CN109588551A - A kind of feed addictive and preparation method thereof for treating metabolic disease - Google Patents
A kind of feed addictive and preparation method thereof for treating metabolic disease Download PDFInfo
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Abstract
The present invention provides a kind of feed addictive and preparation method thereof for treating metabolic disease, and the additive includes composition A and composition B；Wherein composition A is prepared by eggplant processing powder, purple sweet potato processing powder, soya-bean polypeptides, traditional medicine volatile oil, Grape Skin leaching liquor, Cornutcd pugionium extractive, sulfated chitosan, sodium alginate, xylitol；Composition B by: corn, kelp, garlic, honey, apple, bean seedlings, crowndaisy chrysanthemum, sorghum, buckwheat are prepared.Additive of the present invention improves absorption of drugs effect, reduces the oral limitation of polypeptide, and the peptic digest ability promoted improves the immunity of body.Additive raw material utilization rate of the invention is high, and raw material sources are wide, environmentally protective based on natural materials, has good benefit.
Description
Technical field
The invention belongs to cultural technique field, in particular to a kind of feed addictive for treating metabolic disease and its preparation side
Method.
Background technique
Metabolic disease is that aquaculture is most common, one of the disease for endangering most serious, it not only influences the output of milk of poultry, causes
Economic loss, and the quality of cream is influenced, and then jeopardize the health of edible people.It is general mostly targetedly to use by taking milk cow as an example
Inject the methods of antibiotic, magnesium sulfate injection, glucose injection, replenishing vitamins, minerals preventing metabolic diseases.Due to
Drug resistance can be generated to antibiotic, therefore raisers need constantly to put into new chemical drugs, and additive amount can be more and more.
Using the chemicals with toxic side effect, overdose is be easy to cause to cause extremely.Using antibiotic, since antibiotic is in animal
It is unable to get effective degradation in vivo, antibiotic residue easy to form.
Patent of invention CN201310670276.6, a kind of feed addictive increasing milk production of cow contain mountain flour, sulfuric acid
Copper, tricalcium phosphate, cod-liver oil, sodium selenite, sodium bicarbonate, salt, corn germ cake, brewex's grains, rde bean, fumaric acid, in
Herbal mixture.The additive is cooperated using Chinese herbal medicine and other nutritional ingredients, all kinds of nutriments needed for growing rich in milk,
Without hormone, no chemical residues, promotes the production of milk health, increase high-quality milk yield.
Patent of invention CN201410302522.7, the milk cow nonreactive feed containing Chinese herb feed additive, solves existing feeding
The problem of material causes milk constitution poor, and the output of milk and milk production quality not can guarantee, which is made of the raw material of following parts by weight: beautiful
Rice 30-40 parts, 5-15 parts of wheat, 10-20 parts of Cottonseed Meal, 20-30 parts of dregs of beans, 5-15 parts of bean dregs, 3-12 parts of wheat bran, vegetable oil 3-
10 parts, 5-10 parts of mountain flour, 0.5-1 parts of salt, 0.5 part of premix, 3 parts of Chinese herb feed additive；The invention is hormone-free, antibiotic
Equal chemical addition agents, and nutrition is comprehensive, and protein content is high, is easy to milk digestion and absorption, can enhance milk immunity of organisms, increases
Add the output of milk, improves milk quality.
Patent of invention CN201611163474.3, a kind of cattle feed additive of the probiotic bacteria culture medium containing active Chinese drug component,
Fermented and cultured is carried out to microorganism used in meat feed using probiotic bacteria culture medium containing active Chinese drug component；It is prebiotic that this contains active Chinese drug component
The component of bacterium culture medium includes: wheat bran, dregs of beans, corn flour, brown sugar, traditional Chinese medicinal components, precipitated calcium carbonate, yeast extract and fulvic acid；
The traditional Chinese medicinal components include: Radix Astragali, radix scutellariae, Rhizoma Atractylodis Macrocephalae, Poria cocos, hawthorn, fragrant fruit, dried orange peel, Schisandra chinensis, wilsonii, rhizoma polygonati and eclipta.
The invention solves in the prior art that micro organism quantity is less in meat feed addictive, low and in enteron aisle the colonization ability of activity
The problems such as weak, to increase the micro organism quantity in meat feed addictive, promote the activity of microorganism and determine in enteron aisle
Plant ability, and then preferably improve meat.
Enter the high speed development stage using Chinese herbal medicine and natural coarse cereals as with the research of feed addictive, it is main by changing
Kind peptic digest absorption improves internal beneficial flora to enhance immunity of organisms, promotes metabolism.But metabolic disease not only band
The problem of coming appetite and immunity of organisms decline, the Fat Accumulation effect caused by metabolic disease can also enhance, and fatty liver is caused to be sent out
Raw case is also not within minority, but the research of feed addictive prevention fatty liver is fewer and fewer.
