CN113875992A - Polypeptide composition preparation with function of improving immunity and application thereof - Google Patents
Polypeptide composition preparation with function of improving immunity and application thereof Download PDFInfo
- Publication number
- CN113875992A CN113875992A CN202110237175.4A CN202110237175A CN113875992A CN 113875992 A CN113875992 A CN 113875992A CN 202110237175 A CN202110237175 A CN 202110237175A CN 113875992 A CN113875992 A CN 113875992A
- Authority
- CN
- China
- Prior art keywords
- function
- parts
- peptide
- polypeptide composition
- immune
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 77
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 50
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 230000036039 immunity Effects 0.000 title claims description 22
- 230000001105 regulatory effect Effects 0.000 claims abstract description 39
- 230000036737 immune function Effects 0.000 claims abstract description 24
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims abstract description 19
- 101800000068 Antioxidant peptide Proteins 0.000 claims abstract description 18
- 239000008213 purified water Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000004957 immunoregulator effect Effects 0.000 claims description 13
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 10
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 10
- 235000020357 syrup Nutrition 0.000 claims description 10
- 239000006188 syrup Substances 0.000 claims description 10
- 230000033228 biological regulation Effects 0.000 claims description 2
- 235000012054 meals Nutrition 0.000 claims description 2
- 235000020429 malt syrup Nutrition 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 10
- 108060003951 Immunoglobulin Proteins 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 102000018358 immunoglobulin Human genes 0.000 description 9
- 230000003832 immune regulation Effects 0.000 description 8
- 230000007365 immunoregulation Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 230000036541 health Effects 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000000975 bioactive effect Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000032683 aging Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- -1 aromatic amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000013400 design of experiment Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000012803 optimization experiment Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005556 structure-activity relationship Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000001040 synthetic pigment Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a polypeptide composition preparation with an immune function regulating function and application thereof, wherein the composition comprises 10-30 parts of immune regulating peptide, 15-20 parts of antioxidant peptide, 15-35 parts of antibacterial peptide, 25-30 parts of malt syrup and 35-40 parts of purified water.
Description
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a polypeptide composition preparation with an immune regulation function and application thereof.
Background
Modern immune theory considers that human immunity is a result of combined action of immune organs, immune cells and cytokines, the immune function of the body is closely related to aging, generally, the body begins to decline in the age of about 30 years, the change is silent, slow and continuous, and the change trend is aggravated by the increase of the pace of life and the increase of competitive pressure. Therefore, the development of products for enhancing immune function is very important. Many synthetic drugs have been proven to be useful for regulating the immune function of human body, however, most of the immune regulating drugs synthesized by microorganisms or chemical methods have toxicity or side effects, which limits their use in preventing and treating chronic diseases, and the bioactive peptides extracted and separated by animal tissue enzymolysis have the characteristics of good effect, wide sources, low antigenicity, low allergy, safe use and the like, which gradually replace the traditional collagen protein, thus becoming a novel collagen polypeptide resource.
The bioactive peptide refers to a peptide substance with a specific physiological function prepared by carrying out enzymolysis, separation and purification on a protein raw material. The enzymolysis method is a method for obtaining the bioactive peptide safely and effectively in a common use, the enzymolysis reaction process is easy to control, the condition is mild, no harmful substance is generated, the environmental pollution can be reduced, the added value of a product is improved, the profit rate of a processing enterprise and the comprehensive utilization rate of resources can be improved, and the method has great social and economic benefits.
