassum, Agaricus campestris, fructus melo, and fructus Vitis Viniferae, and in eyeball, serum, and semen. Erythritol is the only functional sugar alcohol produced by adopting a microbial fermentation method internationally at present, has good health efficacy and excellent processing characteristics of high thermal stability, small hygroscopicity, low freezing point and the like, and is widely applied to many aspects of food, medicine, chemical industry and the like.
The small molecular walnut peptide is prepared by deep processing of walnut with "brain gold" reputation by means of multi-link biotechnology such as biological low-temperature compound enzymolysis and the like, removing redundant grease in the walnut, and effectively refining nutrient substances of the walnut to form the small molecular walnut peptide rich in 18 amino acids, vitamins and mineral substances. The walnut peptide has extremely strong antibacterial action and extremely wide antibacterial range, and can effectively prevent the colony number of harmful bacteria in a human body and prevent the human body from being injured by the harmful bacteria. On the other hand, the walnut peptide can enhance the phagocytic capacity of phagocyte which plays an important role in the human immune system, and achieves the effect of improving the human immunity by enhancing the capacity of removing apoptotic cells, metabolic wastes and harmful viruses in the human body.
Tea Theanine (L-Theanine) is a special free amino acid in tea and is a main component for promoting the production of body fluid and moistening sweet in tea. The theanine content is about 1-2% of the dry weight of the tea leaves, and a cup of tea contains about 25 mg of theanine. Theanine has no hypnotic effect, can relieve fatigue, reduce blood pressure and improve learning and memory ability, and is rarely used in health food.
Gamma-aminobutyric acid (GABA) is a main inhibitory neurotransmitter of the central nervous system of mammals and has the physiological functions of regulating blood pressure and heart rate, regulating mood, resisting anxiety, depression, tumors, protecting liver and kidney, regulating hormone secretion and the like. At present, food rich in GABA is processed mainly by the modes of treating plant raw materials by anaerobic technology and the like, fermenting microorganisms and adding exogenous materials, and the research on food such as tea, grains, bean products, dairy products, candies, beverages and the like rich in GABA is related to. As a new resource food with various physiological functions, the application of GABA in the food field is greatly developed.
The spina date seed is the kernel of the wild jujube and is a famous traditional Chinese medicine food material. The appearance of the wild jujube is oblate, and is generally common in reddish brown. The spina date seed has the effects of nourishing qi, tranquilizing and allaying excitement, and can relieve mood and improve emotion, and the spina date seed has the effects of nourishing heart and liver channel.
In conclusion, the invention scientifically combines the small molecular active peptide, medicinal and edible herbs and other active ingredients, has synergistic effect, can enhance the cellular immune function, the humoral immune function and the mononuclear-macrophage phagocytic function, and has the function of improving the body immunity. The product of the invention has the advantages of full theoretical basis for improving immunity, reasonable and scientific combination of the active ingredients, and animal experiments prove that the product of the invention has the function of immunity.
The micromolecule active peptide ginseng peptide, bovine bone collagen peptide, sea cucumber peptide, Antarctic krill peptide, walnut peptide and soybean oligopeptide can be commercially available or prepared by adopting a bionic enzymolysis method;
the elderberry juice powder, the cordyceps militaris concentrate, the acerola powder, the spina date seed powder and the tea theanine are commercially available or prepared by adopting the following method: pulverizing the above materials respectively, extracting with water or ethanol of different concentrations, concentrating, drying, or further refining by one or more of ethanol precipitation, water dissolution, organic solvent extraction, flocculation precipitation, and column chromatography, pulverizing, mixing, sieving, and testing to obtain active ingredient extract; the content of active ingredient is not less than 1% calculated on dry product.
The gamma-aminobutyric acid and the erythritol adopt products sold in the market.
Detailed Description
Example 1: 1.25g of ginseng oligopeptide, 28g of bovine bone collagen peptide, 4g of sea cucumber peptide, 24g of erythritol, 2g of elderberry juice powder, 2g of acerola cherry powder, 4g of Antarctic krill peptide and 0.8g of cordyceps militaris concentrate
Taking the formula amount of ginseng oligopeptide, bovine bone collagen peptide, sea cucumber peptide, erythritol, elderberry juice powder, acerola cherry powder, Antarctic krill peptide and cordyceps militaris concentrate, mixing, sieving, adding the formula amount of mannitol, aspartame and magnesium stearate, uniformly mixing, granulating, drying, and pressing into 1000 tablets to obtain the chewable tablet.