Summary of the invention
For the prior art treatment metabolic disease feed addictive to prevent and treat fatty liver research less, function it is few and
The not high feature of absorptivity, the present invention provide a kind of feed addictive and preparation method thereof for treating metabolic disease.
The present invention is achieved by the following technical solutions:
A kind of feed addictive for treating metabolic disease, including composition a and composition b, the composition a is by following parts by weight
Number is than component: 5 ~ 10 parts of powder of eggplant processing, 10 ~ 15 parts of powder of purple sweet potato processing, 5 ~ 10 parts of soya-bean polypeptides, traditional medicine volatile oil 12 ~
18 parts, 1 ~ 4 part of Grape Skin leaching liquor, 2 ~ 8 parts of Cornutcd pugionium extractive, 8 ~ 16 parts of sulfated chitosan solution, sodium alginate 10 ~ 14
Part, 5 ~ 10 parts of xylitol；The composition b includes following weight fraction ratio component: 5 ~ 10 parts of corn, 1 ~ 4 part of kelp, garlic 4 ~
8 parts, 1 ~ 5 part of apple, 1 ~ 6 part of bean seedlings, 2 ~ 6 parts of crowndaisy chrysanthemum, 5 ~ 10 parts of sorghum, 5 ~ 10 parts of buckwheat；
The preparation method of the additive the following steps are included:
A. the preparation of composition a
(1) Grape Skin leaching liquor and Cornutcd pugionium extractive is taken to be added in traditional medicine volatile oil, 50 ~ 60 DEG C of 40 ~ 50min of heating water bath,
Then sulfated chitosan solution is added to be uniformly mixed, obtains mixed liquor 1；
(2) soya-bean polypeptides are added in mixed liquor 1, in vibrating 30 ~ 50min on turbula shaker, sodium alginate is then added
It carries out being mixed to get mixed liquor 2, finally mixed liquor 2 is quickly put into emulsifier and carries out 1 ~ 2h of emulsification, be collected by centrifugation to obtain cream
Change liquid；
(3) by eggplant process powder and purple sweet potato processing powder mix, add emulsion and xylitol, continue mixing 10 ~
15min to get arrive composition a；
B. the preparation of additive
(1) composition b each component is carried out crushed 50 ~ 100 meshes and is dried, mixed after sterilizing, obtain raw material powder c；
(2) by composition a and raw material powder c according to mass ratio (6 ~ 8): (2 ~ 4) mix, and are then made by spray drying
100 ~ 120 μm of particles are to get the feed addictive for arriving treatment metabolic disease.
The present invention is prepared into feed addictive using Cornutcd pugionium extractive combination grape wine brewing waste Grape Skin leaching liquor, benefit
It is crosslinked with sulfated chitosan derivative and soya-bean polypeptides, and wraps up Cornutcd pugionium extractive, Grape Skin under the action of sodium alginate
Extract and traditional medicine volatile oil, then it is prepared by mixing into feed addictive with eggplant and purple sweet potato processing powder, liver cell is improved to each
The absorption for treating the drug of fatty liver, reduces the oral limitation of polypeptide, the peptic digest ability promoted, and raising is immunized
Power enables illness to be restored to normal condition faster.Traditional medicine volatile oil Essential Oil of Radix Angelicae Dahuricae and peppermint oil can improve the suction of cell
Receipts ability, promotes the absorption of drug, and purple sweet potato and eggplant processing powder collaboration improve the antioxidation of lipid, reduce lipid peroxy
Change leads to hepar damnification, and Cornutcd pugionium extractive can promote stomach smooth muscle diastole, improve stomach power, promotes to digest and assimilate, makes machine
Physical efficiency preferably absorbs drug.
Studies have shown that soybean protein has the function of enough reducing serum cholesterol content, compared with soybean protein, soybean is more
Peptide has the function of that significantly more reduction serum cholesterol and hepatic cholesterol, soya-bean polypeptides may be by hindering enteron aisle liner
Sterol absorption, and it is promoted to exclude external mechanism, the content of serum and hepatic tissue cholesterol is reduced, suitable soybean is taken in
Polypeptide can significantly reduce the content of serum cholesterol and triglycerides；Soya-bean polypeptides have the stronger effect for promoting energetic supersession
Fruit, than only with low-calorie diet being the reduction that can more accelerate subcutaneous fat, this is because the intake of soya-bean polypeptides promotes base
Plinth metabolism, greatly increases calorific value after food, ensure that energetic supersession carries out faster；But polypeptide is by the limit of oral absorption
System, since the degradation of digestive ferment and barrier action of alimentary canal mucous membrane etc. influence, the oral bioavailability of polypeptide drug
Spend that lower, half-life period is shorter, the present invention is crosslinked using sulfated chitosan and soya-bean polypeptides, and package traditional medicine volatile oil promotes polypeptide
Absorption rate so that polypeptide is not limited by oral, can significantly more efficient performance biological effect, on the other hand, polypeptide crosslinking
Sulfated chitosan afterwards has better drug inclusiveness, can load more doses in favor of carrying out protection work to liver cell
With, while improving cell absorption efficiency, drug effect is played faster.
