CN1114361C - 减轻对牙齿腐蚀的固体组合物 - Google Patents
减轻对牙齿腐蚀的固体组合物 Download PDFInfo
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- CN1114361C CN1114361C CN98810242A CN98810242A CN1114361C CN 1114361 C CN1114361 C CN 1114361C CN 98810242 A CN98810242 A CN 98810242A CN 98810242 A CN98810242 A CN 98810242A CN 1114361 C CN1114361 C CN 1114361C
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- 206010044038 Tooth erosion Diseases 0.000 title abstract 2
- 208000036595 non-bacterial tooth erosion Diseases 0.000 title abstract 2
- 239000008247 solid mixture Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 96
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 65
- 239000011575 calcium Substances 0.000 claims abstract description 65
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 65
- 239000002253 acid Substances 0.000 claims abstract description 50
- 239000007787 solid Substances 0.000 claims abstract description 25
- 229940043430 calcium compound Drugs 0.000 claims abstract description 11
- 150000001674 calcium compounds Chemical class 0.000 claims abstract description 11
- 239000003513 alkali Substances 0.000 claims abstract description 5
- 229960005069 calcium Drugs 0.000 claims description 64
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 13
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 12
- 235000015165 citric acid Nutrition 0.000 claims description 11
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 9
- 235000010216 calcium carbonate Nutrition 0.000 claims description 9
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 8
- 239000001630 malic acid Substances 0.000 claims description 8
- 235000011090 malic acid Nutrition 0.000 claims description 8
- 230000007800 dental corrosion Effects 0.000 claims description 7
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 5
- 239000001354 calcium citrate Substances 0.000 claims description 5
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 5
- 239000000920 calcium hydroxide Substances 0.000 claims description 5
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 5
- 235000011116 calcium hydroxide Nutrition 0.000 claims description 5
- 230000036541 health Effects 0.000 claims description 5
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 5
- 239000001362 calcium malate Substances 0.000 claims description 4
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 claims description 4
- 229940016114 calcium malate Drugs 0.000 claims description 4
- 235000011038 calcium malates Nutrition 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000019605 sweet taste sensations Nutrition 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 235000011148 calcium chloride Nutrition 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000007937 lozenge Substances 0.000 claims description 3
