CN111394204A - Antibacterial medicated soap and preparation method thereof - Google Patents

Abstract

The invention discloses an antibacterial medicated soap and a preparation method thereof, wherein the antibacterial medicated soap is prepared from the following components in parts by weight: 70-75% of soap base, 12-16% of honeysuckle, 10-14% of dyers woad leaf and 1-2% of sulfur. The preparation method comprises ultrasonic pulverizing, heating and extracting, reflux-extracting with ethanol to obtain effective components of flos Lonicerae and folium Isatidis, mixing with sulfur, adding into soap base containing water, stirring, solidifying in mold, and press-molding. The antibacterial medicated soap has good antibacterial, sterilizing and disinfecting capabilities.

Description

Antibacterial medicated soap and preparation method thereof

Technical Field

The invention relates to a medicated soap, in particular to an antibacterial medicated soap and a preparation method thereof.

Background

Beginning in the spring festival of 2020 to the month 3, the presence and propagation of new types of coronavirus has disconcerted many people.

In response to this sudden public health event, government agencies have had more publicity regarding the health concerns of people. For example, to prevent viral transmission, three things are done to effectively block bacteria:

the mask is worn on the face of people during hand washing, ventilation and going out.

The most prominent form of bacterial transmission is droplet transmission, such as talking, sneezing, coughing, etc., so hand washing is particularly important in addition to wearing a mask and ventilating. Soap is typically used for hand washing.

With the development of epidemic situations, the requirements of people on soap are continuously improved. At present, soaps used by people are all composed of chemical components and have no antibacterial effect.

Disclosure of Invention

In view of the above, the present invention aims to provide an antibacterial medicated soap and a preparation method thereof, wherein the antibacterial medicated soap has good antibacterial, bactericidal and disinfection capabilities.

The adopted technical scheme is as follows:

an antibacterial medicated soap is prepared from the following components in parts by weight: 70-75% of soap base, 12-16% of honeysuckle, 10-14% of dyers woad leaf and 1-2% of sulfur.

Further, the sulfur is 1%.

Further, the antibacterial medicinal soap is prepared from the following components in parts by weight: 75% of soap base, 14% of honeysuckle, 10% of dyers woad leaf and 1% of sulfur.

The preparation method of the antibacterial medicated soap comprises the following steps:

s1, adding 3-4 times of volume of water into mechanically crushed honeysuckle and folium isatidis, performing ultrasonic crushing, heating and extracting, and heating to 95-100 ℃ after crushing by an ultrasonic crusher, and extracting for 1-2 hours; filtering to obtain an extracting solution A and filter residues, adding 80-85% ethanol which is 2-3 times of the total volume of the filter residues, refluxing and extracting for 1-2 hours, filtering, removing the ethanol under reduced pressure to obtain an extracting solution B, uniformly mixing the extracting solution A and the extracting solution B, and concentrating to obtain a concentrated solution;

s2, mixing the concentrated solution prepared in the step S1 with sulfur, adding the mixture into a water-containing soap base, stirring the mixture to be uniform and fully, solidifying the mixture in a mold, and then pressing and molding the mixture.

Further, the particle size of the sulfur is 1-5 μm.

In the invention, the honeysuckle has the functions of resisting pathogenic microorganisms, bacteria and viruses.

In vitro experiments show that the honeysuckle decoction and the alcohol immersion liquid have certain inhibition effects on various gram positive and negative bacteria such as staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, pneumonia bacillus, meningococcus, typhoid bacillus, paratyphoid bacillus, escherichia coli, dysentery bacillus, proteus bacillus, pertussis bacillus, pseudomonas aeruginosa, mycobacterium tuberculosis, vibrio cholerae and the like.

For a description of this in vitro experiment see

http://www.zhongyoo.com/name/j i nyi nhua_634.html

In the invention, the dyers woad leaf has the functions of resisting pathogenic microorganisms, resisting bacteria and resisting viruses.

In vitro experiments show that the folium isatidis decoction has a certain inhibition effect on staphylococcus aureus, streptococcus A, meningococcus, streptococcus pneumoniae, typhoid bacillus, bacillus influenzae, corynebacterium diphtheriae and dysentery bacillus. Folium Isatidis also has inhibitory effect on Japanese encephalitis virus, mumps virus, and influenza virus. In addition, folium Isatidis has effect of killing leptospira.

For a description of this in vitro experiment see

https://www.pchouse.com.cn/bai ke/decorate/1112/155801.html

Therefore, the effective components of the honeysuckle and the indigowoad leaf traditional Chinese medicine can be extracted more fully by adopting ultrasonic crushing, heating and extraction and ethanol reflux extraction, and the efficacy of the traditional Chinese medicine is fully exerted.

Then, the soap base is used as a carrier, so that the drug ingredients can be favorably fully absorbed by water and be dissolved into the soap base under the condition of not damaging the drug effect of the traditional Chinese medicine, and the drug effect of the traditional Chinese medicine can be greatly improved under the assistance of the soap base.

Sulfur is a mineral substance, is acidic and warm in nature, enters kidney and large intestine channels, and has the effects of killing parasites and relieving itching by external application. It is recorded in Shen nong Ben Cao Jing (Shen nong's herbal) for the earliest time, and listed as the 3 rd position of Chinese herbs, and can treat more than 10 kinds of diseases. The emperor's Zhu protocol of the Ming Jian Wen has been preserved with sulfur spring water for ten years.

Sulfur is a multifunctional agent, and has effects of killing mite and killing parasite besides antibacterial effect. It is used for preventing and treating plant diseases and insect pests, and is safe to human and livestock, and is not easy to produce chemical injury to crops.