As a further improvement of the present invention, purple sweet potato processing powder is prepared by following methods:
(1) purple sweet potato is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to purple sweet potato powder to be placed in -80 DEG C of refrigerators；
(2) it is 1:(6 ~ 15 according to solid-liquid ratio) methanol solution that volume fraction is 80% is added in purple sweet potato powder, it is heated to 80 ~
90 DEG C, while 30 ~ 50min is extracted under 50W, 40kHz ultrasound, 5min is then centrifuged at 4000 ~ 10000r/min, in separation
Clear liquid repeats to merge supernatant after extracting 2 times, is then freeze-dried supernatant, obtains purple sweet potato processing powder.
As a further improvement of the present invention, eggplant processing powder is prepared by following methods:
(1) eggplant is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to eggplant powder to be placed in -80 DEG C of refrigerators；
(2) it is 1:(6 ~ 15 according to solid-liquid ratio) methanol solution that volume fraction is 80% is added in eggplant powder, it is heated to 80 ~
90 DEG C, while 30 ~ 50min is extracted under 50W, 40kHz ultrasound, 5min is then centrifuged at 4000 ~ 10000r/min, in separation
Clear liquid repeats to merge supernatant after extracting 2 times, is then freeze-dried supernatant, obtains eggplant processing powder.
Suppression angle glycosides contained in eggplant fiber also has effects that reduce cholesterol, while being rich in citrin, can improve
Fine vascular brittleness prevents thin vessels bleeding, is effectively improved fatty liver hemorrhagic symptom, antioxygen rich in eggplant and purple sweet potato
Compound matter anthocyanidin, the two is used in mixed way in certain proportion can improve inoxidizability；Purple sweet potato is rich in protein, fat, carbon aquation
Object, vitamin, minerals and dietary fiber etc. are closed, can effectively prevention of arterial be hardened, repairing cardiac muscle enhances immunity of organisms,
It can be effectively improved fatty liver hemorrhagic symptom, while the digestive system of illness can be improved, enable to improve feed efficiency, accelerate symptom
Healing；Antioxidation enhances after eggplant and purple sweet potato mixing, and with the increase of the two ratio, collaboration rate is gradually decreased, and is resisted
Aoxidize antagonism, the present invention is it is discovered by experiment that eggplant processing powder and purple sweet potato processing powder amount ratio are 1:(1 ~ 3) when it is anti-
Oxidation is constantly in enhancing trend.
As a further improvement of the present invention, the traditional medicine volatile oil is one of Essential Oil of Radix Angelicae Dahuricae, peppermint oil.
Chinese medicine volatile component is widely present in the sections such as composite family, Rutaceae, Umbelliferae, Zingiber platymiscium, have antibacterial,
The bioactivity such as anti-inflammatory, anticancer, antiviral, are mainly used in cardio-cerebrovascular, central nervous system, respiratory system, stomach and intestine
The disease treatments such as road system, the Chinese medicine containing volatile component have effects that resuscitation with aromatics, priming uplink mostly.Study table
It is bright, Chinese medicine volatile component to the absorption of 5 ingredient of phase and bioavilability there are different degrees of influence, Essential Oil of Radix Angelicae Dahuricae and
Peppermint oil can enhance the mobility of cell membrane, Cell membrane pores is promoted to be formed to improve membrane permeability, so that soya-bean polypeptides,
Grape Skin extract and Cornutcd pugionium extractive can be absorbed faster by liver cell, play the role of liver-protective to prevent fat
Liver.
As a further improvement of the present invention, the sulfated chitosan solution is that sulfated chitosan is dissolved in physiology
Salt water is prepared, and concentration is 50 ~ 100mg/mL.
Sulfated chitosan can be such that the fat deposition in liver is improved by reducing blood lipid level, and reduce
AST, ALT level carry out effective protection liver function, improve the oxidation resistance of purple sweet potato and eggplant, mitigate caused by Liver fatty deposition
Lipid peroxidation damage, prevent and treat the formation of liver fibrosis, inhibit the deterioration of fatty liver；The dosage of chitosan affects drug
Delivery rate, excessive dosage can make slime layer inhibition increase, reduce the mobility of peptide, mentioned so as to cause Grape Skin
Take liquid, the active material delivery rate decline in Cornutcd pugionium extractive.