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 229960002713 calcium chloride Drugs 0.000 claims description 2
- 229960004256 calcium citrate Drugs 0.000 claims description 2
- 239000004281 calcium formate Substances 0.000 claims description 2
- 235000019255 calcium formate Nutrition 0.000 claims description 2
- 229940044172 calcium formate Drugs 0.000 claims description 2
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims description 2
- 229940095618 calcium glycerophosphate Drugs 0.000 claims description 2
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims description 2
- 229940095643 calcium hydroxide Drugs 0.000 claims description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- 229960002401 calcium lactate Drugs 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000003313 weakening effect Effects 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 abstract description 10
- 239000000243 solution Substances 0.000 description 23
- 239000000047 product Substances 0.000 description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 235000013361 beverage Nutrition 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 229960004106 citric acid Drugs 0.000 description 10
- 210000003298 dental enamel Anatomy 0.000 description 9
- 235000010323 ascorbic acid Nutrition 0.000 description 8
- 239000011668 ascorbic acid Substances 0.000 description 8
- 229960005070 ascorbic acid Drugs 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 6
- 235000010755 mineral Nutrition 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- 239000007968 orange flavor Substances 0.000 description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 5
- 235000010234 sodium benzoate Nutrition 0.000 description 5
- 108010010803 Gelatin Proteins 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 4
- 159000000007 calcium salts Chemical class 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
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- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229940049920 malate Drugs 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000019629 palatability Nutrition 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000004299 sodium benzoate Substances 0.000 description 4
- 235000011496 sports drink Nutrition 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 235000001466 Ribes nigrum Nutrition 0.000 description 3
- 241001312569 Ribes nigrum Species 0.000 description 3
- 239000000619 acesulfame-K Substances 0.000 description 3
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- 208000002925 dental caries Diseases 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
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- 239000008103 glucose Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 235000001537 Ribes X gardonianum Nutrition 0.000 description 2
- 235000001535 Ribes X utile Nutrition 0.000 description 2
