BR112019028301A2 - composições e métodos para tratar câncer com o uso de bifidobacterium animalis ssp. lactis - Google Patents

Info

Publication number

BR112019028301A2

BR112019028301A2 BR112019028301-3A BR112019028301A BR112019028301A2 BR 112019028301 A2 BR112019028301 A2 BR 112019028301A2 BR 112019028301 A BR112019028301 A BR 112019028301A BR 112019028301 A2 BR112019028301 A2 BR 112019028301A2

Authority

BR

Brazil

Prior art keywords

carcinoma

fact

cancer

lactis

mage

Prior art date

2017-07-05

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 title claims abstract description 164
• 238000000034 method Methods 0.000 title claims abstract description 132
• 241001134770 Bifidobacterium animalis Species 0.000 title claims abstract description 120
• 229940118852 bifidobacterium animalis Drugs 0.000 title claims abstract description 119
• 206010028980 Neoplasm Diseases 0.000 title claims description 131
• 201000011510 cancer Diseases 0.000 title claims description 73
• -1 bulatacinone Natural products 0.000 claims description 205
• 230000001580 bacterial effect Effects 0.000 claims description 130
• 108090000623 proteins and genes Proteins 0.000 claims description 85
• 241000894006 Bacteria Species 0.000 claims description 72
• 125000003729 nucleotide group Chemical group 0.000 claims description 69
• 239000000427 antigen Substances 0.000 claims description 67
• 239000002773 nucleotide Substances 0.000 claims description 66
• 201000009030 Carcinoma Diseases 0.000 claims description 64
• 108091007433 antigens Proteins 0.000 claims description 60
• 102000036639 antigens Human genes 0.000 claims description 60
• 102000004169 proteins and genes Human genes 0.000 claims description 48
• 230000001332 colony forming effect Effects 0.000 claims description 42
• 102000019034 Chemokines Human genes 0.000 claims description 39
• 108010012236 Chemokines Proteins 0.000 claims description 39
• 102000037865 fusion proteins Human genes 0.000 claims description 38
• 108020001507 fusion proteins Proteins 0.000 claims description 38
• 210000004027 cell Anatomy 0.000 claims description 34
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 32
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 32
• 239000003446 ligand Substances 0.000 claims description 29
• 150000007523 nucleic acids Chemical class 0.000 claims description 28
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims description 27
• 230000027455 binding Effects 0.000 claims description 27
• 208000032839 leukemia Diseases 0.000 claims description 27
• 102100034256 Mucin-1 Human genes 0.000 claims description 25
• 102100032368 Coiled-coil domain-containing protein 110 Human genes 0.000 claims description 24
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 24
• 102000039446 nucleic acids Human genes 0.000 claims description 24
• 108020004707 nucleic acids Proteins 0.000 claims description 24
• 102000005962 receptors Human genes 0.000 claims description 24
• 108020003175 receptors Proteins 0.000 claims description 24
• 206010039491 Sarcoma Diseases 0.000 claims description 23
• 239000003795 chemical substances by application Substances 0.000 claims description 23
• 229920001542 oligosaccharide Polymers 0.000 claims description 22
• 150000001720 carbohydrates Chemical class 0.000 claims description 21
• 230000001900 immune effect Effects 0.000 claims description 21
• 102100023635 Alpha-fetoprotein Human genes 0.000 claims description 20
• 230000008859 change Effects 0.000 claims description 20
• QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical compound O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 claims description 20
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 19
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 19
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 18
• 108020004459 Small interfering RNA Proteins 0.000 claims description 18
• 229950009268 zinostatin Drugs 0.000 claims description 18
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 17
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 17
• 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 17
• 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 17
• 229920001184 polypeptide Polymers 0.000 claims description 17
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 17
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 16
• 101000868824 Homo sapiens Coiled-coil domain-containing protein 110 Proteins 0.000 claims description 16
• 101000620554 Homo sapiens Ras-related protein Rab-38 Proteins 0.000 claims description 16
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 16
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 16
• 108060008487 Myosin Proteins 0.000 claims description 16
• 102000003505 Myosin Human genes 0.000 claims description 16
• 102100022305 Ras-related protein Rab-38 Human genes 0.000 claims description 16
• 102000003425 Tyrosinase Human genes 0.000 claims description 16