As a further improvement of the present invention, the Grape Skin leaching liquor the preparation method is as follows:
(1) grape skin separated after wine brewing is taken, drying and crushing crosses 40 meshes, obtains grape skin powder；
(2) it is 1:(20 ~ 25 according to solid-liquid ratio in grape skin powder) it water is added with lemon acid for adjusting pH to 1 ~ 2 is heated to 70 DEG C
Heat preservation 2 ~ 3h of hydrolysis, is then filtered while hot with 100 mesh nylon cloths to get Grape Skin leaching liquor is arrived；
Dietary fiber is that one kind is difficult to be had by the macromolecule polysaccharide of enzymolysis, digestion in human body, and having prevents gall stone, excludes
Internal harmful metal ion prevents diabetes, reduces serum and cholesterol, prevents the effects of hypertension and heart disease, Grape Skin
In total dietary fiber account for the 75% of skin slag dry mass, soluble dietary fibre content accounts for the 15% of total dietary fiber, is a kind of pre-
The active principle of anti-fatty liver；
As a further improvement of the present invention, the Cornutcd pugionium extractive concentration is 20 ~ 200mg/mL, the preparation method is as follows:
(1) take fresh Pugionium cornutum, cut off its root retain aerial part, clean up be placed on 60 DEG C of forced air dryings 2 in baking oven ~
Then 3h is crushed to obtain Pugionium cornutum powder；
(2) it is 1:(6 ~ 8 according to solid-liquid ratio by Pugionium cornutum powder) ethyl alcohol that volume fraction is 95% is added, it is heated to reflux at 80 ~ 100 DEG C
It extracts 3 times, 2h/ times, filters merging filtrate, obtain filtrate 1；
(3) according to solid-liquid ratio 1:(6 ~ 8 in step (2) is residue obtained) ethyl alcohol of volume fraction 50% is added, according to step (2)
Method extract, obtain filtrate 2；
(4) filtrate 1 and filtrate 2 are merged, being placed in Rotary Evaporators concentration becomes medicinal extract, and volatile dry obtains Cornutcd pugionium extractive；
(5) Cornutcd pugionium extractive being dissolved in the dimethyl sulfoxide that volumetric concentration is 0.03% and being prepared into concentration is 20 ~ 200mg/mL
Solution.
Pugionium cornutum can mitigate hepatic tissue oxidative stress and peroxidatic reaction of lipid, correct disorders of lipid metabolism, improve hepatic tissue
Inflammation damnification, while can improve the oxidation resistance of liver cell by Anti-lipid peroxidation, promote oxidative and anti-oxidative
Between dynamic equilibrium restore, and then protect liver cell structure and function it is complete, be finally reached treatment fatty liver effect；Together
When Pugionium cornutum diastole colonic smooth muscle effect, promote gastric emptying and Intestinal propulsive rate, promote WeiDongLi Capsule, to improve to drug
Absorption efficiency improves drug effect efficiency.
Beneficial effects of the present invention:
1, the feed addictive collocation for the treatment of metabolic disease prepared by the present invention rationally, mutually promotes, can be effectively improved WeiDongLi Capsule, promote
Into digestion and absorption, while the resistivity to fatty liver is improved, improve digestive system, promoted drug absorption, illness can be made
Also it can effectively absorb the drug, the WeiDongLi Capsule of raising and immune Force system make it possible to preferably resist fatty liver and treatment fatty liver,
With good economic benefit.
2, the raw materials of feed additives for the treatment of metabolic disease prepared by the present invention is natural materials, and collaboration promotees between each other
Into being easy to absorb, improve the processing problem of grape wine brewing waste, raw material availability is high, meets sustainable cycle development
Theory, it is environmentally protective, there is good development prospect.
Specific embodiment
Below with reference to embodiment, the present invention is further described.
Embodiment 1
A. the preparation of composition a
(1) 1 part and 2 parts of Cornutcd pugionium extractive of Grape Skin leaching liquor is taken to be added in 12 parts of Essential Oil of Radix Angelicae Dahuricae, 50 DEG C of heating water baths
Then 40min is added 8 parts of sulfated chitosan solution that concentration is 100mg/mL and is uniformly mixed, obtains mixed liquor 1；
(2) 5 parts of soya-bean polypeptides are added in mixed liquor 1, in vibrating 30min on turbula shaker, sodium alginate is then added
10 parts carry out being mixed to get mixed liquor 2, and finally mixed liquor 2 is quickly put into emulsifier and carries out emulsification 1h, is collected by centrifugation to obtain
Emulsion；
(3) 5 parts of eggplant processing powder and purple sweet potato are processed 10 parts of powder and mixed, add emulsion and 5 parts of xylitol, after
It is continuous to mix 10min to get composition a is arrived；
B. the preparation of additive
(1) by 5 parts of corn, 4 parts of kelp, 4 parts of garlic, 5 parts of apple, 1 part of bean seedlings, 2 parts of crowndaisy chrysanthemum, 10 parts of sorghum, 5 parts of buckwheat progress
It crushed 50 meshes and dry, mixed after sterilizing, obtain raw material powder C；
(2) composition a and raw material powder c are mixed according to mass ratio 6:4,100 μm of particles then are made by spray drying,
Obtain medical treatment the feed addictive of metabolic disease.