The immune regulatory peptide is rich in one or more hydrophobic amino acids such as Pro, Leu, Phe, Met and the like, and the relative molecular mass of most immune regulatory peptides is less than 1000 Da. The immunoregulation peptide can regulate the immune function of the body by regulating the growth and development of immune organs (tissues), the activity and the function of immune cells, delayed type allergy, antibody production, the secretion and the expression of cytokines, the release of immune related signal molecules and the like. The antibacterial peptide is a main component of a plurality of biological innate immune systems, plays an important role in protecting host species from microbial invasion, and is found to be mainly composed of hydrophobic amino acids such as Gly, Pro, Ala and Ile and amino acids such as Thr and Lys in a peptide chain by analyzing an amino acid sequence of the antibacterial peptide, wherein the relative molecular mass of the antibacterial peptide is generally more than 1000 Da. Biological oxidation is a free radical mediated oxidation reaction, harmful free radicals such as superoxide anion and hydroxyl are inevitably formed in the metabolism process, cells or tissues are damaged, further diseases are caused, the antioxidant peptide can rapidly react with oxidized substances, the lipid peroxidation inhibiting and free radical scavenging functions are realized, the balance of free radicals of a human body is maintained, the anti-aging and anti-disease capabilities of an organism are improved, the relative molecular mass is mainly 400-plus-1500 Da, and a peptide chain is rich in one or more of hydrophobic amino acids such as Leu, Pro, Val and Gly and aromatic amino acids such as Met, Trp and Phe.
Disclosure of Invention
Aiming at the technical current situation that the existing polypeptide product has complex composition and wide molecular weight range, and active peptide segments with specific efficacies cannot be clearly and clearly distinguished, so that the structure-activity relationship of active peptides and the later application effect thereof are influenced, and the objective of the polypeptide in the application of regulating the immune function in the existing product is not clear and the efficacy cannot be exerted. The invention aims to provide a polypeptide composition preparation with an immune function regulating function and application thereof, wherein the composition comprises 10-30 parts of immune regulating peptide, 15-20 parts of antioxidant peptide, 15-35 parts of antibacterial peptide, 25-30 parts of malt syrup and 35-40 parts of purified water.
In order to achieve the technical purpose, the invention is realized by the following technical scheme:
the invention specifically provides a polypeptide composition preparation with an immune regulation function, which comprises, by weight, 10-30 parts of immune regulation peptide, 15-20 parts of antioxidant peptide, 15-35 parts of antibacterial peptide, 25-30 parts of maltose syrup and 35-40 parts of purified water.
Preferably, the polypeptide composition preparation with the immune function regulating function comprises, by weight, 25 parts of immune regulating peptide, 18 parts of antioxidant peptide, 25 parts of antibacterial peptide, 28 parts of maltose syrup and 38 parts of purified water.
Meanwhile, the invention provides application of a polypeptide composition preparation with an immune regulation function, and the specific application method comprises the following steps:
(1) the polypeptide composition preparation with immunity regulating effect should be taken 5ml before meal.
(2) The preparation is administered 3 times a day for 21 days as a treatment course.
After the technical scheme is adopted, the invention has the following beneficial effects:
(1) the polypeptide composition preparation with the immune function regulating function, provided by the invention, solves the problems that the components of a product with the immune function in the market are mixed and cannot exert the due effect, has definite components, shows that the polypeptide composition with the immune function regulating function has definite function target in regulating the immune system, and has the typical characteristic of a new product. The polypeptide composition preparation with the function of regulating the immunity can obviously improve the content of immunoglobulin in blood, thereby improving the immunity, enhancing the immunity and slowing down the aging.
(2) The invention adopts the immunoregulation peptide, the antibacterial peptide and the antioxidant peptide, has definite molecular weight, easy control of enzymolysis conditions, simpler preparation and suitability for mass production.
(3) The invention adopts the steps of drawing cold after fermentation, pouring into a tank and then filling so as to prevent the temperature of the product from being overhigh, thereby ensuring the stability of the product and solving the problem that the function of the bioactive peptide is poor due to overhigh temperature and inactivation in the conventional transportation process.
Description of the drawings:
is free of
Detailed Description
The present invention will be described below with reference to examples, but the present invention is not limited to the following examples.
The immunoregulatory peptide, the antioxidant peptide, the antibacterial peptide, the maltose syrup and the like adopted by the invention can be purchased through public channels, and equipment and instruments adopted in the process are common equipment in the field.
All materials, practices and instrumentation assays selected for use in the present invention are well known in the art and are not intended to limit the practice of the invention, and other reagents and equipment well known in the art may be suitable for use in the practice of the following embodiments of the invention.