• 108060008724 Tyrosinase Proteins 0.000 claims description 16
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 16
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 16
• 230000001225 therapeutic effect Effects 0.000 claims description 16
• 102100021533 Kita-kyushu lung cancer antigen 1 Human genes 0.000 claims description 15
• 102100022430 Melanocyte protein PMEL Human genes 0.000 claims description 15
• 239000002671 adjuvant Substances 0.000 claims description 15
• 238000009169 immunotherapy Methods 0.000 claims description 15
• BTOTXLJHDSNXMW-POYBYMJQSA-N 2,3-dideoxyuridine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(=O)NC(=O)C=C1 BTOTXLJHDSNXMW-POYBYMJQSA-N 0.000 claims description 14
• 238000011275 oncology therapy Methods 0.000 claims description 14
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 13
• 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims description 13
• 102100040247 Tumor necrosis factor Human genes 0.000 claims description 13
• 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims description 12
• 238000002619 cancer immunotherapy Methods 0.000 claims description 12
• 239000012634 fragment Substances 0.000 claims description 12
• 230000014509 gene expression Effects 0.000 claims description 12
• 201000001441 melanoma Diseases 0.000 claims description 12
• 150000002482 oligosaccharides Chemical class 0.000 claims description 12
• 239000013598 vector Substances 0.000 claims description 12
• 206010009944 Colon cancer Diseases 0.000 claims description 11
• 102000004127 Cytokines Human genes 0.000 claims description 11
• 108090000695 Cytokines Proteins 0.000 claims description 11
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 11
• 229940022399 cancer vaccine Drugs 0.000 claims description 11
• 238000009566 cancer vaccine Methods 0.000 claims description 11
• 241000282414 Homo sapiens Species 0.000 claims description 10
• 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 10
• 102000013691 Interleukin-17 Human genes 0.000 claims description 10
• 108050003558 Interleukin-17 Proteins 0.000 claims description 10
• 102100023123 Mucin-16 Human genes 0.000 claims description 10
• 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 10
• 102100038358 Prostate-specific antigen Human genes 0.000 claims description 10
• 229930006000 Sucrose Natural products 0.000 claims description 10
• 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 10
• 230000003115 biocidal effect Effects 0.000 claims description 10
• 230000002950 deficient Effects 0.000 claims description 10
• 230000028993 immune response Effects 0.000 claims description 10
• 235000013406 prebiotics Nutrition 0.000 claims description 10
• 239000005720 sucrose Substances 0.000 claims description 10
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims description 9
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 9
• 108020004414 DNA Proteins 0.000 claims description 9
• 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims description 9
• 108010063954 Mucins Proteins 0.000 claims description 9
• 102000015728 Mucins Human genes 0.000 claims description 9
• 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims description 9
• 239000003242 anti bacterial agent Substances 0.000 claims description 9
• 150000001875 compounds Chemical class 0.000 claims description 9
• 230000000694 effects Effects 0.000 claims description 9
• 230000002519 immonomodulatory effect Effects 0.000 claims description 9
• 230000001965 increasing effect Effects 0.000 claims description 9
• 238000002560 therapeutic procedure Methods 0.000 claims description 9
• SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims description 8
• LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims description 8
• 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims description 8
• 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 claims description 8
• 102100021222 ATP-dependent Clp protease proteolytic subunit, mitochondrial Human genes 0.000 claims description 8
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 8
• 102100040069 Aldehyde dehydrogenase 1A1 Human genes 0.000 claims description 8
• 102100032959 Alpha-actinin-4 Human genes 0.000 claims description 8
• 101710115256 Alpha-actinin-4 Proteins 0.000 claims description 8
• 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims description 8
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims description 8
• 102100026596 Bcl-2-like protein 1 Human genes 0.000 claims description 8
• 102000015735 Beta-catenin Human genes 0.000 claims description 8
• 108060000903 Beta-catenin Proteins 0.000 claims description 8
• 241000186000 Bifidobacterium Species 0.000 claims description 8
• 108700012439 CA9 Proteins 0.000 claims description 8
• 101150034344 CT83 gene Proteins 0.000 claims description 8
• 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims description 8