The purple sweet potato processing powder is prepared by following methods:
(1) purple sweet potato is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to purple sweet potato powder to be placed in -80 DEG C of refrigerators；
(2) it is that the methanol solution that volume fraction is 80% is added in 1:15 in purple sweet potato powder according to solid-liquid ratio, is heated to 85 DEG C, together
When extract 50min under 50W, 40kHz ultrasound, be then centrifuged 5min at 10000r/min, separate supernatant, repeat to extract 2
Merge supernatant after secondary, be then freeze-dried supernatant, obtains purple sweet potato processing powder.
The eggplant processing powder is prepared by following methods:
(1) eggplant is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to eggplant powder to be placed in -80 DEG C of refrigerators；
(2) it is that the methanol solution that volume fraction is 80% is added in 1:10 in eggplant powder according to solid-liquid ratio, is heated to 80 DEG C, together
When extract 40min under 50W, 40kHz ultrasound, be then centrifuged 5min at 8000r/min, separate supernatant, repeat to extract 2 times
After merge supernatant, then supernatant is freeze-dried, obtain eggplant processing powder.
The Grape Skin leaching liquor the preparation method is as follows:
(1) grape skin separated after wine brewing is taken, drying and crushing crosses 40 meshes, obtains grape skin powder；
(2) water is added for 1:20 according to solid-liquid ratio in grape skin powder and is heated to 70 DEG C of heat preservation water with lemon acid for adjusting pH to 2
2h is solved, is then filtered while hot with 100 mesh nylon cloths to get Grape Skin leaching liquor is arrived.
The Cornutcd pugionium extractive concentration is 20mg/mL, the preparation method is as follows:
(1) take fresh Pugionium cornutum, cut off its root retain aerial part, clean up be placed on 60 DEG C of forced air dryings 2 in baking oven ~
Then 3h is crushed to obtain Pugionium cornutum powder；
It (2) is ethyl alcohol that 1:6 is added that volume fraction is 95% according to solid-liquid ratio by Pugionium cornutum powder, heating and refluxing extraction 3 times at 80 DEG C,
2h/ times, merging filtrate is filtered, filtrate 1 is obtained；
(3) ethyl alcohol of volume fraction 50% is added according to solid-liquid ratio 1:6 in step (2) is residue obtained, according to the side of step (2)
Method extracts, and obtains filtrate 2；
(4) filtrate 1 and filtrate 2 are merged, being placed in Rotary Evaporators concentration becomes medicinal extract, and volatile dry obtains Cornutcd pugionium extractive；
(5) Cornutcd pugionium extractive being dissolved in the dimethyl sulfoxide that volumetric concentration is 0.03% and being prepared into concentration is the molten of 20mg/mL
Liquid.
Embodiment 2
A. the preparation of composition a
(1) 4 parts and 8 parts of Cornutcd pugionium extractive of Grape Skin leaching liquor are taken to be added in 18 parts of Chinese medicine peppermint oil, 50 ~ 60 DEG C of heating water baths
Then 50min is added 16 parts of sulfated chitosan solution that concentration is 50mg/mL and is uniformly mixed, obtains mixed liquor 1；
(2) 10 parts of soya-bean polypeptides are added in mixed liquor 1, in vibrating 50min on turbula shaker, sodium alginate is then added
14 parts carry out being mixed to get mixed liquor 2, and finally mixed liquor 2 is quickly put into emulsifier and carries out emulsification 2h, is collected by centrifugation to obtain
Emulsion；
(3) 10 parts of eggplant processing powder and purple sweet potato are processed 10 parts of powder and mixed, add emulsion and 10 parts of xylitol,
Continue to mix 15min to get composition a is arrived；
B. the preparation of additive
(1) by 10 parts of corn, 1 part of kelp, 4 parts of garlic, 1 part of apple, 6 parts of bean seedlings, 2 parts of crowndaisy chrysanthemum, 5 parts of sorghum, 10 parts of buckwheat into
Row crushes and sieves with 100 mesh sieve and dry, and is mixed after sterilizing, obtains raw material powder C；
(2) composition a and raw material powder c are mixed according to mass ratio 8:2,120 μm of particles then are made by spray drying,
Obtain medical treatment the feed addictive of metabolic disease.
The purple sweet potato processing powder is prepared by following methods:
(1) purple sweet potato is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to purple sweet potato powder to be placed in -80 DEG C of refrigerators；
(2) it is that the methanol solution that volume fraction is 80% is added in 1:6 in purple sweet potato powder according to solid-liquid ratio, is heated to 80 DEG C, simultaneously
30min is extracted under 50W, 40kHz ultrasound, 5min is then centrifuged at 4000r/min, separates supernatant, is repeated after extracting 2 times
Merge supernatant, be then freeze-dried supernatant, obtains purple sweet potato processing powder.
