CN111356464A - 使用动物双歧杆菌乳亚种治疗癌症的组合物及方法 - Google Patents

使用动物双歧杆菌乳亚种治疗癌症的组合物及方法 Download PDF

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Publication number
CN111356464A
CN111356464A CN201880057669.0A CN201880057669A CN111356464A CN 111356464 A CN111356464 A CN 111356464A CN 201880057669 A CN201880057669 A CN 201880057669A CN 111356464 A CN111356464 A CN 111356464A
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carcinoma
mag
cancer
leukemia
bifidobacterium animalis
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Chinese (zh)
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P.桑迪
J.帕普科夫
M.西佐瓦
B.古曼
H.加纳
H.波尼奇特拉
H.吴
W.卡弗里
A.杜塔
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Epiva Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880057669.0A 2017-07-05 2018-07-05 使用动物双歧杆菌乳亚种治疗癌症的组合物及方法 Pending CN111356464A (zh)

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US201762528669P 2017-07-05 2017-07-05
US62/528669 2017-07-05
PCT/US2018/040841 WO2019010255A1 (en) 2017-07-05 2018-07-05 COMPOSITIONS AND METHODS FOR TREATING CANCER USING BIFIDOBACTERIUM ANIMALIS SSP. LACTIS

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EP (1) EP3648780A1 (enExample)
JP (1) JP7254786B2 (enExample)
KR (1) KR102563191B1 (enExample)
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AR (1) AR112328A1 (enExample)
AU (1) AU2018298087A1 (enExample)
BR (1) BR112019028301A2 (enExample)
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112618577A (zh) * 2020-12-15 2021-04-09 深圳君拓生物科技有限公司 动物双歧杆菌在提高肿瘤免疫治疗应答中的作用
CN113368259A (zh) * 2021-06-22 2021-09-10 海南大学 一种基于修饰细菌加载纳米药物的方法及其复合物和在治疗结肠癌中的应用
CN114480229A (zh) * 2022-04-15 2022-05-13 微康益生菌(苏州)股份有限公司 一种动物双歧杆菌乳亚种菌株wkb148及其产品与应用
CN115216423A (zh) * 2022-06-15 2022-10-21 南昌大学 一种动物双歧杆菌sf及其在医药和食品中的应用
CN115363094A (zh) * 2021-11-30 2022-11-22 内蒙古伊利实业集团股份有限公司 乳双歧杆菌bl-99在预防和/或改善胃炎中的应用
CN117327632A (zh) * 2023-12-01 2024-01-02 四川厌氧生物科技有限责任公司 一种动物双歧杆菌及其应用
CN117417866A (zh) * 2023-10-27 2024-01-19 江南大学 一种产胆盐水解酶的动物双歧杆菌及其在新生儿黄疸中的应用
CN121046519A (zh) * 2025-11-05 2025-12-02 中国食品发酵工业研究院有限公司 动物双歧杆菌乳亚种bl-99的活菌定量检测方法及其引物、探针、试剂盒与应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
WO2016196605A1 (en) * 2015-06-01 2016-12-08 The University Of Chicago Treatment of cancer by manipulation of commensal microflora
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
IL265109B2 (en) 2016-09-13 2024-05-01 Allergan Inc Stabilized non-protein clostridial toxin compositions
JP7212945B2 (ja) 2017-05-22 2023-01-26 フォーディー ファーマ リサーチ リミテッド 細菌株を含む組成物
TW201907931A (zh) 2017-05-24 2019-03-01 英商4D製藥研究有限公司 包含細菌菌株之組合物
WO2018229188A1 (en) 2017-06-14 2018-12-20 4D Pharma Research Limited Compositions comprising bacterial strains
MD3804737T2 (ro) 2017-06-14 2022-10-31 4D Pharma Res Limited Compoziții care conțin tulpini bacteriene
CN115813955A (zh) 2017-06-14 2023-03-21 4D制药研究有限公司 包含细菌菌株的组合物
TW201906620A (zh) 2017-07-05 2019-02-16 美商艾弗洛生物科技股份有限公司 使用動物雙岐桿菌乳亞種 (bifidobacterium animalis ssp. lactis) 治療癌症之組合物及方法
EP3768285A1 (en) 2018-03-19 2021-01-27 4D Pharma Research Limited Compositions comprising bacterial strains
CA3106139A1 (en) 2018-07-16 2020-01-23 4D Pharma Research Limited Compositions comprising bacterial strains
MA54161A (fr) 2018-12-12 2022-03-23 4D Pharma Res Ltd Compositions comprenant des souches bactériennes parabacteroides pour le traitement du cancer
WO2020252144A1 (en) * 2019-06-11 2020-12-17 Evelo Biosciences, Inc. Secreted microbial extracellular vesicles
WO2021022110A1 (en) 2019-08-01 2021-02-04 Evelo Biosciences, Inc. Inducing immune effects using bacteria of the genus bifidobacterium
KR102357904B1 (ko) * 2019-10-29 2022-02-04 경희대학교 산학협력단 항암용 금 나노입자
US20240124905A1 (en) * 2021-01-26 2024-04-18 Cb Therapeutics, Inc. Recombinant Polyprenol Diphosphate Synthases
TW202304415A (zh) * 2021-04-08 2023-02-01 美商艾弗洛生物科技股份有限公司 含有細菌的藥物製劑
US20230096810A1 (en) * 2021-09-24 2023-03-30 Johnson & Johnson Consumer Inc. Dosage forms for the delivery of a probiotic
CN114028432A (zh) * 2021-11-05 2022-02-11 上海市第十人民医院 双歧杆菌提升铂类化疗药物敏感性的药物新用途
WO2025071560A1 (en) * 2023-09-28 2025-04-03 Rutgers, The State University Of New Jersey Methods of diagnosing b cell malignancies, detecting b cell malignancy relapse, and treating thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224851A (zh) * 2014-08-15 2014-12-24 任发政 动物双歧杆菌乳酸亚种CGMCC No.9273的应用
CN106110322A (zh) * 2016-07-29 2016-11-16 安徽瀚海博兴生物技术有限公司 一种药物组合物及其在制备治疗癌症药物中的应用
WO2016196605A1 (en) * 2015-06-01 2016-12-08 The University Of Chicago Treatment of cancer by manipulation of commensal microflora