- 235000016919 Ribes petraeum Nutrition 0.000 description 2
- 244000281247 Ribes rubrum Species 0.000 description 2
- 235000002355 Ribes spicatum Nutrition 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- -1 aminoacyl phenyl alanyl methyl ester Chemical class 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000008233 hard water Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 235000015205 orange juice Nutrition 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000000053 physical method Methods 0.000 description 2
- 239000001508 potassium citrate Substances 0.000 description 2
- 229960002635 potassium citrate Drugs 0.000 description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 2
- 235000011082 potassium citrates Nutrition 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 229940038773 trisodium citrate Drugs 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940092124 calcium citrate malate Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 235000019987 cider Nutrition 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229960000673 dextrose monohydrate Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000020509 fortified beverage Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/312—Foods, ingredients or supplements having a functional effect on health having an effect on dental health
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Confectionery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
有降低牙齿腐蚀特性的固体或半固体的酸性口服组合物，于酸性组合物中加入钙，使钙和酸的比例为0.3-0.8，如果需要，组合物的有效pH值，用碱调整后为3.5-4.5。
Description
本发明涉及口服使用的组合物，特别是固体或半固体的酸性制品或口服保健组合物，以及在这种组合物中使用钙来减轻或预防由食用酸性食物引起的牙损伤。具体地说，本发明要解决的是于制品中添加钙带来的可口性问题。
一般认为牙的腐蚀，特别是从牙齿上浸提出钙的酸性食物引起的牙腐蚀速度，比通过正常的矿物质补充而使其更新的速度要快。为了食用或保健的目的，如果按本发明制备产品，并引入口腔，由化学过程造成的钙和磷酸盐从牙齿上溶解或脱出的情况会明显地减少。
钙是身体中最大量的矿物质。大多数钙沉积在骨和牙齿中，但这种矿物质对其他的机体功能，如神经功能的调节、肌肉收缩和血液凝固都是必须的。在用水果成分做的饮料和用硬水做的饮料中(所述硬水在用于饮料生产之前未经软化处理)，钙是常见的成分。这种情况下，钙的浓度值一般为0.005-0.02％w/w。由于对饮食中增加钙离子的一般营养效果感兴趣，使人们对此进行研究，寻找实际的方式使钙离子能以更高的量--0.02％-2％w/w加入。用钙作为饮料中补充物质已在WO88/03762中有所描述。
已知添加苹果酸有助于保持钙在强化钙饮料中的溶解性，从而降低由于沉淀所造成的损失。这是因为形成了可溶性的复合物“柠檬酸苹果酸钙”。另一方面，Lussi等人(1995，“龋报告”(Caries Res)29，349-354)，将饮料的可滴定酸度与其腐蚀可能性联系起来：饮料中酸的浓度越大，对牙齿的损害越大。
在EP 551398(Procter & Gamble)中，描述了一种预防牙釉质腐蚀的方法，包括食用酸性饮料(pH低于5.5)，所述饮料含0.02％-0.15％的钙，钙的形式为柠檬酸苹果酸钙复合物，柠檬酸钙与苹果酸钙的摩尔比为1∶0.5-1∶4.5。在柠檬酸苹果酸钙复合物中，钙的总摩尔数∶柠檬酸钙的总摩尔数∶苹果酸钙的总摩尔数的比为约2∶1∶1到约6∶3∶4。对饮料来说优选复合物的摩尔比为4∶2∶3。US 5073389描述了用柠檬酸苹果酸钙来给糖果制品补充矿物质。
我们发现产品中含有高含量的钙会带来适口性的问题。但是，我们发现使用相对于酸化剂较少量的钙，同时控制组合物的pH值，可以有效地减少牙齿在酸性口服组合物中发生腐蚀而又不致造成适口性变坏。WO97/30601(1997年8月28日公开)公开了含有限定比例的钙和酸化剂，并控制pH值的液体组合物。
本发明提供了一种固体或半固体的口服组合物，含有钙化合物和酸化剂，其特征在于钙的量为0.3-0.8mol/mol酸，组合物中钙和酸化剂的量经过选择，要使组合物的有效pH值为3.5-4.5。
本发明上下文中使用的术语“有效pH”，指的是组合物在凝固(当组合物是经液相中间体制得的情况下)之前的pH值，或当组合物重新形成液体或溶解在液体(如水中)时的pH。术语“凝固”，包括处理或补充液相中间体使之形成固体或半固体。
另一方面，本发明提供钙在含有钙化合物和酸化剂的口服施用固体或半固体酸性组合物中，作为牙齿腐蚀抑制剂的用途，其特征在于钙的含量为0.3-0.8mol/mol酸，组合物中钙和酸化剂的量经过选择，以使组合物的有效pH值为3.5-4.5。
