CN111479925B - 具有y182t突变的t细胞-抗原偶联物及其方法和用途 - Google Patents

具有y182t突变的t细胞-抗原偶联物及其方法和用途 Download PDF

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CN111479925B
CN111479925B CN201880080477.1A CN201880080477A CN111479925B CN 111479925 B CN111479925 B CN 111479925B CN 201880080477 A CN201880080477 A CN 201880080477A CN 111479925 B CN111479925 B CN 111479925B
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polynucleotide sequence
ligand
acid sequence
antigen
polypeptide
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CN111479925A (zh
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克里斯托弗·W·赫尔森
乔纳森·布拉姆森
安娜·德沃尔金-赫瓦
嘉琳娜·F·丹尼索瓦
克塞尼娅·贝兹韦尔布纳亚
肯尼斯·安东尼·牧瓦瓦司
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McMaster University
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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CN201880080477.1A 2017-10-12 2018-10-12 具有y182t突变的t细胞-抗原偶联物及其方法和用途 Active CN111479925B (zh)

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US201762571354P 2017-10-12 2017-10-12
US62/571,354 2017-10-12
PCT/CA2018/051290 WO2019071358A1 (en) 2017-10-12 2018-10-12 Y182T MUTATION T CELL ANTIGEN COUPLEUR AND METHODS AND USES THEREOF

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EP (1) EP3694997A4 (https=)
JP (1) JP7227630B2 (https=)
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AU (1) AU2018349093A1 (https=)
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