The eggplant processing powder is prepared by following methods:
(1) eggplant is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to eggplant powder to be placed in -80 DEG C of refrigerators；
(2) it is that the methanol solution that volume fraction is 80% is added in 1:5 in eggplant powder according to solid-liquid ratio, is heated to 90 DEG C, together
When extract 50min under 50W, 40kHz ultrasound, be then centrifuged 5min at 10000r/min, separate supernatant, repeat to extract 2
Merge supernatant after secondary, be then freeze-dried supernatant, obtains eggplant processing powder.
The Grape Skin leaching liquor the preparation method is as follows:
(1) grape skin separated after wine brewing is taken, drying and crushing crosses 40 meshes, obtains grape skin powder；
(2) water is added for 1:25 according to solid-liquid ratio in grape skin powder and is heated to 70 DEG C of heat preservation water with lemon acid for adjusting pH to 1
3h is solved, is then filtered while hot with 100 mesh nylon cloths to get Grape Skin leaching liquor is arrived.
The Cornutcd pugionium extractive concentration is 200mg/mL, the preparation method is as follows:
(1) fresh Pugionium cornutum is taken, its root is cut off and retains aerial part, clean up and be placed on 60 DEG C of forced air dryings in baking oven
Then 3h is crushed to obtain Pugionium cornutum powder；
It (2) is ethyl alcohol that 1:8 is added that volume fraction is 95% according to solid-liquid ratio by Pugionium cornutum powder, heating and refluxing extraction 3 times at 100 DEG C,
2h/ times, merging filtrate is filtered, filtrate 1 is obtained；
(3) ethyl alcohol of volume fraction 50% is added according to solid-liquid ratio 1:8 in step (2) is residue obtained, according to the side of step (2)
Method extracts, and obtains filtrate 2；
(4) filtrate 1 and filtrate 2 are merged, being placed in Rotary Evaporators concentration becomes medicinal extract, and volatile dry obtains Cornutcd pugionium extractive；
(5) Cornutcd pugionium extractive being dissolved in the dimethyl sulfoxide that volumetric concentration is 0.03% and being prepared into concentration is 200mg/mL's
Solution.
Embodiment 3
A. the preparation of composition a
(1) 2 parts and 4 parts of Cornutcd pugionium extractive of Grape Skin leaching liquor are taken to be added in 15 parts of Essential Oil of Radix Angelicae Dahuricae, 55 DEG C of heating water baths
Then 45min is added 12 parts of sulfated chitosan solution that concentration is 80mg/mL and is uniformly mixed, obtains mixed liquor 1；
(2) 8 parts of soya-bean polypeptides are added in mixed liquor 1, in vibrating 40min on turbula shaker, sodium alginate is then added
12 parts carry out being mixed to get mixed liquor 2, and finally mixed liquor 2 is quickly put into emulsifier and carries out emulsification 2h, is collected by centrifugation to obtain
Emulsion；
(3) 8 parts of eggplant processing powder and purple sweet potato are processed 8 parts of powder and mixed, add emulsion and 8 parts of xylitol, after
It is continuous to mix 12min to get composition a is arrived；
B. the preparation of additive
(1) by 8 parts of corn, 2 parts of kelp, 5 parts of garlic, 4 parts of apple, 4 parts of bean seedlings, 4 parts of crowndaisy chrysanthemum, 7 parts of sorghum, 8 parts of buckwheat progress
It crushed 80 meshes and dry, mixed after sterilizing, obtain raw material powder C；
(2) composition a and raw material powder c are mixed according to mass ratio 7:3,100 μm of particles then are made by spray drying,
Obtain medical treatment the feed addictive of metabolic disease.
The purple sweet potato processing powder is prepared by following methods:
(1) purple sweet potato is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to purple sweet potato powder to be placed in -80 DEG C of refrigerators；
(2) it is that the methanol solution that volume fraction is 80% is added in 1:12 in purple sweet potato powder according to solid-liquid ratio, is heated to 90 DEG C, together
When extract 50min under 50W, 40kHz ultrasound, be then centrifuged 5min at 10000r/min, separate supernatant, repeat to extract 2
Merge supernatant after secondary, be then freeze-dried supernatant, obtains purple sweet potato processing powder.
The eggplant processing powder is prepared by following methods:
(1) eggplant is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to eggplant powder to be placed in -80 DEG C of refrigerators；
(2) it is that the methanol solution that volume fraction is 80% is added in 1:8 in eggplant powder according to solid-liquid ratio, is heated to 85 DEG C, simultaneously
40min is extracted under 50W, 40kHz ultrasound, 5min is then centrifuged at 6000r/min, separates supernatant, is repeated after extracting 2 times
Merge supernatant, be then freeze-dried supernatant, obtains eggplant processing powder.
