CN1114613C - 蛋白质溶液的铝/铁处理和膜浓缩方法 - Google Patents

蛋白质溶液的铝/铁处理和膜浓缩方法 Download PDF

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Publication number
CN1114613C
CN1114613C CN96194380.7A CN96194380A CN1114613C CN 1114613 C CN1114613 C CN 1114613C CN 96194380 A CN96194380 A CN 96194380A CN 1114613 C CN1114613 C CN 1114613C
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China
Prior art keywords
protein solution
test
aluminum
concentration
protein
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Expired - Fee Related
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CN96194380.7A
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English (en)
Chinese (zh)
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CN1186498A (zh
Inventor
T·K·尼尔森
M·A·拉斯特森
N－V·尼尔森
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Novozymes AS
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Novozymes AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN96194380.7A 1995-06-02 1996-05-31 蛋白质溶液的铝/铁处理和膜浓缩方法 Expired - Fee Related CN1114613C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK62695 1995-06-02
DK0626/95 1995-06-02
DK0626/1995 1995-06-02

Publications (2)

Publication Number Publication Date
CN1186498A CN1186498A (zh) 1998-07-01
CN1114613C true CN1114613C (zh) 2003-07-16

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ID=8095720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96194380.7A Expired - Fee Related CN1114613C (zh) 1995-06-02 1996-05-31 蛋白质溶液的铝/铁处理和膜浓缩方法

Country Status (9)

Country Link
EP (1) EP0828753B1 (enExample)
JP (1) JPH11511118A (enExample)
CN (1) CN1114613C (enExample)
AT (1) ATE235506T1 (enExample)
AU (1) AU5996996A (enExample)
DE (1) DE69626976T2 (enExample)
DK (1) DK0828753T3 (enExample)
IN (1) IN181859B (enExample)
WO (1) WO1996038469A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2810667B1 (fr) * 2000-06-23 2004-09-03 Warner Lambert Co Procede d'isolement et de purification d'une proteine, et proteine obtenue
JP2004533220A (ja) 2001-02-21 2004-11-04 ディヴァーサ コーポレイション αアミラーゼ活性を有する酵素及びその使用方法
US7659102B2 (en) 2001-02-21 2010-02-09 Verenium Corporation Amylases, nucleic acids encoding them and methods for making and using them
WO2002092802A1 (en) * 2001-05-14 2002-11-21 Diversa Corporation Novel methods of enzyme purification
ATE382057T1 (de) 2001-06-28 2008-01-15 Novo Nordisk As Stabile formulierung von modifiziertem glp-1
CN100487114C (zh) * 2001-12-11 2009-05-13 诺维信公司 从发酵液收获晶体
US7118891B2 (en) 2001-12-11 2006-10-10 Novozymes A/S Crystal harvest from fermentation broth
JP4778418B2 (ja) 2003-03-06 2011-09-21 ヴェレニウム コーポレイション アミラーゼ、それをコードする核酸並びにその製造および使用方法
KR101308912B1 (ko) 2003-06-03 2013-09-23 노보 노르디스크 에이/에스 안정화된 약학적 펩티드 조성물
WO2004105790A1 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
SI1687019T1 (en) 2003-11-20 2018-04-30 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
WO2006024631A2 (en) 2004-08-31 2006-03-09 Novo Nordisk A/S Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
EP2494983B1 (en) 2004-11-12 2019-04-24 Novo Nordisk A/S Stable formulations of glp-1
TW200801039A (en) * 2005-09-15 2008-01-01 Wyeth Corp Separation methods
DK2479266T3 (en) 2006-12-21 2016-06-20 Basf Enzymes Llc Amylases and glucoamylases, nucleic acids encoding them, and methods of making and using the same
TW201303022A (zh) * 2011-03-29 2013-01-16 Danisco Us Inc 泡沫控制的方法
WO2014068083A1 (en) 2012-11-01 2014-05-08 Novozymes A/S Method for removal of dna
DK3071589T3 (en) 2013-11-19 2018-06-14 Kemira Oyj METHOD OF REDUCING THE COLOR OF A BIOTECHNOLOGICAL LIQUID
RS65380B1 (sr) 2017-08-24 2024-04-30 Novo Nordisk As Glp-1 kompozicije i njihova upotreba
CN108949703A (zh) * 2018-06-28 2018-12-07 大连理工大学 一种半纤维小体类似物粗提纯方法
US12146171B2 (en) 2019-06-13 2024-11-19 Basf Se Method of recovering a protein from fermentation broth using a divalent cation
CN115135304A (zh) 2020-02-18 2022-09-30 诺和诺德股份有限公司 Glp-1组合物及其用途
MX2023003276A (es) 2020-09-22 2023-05-03 Basf Se Método para recuperar una proteína de un caldo de fermentación que comprende un alto grado de células lisadas.
CN112500471B (zh) * 2020-12-22 2022-09-27 中美华世通生物医药科技(武汉)股份有限公司 一种制备高澄清度蛋白琥珀酸铁的方法
CN119654420A (zh) 2022-08-02 2025-03-18 巴斯夫欧洲公司 使用芽孢杆菌宿主细胞的稳定的蛋白质生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795586A (en) * 1969-08-11 1974-03-05 Pabst Brewing Co Recovery of enzymes
PL270368A1 (en) * 1987-01-30 1988-10-13 Int Minerals & Chem Corp Method for recovery of somatotropins from diluted water solutions
US4894444A (en) * 1987-07-16 1990-01-16 Merck & Co., Inc. Recovery and purification of immunogens from immunogen-alum complexes
DE3915277A1 (de) * 1989-05-10 1990-11-15 Henkel Kgaa Verfahren zur reinigung von enzymfluessigkonzentraten
DE4037530A1 (de) * 1990-11-26 1992-05-27 Henkel Kgaa Faellungsverfahren fuer exocellulaere proteine
DK91092D0 (enExample) * 1992-07-10 1992-07-10 Novo Nordisk As

Also Published As

Publication number Publication date
AU5996996A (en) 1996-12-18
CN1186498A (zh) 1998-07-01
DK0828753T3 (da) 2003-06-30
WO1996038469A1 (en) 1996-12-05
JPH11511118A (ja) 1999-09-28
ATE235506T1 (de) 2003-04-15
EP0828753A1 (en) 1998-03-18
DE69626976T2 (de) 2004-03-04
IN181859B (enExample) 1998-10-03
EP0828753B1 (en) 2003-03-26
DE69626976D1 (de) 2003-04-30

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