• 102100039510 Cancer/testis antigen 2 Human genes 0.000 claims description 8
• 108010051152 Carboxylesterase Proteins 0.000 claims description 8
• 102000013392 Carboxylesterase Human genes 0.000 claims description 8
• 102100026548 Caspase-8 Human genes 0.000 claims description 8
• 108090000538 Caspase-8 Proteins 0.000 claims description 8
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims description 8
• 102100039361 Chondrosarcoma-associated gene 2/3 protein Human genes 0.000 claims description 8
• 102000011591 Cleavage And Polyadenylation Specificity Factor Human genes 0.000 claims description 8
• 108010076130 Cleavage And Polyadenylation Specificity Factor Proteins 0.000 claims description 8
• 102100024342 Contactin-2 Human genes 0.000 claims description 8
• 108010060267 Cyclin A1 Proteins 0.000 claims description 8
• 108010058546 Cyclin D1 Proteins 0.000 claims description 8
• 102100025176 Cyclin-A1 Human genes 0.000 claims description 8
• 102100038111 Cyclin-dependent kinase 12 Human genes 0.000 claims description 8
• 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims description 8
• 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims description 8
• 102100026245 E3 ubiquitin-protein ligase RNF43 Human genes 0.000 claims description 8
• 102100037238 E3 ubiquitin-protein ligase UBR4 Human genes 0.000 claims description 8
• 108010055191 EphA3 Receptor Proteins 0.000 claims description 8
• 102100030324 Ephrin type-A receptor 3 Human genes 0.000 claims description 8
• 102100028073 Fibroblast growth factor 5 Human genes 0.000 claims description 8
• 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims description 8
• 102100024405 GPI-linked NAD(P)(+)-arginine ADP-ribosyltransferase 1 Human genes 0.000 claims description 8
• 101710144640 GPI-linked NAD(P)(+)-arginine ADP-ribosyltransferase 1 Proteins 0.000 claims description 8
• 101710113436 GTPase KRas Proteins 0.000 claims description 8
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 8
• 102000010956 Glypican Human genes 0.000 claims description 8
• 108050001154 Glypican Proteins 0.000 claims description 8
• 108050007237 Glypican-3 Proteins 0.000 claims description 8
• 102100031493 Growth arrest-specific protein 7 Human genes 0.000 claims description 8
• 102100039317 HAUS augmin-like complex subunit 3 Human genes 0.000 claims description 8
• 108010036972 HLA-A11 Antigen Proteins 0.000 claims description 8
• 101000750222 Homo sapiens ATP-dependent Clp protease proteolytic subunit, mitochondrial Proteins 0.000 claims description 8
• 101000890570 Homo sapiens Aldehyde dehydrogenase 1A1 Proteins 0.000 claims description 8
• 101000765923 Homo sapiens Bcl-2-like protein 1 Proteins 0.000 claims description 8
• 101100059307 Homo sapiens CCDC110 gene Proteins 0.000 claims description 8
• 101000741445 Homo sapiens Calcitonin Proteins 0.000 claims description 8
• 101000932890 Homo sapiens Calcitonin gene-related peptide 1 Proteins 0.000 claims description 8
• 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 claims description 8
• 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims description 8
• 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims description 8
• 101000745414 Homo sapiens Chondrosarcoma-associated gene 2/3 protein Proteins 0.000 claims description 8
• 101000909516 Homo sapiens Contactin-2 Proteins 0.000 claims description 8
• 101000884345 Homo sapiens Cyclin-dependent kinase 12 Proteins 0.000 claims description 8
• 101000864646 Homo sapiens Dickkopf-related protein 1 Proteins 0.000 claims description 8
• 101000692702 Homo sapiens E3 ubiquitin-protein ligase RNF43 Proteins 0.000 claims description 8
• 101000807547 Homo sapiens E3 ubiquitin-protein ligase UBR4 Proteins 0.000 claims description 8
• 101001060267 Homo sapiens Fibroblast growth factor 5 Proteins 0.000 claims description 8
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 8
• 101000923044 Homo sapiens Growth arrest-specific protein 7 Proteins 0.000 claims description 8
• 101001035819 Homo sapiens HAUS augmin-like complex subunit 3 Proteins 0.000 claims description 8
• 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims description 8
• 101001027621 Homo sapiens Kinesin-like protein KIF20A Proteins 0.000 claims description 8
• 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 claims description 8
• 101001134060 Homo sapiens Melanocyte-stimulating hormone receptor Proteins 0.000 claims description 8
• 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims description 8
• 101001036406 Homo sapiens Melanoma-associated antigen C1 Proteins 0.000 claims description 8
• 101000978949 Homo sapiens NADP-dependent malic enzyme Proteins 0.000 claims description 8
• 101000588345 Homo sapiens Nuclear transcription factor Y subunit gamma Proteins 0.000 claims description 8
• 101000829725 Homo sapiens Phospholipid hydroperoxide glutathione peroxidase Proteins 0.000 claims description 8
• 101000610208 Homo sapiens Poly(A) polymerase gamma Proteins 0.000 claims description 8