Example 1: polypeptide composition preparation with function of regulating immunity
A polypeptide composition preparation with an immune regulation function comprises, by weight, 10-30 parts of immune regulation peptide, 15-20 parts of antioxidant peptide, 15-35 parts of antibacterial peptide, 25-30 parts of malt syrup and 35-40 parts of purified water.
Example 2: polypeptide composition preparation with function of regulating immunity
The present example provides a polypeptide composition preparation with immunoregulatory function based on example 1, which includes immunoregulatory peptide 10g, antioxidant peptide 15g, antibacterial peptide 15g, maltose syrup 25g, and purified water 35 g.
Example 3: polypeptide composition preparation with function of regulating immunity
The present example provides a polypeptide composition preparation with immunoregulatory function based on example 1, which includes immunoregulatory peptide 15g, antioxidant peptide 16g, antibacterial peptide 16g, maltose syrup 26g, and purified water 36 g.
Example 4: polypeptide composition preparation with function of regulating immunity
The present example provides a polypeptide composition preparation with immunoregulatory function based on example 1, which includes immunoregulatory peptide 17g, antioxidant peptide 17g, antibacterial peptide 17g, maltose syrup 27g, and purified water 37 g.
Example 5: polypeptide composition preparation with function of regulating immunity
The present example provides a polypeptide composition preparation with immunoregulatory function based on example 1, which includes immunoregulatory peptide 25g, antioxidant peptide 18g, antibacterial peptide 25g, maltose syrup 28g, and purified water 38 g.
Example 6: polypeptide composition preparation with function of regulating immunity
The present example provides a polypeptide composition preparation with immunoregulatory function based on example 1, which includes immunoregulatory peptide 30g, antioxidant peptide 20g, antibacterial peptide 35g, maltose syrup 30g, and purified water 40 g.
Example 7: orthogonal experiment of polypeptide composition preparation formula with immune regulation function
Taking the addition amount of the immunoregulatory peptide (A), the addition amount of the antioxidant peptide (B) and the addition amount of the antibacterial peptide (C) as test factors, taking the immunoglobulin in blood as an investigation index, adopting a comprehensive evaluation method, and selecting L9(33) Orthogonal assays formulation of polypeptide compositions with modulating immune function, three levels per factor setting are shown in table 1.
Table 1: l is9(33) Orthogonal test factor level design table
Table 2: polypeptide composition preparation L with immune function regulation function9(33) Results of orthogonal optimization experiments
As can be seen from tables 1 and 2, the influence sequence of the modifiers on the comprehensive score for regulating the immune function is B & gtC & gtA, namely, antioxidant peptide & gtantibacterial peptide & gtimmune regulatory peptide, and the optimal combination is A2B2C2The optimal formula of the modifier is 25g of immunoregulation peptide, 18g of antioxidant peptide and 25g of antibacterial peptide.
Example 8: research on effect of polypeptide composition preparation with immune regulation function on mouse immune system
Based on examples 1-7, the effect of drenching the polypeptide composition with the immunoregulation function (examples 2-6) provided by the formulation of example 1 of the invention and the commercial immunoregulation health product (control 1) on mice was tested.
(1) Design of experiments
Test animals: 70 weak mice with 15 days of weaning, half male and half female, 10-12g of body weight.
The test method comprises the following steps: randomly dividing all mice into three groups, namely a test group, a comparison group and a blank group, measuring the content of immunoglobulin of each mouse, and drenching each group of mice with 0.5ml of test sample three times a day for 21d continuously. The test group was drenched with the product of the invention, the contrast group was drenched with the health product for adjusting immune function sold in the market, and the blank group was drenched with normal saline. After being continuously drenched and smeared for 21 days, the mice are subjected to blood drawing test, immunoglobulin of each mouse is detected by an immune ball detection kit, and the increase of the immunoglobulin of each group of mice is compared, wherein the test result is shown in table 3.
