CN1114613C - 蛋白质溶液的铝/铁处理和膜浓缩方法 - Google Patents

蛋白质溶液的铝/铁处理和膜浓缩方法 Download PDF

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Publication number
CN1114613C
CN1114613C CN96194380.7A CN96194380A CN1114613C CN 1114613 C CN1114613 C CN 1114613C CN 96194380 A CN96194380 A CN 96194380A CN 1114613 C CN1114613 C CN 1114613C
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China
Prior art keywords
protein solution
test
aluminum
concentration
protein
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Expired - Fee Related
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CN96194380.7A
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English (en)
Chinese (zh)
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CN1186498A (zh
Inventor
T·K·尼尔森
M·A·拉斯特森
N－V·尼尔森
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Novozymes AS
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Novozymes AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN96194380.7A 1995-06-02 1996-05-31 蛋白质溶液的铝/铁处理和膜浓缩方法 Expired - Fee Related CN1114613C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK0626/95 1995-06-02
DK62695 1995-06-02
DK0626/1995 1995-06-02

Publications (2)

Publication Number Publication Date
CN1186498A CN1186498A (zh) 1998-07-01
CN1114613C true CN1114613C (zh) 2003-07-16

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ID=8095720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96194380.7A Expired - Fee Related CN1114613C (zh) 1995-06-02 1996-05-31 蛋白质溶液的铝/铁处理和膜浓缩方法

Country Status (9)

Country Link
EP (1) EP0828753B1 (enExample)
JP (1) JPH11511118A (enExample)
CN (1) CN1114613C (enExample)
AT (1) ATE235506T1 (enExample)
AU (1) AU5996996A (enExample)
DE (1) DE69626976T2 (enExample)
DK (1) DK0828753T3 (enExample)
IN (1) IN181859B (enExample)
WO (1) WO1996038469A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2810667B1 (fr) * 2000-06-23 2004-09-03 Warner Lambert Co Procede d'isolement et de purification d'une proteine, et proteine obtenue
US7659102B2 (en) 2001-02-21 2010-02-09 Verenium Corporation Amylases, nucleic acids encoding them and methods for making and using them
MXPA03007527A (es) 2001-02-21 2004-07-30 Diversa Corp Enzimas que tienen actividad de alfa amilasa y metodos de uso de las mismas.
US20030013172A1 (en) * 2001-05-14 2003-01-16 Joel Gerendash Novel methods of enzyme purification
ES2298378T3 (es) 2001-06-28 2008-05-16 Novo Nordisk A/S Formulacion estable de glp-1 modificado.
US7118891B2 (en) 2001-12-11 2006-10-10 Novozymes A/S Crystal harvest from fermentation broth
ATE547518T1 (de) * 2001-12-11 2012-03-15 Novozymes As Verfahren zur sammlung von kristallinen partikeln aus fermentationsbrühe
CA2515340C (en) 2003-03-06 2016-04-26 Diversa Corporation Amylases, nucleic acids encoding them and methods for making and using them
EP1633391B1 (en) 2003-06-03 2011-10-19 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
JP4936884B2 (ja) 2003-06-03 2012-05-23 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
KR101243648B1 (ko) 2003-11-20 2013-03-14 노보 노르디스크 에이/에스 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제
JP4965446B2 (ja) 2004-08-31 2012-07-04 ノヴォ ノルディスク アー／エス ペプチド、ポリペプチド及びタンパク質の安定化のためのトリス（ヒドロキシメチル）アミノメタンの使用
MX2007005521A (es) 2004-11-12 2007-05-18 Novo Nordisk As Formulaciones estables de peptidos insulinotropicos.
US7855280B2 (en) 2005-09-15 2010-12-21 Wyeth Llc Separation methods
ES2531167T5 (es) 2006-12-21 2018-05-21 Basf Enzymes Llc Amilasas y glucoamilasas, ácidos nucleicos que las codifican y métodos para formarlas y utilizarlas
US20120252066A1 (en) * 2011-03-29 2012-10-04 Heng Meng H Methods of foam control
WO2014068083A1 (en) 2012-11-01 2014-05-08 Novozymes A/S Method for removal of dna
DK3071589T3 (en) 2013-11-19 2018-06-14 Kemira Oyj METHOD OF REDUCING THE COLOR OF A BIOTECHNOLOGICAL LIQUID
CN118903385A (zh) 2017-08-24 2024-11-08 诺和诺德股份有限公司 Glp-1组合物及其用途
CN108949703A (zh) * 2018-06-28 2018-12-07 大连理工大学 一种半纤维小体类似物粗提纯方法
FI3983425T3 (fi) 2019-06-13 2025-11-19 Basf Se Menetelmä proteiinin talteen ottamiseksi käymisliemestä käyttämällä divalenttista kationia
EP4537848A3 (en) 2020-02-18 2025-06-25 Novo Nordisk A/S Glp-1 compositions and uses thereof
EP4217366A1 (en) 2020-09-22 2023-08-02 Basf Se Method for recovering a protein from a fermentation broth comprising a high degree of lysed cells
CN112500471B (zh) * 2020-12-22 2022-09-27 中美华世通生物医药科技(武汉)股份有限公司 一种制备高澄清度蛋白琥珀酸铁的方法
EP4565711A1 (en) 2022-08-02 2025-06-11 Basf Se Stabilized protein production process using bacillus host cells with salt feed

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795586A (en) * 1969-08-11 1974-03-05 Pabst Brewing Co Recovery of enzymes
EP0277043A3 (en) * 1987-01-30 1989-08-23 IMCERA Group Inc. Method for recovering somatotropins from dilute aqueous solution
US4894444A (en) * 1987-07-16 1990-01-16 Merck & Co., Inc. Recovery and purification of immunogens from immunogen-alum complexes
DE3915277A1 (de) * 1989-05-10 1990-11-15 Henkel Kgaa Verfahren zur reinigung von enzymfluessigkonzentraten
DE4037530A1 (de) * 1990-11-26 1992-05-27 Henkel Kgaa Faellungsverfahren fuer exocellulaere proteine
DK91092D0 (enExample) * 1992-07-10 1992-07-10 Novo Nordisk As

Also Published As

Publication number Publication date
ATE235506T1 (de) 2003-04-15
DK0828753T3 (da) 2003-06-30
JPH11511118A (ja) 1999-09-28
DE69626976D1 (de) 2003-04-30
AU5996996A (en) 1996-12-18
CN1186498A (zh) 1998-07-01
EP0828753B1 (en) 2003-03-26
WO1996038469A1 (en) 1996-12-05
EP0828753A1 (en) 1998-03-18
DE69626976T2 (de) 2004-03-04
IN181859B (enExample) 1998-10-03

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Address after: Denmark bagsvaerd

Applicant after: NOVOZYMES A/S

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Applicant before: Novo Nordisk A/S

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Granted publication date: 20030716

Termination date: 20120531