• 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims description 8
• 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 claims description 8
• 101000877404 Homo sapiens Protein enabled homolog Proteins 0.000 claims description 8
• 101001067951 Homo sapiens Protein phosphatase 1 regulatory subunit 3B Proteins 0.000 claims description 8
• 101000842302 Homo sapiens Protein-cysteine N-palmitoyltransferase HHAT Proteins 0.000 claims description 8
• 101000613391 Homo sapiens Protocadherin beta-16 Proteins 0.000 claims description 8
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 8
• 101000591201 Homo sapiens Receptor-type tyrosine-protein phosphatase kappa Proteins 0.000 claims description 8
• 101001073409 Homo sapiens Retrotransposon-derived protein PEG10 Proteins 0.000 claims description 8
• 101000821981 Homo sapiens Sarcoma antigen 1 Proteins 0.000 claims description 8
• 101000665150 Homo sapiens Small nuclear ribonucleoprotein Sm D1 Proteins 0.000 claims description 8
• 101000665250 Homo sapiens Small nuclear ribonucleoprotein Sm D2 Proteins 0.000 claims description 8
• 101001056234 Homo sapiens Sperm mitochondrial-associated cysteine-rich protein Proteins 0.000 claims description 8
• 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 claims description 8
• 101000648075 Homo sapiens Trafficking protein particle complex subunit 1 Proteins 0.000 claims description 8
• 101000664703 Homo sapiens Transcription factor SOX-10 Proteins 0.000 claims description 8
• 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 claims description 8
• 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims description 8
• 102000000588 Interleukin-2 Human genes 0.000 claims description 8
• 108010002350 Interleukin-2 Proteins 0.000 claims description 8
• 102000004889 Interleukin-6 Human genes 0.000 claims description 8
• 108090001005 Interleukin-6 Proteins 0.000 claims description 8
• 102100037694 Kinesin-like protein KIF20A Human genes 0.000 claims description 8
• 102100031413 L-dopachrome tautomerase Human genes 0.000 claims description 8
• 101710093778 L-dopachrome tautomerase Proteins 0.000 claims description 8
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 8
• 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 claims description 8
• 102100030417 Matrilysin Human genes 0.000 claims description 8
• 108090000855 Matrilysin Proteins 0.000 claims description 8
• 102100034216 Melanocyte-stimulating hormone receptor Human genes 0.000 claims description 8
• 102100039447 Melanoma-associated antigen C1 Human genes 0.000 claims description 8
• 241001482085 Meloe Species 0.000 claims description 8
• 102100022913 NAD-dependent protein deacetylase sirtuin-2 Human genes 0.000 claims description 8
• 102100031719 Nuclear transcription factor Y subunit gamma Human genes 0.000 claims description 8
• 108060006580 PRAME Proteins 0.000 claims description 8
• 102000036673 PRAME Human genes 0.000 claims description 8
• 108050007154 PWWP domain-containing DNA repair factor 3A Proteins 0.000 claims description 8
• 102100034640 PWWP domain-containing DNA repair factor 3A Human genes 0.000 claims description 8
• 101710199379 Pituitary tumor-transforming gene 1 protein-interacting protein Proteins 0.000 claims description 8
• 102100040153 Poly(A) polymerase gamma Human genes 0.000 claims description 8
• 102100037686 Protein SSX2 Human genes 0.000 claims description 8
• 102100035093 Protein enabled homolog Human genes 0.000 claims description 8
• 102100034504 Protein phosphatase 1 regulatory subunit 3B Human genes 0.000 claims description 8
• 102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 claims description 8
• 108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 claims description 8
• 102100040927 Protocadherin beta-16 Human genes 0.000 claims description 8
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 8
• 102100034089 Receptor-type tyrosine-protein phosphatase kappa Human genes 0.000 claims description 8
• 102100037421 Regulator of G-protein signaling 5 Human genes 0.000 claims description 8
• 101710140403 Regulator of G-protein signaling 5 Proteins 0.000 claims description 8
• 102100035844 Retrotransposon-derived protein PEG10 Human genes 0.000 claims description 8
• 108700019345 SYT-SSX fusion Proteins 0.000 claims description 8
• 102100021466 Sarcoma antigen 1 Human genes 0.000 claims description 8
• 101710173693 Short transient receptor potential channel 1 Proteins 0.000 claims description 8
• 101710173694 Short transient receptor potential channel 2 Proteins 0.000 claims description 8
• 108010041216 Sirtuin 2 Proteins 0.000 claims description 8
• 102100038685 Small nuclear ribonucleoprotein Sm D2 Human genes 0.000 claims description 8
• 102100026503 Sperm mitochondrial-associated cysteine-rich protein Human genes 0.000 claims description 8
• 102100022441 Sperm surface protein Sp17 Human genes 0.000 claims description 8