Table 3: effect of different groups on the increase of mouse immunoglobulin
As can be seen from the data in Table 3, the immunoglobulin content in the blood of the test groups of examples 2-6 was significantly higher than that of the control group 1 in the immunoglobulin kit data. The polypeptide composition preparation with the function of regulating the immunity can obviously improve the content of immunoglobulin in blood, thereby improving the immunity, enhancing the immunity and slowing down the aging.
Example 9: comparison test of nutritional, sanitary and physicochemical quality indexes of polypeptide composition preparation with immunity regulating function
The polypeptide composition with the immune function regulating function prepared in the formula of the embodiment 2 and the embodiment 6 of the invention and a commercial health product (contrast 1) with the immune function regulating function are subjected to comparative tests on toxicological, sanitary, physicochemical quality and sensory indexes, and statistical results are shown in table 4.
Table 4: statistical table for comparison test result of sanitary, physicochemical quality index
As can be seen from the data in Table 4, the polypeptide composition preparation for regulating immune function prepared according to the formulation in examples 2-6 of the present invention does not contain any chemically synthesized preservative, synthetic pigment or synthetic essence, compared with the commercially available health product for regulating immune function (control 1), and meets the green processing connotation. Compared with the reference 1, the formula of the embodiment 5 of the invention has different preparation processes, but the product has large difference in quality, and the polypeptide composition with the immune function regulating function obtained by the preparation process of the invention has definite components, which shows that the function target of regulating the immune system is definite, and the problem that the components of the commercially available immune function products are complicated and mixed together and cannot exert the effect is solved.
Example 10: the polypeptide composition preparation with the function of regulating immunity has influence on various indexes of mice
The influence of the polypeptide composition preparation with immunoregulation function on the growth performance of the weak weaned mice shown in table 5 is obtained by recording the body indexes such as feed intake, diarrhea rate, daily gain and the like of 70 mice which had been drunk with the polypeptide composition with immunoregulation function (groups 2-6) in example 8 of the present invention and a commercial health product with immunoregulation function (control 1).
Table 5: influence table of polypeptide composition preparation with immune function on growth performance of weaned weak mice
The results show that the polypeptide composition preparation with the function of regulating immunity, which is prepared by the invention, can promote the development of the small animals, enhance the immunity of the small animals, increase the survival rate, inhibit the growth of harmful microorganisms and enhance the physique of the small animals.
The above examples are merely illustrative for clearly illustrating the present invention and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications can be made while remaining within the scope of the present invention.
Claims (3)
1. A polypeptide composition preparation with an immune function regulating function is characterized by comprising, by weight, 10-30 parts of immune regulating peptide, 15-20 parts of antioxidant peptide, 15-35 parts of antibacterial peptide, 25-30 parts of maltose syrup and 35-40 parts of purified water.
2. The preparation of the polypeptide composition with the function of regulating the immunity according to claim 1, wherein the preparation of the polypeptide composition comprises 25 parts of immunoregulatory peptide, 18 parts of antioxidant peptide, 25 parts of antibacterial peptide, 28 parts of maltose syrup and 38 parts of purified water in parts by weight.