另一个方面，本发明提供降低固体或半固体酸性口服组合物对牙齿腐蚀可能性的方法，包括在酸性口服组合物中添加钙，使钙的含量为0.3-0.8mol/mol酸，且有效pH值为3.5-4.5，如果必要或需要，通过添加碱获得3.5-4.5的有效pH值。
本发明还涉及一种减少由口服施用的固体或半固体酸性组合物酸引起的牙齿腐蚀的方法，所述组合物含有钙化合物和酸化剂，其特征在于钙的含量为0.3-0.8mol/mol酸，组合物中钙和酸化剂的量经过选择，以使组合物的有效pH值为3.5-4.5。
本发明进一步涉及含有钙化合物和酸化剂的固体或半固体组合物，在生产降低由口服施用组合物中酸引起的牙齿腐蚀的药物中的用途，其特征在于钙的含量为0.3-0.8mol/mol酸，组合物中钙和酸化剂的量经过选择，以使组合物的有效pH值为3.5-4.5。
还有一个方面，本发明提供一种制备本发明组合物的方法，包括将钙化合物与酸化剂混合，使钙的含量为0.3-0.8mol/mol酸，组合物中钙和酸化剂的量经过选择，以使组合物的有效pH值为3.5-4.5。如果必要或需要，通过添加碱获得3.5-4.5的有效pH值。
本发明特别适合于口服的固体或半固体酸性物质，如熬煮甜味品、糖果、片剂、锭剂、硬糖、口香糖、胶冻软糖、胶质软糖、透明的果味糖果、干粉掺混物，如用于溶解在水中的粉末饮料等等甜味品或口服保健组合物。半固体制品还包括乳品，如酸奶、凝乳或冷冻饮料。
在组合物凝固之前，最好用WO97/30601中所述的技术制备和测试，该文献全部内容在此引作参考。
为了保持在强烈味道下仍具有可口性，本发明组合物的有效pH高于供人们消费的普通酸基产品的pH，普通酸基产品的有效pH一般约为3。本发明在实践中没有使产品味道变差。尽管有效pH值提高到4左右预计将会使酸化剂带来的强烈味道减弱，而令人惊异的是，本发明的钙掺入可以缓和这种情况。
另一个优点来自于本发明使用的少量钙，适宜以碱性盐的形式加入。制剂的缓冲能力由于酸的部分中和而降低，这使得唾液能更迅速地中和口腔中剩余的酸性物质。
本发明组合物中使用的钙的绝对浓度没有严格限制，可以根据存在的酸的性质和浓度而变化。酸性组合物可以包括有机和/或无机酸，可以补充维生素，如抗坏血酸。钙的浓度可以为0.001mol/升到大于0.25mol/升。一般为0.002mol/升到0.1mol/升，最好为0.01mol/升到0.05mol/升。
钙可以以任何适宜的形式添加，较方便的是可溶性的盐，如碳酸钙、氢氧化钙、柠檬酸钙、苹果酸钙、乳酸钙、氯化钙、甘油磷酸钙或甲酸钙，或任何其他能将对组合物不利风味影响减至最小的盐。
本发明的组合物可以这样制备，将酸(如柠檬酸)及其相应的钙盐(如柠檬酸钙)或另一种钙盐混合。将酸与碱性钙盐，如碳酸钙或氢氧化钙混合有助于将制剂中的酸浓度减至最小。酸也可以与无机钙盐如氯化钙混合。钙与酸的摩尔比可以为0.3-0.75，一般为0.3-0.7，更典型地为0.3-0.65，最好为0.3-0.60，优选0.3-0.55或0.4-0.55。最优选的摩尔比为至少0.4，约0.5特别有效。
通过添加钙化合物使其与酸的比例适当，可将制剂的有效pH调整到理想范围。如果必要，根据存在的酸，可以通过使用碱，如氢氧化钠，或适宜的盐，如柠檬酸钠、苹果酸钠或乳酸钠进一步调整有效pH值。组合物的有效pH优选不大于4，最优选为3.7-3.9。有效pH值为约3.8的组合物被发现特别有效。
一般来说，本发明组合物中酸的浓度，例如水果制作的制品中的柠檬酸或苹果酸浓度在0.01％w/w-4％w/w，最好为0.1％w/w-1％w/w。也可以使用其他通常用于本发明制品的可饮用酸，如乳酸。也可以使用可饮用酸的混合物。
在优选实施方案中，酸性组合物以天然果汁，如黑醋栗汁制备的浓缩液为基础，例如增香的糖浆浓缩液。钙可以以适宜的形式添加到浓缩液中，再将所得的组合物制成固体或半固体。优选产品含有少量的糖或碳水化合物，或者是含有强甜味剂的低卡路里型产品。
口服组合物中可以含有镁或其他离子，作为附加的矿物质补充。还可以含有有效量的苹果酸或其可饮用的盐，以便保持钙的溶解性从而防止沉淀或将不溶性钙盐的沉淀减至最小。苹果酸的添加量可以为饮料总酸度的10％，其余的酸度可以由其他的、优选是天然存在的酸如柠檬酸或抗坏血酸提供。
本发明可以应用到以浓缩液为基础的产品中，特别是含有黑醋栗汁或提取物，或添加维生素的健康食品中。组合物的凝固采用已知的方法，如冷冻、蒸煮、胶凝或通过形成固体或半固体乳化物或凝胶来实现。在标准的糖食教材，如E.B.Jackson的“糖食生产”(第2版)中可以找到适宜的配制技术。
本发明特别适用于含有天然或添加柠檬酸的产品。产品可以不增甜或用糖或强甜味剂，如糖精、门冬氨酰苯基丙氨酰甲基酯，或本领域已知的其他甜味剂增甜。产品还可以含有其他的常规添加剂，如苯甲酸钠、山梨酸、酸式偏亚硫酸钠、抗坏血酸、风味剂和着色剂。
该产品可以按常规方法将各成分混合制得。如果需要，在添加到其他成分之前，可以先将各成分溶解在水或热水中。通常浓缩液要经过巴氏消毒。
本发明由下面的实施例举例说明：
实施例1
一开始将下面的成分混合制得浓缩产品。
最后，将碳酸钙添加到其他成分中。浓缩黑醋栗汁 SG 1.27 84升天冬氨酰苯基丙氨酰甲基酯* 1.15Kg乙酰舒泛K 1.8Kg抗坏血酸 0.8Kg苯甲酸钠 0.325Kg酸式偏亚硫酸钠 0.145Kg黑醋栗调味剂 0.3升水 加至最终体积为1000升碳酸钙 4.2Kg
*以天冬甜素(RTM)出售
钙∶酸的摩尔比为0.5
用氢氧化钠溶液将浓缩液的pH值调节到3.7。按如下方法对浓缩制剂进行体外平测法试验。在37℃下将平板状牙釉质部分暴露于pH为3.85的测试溶液(用水稀释浓液5倍)中30分钟。以物理测量在此过程中损失的釉质深度来评价腐蚀力。而对照制剂含有14mM柠檬酸，pH值为3.2，结果损失了4微米釉质，另一个对照例为含有14mM柠檬酸，pH 3.85的制剂，损失了1.8微米，经过调节pH值并添加钙的试验制剂包括14mM柠檬酸，7mM钙，pH值为3.85，只损失了0.17微米的釉质。由此证明了本发明的功效。
此溶液或稀释前的浓缩液可以按下面实施例5或6凝固。
实施例2
将下面的成分混合制备溶液：
成分 ％w/v
苯甲酸钠 0.01
苹果酸 0.30
风味剂 0.1
人造甜味剂 0.05
水 补差 99.5
氢氧化钙 0.083
所得组合物的pH一般为3.85，钙与酸的摩尔比为0.5。可以按下面的实施例5或6将此溶液凝固。
按如下方法对浓缩配剂进行体外平测法试验。在37℃下将平板状牙釉质部分暴露于测试溶液30分钟。物理测量在此过程中损失的釉质深度，来评价腐蚀力。对照制剂不添加氢氧化钙，pH值为2.5，结果损失8.1微米釉质，另一个对照制剂用氢氧化钠将pH值提高到3.85，损失1.65微米，而本文上面详述的组合物仅损失了0.6微米釉质，表明了其在减少牙齿腐蚀方面的功效。