Example 2: 28g of ginseng oligopeptide, 6.25g of bovine bone collagen peptide, 24g of sea cucumber peptide, 3.2g of erythritol, 0.4g of elderberry juice powder, 0.4g of acerola cherry powder, 12g of Antarctic krill peptide and 4g of cordyceps militaris concentrate
Taking the prescribed amount of ginseng oligopeptide, bovine bone collagen peptide, sea cucumber peptide, erythritol, elderberry juice powder, acerola cherry powder, Antarctic krill peptide and cordyceps militaris concentrate, mixing, sieving, adding the prescribed amount of starch, mixing uniformly, granulating, adding talcum powder, mixing uniformly, pressing into 1000 tablets, and coating to obtain the tablets.
Example 3: 24g of ginseng oligopeptide, 12.5g of bovine bone collagen peptide, 12g of sea cucumber peptide, 8g of erythritol, 0.8g of elderberry juice powder, 0.8g of acerola cherry powder, 8g of Antarctic krill peptide and 4g of cordyceps militaris concentrate
Mixing the formulated amounts of Ginseng radix oligopeptide, Os bovis Seu Bubali collagen peptide, Stichopus japonicus peptide, erythritol, caulis et folium Sambuci Williamsii juice powder, acerola cherry powder, Antarctic krill peptide, and Cordyceps militaris concentrate, sieving, adding the formulated amounts of citric acid, stevioside, and edible essence, pulverizing, sieving, mixing, and packaging to obtain granule.
Example 4: 25g of ginseng oligopeptide, 25g of bovine bone collagen peptide, 10g of sea cucumber peptide, 4g of erythritol, 1.25g of elderberry juice powder, 1.25g of acerola cherry powder, 10g of antarctic krill peptide and 2g of cordyceps militaris concentrate.
Mixing the formulated amounts of Ginseng radix oligopeptide, Os bovis Seu Bubali collagen peptide, Stichopus japonicus peptide, erythritol, caulis et folium Sambuci Williamsii juice powder, acerola cherry powder, Antarctic krill peptide, and Cordyceps militaris concentrate, sieving, adding the formulated amounts of citric acid, stevioside, and edible essence, mixing, and packaging to obtain solid beverage.
Example 5: 28.75g of yak bone collagen peptide, 7.5g of ginseng peptide, 25g of erythritol, 5g of elderberry juice powder, 5g of acerola cherry powder, 50g of wild jujube kernel powder, 7.5g of soybean polypeptide, 12.5g of gamma-aminobutyric acid, 10g of tea theanine and 7.5g of walnut peptide
Taking the prescribed amount of bovine bone collagen peptide, spina date seed powder, erythritol, gamma-aminobutyric acid, theanine, walnut peptide, ginseng peptide, soybean polypeptide, elderberry juice powder and acerola cherry powder, sieving, adding the prescribed amount of citric acid, stevioside and edible essence, crushing, sieving, uniformly mixing and packaging to obtain the granules.
Example 5: functional pharmacological test
Experiment on weight effect on immune organs: using the samples obtained in examples 1, 2, 3, 4 and 5 as test samples, 60 6-8 week old clean female BALB/c mice were housed on a standard diet for one week prior to testing. One week after the pre-feeding, 60 mice were randomly divided into 6 groups of 10 mice each. The mice in the blank control group were gavaged with the same amount of physiological saline. The gavage is carried out once a day for 4 weeks. The recommended amount of the composition according to the invention for a human is 8g/60Kg body weight each time, i.e. 0.13g/Kg body weight, once to twice a day. The experiment is carried out by feeding twice a day, converting the dosage of the mice, carrying out intragastric administration for four weeks, carrying out cervical dislocation to kill the mice, then picking the thymus and the spleen, stripping the surrounding connective tissues, weighing, calculating the ratio of the thymus and the body weight respectively, and taking the ratio as the corresponding immune organ index of the mice, wherein the specific experiment result is shown in table 1.
TABLE 1 immune organ index and phagocytosis index of groups of mice
Figure BSA0000208921970000061
The experimental results in table 1 show that the spleen index and the thymus index of the composition provided by the invention are obviously higher than those of a control group after the composition is fed to mice, and the composition provided by the invention has a very good effect of enhancing the nonspecific immune function of an organism.
The above-mentioned contents are only basic descriptions under the concept of the present invention, and any changes, additions, deletions and modifications made according to the technical scheme of the main formula of the present invention shall fall within the protection scope of the present invention.

Claims (14)

1. The composition with the function of improving immunity is characterized by comprising the following active ingredients: ginseng oligopeptide, bovine bone collagen peptide, erythritol, elderberry juice powder and acerola cherry powder.