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID29150A (id) 1999-01-15 2001-08-02 Entpr Ireland Cs Penggunaan lactobacillus salivarius
US20030092163A1 (en) 2001-07-26 2003-05-15 Collins John Kevin Probiotic bifidobacterium strains
GB0307026D0 (en) 2003-03-27 2003-04-30 Rowett Res Inst Bacterial supplement
EP1481681A1 (en) 2003-05-30 2004-12-01 Claudio De Simone Lactic acid bacteria combination and compositions thereof
JP4683881B2 (ja) 2003-08-27 2011-05-18 有限会社アーク技研 抗腫瘍活性剤
GB0323039D0 (en) 2003-10-01 2003-11-05 Danisco Method
EP1714660A1 (en) 2005-04-21 2006-10-25 N.V. Nutricia Uronic acid and probiotics
WO2007140613A1 (en) 2006-06-06 2007-12-13 Mcgill University Fermented milk product and use thereof
US20080069861A1 (en) 2006-09-19 2008-03-20 National Starch And Chemical Investment Holding Corporation Probiotic/Non-Probiotic Combinations
EP1920782A1 (en) 2006-11-10 2008-05-14 Glycotope Gmbh Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof
RU2473681C2 (ru) 2007-03-28 2013-01-27 Элиментари Хелт Лимитед ПРОБИОТИЧЕСКИЙ ШТАММ Bifidobacterium longum, КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ТАКОЙ ШТАММ, И ЕГО ПРИМЕНЕНИЕ
RU2466185C2 (ru) 2007-03-28 2012-11-10 Элиментари Хелт Лимитед ПРОБИОТИЧЕСКИЙ ШТАММ Bifidobacterium longum, ПРОБИОТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЯ ШТАММА Bifidobacterium longum
EP1997907A1 (en) 2007-06-01 2008-12-03 Friesland Brands B.V. Bifidobacteria
HUP0700552A2 (en) 2007-08-27 2009-03-30 Janos Dr Feher Method and composition inhibiting inflammation
ES2431572T3 (es) 2007-10-20 2013-11-27 Université de Liège Especies bifidobacterianas
WO2009149149A1 (en) 2008-06-04 2009-12-10 Trustees Of Dartmouth College Prevention or treatment of immune-relevant disease by modification of microfloral populations
RU2546251C2 (ru) 2009-11-11 2015-04-10 Алиментари Хелс Лимитед Пробиотический штамм бифидобактерий
WO2012142605A1 (en) 2011-04-15 2012-10-18 Samaritan Health Services Rapid recolonization deployment agent
AU2014239883B2 (en) * 2013-03-14 2019-01-17 Therabiome, Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
EP3033091B1 (en) 2013-08-16 2022-09-07 Versitech Limited Probiotic composition and use thereof in the prevention and treatment of hepatocellular carcinoma
WO2015038731A1 (en) 2013-09-12 2015-03-19 The Johns Hopkins University Biofilm formation to define risk for colon cancer
EP2876167A1 (en) 2013-11-21 2015-05-27 Institut Gustave Roussy Microbiota composition, as a marker of responsiveness to chemotherapy, and use of microbial modulators (pre-,pro- or synbiotics) for improving the efficacy of a cancer treatment
CA2946463A1 (en) 2014-05-05 2015-11-12 Giovanni Mogna Therapy for use in the treatment of tumors, acquired immunodeficiency syndrome and leukemias by dual immune biostimulation
MA41020A (fr) 2014-11-25 2017-10-03 Evelo Biosciences Inc Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome
KR102735818B1 (ko) 2015-01-23 2024-11-28 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 암 예방에서 단쇄 지방산의 용도
WO2016172658A2 (en) 2015-04-23 2016-10-27 Kaleido Biosciences, Inc. Microbiome regulators and related uses thereof
EP3964234A1 (en) 2015-04-23 2022-03-09 Kaleido Biosciences, Inc. Glycan therapeutics and methods of treatment
MD3650033T2 (ro) 2015-06-15 2022-08-31 4D Pharma Res Ltd Compoziții conţinând tulpini bacteriene
TW201906620A (zh) 2017-07-05 2019-02-16 美商艾弗洛生物科技股份有限公司 使用動物雙岐桿菌乳亞種 (bifidobacterium animalis ssp. lactis) 治療癌症之組合物及方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224851A (zh) * 2014-08-15 2014-12-24 任发政 动物双歧杆菌乳酸亚种CGMCC No.9273的应用
WO2016196605A1 (en) * 2015-06-01 2016-12-08 The University Of Chicago Treatment of cancer by manipulation of commensal microflora
CN106110322A (zh) * 2016-07-29 2016-11-16 安徽瀚海博兴生物技术有限公司 一种药物组合物及其在制备治疗癌症药物中的应用