实施例3
将下面的成分混合制备溶液：
成分 ％w/w
糖 10
苯甲酸钠 0.01
橙汁 5.04
抗坏血酸 0.03
柠檬酸一水合物 0.15
风味剂 0.005
着色剂 0.004
水 补差 86
碳酸钙 0.048
氢氧化钠 足以将pH值调整到 3.9
二氧化碳 0.48
在此溶液中，钙∶酸的摩尔比为0.46(橙汁通常为1％w/w柠檬酸)。
然后将该溶液按下面所述的实施例5或6凝固。
实施例4
将下面的成分混合制备溶液：成分 ％w/w糖 8苯甲酸钠 0.01苹果汁 10抗坏血酸 0.03苹果酸 0.15风味剂 0.005着色剂 0.004水 补差 82碳酸钙 0.093氢氧化钠 足以将pH值调整到 3.9
在此溶液中，钙∶酸的摩尔比为0.74(苹果汁通常为0.6％w/w苹果酸)。然后将该溶液按下面所述的实施例5或6凝固。
实施例5
凝固技术
可以通过冷冻将浓缩液凝固，如在低于-5℃的温度下，优选在-20℃左右的温度下冷冻。可以将溶液蒸煮，如煮10分钟，直至到达固化点，然后冷却，如果需要的话进行模制。可以加入溶解的粉末明胶(按厂商的说明)使产品凝固。
实施例6
黑醋栗果冻
成分 克
葡萄糖浆 564
明胶190块状 93
水 152
浓缩液(如实施例1) 191
方法
将葡萄糖浆煮至85％固体，将明胶浸于热水中使其溶解。将明胶溶液和浓缩液加入到葡萄糖浆溶液中。将混合物于玉米粉中模制，放置过夜。
实施例7
干粉橙味运动饮料
用螺旋叶片混合器将各成分干混在一起直到得到均匀的混合物。然后将产品装入适宜的包装中，如小袋，罐或桶中。
成分 kg
葡萄糖一水合物 389.12
麦芽糖糊精 523.37
天冬甜素 0.58
乙酰舒泛K 0.37
柠檬酸三钠 16.54
氯化钠 9.34
柠檬酸 36.97
抗坏血酸 1.17
柠檬酸钾 2.33
碳酸钙 11.46
橙味香精 2.92
β-胡萝卜素(1％) 5.84
总计 1000.00kg
将50g粉末溶解在500ml水中制得橙味运动饮料。
该饮料的pH值为4，钙与酸的摩尔比为0.6。
实施例8
干粉低卡路里橙味运动饮料
用螺旋叶片混合器将各成分干混在一起，直到获得均匀的混合物。然后将产品装入适宜的包装中，如小袋、罐或桶中。
成分 kg
麦芽糖糊精 129.52
天冬甜素 30.73
乙酰舒泛K 9.77
柠檬酸三钠 153.07
氯化钠 59.81
柠檬酸 353.23
抗坏血酸 27.55
柠檬酸钾 21.55
碳酸钙 109.50
橙味香精 35.09
β-胡萝卜素(1％) 70.18
总计 1000.00kg
将4g粉末溶解在500ml水中，制得低卡路里橙味运动饮料。该饮料的pH值为4，钙与酸的摩尔比为0.6。
Claims (18)
1.一种固体或半固体的口服组合物，含有钙化合物和酸化剂，其特征在于组合物中钙含量为0.3-0.65mol/mol酸，钙和酸化剂的比例经过选择，以使组合物的有效pH值为3.5-4.5。
2.权利要求1的组合物，其中钙的含量为0.3-0.55mol/mol酸。
3.权利要求1的组合物，其中钙的含量为至少0.4mol/mol酸。
4.权利要求1-3任一项的组合物，其中组合物的有效pH值不大于4。
5.权利要求4的组合物，其中的有效pH值为3.7-3.9。
6.权利要求1的组合物，其中的酸是柠檬酸、苹果酸或乳酸或它们的混合物。
7.权利要求1的组合物，其中的钙化合物是碳酸钙、氢氧化钙、柠檬酸钙、苹果酸钙、乳酸钙、氯化钙、甘油磷酸钙或甲酸钙。
8.权利要求1的组合物，该组合物是一种甜味品。
9.权利要求8的组合物，其中的甜味品是锭剂。
10.权利要求1的组合物，该组合物是口服保健组合物。
11.钙在制造口服施用的、含有钙化合物和酸化剂的固体或半固体组合物中，为减弱酸引起的牙齿腐蚀作用的用途，其中钙在组合物中的含量为0.3-0.8mol/mol酸，组合物中钙和酸化剂的量经过选择，以使组合物的有效pH值为3.5-4.5。
12.权利要求11的用途，其中钙的存在量为0.3-0.75mol/mol酸。
13.权利要求11的用途，其中钙的存在量为0.3-0.65mol/mol酸。
14.权利要求11的用途，其中钙的存在量为0.3-0.55mol/mol酸。
15.权利要求11的用途，其中钙的存在量为至少0.4mol/mol酸。
16.权利要求11-15任一项权利要求的用途，其中组合物的有效pH值不大于4。
17.权利要求16的用途，其中的有效pH值为3.7-3.9。
18.一种制备含钙化合物和酸化剂的固体或半固体组合物的方法，该组合物其特征在于，钙的含量为0.3-0.65mol/mol酸，组合物的有效pH值为3.5-4.5，该方法包括将钙化合物与酸化剂混合，要使钙的存在量为0.3-0.65mol/mol酸，并通过在该组合物中加入碱而使该组合物有效pH值达3.5-4.5。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9717598.8 | 1997-08-19 | ||
| GBGB9717598.8A GB9717598D0 (en) | 1997-08-19 | 1997-08-19 | Novel composition and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1276705A CN1276705A (zh) | 2000-12-13 |
| CN1114361C true CN1114361C (zh) | 2003-07-16 |
Family
ID=10817742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98810242A Expired - Fee Related CN1114361C (zh) | 1997-08-19 | 1998-08-11 | 减轻对牙齿腐蚀的固体组合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6383473B1 (zh) |
| EP (1) | EP1006816B1 (zh) |
| JP (2) | JP2001515019A (zh) |
| KR (1) | KR100516038B1 (zh) |
| CN (1) | CN1114361C (zh) |
| AR (1) | AR016824A1 (zh) |
| AT (1) | ATE360374T1 (zh) |
| AU (1) | AU738343B2 (zh) |