• 108010002687 Survivin Proteins 0.000 claims description 8
• 108010017842 Telomerase Proteins 0.000 claims description 8
• 102100025256 Trafficking protein particle complex subunit 1 Human genes 0.000 claims description 8
• 102100038808 Transcription factor SOX-10 Human genes 0.000 claims description 8
• 102100033579 Trophoblast glycoprotein Human genes 0.000 claims description 8
• LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 claims description 8
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 8
• 239000002253 acid Substances 0.000 claims description 8
• 210000000612 antigen-presenting cell Anatomy 0.000 claims description 8
• 230000004069 differentiation Effects 0.000 claims description 8
• 230000012010 growth Effects 0.000 claims description 8
• 230000000968 intestinal effect Effects 0.000 claims description 8
• 229960005489 paracetamol Drugs 0.000 claims description 8
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 8
• 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims description 8
• 229920001282 polysaccharide Polymers 0.000 claims description 8
• 235000002020 sage Nutrition 0.000 claims description 8
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims description 8
• 102100026802 72 kDa type IV collagenase Human genes 0.000 claims description 7
• 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims description 7
• 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 claims description 7
• 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims description 7
• 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 claims description 7
• 102100031334 Elongation factor 2 Human genes 0.000 claims description 7
• 102100031546 HLA class II histocompatibility antigen, DO beta chain Human genes 0.000 claims description 7
• 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 7
• 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 7
• 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 claims description 7
• 101000971605 Homo sapiens Kita-kyushu lung cancer antigen 1 Proteins 0.000 claims description 7
• 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims description 7
• 101001057156 Homo sapiens Melanoma-associated antigen C2 Proteins 0.000 claims description 7
• 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims description 7
• 101000601724 Homo sapiens Paired box protein Pax-5 Proteins 0.000 claims description 7
• 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 7
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 7
• 108010074328 Interferon-gamma Proteins 0.000 claims description 7
• 102000000589 Interleukin-1 Human genes 0.000 claims description 7
• 108010002352 Interleukin-1 Proteins 0.000 claims description 7
• 102100027252 Melanoma-associated antigen C2 Human genes 0.000 claims description 7
• 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims description 7
• 108010008707 Mucin-1 Proteins 0.000 claims description 7
• 102100037504 Paired box protein Pax-5 Human genes 0.000 claims description 7
• 108010077519 Peptide Elongation Factor 2 Proteins 0.000 claims description 7
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 7
• 108700019889 TEL-AML1 fusion Proteins 0.000 claims description 7
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 7
• 150000004676 glycans Chemical class 0.000 claims description 7
• 210000002865 immune cell Anatomy 0.000 claims description 7
• 210000001616 monocyte Anatomy 0.000 claims description 7
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 7
• 239000005017 polysaccharide Substances 0.000 claims description 7
• 238000001959 radiotherapy Methods 0.000 claims description 7
• 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 7
• 101710151806 72 kDa type IV collagenase Proteins 0.000 claims description 6
• 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 claims description 6
• 239000002028 Biomass Substances 0.000 claims description 6
• 241000283690 Bos taurus Species 0.000 claims description 6
• 102100036850 C-C motif chemokine 23 Human genes 0.000 claims description 6
• 101150108242 CDC27 gene Proteins 0.000 claims description 6
• 102100034357 Casein kinase I isoform alpha Human genes 0.000 claims description 6
• 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 claims description 6
• 101000713081 Homo sapiens C-C motif chemokine 23 Proteins 0.000 claims description 6
• 101000994700 Homo sapiens Casein kinase I isoform alpha Proteins 0.000 claims description 6
• 101000619805 Homo sapiens Peroxiredoxin-5, mitochondrial Proteins 0.000 claims description 6
• 102000003814 Interleukin-10 Human genes 0.000 claims description 6
• 108090000174 Interleukin-10 Proteins 0.000 claims description 6
• 108010065805 Interleukin-12 Proteins 0.000 claims description 6
• 102000013462 Interleukin-12 Human genes 0.000 claims description 6
• 102000003816 Interleukin-13 Human genes 0.000 claims description 6
• 108090000176 Interleukin-13 Proteins 0.000 claims description 6
