CN114404515B - Soft-shelled turtle capsule - Google Patents
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- CN114404515B CN114404515B CN202210117645.8A CN202210117645A CN114404515B CN 114404515 B CN114404515 B CN 114404515B CN 202210117645 A CN202210117645 A CN 202210117645A CN 114404515 B CN114404515 B CN 114404515B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a soft-shelled turtle capsule, which comprises the following raw material medicines: soft-shelled turtle shell, astragalus root, prepared rehmannia root, apocynum venetum and dwarf lilyturf tuber have the advantages of remarkable effects in relieving fatigue and enhancing immunity.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a soft-shelled turtle capsule.
Background
Soft-shelled turtle, also called soft-shelled turtle, and fish, has good edible value and high economic value. The soft-shelled turtle is taken by people to nourish the body, and the history of medical diseases is very long. The nourishing and medicinal effects of soft-shelled turtle are recorded in the whole body of soft-shelled turtle meat, turtle shell, turtle blood, etc.
The whole body of the soft-shelled turtle is precious, and has high edible and medicinal values. The turtle shell can nourish yin, and can subdue yang, pacify liver and stop wind. The turtle shell can nourish yin and enrich blood, clear liver and defervesce, and promote hardness to remove blood stasis; the turtle meat has the defects of labor injury, yang-strengthening and qi-strengthening and yin-strengthening; the turtle blood enters liver channels, has the effects of dispelling wind, dredging collaterals and promoting the production of decoction and treating fatigue heat; for chronic dysentery due to yin deficiency, turtle egg is used to nourish kidney yin and treat colonic dysentery; the turtle gall is capable of cooling blood and resolving hemorrhoids, and the turtle fat is a tonic.
Modern scientific experiments prove that: the turtle contains more than 50% of protein, unsaturated fatty acid and amino acid necessary for human body, and rich amino acid contains ferrous iron absorbable by human body, vg, vss and folic acid which play an important role in iron metabolism, so that the turtle can better promote the hematopoietic function of human body, contains soluble low molecular peptide and microelements such as zinc, calcium and the like which play an important role in hormone metabolism and promote growth, and especially contains high calcium content, wherein the calcium is the basis of human life. The turtle shell also contains a large amount of animal glue, keratin, iodine and vitamin D; the turtle skirt is rich in vitamin B; the turtle fat is rich in highly unsaturated fatty acids EPA and DHA; the turtle bile contains trihydroxy cholesteryl ester and another lactone compound with one more CH; recently, two oxidation-resistant enzymes with medical value are separated from turtle blood. The components are all health care factors which are acknowledged by the international medical community and are used for resisting oxidation, resisting cancer, resisting aging and improving the immune function, these factors are enriched in the body of soft-shelled turtle, so that it has the very precious functions of nourishing and health-care, nourishing and building body, resisting cancer and resisting senility.
The shell, blood, head, fat and egg of Amyda sinensis can be used as medicines. Turtle shell has effects of nourishing yin, replenishing blood, relieving fever and dredging. Can be used for treating sore, hemorrhoid, yin toxin, dystocia, puerperal deficiency, liver cirrhosis, splenomegaly, and hematopoiesis of bone marrow. Soft-shelled turtle blood is salty and nontoxic in taste and can be used as blood-replenishing agent. Mixing Amyda sinensis blood with Mel, and drinking for diabetics can reduce blood sugar. Pityrosporum is indicated for diarrhea and malaria.
In addition to fresh and alive cooking of soft-shelled turtles or taking advantage of parts such as crustaceans, deep processing, development and utilization are rarely considered. In recent years, with the development of the turtle artificial breeding industry, parts of turtle series products, such as health care products such as turtle oral liquid, whole turtle powder, capsules and the like, are sequentially researched and developed. At present, the soft-shelled turtle series products circulated in the domestic market mainly comprise the following categories: 1. canned soft-shelled turtle; 2. soft-shelled turtle wine; 3. health beverage of Amyda sinensis; 4. a first fish meal; 5. adding soft-shelled turtle series health food; 6. active calcium of the turtle bone; 7. chitosan extracted from turtle shell, etc. Most of the soft-shelled turtle series production processes are rough, the variety is monotonous, and the products only contain soft-shelled turtle active ingredients.
