EA202091328A1 - Антитела с повышенной аффинностью к рецептору эпидермального фактора роста и происходящие из них фрагменты - Google Patents
Антитела с повышенной аффинностью к рецептору эпидермального фактора роста и происходящие из них фрагментыInfo
- Publication number
- EA202091328A1 EA202091328A1 EA202091328A EA202091328A EA202091328A1 EA 202091328 A1 EA202091328 A1 EA 202091328A1 EA 202091328 A EA202091328 A EA 202091328A EA 202091328 A EA202091328 A EA 202091328A EA 202091328 A1 EA202091328 A1 EA 202091328A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- present
- fragments
- egfr
- growth factor
- disclosed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем изобретении предложены новые антитела (AT) и фрагменты, которые распознают внеклеточную область рецептора эпидермального фактора роста человека (hEGFR) с более высокой аффинностью, чем AT нимотузумаб, что позволяет более эффективно распознавать линии со средней экспрессией EGFR. Настоящее изобретение также относится к фармацевтическим композициям, содержащим в качестве активного начала раскрытые в настоящем изобретении AT и их фрагменты, и к их применению при лечении опухолей с экспрессией EGFR. Кроме того, настоящее изобретение относится к применению раскрытых в настоящей заявке AT и фрагментов, связанных с радиоизотопом или флуорофором, для локализации EGFR-положительных опухолей. Кроме того, раскрытые в настоящем изобретении AT и их фрагменты могут быть применены для направления иммунного ответа на EGFR-положительные опухолевые клетки при их слиянии с белком или белковыми доменами, представляющими иммунологический интерес.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2017000148A CU24558B1 (es) | 2017-11-28 | 2017-11-28 | Anticuerpos monoclonales que reconocen al receptor del factor de crecimiento epidérmico y sus fragmentos derivados |
| PCT/CU2018/050004 WO2019105492A1 (es) | 2017-11-28 | 2018-11-20 | Anticuerpos de afinidad incrementada por el receptor del factor de crecimiento epidérmico y sus fragmentos derivados |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202091328A1 true EA202091328A1 (ru) | 2020-09-17 |
Family
ID=64959051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202091328A EA202091328A1 (ru) | 2017-11-28 | 2018-11-20 | Антитела с повышенной аффинностью к рецептору эпидермального фактора роста и происходящие из них фрагменты |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11718676B2 (ru) |
| EP (1) | EP3719037A1 (ru) |
| JP (1) | JP7396992B2 (ru) |
| KR (1) | KR20200090236A (ru) |
| CN (1) | CN111417654B (ru) |
| AR (1) | AR113843A1 (ru) |
| AU (1) | AU2018377764B2 (ru) |
| BR (1) | BR112020010075A2 (ru) |
| CA (1) | CA3082759A1 (ru) |
| CU (1) | CU24558B1 (ru) |
| EA (1) | EA202091328A1 (ru) |
| MX (1) | MX2020005490A (ru) |
| NZ (1) | NZ765527A (ru) |
| SG (1) | SG11202004746VA (ru) |
| TW (1) | TWI820058B (ru) |
| WO (1) | WO2019105492A1 (ru) |
| ZA (1) | ZA202003866B (ru) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| PT1859793E (pt) * | 2005-02-28 | 2011-07-05 | Eisai R&D Man Co Ltd | Uso combinado inovador de um composto de sulfonamida no tratamento oncológico |
| EP2190878A1 (en) * | 2007-09-06 | 2010-06-02 | Genmab A/S | Novel methods and antibodies for treating cancer |
| WO2012033953A1 (en) * | 2010-09-08 | 2012-03-15 | Halozyme, Inc. | Methods for assessing and identifying or evolving conditionally active therapeutic proteins |
| US8691231B2 (en) * | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| CN104379602B (zh) * | 2012-03-08 | 2017-05-03 | 哈洛齐梅公司 | 具有条件活性的抗表皮生长因子受体抗体及其使用方法 |
| TR201902494T4 (tr) * | 2012-10-12 | 2019-03-21 | Medimmune Ltd | Pirrolobenzodiazepinler ve onların konjugatları. |
| CN106459924A (zh) * | 2014-04-23 | 2017-02-22 | 得克萨斯州大学系统董事会 | 用于疗法中的嵌合抗原受体(car)及其制备方法 |
| CN104530237B (zh) * | 2014-12-31 | 2017-09-05 | 百泰生物药业有限公司 | 抗Her1的治疗性抗体 |
| SG10201908685QA (en) * | 2015-06-22 | 2019-10-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| US20180221478A1 (en) * | 2015-07-27 | 2018-08-09 | Innocimab Pte Ltd | Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using using monoclonal antibodies against the epidermal growth factor receptor (egfr) |
-
2017
- 2017-11-28 CU CU2017000148A patent/CU24558B1/es unknown
-
2018
- 2018-11-20 CN CN201880077704.5A patent/CN111417654B/zh active Active
- 2018-11-20 CA CA3082759A patent/CA3082759A1/en active Pending
- 2018-11-20 KR KR1020207018489A patent/KR20200090236A/ko not_active Application Discontinuation
- 2018-11-20 EA EA202091328A patent/EA202091328A1/ru unknown
- 2018-11-20 SG SG11202004746VA patent/SG11202004746VA/en unknown
- 2018-11-20 MX MX2020005490A patent/MX2020005490A/es unknown
- 2018-11-20 JP JP2020547282A patent/JP7396992B2/ja active Active
- 2018-11-20 AU AU2018377764A patent/AU2018377764B2/en active Active
- 2018-11-20 BR BR112020010075-7A patent/BR112020010075A2/pt unknown
- 2018-11-20 NZ NZ765527A patent/NZ765527A/en unknown
- 2018-11-20 WO PCT/CU2018/050004 patent/WO2019105492A1/es unknown
- 2018-11-20 EP EP18830130.3A patent/EP3719037A1/en active Pending
- 2018-11-20 US US16/767,356 patent/US11718676B2/en active Active
- 2018-11-26 TW TW107142095A patent/TWI820058B/zh active
- 2018-11-27 AR ARP180103458A patent/AR113843A1/es unknown
-
2020
- 2020-06-25 ZA ZA2020/03866A patent/ZA202003866B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20210002375A1 (en) | 2021-01-07 |
| TW201932485A (zh) | 2019-08-16 |
| TWI820058B (zh) | 2023-11-01 |
| BR112020010075A2 (pt) | 2020-10-13 |
| CU24558B1 (es) | 2021-12-08 |
| MX2020005490A (es) | 2020-09-03 |
| JP7396992B2 (ja) | 2023-12-12 |
| JP2021504484A (ja) | 2021-02-15 |
| NZ765527A (en) | 2024-02-23 |
| ZA202003866B (en) | 2022-06-29 |
| AU2018377764A1 (en) | 2020-07-09 |
| CU20170148A7 (es) | 2019-07-04 |
| CA3082759A1 (en) | 2019-06-06 |
| CN111417654A (zh) | 2020-07-14 |
| AU2018377764B2 (en) | 2022-09-29 |
| CN111417654B (zh) | 2023-11-10 |
| AR113843A1 (es) | 2020-06-17 |
| US11718676B2 (en) | 2023-08-08 |
| WO2019105492A1 (es) | 2019-06-06 |
| KR20200090236A (ko) | 2020-07-28 |
| EP3719037A1 (en) | 2020-10-07 |
| SG11202004746VA (en) | 2020-06-29 |
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