• 102100022078 Peroxiredoxin-5, mitochondrial Human genes 0.000 claims description 6
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 6
• 108010056708 bcr-abl Fusion Proteins Proteins 0.000 claims description 6
• 102000004441 bcr-abl Fusion Proteins Human genes 0.000 claims description 6
• 210000004443 dendritic cell Anatomy 0.000 claims description 6
• 239000003102 growth factor Substances 0.000 claims description 6
• 230000002401 inhibitory effect Effects 0.000 claims description 6
• 238000001990 intravenous administration Methods 0.000 claims description 6
• 210000004072 lung Anatomy 0.000 claims description 6
• 210000002540 macrophage Anatomy 0.000 claims description 6
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 6
• 230000001105 regulatory effect Effects 0.000 claims description 6
• 238000007920 subcutaneous administration Methods 0.000 claims description 6
• 102000004190 Enzymes Human genes 0.000 claims description 5
• 108090000790 Enzymes Proteins 0.000 claims description 5
• 102100021866 Hepatocyte growth factor Human genes 0.000 claims description 5
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims description 5
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 5
• 102100039897 Interleukin-5 Human genes 0.000 claims description 5
• 108010002616 Interleukin-5 Proteins 0.000 claims description 5
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 5
• 206010025323 Lymphomas Diseases 0.000 claims description 5
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims description 5
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 5
• 108010025020 Nerve Growth Factor Proteins 0.000 claims description 5
• 102100029268 Neurotrophin-3 Human genes 0.000 claims description 5
• 108091008606 PDGF receptors Proteins 0.000 claims description 5
• 241001494479 Pecora Species 0.000 claims description 5
• 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 claims description 5
• 102100033237 Pro-epidermal growth factor Human genes 0.000 claims description 5
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims description 5
• FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims description 5
• 230000004913 activation Effects 0.000 claims description 5
• 239000002246 antineoplastic agent Substances 0.000 claims description 5
• 229940127089 cytotoxic agent Drugs 0.000 claims description 5
• 239000002702 enteric coating Substances 0.000 claims description 5
• 238000009505 enteric coating Methods 0.000 claims description 5
• 229940088598 enzyme Drugs 0.000 claims description 5
• 210000003714 granulocyte Anatomy 0.000 claims description 5
• 239000003112 inhibitor Substances 0.000 claims description 5
• 108020004999 messenger RNA Proteins 0.000 claims description 5
• 229960000485 methotrexate Drugs 0.000 claims description 5
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims description 5
• 102100022987 Angiogenin Human genes 0.000 claims description 4
• 101800001382 Betacellulin Proteins 0.000 claims description 4
• 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims description 4
• 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims description 4
• 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims description 4
• 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims description 4
• 102100036845 C-C motif chemokine 22 Human genes 0.000 claims description 4
• 102100024210 CD166 antigen Human genes 0.000 claims description 4
• 241000283707 Capra Species 0.000 claims description 4
• 108010092160 Dactinomycin Proteins 0.000 claims description 4
• 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims description 4
• 241000282326 Felis catus Species 0.000 claims description 4
• 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims description 4
• 108090000381 Fibroblast growth factor 4 Proteins 0.000 claims description 4
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims description 4
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 4
• 235000010469 Glycine max Nutrition 0.000 claims description 4
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 4
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 4
• 108010041834 Growth Differentiation Factor 15 Proteins 0.000 claims description 4
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims description 4
• 101001002470 Homo sapiens Interferon lambda-1 Proteins 0.000 claims description 4
• 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 claims description 4
• 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims description 4
• 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 claims description 4
• 102100020990 Interferon lambda-1 Human genes 0.000 claims description 4
• 102100020989 Interferon lambda-2 Human genes 0.000 claims description 4
• 101710099622 Interferon lambda-2 Proteins 0.000 claims description 4
• 102000008070 Interferon-gamma Human genes 0.000 claims description 4