At present, researches show that the effective components in the soft-shelled turtle can be effectively exerted by matching the soft-shelled turtle with traditional Chinese medicinal materials.
Chinese patent application CN1943695A discloses a preparation of soft-shelled turtle and its production process, which comprises freezing Amyda sinensis with liquid nitrogen, pulverizing into dry powder, extracting fructus Lycii, poria and rhizoma Dioscoreae with water, concentrating the water extract to obtain soft extract, and mixing completely and stirring. The invention is a purely natural biological product, takes fresh soft-shelled turtle as raw material, fully utilizes all active ingredients of soft-shelled turtle, has simple and quick whole production process, has no intervention of high temperature, acid, alkali, enzyme and the like, not only completely retains nutrient components and active substances of soft-shelled turtle, but also can not bring other harmful substances, and the product is rich in protein and various unsaturated fatty acids and amino acids necessary for human body, reasonably adds medicinal and edible traditional Chinese medicinal materials, has balanced and comprehensive nourishing value, and can regulate immunity, resist fatigue, strengthen kidney and nourish essence, regulate endocrine and restore primordial qi. However, the efficacy of the soft-shelled turtle preparation in aspects of immunoregulation, anti-fatigue and the like is still to be further improved.
Therefore, it is very necessary to develop a soft-shelled turtle capsule which solves the above technical problems.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the soft-shelled turtle capsule with remarkable effects on relieving fatigue and enhancing immunity.
The invention is realized by the following technical scheme:
a soft-shelled turtle composition comprises the following raw materials: soft-shelled turtle shell, astragalus root, prepared rehmannia root, apocynum venetum and dwarf lilyturf tuber.
Preferably, the turtle composition comprises the following raw materials in parts by weight: 70-95 parts of turtle shell, 51-64 parts of astragalus, 30-45 parts of prepared rehmannia root, 25-50 parts of apocynum venetum and 20-35 parts of dwarf lilyturf tuber.
More preferably, the mass ratio of the turtle shell to the astragalus to the apocynum venetum is 2-2.5:1.5-2:1.
the invention also relates to a preparation process of the turtle compound, which comprises the following steps:
(1) Pulverizing carapax Trionycis, and drying to obtain substance A;
(2) Mixing radix astragali and herba Apocyni Veneti, pulverizing, extracting with ethanol for 1-2 times, filtering, and mixing filtrates to obtain substance B;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, extracting with ethanol for 1-2 times, filtering, and mixing filtrates to obtain substance C;
(4) Concentrating and drying the substances B and C respectively, mixing, and adding the substance A.
Preferably, in the step (2), astragalus and apocynum venetum are mixed and crushed, and then added with 55-75% ethanol in an amount which is 4-8 times that of the astragalus and apocynum venetum, and the mixture is heated and extracted for 1-2 times at 40-60 ℃ for 1-2 hours each time, filtered, and the filtrate is combined to obtain the substance B.
Preferably, in the step (3), the prepared rehmannia root and the dwarf lilyturf tuber are mixed and crushed, and are added with 5-10 times of 60-70% ethanol for reflux extraction for 1-2 times, each time for 1-2 hours, and the filtrate is filtered and combined to obtain the substance C.
Preferably, citric acid is added in the extraction process of the step (3), and the pH is adjusted to 5.0-6.0.
The invention also relates to a soft-shelled turtle capsule which comprises the soft-shelled turtle composition or the soft-shelled turtle composition prepared by the preparation process and pharmaceutically acceptable auxiliary materials.
Preferably, the auxiliary material comprises a capsule shell.
More preferably, the capsule shell is a pharmaceutical gelatin hard capsule.
The beneficial effects of the invention are as follows:
the composition has remarkable effects on relieving fatigue and enhancing immunity by synergism of the components, and particularly has further improved effects on relieving fatigue and enhancing immunity by optimizing the mass ratio of the turtle shell, the astragalus and the apocynum venetum.