3. The specific use of the polypeptide composition preparation with immune function regulation function of claim 1, wherein the specific use comprises the following steps:
(1) the polypeptide composition preparation with the function of regulating immunity is taken 5ml before meals;
(2) the preparation is administered 3 times a day for 21 days as a treatment course.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110237175.4A CN113875992A (en) | 2021-03-03 | 2021-03-03 | Polypeptide composition preparation with function of improving immunity and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110237175.4A CN113875992A (en) | 2021-03-03 | 2021-03-03 | Polypeptide composition preparation with function of improving immunity and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113875992A true CN113875992A (en) | 2022-01-04 |
Family
ID=79013079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110237175.4A Pending CN113875992A (en) | 2021-03-03 | 2021-03-03 | Polypeptide composition preparation with function of improving immunity and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113875992A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107746428A (en) * | 2017-12-01 | 2018-03-02 | 浙江熊猫乳业集团股份有限公司 | A kind of biologically active polypeptide DERFFSDKIA and its preparation method and application |
| CN111557449A (en) * | 2020-05-19 | 2020-08-21 | 北京美信高科科技有限责任公司 | Composition with function of improving immunity and preparation method thereof |
| CN111848817A (en) * | 2020-07-28 | 2020-10-30 | 中国农业大学 | Multifunctional hybrid peptide with antibacterial, antiviral, immunoregulatory and anti-inflammatory activities, and preparation method and application thereof |
-
2021
- 2021-03-03 CN CN202110237175.4A patent/CN113875992A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107746428A (en) * | 2017-12-01 | 2018-03-02 | 浙江熊猫乳业集团股份有限公司 | A kind of biologically active polypeptide DERFFSDKIA and its preparation method and application |
| CN111557449A (en) * | 2020-05-19 | 2020-08-21 | 北京美信高科科技有限责任公司 | Composition with function of improving immunity and preparation method thereof |
| CN111848817A (en) * | 2020-07-28 | 2020-10-30 | 中国农业大学 | Multifunctional hybrid peptide with antibacterial, antiviral, immunoregulatory and anti-inflammatory activities, and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 梁艺英: "《保健食品研发与审评》", 中国医药科技出版社, pages: 330 - 331 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3231437B1 (en) | Aging inhibitor | |
| Yu et al. | Scavenging and anti-fatigue activity of fermented defatted soybean peptides | |
| CN1896268B (en) | Extraction method of activated micromolecular sheept germine from sheep embryo and its use | |
| CN108033997B (en) | Polypeptide FKGPACA with antioxidant function and application thereof | |
| CN106666484B (en) | Sturgeon composite powder, sturgeon bone wine and application | |
| CN111494495A (en) | Application of litchi pulp dietary fiber-bonded phenol adduct in preparation of preparation for improving intestinal microecology | |
| CN110227046A (en) | A kind of compact skin, the facial treatment essence liquid for desalinating microgroove and preparation method thereof | |
| Takahashi et al. | Dietary supplementation of glycine modulates inflammatory response indicators in broiler chickens | |
| KR20090103869A (en) | Ceramide synthesis accelerators, cosmetic preparation, skin preparation for external use, method of preventing aging, and method of diminishing wrinkle | |
| JP6555674B1 (en) | Anti-aging agent for skin and anti-aging-related gene expression regulating agent | |
| CN113875992A (en) | Polypeptide composition preparation with function of improving immunity and application thereof | |
| CN108218958B (en) | Polypeptide SVLGTGC with antioxidant function and application thereof | |
| CN118475341A (en) | Cosmetic composition comprising a strain of propionibacterium for preventing or ameliorating inflammatory skin diseases | |
| CN115786434A (en) | Pigeon meat antioxidant peptide and anti-fatigue peptide and preparation method thereof | |
| CN106084007B (en) | A kind of the separation identification and functional analysis of yellow meal worm natural anti-oxidation octapeptide | |
| KR101853299B1 (en) | Cosmetic composition comprising the cell mimesis complex as active ingredient | |
| HU186767B (en) | Process for producing compositions for treating dermatologicalanomalys | |
| CN109998055B (en) | Hemp seed antioxidant polypeptide chewable tablet and preparation method thereof | |
| CN108794574B (en) | Antioxidant active peptide and application thereof | |
| KR100403565B1 (en) | a manufacturing process feeds which be made from a Tofuwast redkoji containing monacolin | |
| KR101888756B1 (en) | FOOD COMPOSITION CONTAINING HYDROLYSATE DERIVED FROM Hippocampus abdominalis AND EXTRACT OF RED GINSENG FOR RELIEVING FATIGUE | |
| KR102681818B1 (en) | Method for preparing spirulina extract with increased branched chain amino acid content | |
| CN113881610B (en) | Bacteroides thetaiotaomicron BP8E and application thereof | |
| US20240180814A1 (en) | Method for improving skin complexion by using rosa canina extract | |
| US20230119686A1 (en) | Method for improving skin condition with redlove apples extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20220104 |