• 102000003815 Interleukin-11 Human genes 0.000 claims description 4
• 108090000177 Interleukin-11 Proteins 0.000 claims description 4
• 102000003812 Interleukin-15 Human genes 0.000 claims description 4
• 108090000172 Interleukin-15 Proteins 0.000 claims description 4
• 102100021596 Interleukin-31 Human genes 0.000 claims description 4
• 101710181613 Interleukin-31 Proteins 0.000 claims description 4
• 102000004388 Interleukin-4 Human genes 0.000 claims description 4
• 108090000978 Interleukin-4 Proteins 0.000 claims description 4
• 102100021592 Interleukin-7 Human genes 0.000 claims description 4
• 108010002586 Interleukin-7 Proteins 0.000 claims description 4
• 102000004890 Interleukin-8 Human genes 0.000 claims description 4
• 108090001007 Interleukin-8 Proteins 0.000 claims description 4
• 102100026871 Interleukin-9 Human genes 0.000 claims description 4
• 108010002335 Interleukin-9 Proteins 0.000 claims description 4
• 102100024144 Lengsin Human genes 0.000 claims description 4
• 101710113750 Lengsin Proteins 0.000 claims description 4
• 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 claims description 4
• 108090000742 Neurotrophin 3 Proteins 0.000 claims description 4
• 102000008108 Osteoprotegerin Human genes 0.000 claims description 4
• 108010035042 Osteoprotegerin Proteins 0.000 claims description 4
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 4
• 102100030304 Platelet factor 4 Human genes 0.000 claims description 4
• 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 4
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 4
• 101710104378 Putative malate oxidoreductase [NAD] Proteins 0.000 claims description 4
• 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims description 4
• 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims description 4
• 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 claims description 4
• 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 4
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 4
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims description 4
• 108010072788 angiogenin Proteins 0.000 claims description 4
• 230000002238 attenuated effect Effects 0.000 claims description 4
• 210000004556 brain Anatomy 0.000 claims description 4
• 230000003399 chemotactic effect Effects 0.000 claims description 4
• 229950009791 durvalumab Drugs 0.000 claims description 4
• 229960002949 fluorouracil Drugs 0.000 claims description 4
• CHPZKNULDCNCBW-UHFFFAOYSA-N gallium nitrate Chemical compound [Ga+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O CHPZKNULDCNCBW-UHFFFAOYSA-N 0.000 claims description 4
• 229960001101 ifosfamide Drugs 0.000 claims description 4
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims description 4
• 230000008595 infiltration Effects 0.000 claims description 4
• 238000001764 infiltration Methods 0.000 claims description 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 4
• 229940100601 interleukin-6 Drugs 0.000 claims description 4
• 229960001428 mercaptopurine Drugs 0.000 claims description 4
• 229960001156 mitoxantrone Drugs 0.000 claims description 4
• PVYJZLYGTZKPJE-UHFFFAOYSA-N streptonigrin Chemical compound C=1C=C2C(=O)C(OC)=C(N)C(=O)C2=NC=1C(C=1N)=NC(C(O)=O)=C(C)C=1C1=CC=C(OC)C(OC)=C1O PVYJZLYGTZKPJE-UHFFFAOYSA-N 0.000 claims description 4
• 229960003087 tioguanine Drugs 0.000 claims description 4
• 241000701161 unidentified adenovirus Species 0.000 claims description 4
• 239000013603 viral vector Substances 0.000 claims description 4
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
• 244000303258 Annona diversifolia Species 0.000 claims description 3
• 235000002198 Annona diversifolia Nutrition 0.000 claims description 3
• 108010074708 B7-H1 Antigen Proteins 0.000 claims description 3
• 102100028239 Basal cell adhesion molecule Human genes 0.000 claims description 3
• 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 claims description 3
• 102100022526 Bone morphogenetic protein 5 Human genes 0.000 claims description 3
• 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 3
• 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 3
• 102100025277 C-X-C motif chemokine 13 Human genes 0.000 claims description 3
• 241000282836 Camelus dromedarius Species 0.000 claims description 3
• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims description 3
• 102100038916 Caspase-5 Human genes 0.000 claims description 3
• 241000282693 Cercopithecidae Species 0.000 claims description 3
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 3
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 3
• 108010024212 E-Selectin Proteins 0.000 claims description 3
• 102100023471 E-selectin Human genes 0.000 claims description 3
• 101800003838 Epidermal growth factor Proteins 0.000 claims description 3
• 241000283074 Equus asinus Species 0.000 claims description 3
• 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims description 3
• 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 3