The inventor finds that the fatigue relieving and immunity enhancing effects of the composition can be remarkably improved by jointly extracting astragalus and apocynum venetum in the process of preparing the composition.
In addition, in the extraction process of the prepared rehmannia root and the dwarf lilyturf tuber, the pH is adjusted by adding citric acid, and the effects of relieving fatigue and enhancing immunity are unexpectedly found to be further improved.
Detailed Description
The invention will be further described with reference to specific embodiments, and advantages and features of the invention will become apparent from the description. These examples are merely exemplary and do not limit the scope of the invention in any way. It will be understood by those skilled in the art that various changes and substitutions of details and forms of the technical solution of the present invention may be made without departing from the spirit and scope of the present invention, but these changes and substitutions fall within the scope of the present invention.
Example 1
The turtle composition comprises the following raw materials in parts by weight: 70 parts of turtle shell, 51 parts of astragalus, 30 parts of prepared rehmannia root, 25 parts of apocynum venetum and 20 parts of dwarf lilyturf tuber.
The preparation process of the turtle composition comprises the following steps:
(1) Freezing and pulverizing carapax Trionycis at-150deg.C, sieving with 60 mesh sieve, lyophilizing, and sterilizing to obtain substance A;
(2) Mixing radix astragali and herba Apocyni Veneti, pulverizing, sieving with 20 mesh sieve, adding 4 times of 55% ethanol, heating and extracting at 40deg.C for 2 hr, filtering, and collecting filtrate to obtain substance B;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, sieving with 20 mesh sieve, adding 5 times of 60% ethanol and citric acid, adjusting pH to 5.0, reflux extracting for 2 hr, filtering, and collecting filtrate to obtain substance C;
(4) Concentrating and drying the substances B and C respectively, mixing, and adding the substance A.
Example 2
The turtle composition comprises the following raw materials in parts by weight: 95 parts of turtle shell, 64 parts of astragalus, 45 parts of prepared rehmannia root, 50 parts of apocynum venetum and 35 parts of dwarf lilyturf tuber.
The preparation process of the turtle composition comprises the following steps:
(1) Freezing and pulverizing carapax Trionycis at-150deg.C, sieving with 60 mesh sieve, lyophilizing, and sterilizing to obtain substance A;
(2) Mixing radix astragali and herba Apocyni Veneti, pulverizing, sieving with 20 mesh sieve, adding 8 times of 75% ethanol, extracting at 60deg.C for 2 times each for 1 hr, filtering, and mixing filtrates to obtain substance B;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, sieving with 20 mesh sieve, adding 10 times of 70% ethanol and citric acid, adjusting pH to 6.0, reflux-extracting for 2 times each for 1 hr, filtering, and mixing filtrates to obtain substance C;
(4) Concentrating and drying the substances B and C respectively, mixing, and adding the substance A.
Example 3
The turtle composition comprises the following raw materials in parts by weight: 85 parts of turtle shell, 56 parts of astragalus, 38 parts of prepared rehmannia root, 35 parts of apocynum venetum and 25 parts of dwarf lilyturf tuber.
The preparation process of the turtle composition comprises the following steps:
(1) Freezing and pulverizing carapax Trionycis at-150deg.C, sieving with 60 mesh sieve, lyophilizing, and sterilizing to obtain substance A;
(2) Mixing radix astragali and herba Apocyni Veneti, pulverizing, sieving with 20 mesh sieve, adding 6 times of 65% ethanol, extracting at 50deg.C for 2 times each for 1.5 hr, filtering, and mixing filtrates to obtain substance B;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, sieving with 20 mesh sieve, adding 8 times of 65% ethanol and citric acid, adjusting pH to 5.5, reflux-extracting for 2 times each for 1.5 hr, filtering, and mixing filtrates to obtain substance C;
(4) Concentrating and drying the substances B and C respectively, mixing, and adding the substance A.
Comparative example 1
A soft-shelled turtle composition is different from example 3 only in that the total amount of soft-shelled turtle shell, astragalus root and apocynum venetum is unchanged in parts by weight, the mass ratio is 2.8:1.2:1, and the other conditions are the same.
Comparative example 2
A soft-shelled turtle composition was different from example 3 only in that citric acid was not added in step (3), and the other conditions were the same.