The Grape Skin leaching liquor the preparation method is as follows:
(1) grape skin separated after wine brewing is taken, drying and crushing crosses 40 meshes, obtains grape skin powder；
(2) water is added for 1:23 according to solid-liquid ratio in grape skin powder and is heated to 70 DEG C of heat preservation water with lemon acid for adjusting pH to 2
2h is solved, is then filtered while hot with 100 mesh nylon cloths to get Grape Skin leaching liquor is arrived.
The Cornutcd pugionium extractive concentration is 100mg/mL, the preparation method is as follows:
(1) take fresh Pugionium cornutum, cut off its root retain aerial part, clean up be placed on 60 DEG C of forced air dryings 2 in baking oven ~
Then 3h is crushed to obtain Pugionium cornutum powder；
It (2) is ethyl alcohol that 1:7 is added that volume fraction is 95% according to solid-liquid ratio by Pugionium cornutum powder, heating and refluxing extraction 3 times at 95 DEG C,
2h/ times, merging filtrate is filtered, filtrate 1 is obtained；
(3) ethyl alcohol of volume fraction 50% is added according to solid-liquid ratio 1:7 in step (2) is residue obtained, according to the side of step (2)
Method extracts, and obtains filtrate 2；
(4) filtrate 1 and filtrate 2 are merged, being placed in Rotary Evaporators concentration becomes medicinal extract, and volatile dry obtains Cornutcd pugionium extractive；
(5) Cornutcd pugionium extractive being dissolved in the dimethyl sulfoxide that volumetric concentration is 0.03% and being prepared into concentration is 100mg/mL's
Solution.
Test example
Embodiment 1 ~ 3 and common commercially available feed addictive cooperation normal diet is used to feed respectively, then to progress meat survey
It comments, nutritive value assessment, meat health status and chicken safety assessment.Wherein meat assessment is to invite 500 subjects couple
Meat is foretasted, and is then given a mark, be as a result divided into it is excellent, good, in, poor four etc..Nutritive value assessment is must to the human body in meat
Need the important nutritive value index such as protein, fat to be tested, then give a mark, be as a result divided into it is excellent, good, in, poor four etc..Meat is strong
Health situation assessment be to test the meat speed of growth, final weight, sick frequency, then give a mark, be as a result divided into it is excellent, good, in,
Poor four etc., chicken safety assessment is surveyed to the content at residual antibiotic and other improper chemical substances in meat
It is fixed, according to measurement result, be divided into it is excellent, good, in, poor four etc..Evaluating result is shown in Table 1.
Table 1
As shown in Table 1, feed addictive prepared by the present invention can more efficient promotion items compared to common commercially available additive
Growth indexes improve meat quality, can preferably improve the economic value of meat cultivation.
Above embodiments are only exemplary embodiment of the present invention, are not used in the limitation present invention, protection scope of the present invention
It is defined by the claims.Those skilled in the art can make various repair to the present invention within the spirit and scope of the present invention
Change or equivalent replacement, this modification or equivalent replacement also should be regarded as being within the scope of the present invention.
Claims (8)
1. a kind of feed addictive for treating metabolic disease, including composition a and composition b, which is characterized in that the composition
A is prepared by following weight fraction ratio component: eggplant processes 5 ~ 10 parts of powder, purple sweet potato processes 10 ~ 15 parts of powder, soya-bean polypeptides
5 ~ 10 parts, 12 ~ 18 parts of traditional medicine volatile oil, 1 ~ 4 part of Grape Skin leaching liquor, 2 ~ 8 parts of Cornutcd pugionium extractive, sulfated chitosan solution 8 ~
16 parts, 10 ~ 14 parts of sodium alginate, 5 ~ 10 parts of xylitol；The composition b includes following weight fraction ratio component: corn 5 ~ 10
Part, 1 ~ 4 part of kelp, 4 ~ 8 parts of garlic, 1 ~ 5 part of apple, 1 ~ 6 part of bean seedlings, 2 ~ 6 parts of crowndaisy chrysanthemum, 5 ~ 10 parts of sorghum, 5 ~ 10 parts of buckwheat.