| BR (1) | BR9811914B1 (zh) |
| CA (1) | CA2301136C (zh) |
| CO (1) | CO4960655A1 (zh) |
| CY (1) | CY1107684T1 (zh) |
| CZ (1) | CZ299644B6 (zh) |
| DE (1) | DE69837668T2 (zh) |
| DK (1) | DK1006816T3 (zh) |
| EA (1) | EA002972B1 (zh) |
| ES (1) | ES2285783T3 (zh) |
| GB (1) | GB9717598D0 (zh) |
| HK (1) | HK1028526A1 (zh) |
| HU (1) | HUP0003056A3 (zh) |
| MY (1) | MY118918A (zh) |
| NZ (1) | NZ502631A (zh) |
| PL (1) | PL338710A1 (zh) |
| PT (1) | PT1006816E (zh) |
| UA (1) | UA65581C2 (zh) |
| WO (1) | WO1999008550A1 (zh) |
| ZA (1) | ZA987420B (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9603518D0 (en) * | 1996-02-20 | 1996-04-17 | Smithkline Beecham Plc | Novel process |
| GB9819530D0 (en) | 1998-09-09 | 1998-10-28 | Smithkline Beecham Plc | Novel compositions and use |
| US10470985B2 (en) | 1999-11-12 | 2019-11-12 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US6685920B2 (en) | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US20040146466A1 (en) | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US6447754B1 (en) * | 2000-01-24 | 2002-09-10 | Akpharma Inc. | Oral rinse methods and compositions |
| GB0007421D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Plc | Novel use |
| GB0018849D0 (en) * | 2000-08-01 | 2000-09-20 | Smithkline Beecham Plc | Novel composition and use |
| EP1657984A1 (en) * | 2003-07-31 | 2006-05-24 | Shannon Minerals Ltd. | Ready-to-drink formulation containing an active ingredient |
| US7927640B2 (en) | 2004-02-02 | 2011-04-19 | Delavau Llc | Calcium fortification of bread dough |
| US7169417B2 (en) * | 2004-02-02 | 2007-01-30 | Delavau Llc | Calcium fortification of bread dough |
| JP2008507480A (ja) | 2004-07-23 | 2008-03-13 | トムス グルッペン エー／エス | 唾液中における浸食可能性のない酸性固形口腔用組成物および唾液中の浸食可能性を測定する方法 |
| GB0506015D0 (en) * | 2005-03-23 | 2005-04-27 | Glaxo Group Ltd | Novel use |
| US20070237855A1 (en) * | 2006-04-05 | 2007-10-11 | Cadbury Adams Usa Llc | Calcium phosphate complex in acid containing confectionery |
| US20090162490A1 (en) * | 2007-12-20 | 2009-06-25 | Tropicana Products, Inc. | Calcium-fortified beverages and method of making thereof |
| DE102008014225A1 (de) * | 2008-03-16 | 2009-09-17 | MEDERER Süßwarenvertriebs GmbH | Remineralisierende Zahnpflegemittel und Verfahren zu deren Herstellung |
| DE102008014227A1 (de) * | 2008-03-16 | 2009-10-01 | Nova Dentalia Zahnpflege Gmbh | Remineralisierende Speichelersatzmittel und Verfahren zu deren Herstellung |
| AU2010292276B2 (en) | 2009-09-11 | 2014-07-17 | The Procter & Gamble Company | Methods and compositions for hydrophobic modification of oral cavity surfaces |
| US10123953B2 (en) | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
| JP2019189532A (ja) * | 2018-04-18 | 2019-10-31 | 青木 文夫 | ビタミンｃ混合物 |
| EP3958983A1 (en) | 2019-04-26 | 2022-03-02 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