2. The composition with the function of improving immunity according to claim 1, which is characterized by comprising the following active ingredients in parts by weight: 1-35 parts of ginseng oligopeptide, 5-35 parts of bovine bone collagen peptide, 4-30 parts of erythritol, 0.5-5 parts of elderberry juice powder and 0.5-5 parts of acerola cherry powder.
3. The composition with the function of improving immunity according to claim 2, which is characterized by comprising the following active ingredients in parts by weight: 5-30 parts of ginseng oligopeptide, 10-30 parts of bovine bone collagen peptide, 4-10 parts of erythritol, 1-2.5 parts of elderberry juice powder and 1-2.5 parts of acerola cherry powder.
4. The composition with the function of improving immunity according to any one of claims 1 to 3, characterized in that the active ingredients further comprise: sea cucumber peptide, Antarctic krill peptide and Cordyceps militaris concentrate.
5. The composition with the function of improving immunity according to claim 4, which is characterized by comprising, by weight, 5-30 parts of sea cucumber peptide, 5-15 parts of Antarctic krill peptide and 1-5 parts of Cordyceps militaris concentrate.
6. The composition with the function of improving immunity according to any one of claims 1 to 5, wherein the composition is prepared from the following active ingredients in parts by weight: 31.25 parts of ginseng oligopeptide, 31.25 parts of bovine bone collagen peptide, 12.5 parts of sea cucumber peptide, 5 parts of erythritol, 1.5625 parts of elderberry juice powder, 1.5625 parts of acerola cherry powder, 12.5 parts of antarctic scale shrimp peptide and 2.5 parts of cordyceps militaris concentrate.
7. The composition with the function of improving immunity according to any one of claims 1 to 3, characterized in that the active ingredients further comprise: spine date seed powder, tea theanine, gamma-aminobutyric acid, walnut peptide and soybean polypeptide.
8. The composition with the function of improving immunity according to claim 7, is characterized by comprising, by weight, 10-50 parts of wild jujube kernel powder, 1-10 parts of tea theanine, 2-15 parts of gamma-aminobutyric acid, 1-10 parts of walnut peptide and 1-10 parts of soybean polypeptide.
9. The composition with the function of improving immunity according to any one of claims 1 to 3, 7 or 8, characterized in that the active ingredients for preparing the composition are as follows according to the parts by weight: 7.1875 parts of bovine bone collagen peptide, 1.875 parts of ginseng peptide, 6.25 parts of erythritol, 1.25 parts of elderberry juice powder, 1.25 parts of acerola cherry powder, 12.5 parts of wild jujube kernel powder, 1.875 parts of soybean polypeptide, 3.125 parts of gamma-aminobutyric acid, 2.1875 parts of tea theanine and 1.875 parts of walnut peptide.
10. The composition with the function of improving immunity according to any one of claims 1 to 9, wherein the preparation is an oral preparation; the method comprises the following steps: granule, powder, solid beverage, tablet, milk tablet, yogurt tablet, colostrum tablet, chewable tablet, bagged tea, decocted tea, beverage, sugar, medicated wine, confection, etc.
11. The composition with the function of improving immunity according to claim 10, characterized in that the preparation comprises an auxiliary material in addition to the active ingredient; the auxiliary materials comprise citric acid, stevioside, edible essence, natural menthol, strawberry essence, starch, mannitol, aspartame, magnesium stearate, xylitol and microcrystalline cellulose.
12. The composition with the function of improving immunity according to any one of claims 10 to 11, wherein the preparation comprises 40 to 90 parts of active ingredients and 10 to 60 parts of auxiliary materials by weight.
13. The composition with the function of improving immunity according to any one of claims 1 to 12, wherein the preparation process of the composition comprises the following steps: taking the active ingredients with the prescription amount, sieving, mixing, adding auxiliary materials, crushing, sieving, uniformly mixing, and preparing the required oral preparation according to the conventional process.
14. The composition with the function of improving immunity according to claim 13, wherein the preparation method of the solid beverage comprises the following steps: taking the active ingredients according to the prescription amount, sieving, mixing, adding the auxiliary materials according to the prescription amount, crushing, sieving, uniformly mixing and packaging to obtain the solid beverage.
CN202010434828.3A 2020-05-19 2020-05-19 Composition with function of improving immunity and preparation method thereof Pending CN111557449A (en)

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CN115024491A (en) * 2022-06-10 2022-09-09 百威(武汉)啤酒有限公司 Composition for assisting sleep and application thereof, beverage containing composition and preparation method

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