2. the preparation method of the feed addictive for the treatment of metabolic disease as described in claim 1, which is characterized in that including following step
It is rapid:
A. the preparation of composition a
(1) Grape Skin leaching liquor and Cornutcd pugionium extractive is taken to be added in traditional medicine volatile oil, 50 ~ 60 DEG C of 40 ~ 50min of heating water bath,
Then sulfated chitosan solution is added to be uniformly mixed, obtains mixed liquor 1；
(2) soya-bean polypeptides are added in mixed liquor 1, in vibrating 30 ~ 50min on turbula shaker, sodium alginate is then added
It carries out being mixed to get mixed liquor 2, finally mixed liquor 2 is quickly put into emulsifier and carries out 1 ~ 2h of emulsification, be collected by centrifugation to obtain cream
Change liquid；
(3) by eggplant process powder and purple sweet potato processing powder mix, add emulsion and xylitol, continue mixing 10 ~
15min to get arrive composition a；
B. the preparation of additive
(1) composition b each component is carried out crushed 50 ~ 100 meshes and is dried, mixed after sterilizing, obtain raw material powder C；
(2) by composition a and raw material powder c according to mass ratio (6 ~ 8): (2 ~ 4) mix, and are then made by spray drying
100 ~ 120 μm of particles are to get the feed addictive for arriving treatment metabolic disease.
3. the preparation method of the feed addictive for the treatment of metabolic disease according to claim 2, which is characterized in that in described
Medicine volatile oil is one of Essential Oil of Radix Angelicae Dahuricae, peppermint oil.
4. the preparation method of the feed addictive for the treatment of metabolic disease according to claim 2, which is characterized in that the sulphur
Acidified chitosan solution is that sulfated chitosan is dissolved in physiological saline to be prepared, and concentration is 50 ~ 100mg/mL.
5. the preparation method of the feed addictive for the treatment of metabolic disease according to claim 2, which is characterized in that the purple
Potato processing powder is prepared by following methods:
(1) purple sweet potato is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to purple sweet potato powder to be placed in -80 DEG C of refrigerators；
(2) it is 1:(6 ~ 15 according to solid-liquid ratio) methanol solution that volume fraction is 80% is added in purple sweet potato powder, it is heated to 80 ~
90 DEG C, while 30 ~ 50min is extracted under 50W, 40kHz ultrasound, 5min is then centrifuged at 4000 ~ 10000r/min, in separation
Clear liquid repeats to merge supernatant after extracting 2 times, is then freeze-dried supernatant, obtains purple sweet potato processing powder.
6. the preparation method of the feed addictive for the treatment of metabolic disease according to claim 2, which is characterized in that the eggplant
Son processing powder is prepared by following methods:
(1) eggplant is cleaned and is dried, smashed to pieces after being cut into small pieces, it is quick-frozen and be dried to eggplant powder to be placed in -80 DEG C of refrigerators；
(2) it is 1:(6 ~ 15 according to solid-liquid ratio) methanol solution that volume fraction is 80% is added in eggplant powder, it is heated to 80 ~
90 DEG C, while 30 ~ 50min is extracted under 50W, 40kHz ultrasound, 5min is then centrifuged at 4000 ~ 10000r/min, in separation
Clear liquid repeats to merge supernatant after extracting 2 times, is then freeze-dried supernatant, obtains eggplant processing powder.
7. the preparation method of the feed addictive for the treatment of metabolic disease according to claim 2, which is characterized in that the Portugal
Grape skin leaching liquor the preparation method is as follows:
(1) grape skin separated after wine brewing is taken, drying and crushing crosses 40 meshes, obtains grape skin powder；
(2) it is 1:(20 ~ 25 according to solid-liquid ratio in grape skin powder) it water is added with lemon acid for adjusting pH to 1 ~ 2 is heated to 70 DEG C
Heat preservation 2 ~ 3h of hydrolysis, is then filtered while hot with 100 mesh nylon cloths to get Grape Skin leaching liquor is arrived.
8. the preparation method of the feed addictive for the treatment of metabolic disease according to claim 2, which is characterized in that the sand
Mustard extract concentrations are 20 ~ 200mg/mL, the preparation method is as follows:
(1) take fresh Pugionium cornutum, cut off its root retain aerial part, clean up be placed on 60 DEG C of forced air dryings 2 in baking oven ~
Then 3h is crushed to obtain Pugionium cornutum powder；
(2) it is 1:(6 ~ 8 according to solid-liquid ratio by Pugionium cornutum powder) ethyl alcohol that volume fraction is 95% is added, it is heated to reflux at 80 ~ 100 DEG C
It extracts 3 times, 2h/ times, filters merging filtrate, obtain filtrate 1；
(3) according to solid-liquid ratio 1:(6 ~ 8 in step (2) is residue obtained) ethyl alcohol of volume fraction 50% is added, according to step (2)
Method extract, obtain filtrate 2；
(4) filtrate 1 and filtrate 2 are merged, being placed in Rotary Evaporators concentration becomes medicinal extract, and volatile dry obtains Cornutcd pugionium extractive；
(5) Cornutcd pugionium extractive being dissolved in the dimethyl sulfoxide that volumetric concentration is 0.03% and being prepared into concentration is 20 ~ 200mg/mL
Solution.
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Cited By (1)
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| CN114081903A (en) * | 2021-10-30 | 2022-02-25 | 内蒙古自治区农牧业科学院 | Plant extract with antibacterial effect, and extraction method and application thereof |
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