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| US4851221A (en) * | 1985-02-19 | 1989-07-25 | Mission Pharmacal Company | Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid |
| US5028446A (en) * | 1987-07-31 | 1991-07-02 | Kraft General Foods, Inc. | Process for making calcium beverages containing rapidly solubilized calcium fumarate |
| WO1997030601A1 (en) * | 1996-02-20 | 1997-08-28 | Smithkline Beecham Plc | Liquid oral compositions comprising a calcium compound and an acidulant |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE332342C (sv) | 1968-12-04 | 1972-11-13 | Astra Home Prod Ab | Pulverdryckblandning |
| IE42129B1 (en) * | 1974-10-10 | 1980-06-04 | Procter & Gamble | Compositions for remineralizing tooth enamel |
| US4551342A (en) | 1983-02-01 | 1985-11-05 | The Procter & Gamble Company | Beverages containing specific cation-edible acid mixtures for improved flavor impression |
| US4737375A (en) * | 1985-12-26 | 1988-04-12 | The Procter & Gamble Company | Beverages and beverage concentrates nutritionally supplemented with calcium |
| US4722847A (en) | 1986-05-07 | 1988-02-02 | The Procter & Gamble Company | Fruit juice beverages and juice concentrates nutritionally supplemented with calcium |
| US4830862A (en) | 1987-07-31 | 1989-05-16 | The Procter & Gamble Company | Calcium-supplemented beverages and beverage concentrates containing low levels of sulfate |
| GB2207335A (en) | 1987-07-31 | 1989-02-01 | Procter & Gamble | Calcium-supplemented beverages and beverage concentrates containing low levels of chloride |
| US5108761A (en) * | 1990-10-01 | 1992-04-28 | The Procter & Gamble Company | Method of preventing tooth enamel erosion utilizing an acidic beverage containing calcium |
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| ATE198122T1 (de) | 1992-10-21 | 2001-01-15 | Procter & Gamble | Konzentrierte, bioverfügbare kalziumquelle |
| EP0634110A3 (en) * | 1993-07-08 | 1995-02-01 | Eckes Ag | Fluid food. |
| US5424082A (en) | 1994-03-03 | 1995-06-13 | The Proctor & Gamble Company | Calcium and vitamin C containing beverage products with improved color stability |
| US5474793A (en) | 1994-05-10 | 1995-12-12 | Meyer; Larry E. | Process for preparing calcium-supplemented not-from-concentrate fruit juice beverages |
| US5500232A (en) | 1994-10-06 | 1996-03-19 | Bristol-Myers Squibb Company | Calcium fortified beverages |
| TW323330B (zh) | 1994-10-17 | 1997-12-21 | Toshiba Co Ltd | |
| US5817351A (en) | 1995-04-07 | 1998-10-06 | Abbott Laboratories | Calcium fortified low pH beverage |
| US5597595A (en) | 1995-04-07 | 1997-01-28 | Abbott Laboratories | Low pH beverage fortified with calcium and vitamin D |
| GB9525290D0 (en) | 1995-12-11 | 1996-02-07 | Whittle Brian A | Nutritional compositions |
