CN111417654B - 具有增加的对于表皮生长因子受体的亲和力的抗体及其衍生片段 - Google Patents
具有增加的对于表皮生长因子受体的亲和力的抗体及其衍生片段 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2017000148A CU24558B1 (es) | 2017-11-28 | 2017-11-28 | Anticuerpos monoclonales que reconocen al receptor del factor de crecimiento epidérmico y sus fragmentos derivados |
| CU2017-0148 | 2017-11-28 | ||
| PCT/CU2018/050004 WO2019105492A1 (es) | 2017-11-28 | 2018-11-20 | Anticuerpos de afinidad incrementada por el receptor del factor de crecimiento epidérmico y sus fragmentos derivados |
Publications (2)
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| CN111417654A CN111417654A (zh) | 2020-07-14 |
| CN111417654B true CN111417654B (zh) | 2023-11-10 |
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| EP (1) | EP3719037A1 (es) |
| JP (1) | JP7396992B2 (es) |
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| AU (1) | AU2018377764B2 (es) |
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| EA (1) | EA202091328A1 (es) |
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| SG (1) | SG11202004746VA (es) |
| TW (1) | TWI820058B (es) |
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| ZA (1) | ZA202003866B (es) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054609C (zh) * | 1994-11-18 | 2000-07-19 | 分子免疫中心 | 识别表皮生长因子受体的人源化和嵌合体单克隆抗体 |
| CN104530237A (zh) * | 2014-12-31 | 2015-04-22 | 百泰生物药业有限公司 | 抗Her1的治疗性抗体 |
| WO2017017133A1 (en) * | 2015-07-27 | 2017-02-02 | Innocimab Pte Ltd | Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using using monoclonal antibodies against the epidermal growth factor receptor (egfr) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070108270A (ko) | 2005-02-28 | 2007-11-08 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 술폰아미드 화합물의 신규 병용 |
| EP2190878A1 (en) * | 2007-09-06 | 2010-06-02 | Genmab A/S | Novel methods and antibodies for treating cancer |
| JP6121904B2 (ja) * | 2010-09-08 | 2017-04-26 | ハロザイム インコーポレイテッド | 条件的活性治療用タンパク質を評価および同定する、または発展させる方法 |
| US8691231B2 (en) * | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| CN104379602B (zh) | 2012-03-08 | 2017-05-03 | 哈洛齐梅公司 | 具有条件活性的抗表皮生长因子受体抗体及其使用方法 |
| NZ705910A (en) | 2012-10-12 | 2018-09-28 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| EP3134437A1 (en) | 2014-04-23 | 2017-03-01 | Board of Regents, The University of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| CN108025084B (zh) | 2015-06-22 | 2024-08-09 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc） |
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2017
- 2017-11-28 CU CU2017000148A patent/CU24558B1/es unknown
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2018
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- 2018-11-27 AR ARP180103458A patent/AR113843A1/es unknown
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054609C (zh) * | 1994-11-18 | 2000-07-19 | 分子免疫中心 | 识别表皮生长因子受体的人源化和嵌合体单克隆抗体 |
| CN104530237A (zh) * | 2014-12-31 | 2015-04-22 | 百泰生物药业有限公司 | 抗Her1的治疗性抗体 |
| WO2017017133A1 (en) * | 2015-07-27 | 2017-02-02 | Innocimab Pte Ltd | Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using using monoclonal antibodies against the epidermal growth factor receptor (egfr) |
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| Talavera 等.Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation.Cancer Research.2009,第69卷(第14期),5851-5859. * |
| 于礼 ; 梁米芳 ; .基因工程抗体亲和力成熟研究进展.中国医药生物技术.2012,第07卷(第04期),286-289. * |
| 张娜 ; 李平 ; .尼妥珠单抗在肿瘤疾病中的应用.实用医学杂志.2011,第27卷(第03期),533-534. * |
| 盛唯瑾 ; 尚伯杨 ; 苗庆芳 ; 甄永苏 ; .抗表皮生长因子受体的单链抗体ER(Fv)的构建及其抗肿瘤活性研究.中国药学杂志.2011,第46卷(第18期),1393-1398. * |
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| AU2018377764A1 (en) | 2020-07-09 |
| BR112020010075A2 (pt) | 2020-10-13 |
| NZ765527A (en) | 2024-02-23 |
| CN111417654A (zh) | 2020-07-14 |
| KR102708617B1 (ko) | 2024-09-25 |
| JP7396992B2 (ja) | 2023-12-12 |
| CU20170148A7 (es) | 2019-07-04 |
| EA202091328A1 (ru) | 2020-09-17 |
| TWI820058B (zh) | 2023-11-01 |
| KR20200090236A (ko) | 2020-07-28 |
| JP2021504484A (ja) | 2021-02-15 |
| TW201932485A (zh) | 2019-08-16 |
| AR113843A1 (es) | 2020-06-17 |
| ZA202003866B (en) | 2022-06-29 |
| AU2018377764B2 (en) | 2022-09-29 |
| EP3719037A1 (en) | 2020-10-07 |
| SG11202004746VA (en) | 2020-06-29 |
| MX2020005490A (es) | 2020-09-03 |
| US11718676B2 (en) | 2023-08-08 |
| WO2019105492A1 (es) | 2019-06-06 |
| CA3082759A1 (en) | 2019-06-06 |
| CU24558B1 (es) | 2021-12-08 |
| US20210002375A1 (en) | 2021-01-07 |
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