CN111373026A - 用于基因测序的流路装置、其工作方法及其测序仪 - Google Patents

用于基因测序的流路装置、其工作方法及其测序仪 Download PDF

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Publication number
CN111373026A
CN111373026A CN201780081700.XA CN201780081700A CN111373026A CN 111373026 A CN111373026 A CN 111373026A CN 201780081700 A CN201780081700 A CN 201780081700A CN 111373026 A CN111373026 A CN 111373026A
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pipeline
reagent
sequencing
sample introduction
bypass
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CN111373026B (zh
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隋相坤
邢楚填
王妍
梁埈模
布莱恩·基思·豪泽尔
朱里奥·福卡拉奇
刘健
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MGI Tech Co Ltd
Complete Genomics Inc
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Complete Genomics Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/04Apparatus for enzymology or microbiology with gas introduction means

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Abstract

本发明涉及一种用于基因测序的流路装置及其工作方法、以及含有该流路装置的测序仪。该用于基因测序的流路装置包括试剂供应系统,该试剂供应系统包括:进样管道,用于供应试剂,该试剂包括第一试剂和第二试剂;测序管道,该测序管道与该进样管道相连通;旁路管道,该旁路管道与该进样管道相连通,且与该测序管道并联连接;以及换路部件,用于连接该进样管道、该测序管道和该旁路管道。当该测序管道充满该第一试剂时,将气体、该第二试剂依序输入该进样管道,该第二试剂的输入使该进样管道内的气体全部排入该旁路管道,再将该第二试剂经由该进样管道、该换路部件,进入该测序管道,以将该第一试剂替代为该第二试剂。

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PCT国内申请,说明书已公开。

Claims (13)

  1. PCT国内申请,权利要求书已公开。
CN201780081700.XA 2017-11-30 2017-11-30 用于基因测序的流路装置、其工作方法及其测序仪 Active CN111373026B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115870027A (zh) * 2023-02-13 2023-03-31 深圳赛陆医疗科技有限公司 流体系统、分析仪器及流体输送方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4036203A4 (en) * 2019-09-24 2023-07-05 MGI Tech Co., Ltd. FLUID TRANSPORT SYSTEM AND METHOD AND FLUID USE DEVICE APPLICATION SYSTEM AND METHOD

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206573A (zh) * 2011-03-22 2011-10-05 博奥生物有限公司 用于微阵列芯片的自动进样装置及自动进样杂交微阵列芯片
CN102590537A (zh) * 2012-02-29 2012-07-18 福州大学 催化剂及材料的评价系统
US20150060303A1 (en) * 2012-03-29 2015-03-05 Fraunhofer-Gesellschaft Zur Foerderung Der Angewan Forschung E.V. Integrated disposable chip cartridge system for mobile multiparameter analyses of chemical and/or biological substances
CN105733936A (zh) * 2014-12-12 2016-07-06 深圳华大基因研究院 基因测序仪
CN106199032A (zh) * 2016-06-30 2016-12-07 南京润泽流体控制设备有限公司 无交叉污染的进样装置及其控制方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105199951B (zh) * 2015-10-27 2016-11-16 北京中科紫鑫科技有限责任公司 一种dna测序仪的供液系统
CN105385589B (zh) * 2015-11-02 2016-08-31 北京中科紫鑫科技有限责任公司 一种泵阀选择试剂的箱式dna测序仪

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206573A (zh) * 2011-03-22 2011-10-05 博奥生物有限公司 用于微阵列芯片的自动进样装置及自动进样杂交微阵列芯片
CN102590537A (zh) * 2012-02-29 2012-07-18 福州大学 催化剂及材料的评价系统
US20150060303A1 (en) * 2012-03-29 2015-03-05 Fraunhofer-Gesellschaft Zur Foerderung Der Angewan Forschung E.V. Integrated disposable chip cartridge system for mobile multiparameter analyses of chemical and/or biological substances
CN105733936A (zh) * 2014-12-12 2016-07-06 深圳华大基因研究院 基因测序仪
CN106199032A (zh) * 2016-06-30 2016-12-07 南京润泽流体控制设备有限公司 无交叉污染的进样装置及其控制方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115870027A (zh) * 2023-02-13 2023-03-31 深圳赛陆医疗科技有限公司 流体系统、分析仪器及流体输送方法
CN115870027B (zh) * 2023-02-13 2023-09-29 深圳赛陆医疗科技有限公司 流体系统、分析仪器及流体输送方法

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