Comparative example 3
A soft-shelled turtle composition differs from example 3 only in that astragalus and apocynum venetum are extracted separately in step (2), and the other conditions are the same, specifically as follows:
(1) Freezing and pulverizing carapax Trionycis at-150deg.C, sieving with 60 mesh sieve, lyophilizing, and sterilizing to obtain substance A;
(2) Pulverizing radix astragali, sieving with 20 mesh sieve, adding 6 times of 65% ethanol, extracting at 50deg.C for 2 times each for 1.5 hr, filtering, and mixing filtrates to obtain substance B1; pulverizing herba Apocyni Veneti, sieving with 20 mesh sieve, adding 6 times of 65% ethanol, extracting at 50deg.C for 2 times each for 1.5 hr, filtering, and mixing filtrates to obtain substance B2;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, sieving with 20 mesh sieve, adding 8 times of 65% ethanol and citric acid, adjusting pH to 5.5, reflux-extracting for 2 times each for 1.5 hr, filtering, and mixing filtrates to obtain substance C;
(4) Concentrating and drying the substances B1, B2 and C respectively, mixing, and adding the substance A.
Comparative example 4
A turtle composition differs from example 3 only in that astragalus and apocynum venetum are not contained, the total amount of turtle shell is 176 parts, and the other conditions are the same.
Comparative example 5
A turtle composition differs from example 3 only in that no turtle shell is contained, the total amount of astragalus and apocynum venetum in parts is 176 parts, the mass ratio is not changed to 1.6:1, and the other conditions are the same.
Application example
The soft-shelled turtle capsules were prepared by filling the soft-shelled turtle compositions described in any one of examples 1 to 3 or comparative examples 1 to 5 with a pharmaceutically acceptable gelatin.
Test example 1
Fatigue relief test
And carrying out a load swimming experiment according to the technical specification of health food inspection and evaluation.
Experimental animals: SPF grade ICR mice, weighing 18-22g, 6 per group.
Dosage is as follows: once daily, the recommended amount of human body is 10mg/kg, and the recommended amount of human body is 10 times as the dosage of the mice, namely 0.1g/kg, and the administration time of the tested sample is 30 days. The mice of each of the examples and comparative examples were given a suspension of the composition in water for administration by gavage, and an equal volume of distilled water was used as a blank.
The experimental steps are as follows: after the last administration of the test sample for 30min, the mice were kept swimming in a swimming box. The depth of water is 40cm, the water temperature is 25+/-1.0 ℃, and the root of the rat tail is loaded with lead skin with 5% of the weight. The time from the start of the swimming of the mice to death (or dizziness) was recorded as the swimming time of the mice (as a resultIndicated) as shown in table 1.
TABLE 1
Note that: different letters indicate that there was a significant difference between the two groups (P < 0.05).
Test example 2
Test for enhancing immunity
ConA-induced mouse spleen lymphocyte transformation experiments were performed by MTT method with reference to "technical Specification for health food inspection and evaluation".
Experimental animals: SPF KM mice, weighing 18-22g, temperature 22-25deg.C, and relative humidity 60-70%, 6 per group.
Dosage is as follows: once daily, at a dose of 0.15g/kg, and the test sample was administered for 30 days. The mice of each of the examples and comparative examples were given a suspension of the composition in water for administration by gavage, and an equal volume of distilled water was used as a blank.
The experimental steps are as follows: after the final administration of the test sample for 30min, mice were sacrificed for cervical dislocation, spleens were aseptically removed, and the remaining steps were referred to "health food test and evaluation technical Specification", and the proliferation capacity of lymphocytes=ConA well OD value-control well OD value, and the results are shown in Table 2.
TABLE 2
| Proliferation capacity of lymphocytes | |
| Blank control group | 0.064±0.012 a |
| Example 1 | 0.139±0.026 b |
| Example 2 | 0.137±0.018 b |
| Example 3 | 0.156±0.031 c |
| Comparative example 1 | 0.135±0.014 b |
| Comparative example 2 | 0.141±0.027 b |
| Comparative example 3 | 0.142±0.025 b |
| Comparative example 4 | 0.114±0.019 d |
| Comparative example 5 | 0.107±0.023 d |
Note that: different letters indicate that there was a significant difference between the two groups (P < 0.05).