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022127789A1 (zh) * 2020-12-15 2022-06-23 深圳君拓生物科技有限公司 动物双歧杆菌在提高肿瘤免疫治疗应答中的作用
CN112618577A (zh) * 2020-12-15 2021-04-09 深圳君拓生物科技有限公司 动物双歧杆菌在提高肿瘤免疫治疗应答中的作用
CN113368259A (zh) * 2021-06-22 2021-09-10 海南大学 一种基于修饰细菌加载纳米药物的方法及其复合物和在治疗结肠癌中的应用
CN113368259B (zh) * 2021-06-22 2022-07-22 海南大学 一种基于修饰细菌加载纳米药物的方法及其复合物和在治疗结肠癌中的应用
CN115363094A (zh) * 2021-11-30 2022-11-22 内蒙古伊利实业集团股份有限公司 乳双歧杆菌bl-99在预防和/或改善胃炎中的应用
CN114480229A (zh) * 2022-04-15 2022-05-13 微康益生菌(苏州)股份有限公司 一种动物双歧杆菌乳亚种菌株wkb148及其产品与应用
CN114480229B (zh) * 2022-04-15 2022-08-09 微康益生菌(苏州)股份有限公司 一种动物双歧杆菌乳亚种菌株wkb148及其产品与应用
CN115216423A (zh) * 2022-06-15 2022-10-21 南昌大学 一种动物双歧杆菌sf及其在医药和食品中的应用
CN117417866A (zh) * 2023-10-27 2024-01-19 江南大学 一种产胆盐水解酶的动物双歧杆菌及其在新生儿黄疸中的应用
CN117417866B (zh) * 2023-10-27 2026-02-27 江南大学 一种产胆盐水解酶的动物双歧杆菌及其在新生儿黄疸中的应用
CN117327632A (zh) * 2023-12-01 2024-01-02 四川厌氧生物科技有限责任公司 一种动物双歧杆菌及其应用
CN117327632B (zh) * 2023-12-01 2024-02-13 四川厌氧生物科技有限责任公司 一种动物双歧杆菌及其应用
CN121046519A (zh) * 2025-11-05 2025-12-02 中国食品发酵工业研究院有限公司 动物双歧杆菌乳亚种bl-99的活菌定量检测方法及其引物、探针、试剂盒与应用

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JP7254786B2 (ja) 2023-04-10
CA3068757A1 (en) 2019-01-10
AR112328A1 (es) 2019-10-16
US20190192585A1 (en) 2019-06-27
BR112019028301A2 (pt) 2020-07-14
US10576111B2 (en) 2020-03-03
KR20200024911A (ko) 2020-03-09
US20190224253A1 (en) 2019-07-25
MA51770A (fr) 2020-05-13
US20210093680A1 (en) 2021-04-01
TW201906620A (zh) 2019-02-16
AU2018298087A1 (en) 2020-01-23
JP2020526581A (ja) 2020-08-31
KR102563191B1 (ko) 2023-08-02
WO2019010255A1 (en) 2019-01-10
EP3648780A1 (en) 2020-05-13
US10792314B2 (en) 2020-10-06

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