| AU4083597A (en) | 1996-09-27 | 1998-04-17 | Enamelon, Inc. | Improved products and methods for the remineralization and prevention of demineralization of teeth |
| US6159448A (en) | 1996-09-27 | 2000-12-12 | Enamelon, Inc. | Products and methods for the remineralization and prevention of demineralization of teeth |
-
1997
- 1997-08-19 GB GBGB9717598.8A patent/GB9717598D0/en active Pending
-
1998
- 1998-08-11 EP EP98947428A patent/EP1006816B1/en not_active Expired - Lifetime
- 1998-08-11 AU AU94351/98A patent/AU738343B2/en not_active Ceased
- 1998-08-11 CN CN98810242A patent/CN1114361C/zh not_active Expired - Fee Related
- 1998-08-11 DK DK98947428T patent/DK1006816T3/da active
- 1998-08-11 CA CA2301136A patent/CA2301136C/en not_active Expired - Fee Related
- 1998-08-11 DE DE69837668T patent/DE69837668T2/de not_active Expired - Lifetime
- 1998-08-11 BR BRPI9811914-1A patent/BR9811914B1/pt not_active IP Right Cessation
- 1998-08-11 KR KR10-2000-7001583A patent/KR100516038B1/ko not_active IP Right Cessation
- 1998-08-11 PT PT98947428T patent/PT1006816E/pt unknown
- 1998-08-11 HU HU0003056A patent/HUP0003056A3/hu unknown
- 1998-08-11 JP JP2000509306A patent/JP2001515019A/ja not_active Withdrawn
- 1998-08-11 NZ NZ502631A patent/NZ502631A/en not_active IP Right Cessation
- 1998-08-11 PL PL98338710A patent/PL338710A1/xx unknown
- 1998-08-11 CZ CZ20000589A patent/CZ299644B6/cs not_active IP Right Cessation
- 1998-08-11 US US09/485,898 patent/US6383473B1/en not_active Expired - Lifetime
- 1998-08-11 WO PCT/EP1998/005119 patent/WO1999008550A1/en active IP Right Grant
- 1998-08-11 AT AT98947428T patent/ATE360374T1/de active
- 1998-08-11 ES ES98947428T patent/ES2285783T3/es not_active Expired - Lifetime
- 1998-08-11 EA EA200000142A patent/EA002972B1/ru not_active IP Right Cessation
- 1998-08-17 MY MYPI98003729A patent/MY118918A/en unknown
- 1998-08-18 ZA ZA9807420A patent/ZA987420B/xx unknown
- 1998-08-18 CO CO98046965A patent/CO4960655A1/es unknown
- 1998-08-18 AR ARP980104069A patent/AR016824A1/es unknown
- 1998-11-08 UA UA2000020917A patent/UA65581C2/uk unknown
-
2000
- 2000-11-21 HK HK00107442A patent/HK1028526A1/xx not_active IP Right Cessation
-
2002
- 2002-01-17 US US10/051,846 patent/US20020090347A1/en not_active Abandoned
-
2007
- 2007-06-22 CY CY20071100837T patent/CY1107684T1/el unknown
-
2008
- 2008-09-05 JP JP2008228352A patent/JP2009062370A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851221A (en) * | 1985-02-19 | 1989-07-25 | Mission Pharmacal Company | Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid |
| US5028446A (en) * | 1987-07-31 | 1991-07-02 | Kraft General Foods, Inc. | Process for making calcium beverages containing rapidly solubilized calcium fumarate |
| WO1997030601A1 (en) * | 1996-02-20 | 1997-08-28 | Smithkline Beecham Plc | Liquid oral compositions comprising a calcium compound and an acidulant |
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