The foregoing detailed description is directed to one of the possible embodiments of the present invention, which is not intended to limit the scope of the invention, but is to be accorded the full scope of all such equivalents and modifications so as not to depart from the scope of the invention.
Claims (5)
1. The turtle composition for relieving fatigue and enhancing immunity is characterized by comprising the following raw materials in parts by weight: 70-95 parts of turtle shell, 51-64 parts of astragalus, 30-45 parts of prepared rehmannia root, 25-50 parts of apocynum venetum and 20-35 parts of dwarf lilyturf tuber;
the mass ratio of the soft-shelled turtle shell to the astragalus to the apocynum venetum is 2-2.5:1.5-2:1, a step of;
the preparation process of the turtle composition comprises the following steps:
(1) Pulverizing carapax Trionycis, and drying to obtain substance A;
(2) Mixing radix astragali and herba Apocyni Veneti, pulverizing, adding 4-8 times of 55-75% ethanol, heating and extracting at 40-60deg.C for 1-2 times each for 1-2 hr, filtering, and mixing filtrates to obtain substance B;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, reflux extracting with 5-10 times of 60-70% ethanol for 1-2 times each for 1-2 hr, filtering, and mixing filtrates to obtain substance C; adding citric acid in the extraction process of the step (3), and adjusting the pH to 5.0-6.0;
(4) Concentrating and drying the substances B and C respectively, mixing, and adding the substance A.
2. A process for preparing a fatigue-relieving and immunity-enhancing turtle composition as claimed in claim 1, comprising the steps of:
(1) Pulverizing carapax Trionycis, and drying to obtain substance A;
(2) Mixing radix astragali and herba Apocyni Veneti, pulverizing, adding 4-8 times of 55-75% ethanol, heating and extracting at 40-60deg.C for 1-2 times each for 1-2 hr, filtering, and mixing filtrates to obtain substance B;
(3) Mixing radix rehmanniae Preparata and radix Ophiopogonis, pulverizing, reflux extracting with 5-10 times of 60-70% ethanol for 1-2 times each for 1-2 hr, filtering, and mixing filtrates to obtain substance C; adding citric acid in the extraction process of the step (3), and adjusting the pH to 5.0-6.0;
(4) Concentrating and drying the substances B and C respectively, mixing, and adding the substance A.
3. The soft-shelled turtle capsule for relieving fatigue and enhancing immunity is characterized by comprising the soft-shelled turtle composition for relieving fatigue and enhancing immunity according to claim 1 or prepared by the preparation process according to claim 2 and pharmaceutically acceptable auxiliary materials.
4. A fatigue-relieving, immunity-enhancing soft-shelled turtle capsule according to claim 3, wherein the auxiliary material comprises a capsule shell.
5. The fatigue-relieving, immunity-enhancing soft-shelled turtle capsule of claim 4, wherein the capsule shell is a pharmaceutically acceptable gelatin hard capsule.
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| CN202210117645.8A CN114404515B (en) | 2022-02-08 | 2022-02-08 | Soft-shelled turtle capsule |
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| CN202210117645.8A CN114404515B (en) | 2022-02-08 | 2022-02-08 | Soft-shelled turtle capsule |
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| CN104997926A (en) * | 2015-08-19 | 2015-10-28 | 宫锡和 | Preparation method of traditional Chinese medicine preparation for treating gynaecology and internal haemorrhage |
| CN107970383A (en) * | 2017-12-05 | 2018-05-01 | 张朋朋 | Pharmaceutical composition for treating female postpartum disease and preparation method thereof |
| CN108095078A (en) * | 2017-12-19 | 2018-06-01 | 山西振东制药股份有限公司 | Strengthen immunity fatigue-relieving composition and preparation method thereof |
| CN111588800B (en) * | 2020-05-29 | 2022-02-18 | 中国中医科学院中医基础理论研究所 | Traditional Chinese medicine composition and preparation method and application thereof |
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