In the invention, the sulfur has better disinfection and sterilization effects.

The sulfur may be sublimed sulfur or precipitated sulfur. Sublimed sulfur, also known as sulfur bloom, contacts skin and tissues to generate sulfide under the action of secretion, thereby softening and sterilizing the skin. The settled sulfur is also called sulfur emulsion, and can generate hydrogen sulfide and pentathiosulfonic acid under the action of secretion when contacting with skin, and has the functions of sterilizing and killing scabies.

Therefore, the concentrated solution is mixed with sulfur and added into the soap base containing water, so that the sulfur, the honeysuckle and the dyers woad leaf are cooperatively born on the soap base, and the antibacterial, sterilizing and disinfecting synergistic effects of the antibacterial medical soap can be exerted, thereby enhancing the disease resistance of the skin.

The amount of sulfur is preferably 1% by weight of the whole formulation.

In conclusion, the antibacterial medical soap has good antibacterial, sterilizing and disinfecting capabilities. Meanwhile, the soap base has a cleaning function.

Detailed Description

The present invention is described in detail below with reference to specific examples, but the use and purpose of these exemplary embodiments are merely to exemplify the present invention, and do not set forth any limitation on the actual scope of the present invention in any form, and the scope of the present invention is not limited thereto.

Example 1

An antibacterial medicated soap is prepared from the following components in parts by weight: 75% of soap base, 12% of honeysuckle, 12% of dyers woad leaf and 1% of sulfur.

The preparation method of the antibacterial medicated soap comprises the following steps:

s1, adding 3-4 times of volume of water into mechanically crushed honeysuckle and folium isatidis, performing ultrasonic crushing, heating and extracting, and heating to 95-100 ℃ after crushing by an ultrasonic crusher, and extracting for 1-2 hours; filtering to obtain an extracting solution A and filter residues, adding 80-85% ethanol which is 2-3 times of the total volume of the filter residues, refluxing and extracting for 1-2 hours, filtering, removing the ethanol under reduced pressure to obtain an extracting solution B, uniformly mixing the extracting solution A and the extracting solution B, and concentrating to obtain a concentrated solution;

s2, mixing the concentrated solution prepared in the step S1 with sulfur with the particle size of 1-5 mu m, adding the mixture into a water-containing soap base, stirring the mixture fully and uniformly, solidifying the mixture in a mold, and then pressing and molding the mixture.

Example 2

Referring to example 1, unlike example 1, the antibacterial medical soap of this example is made of the following components in weight ratio: 75% of soap base, 14% of honeysuckle, 10% of dyers woad leaf and 1% of sulfur.

Example 3

Referring to example 1, unlike example 1, the antibacterial medical soap of this example is made of the following components in weight ratio: 75% of soap base, 13% of honeysuckle, 11% of dyers woad leaf and 1% of sulfur.

Example 4

In order to prove the effect of the antibacterial medicated soap, the following pharmacological tests are carried out:

the antibacterial medical soap of example 2 was first rubbed with warm water to form an antibacterial medical soap rubbing solution, colonies of gonococcus, staphylococcus aureus, staphylococcus albus, bacillus, escherichia coli, and pathogenic fungi were placed in the antibacterial medical soap rubbing solution for one minute, inoculated, and cultured in a 37 ℃ incubator (22 ℃ and 35 ℃ for fungi) for 24 hours, 48 hours, and 72 hours, and no bacterial growth was observed. Placing the treponema pallidum in antibacterial soap scrubbing solution, and performing smear microscopy after 2 minutes to show that the treponema pallidum loses activity.

And (4) test conclusion: can effectively inhibit treponema pallidum within 2 minutes, and can kill gonococcus, staphylococcus aureus, staphylococcus albus, bacillus, escherichia coli and most pathogenic fungi within 1 minute.

Therefore, the antibacterial medicated soap has good antibacterial, sterilizing and disinfecting capabilities.

The above-listed detailed description is only a specific description of a possible embodiment of the present invention, and they are not intended to limit the scope of the present invention, and equivalent embodiments or modifications made without departing from the technical spirit of the present invention should be included in the scope of the present invention.

Claims (5)

1. The antibacterial medicated soap is characterized by being prepared from the following components in parts by weight: 70-75% of soap base, 12-16% of honeysuckle, 10-14% of dyers woad leaf and 1-2% of sulfur.

2. The antibacterial medicated soap of claim 1, wherein the sulfur is 1%.

3. The antibacterial medicated soap according to claim 2, which is prepared from the following components in parts by weight: 75% of soap base, 14% of honeysuckle, 10% of dyers woad leaf and 1% of sulfur.

4. A method of making an antibacterial medicated soap as claimed in any one of claims 1 to 3 comprising the steps of:

s1, adding 3-4 times of volume of water into mechanically crushed honeysuckle and folium isatidis, performing ultrasonic crushing, heating and extracting, and heating to 95-100 ℃ after crushing by an ultrasonic crusher, and extracting for 1-2 hours; filtering to obtain an extracting solution A and filter residues, adding 80-85% ethanol which is 2-3 times of the total volume of the filter residues, refluxing and extracting for 1-2 hours, filtering, removing the ethanol under reduced pressure to obtain an extracting solution B, uniformly mixing the extracting solution A and the extracting solution B, and concentrating to obtain a concentrated solution;

s2, mixing the concentrated solution prepared in the step S1 with sulfur, adding the mixture into a water-containing soap base, stirring the mixture to be uniform and fully, solidifying the mixture in a mold, and then pressing and molding the mixture.

5. The method for preparing antibacterial medicated soap according to claim 4, wherein the particle size of the sulfur is 1 to 5 μm.