• 244000068988 Glycine max Species 0.000 claims description 3
• 241000282575 Gorilla Species 0.000 claims description 3
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 3
• 229920002907 Guar gum Polymers 0.000 claims description 3
• 102400001369 Heparin-binding EGF-like growth factor Human genes 0.000 claims description 3
• 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims description 3
• 108090001101 Hepsin Proteins 0.000 claims description 3
• 102000004989 Hepsin Human genes 0.000 claims description 3
• 101000741072 Homo sapiens Caspase-5 Proteins 0.000 claims description 3
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims description 3
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 3
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 3
• 102100037852 Insulin-like growth factor I Human genes 0.000 claims description 3
• 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 claims description 3
• 102000004883 Insulin-like growth factor-binding protein 6 Human genes 0.000 claims description 3
• 108090001014 Insulin-like growth factor-binding protein 6 Proteins 0.000 claims description 3
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 3
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 3
• 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims description 3
• 102100037850 Interferon gamma Human genes 0.000 claims description 3
• 102000003777 Interleukin-1 beta Human genes 0.000 claims description 3
• 108090000193 Interleukin-1 beta Proteins 0.000 claims description 3
• 101800003050 Interleukin-16 Proteins 0.000 claims description 3
• 102000049772 Interleukin-16 Human genes 0.000 claims description 3
• 102000003810 Interleukin-18 Human genes 0.000 claims description 3
• 108090000171 Interleukin-18 Proteins 0.000 claims description 3
• 108010082786 Interleukin-1alpha Proteins 0.000 claims description 3
• 102000004195 Isomerases Human genes 0.000 claims description 3
• 108090000769 Isomerases Proteins 0.000 claims description 3
• 102100033467 L-selectin Human genes 0.000 claims description 3
• 241000124008 Mammalia Species 0.000 claims description 3
• 108010052285 Membrane Proteins Proteins 0.000 claims description 3
• 102000003683 Neurotrophin-4 Human genes 0.000 claims description 3
• 108090000099 Neurotrophin-4 Proteins 0.000 claims description 3
• 108010081689 Osteopontin Proteins 0.000 claims description 3
• 241000282577 Pan troglodytes Species 0.000 claims description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
• 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims description 3
• 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 claims description 3
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims description 3
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims description 3
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims description 3
• 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims description 3
• 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims description 3
• 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 3
• 101800004564 Transforming growth factor alpha Proteins 0.000 claims description 3
• 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 3
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
• 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims description 3
• 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims description 3
• 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims description 3
• 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims description 3
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
• 150000008209 arabinosides Chemical class 0.000 claims description 3
• 210000003719 b-lymphocyte Anatomy 0.000 claims description 3
• 230000033228 biological regulation Effects 0.000 claims description 3
• 229960004630 chlorambucil Drugs 0.000 claims description 3
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims description 3
• 229960004397 cyclophosphamide Drugs 0.000 claims description 3
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 3
• 239000002158 endotoxin Substances 0.000 claims description 3
• 229940116977 epidermal growth factor Drugs 0.000 claims description 3
• 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 3
• 150000003271 galactooligosaccharides Chemical class 0.000 claims description 3
• 239000000665 guar gum Substances 0.000 claims description 3
• 235000010417 guar gum Nutrition 0.000 claims description 3
• 229960002154 guar gum Drugs 0.000 claims description 3
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 3
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 3
• 229920006008 lipopolysaccharide Polymers 0.000 claims description 3
• 229960004857 mitomycin Drugs 0.000 claims description 3
• 210000003205 muscle Anatomy 0.000 claims description 3
• 210000000440 neutrophil Anatomy 0.000 claims description 3
• 229960003301 nivolumab Drugs 0.000 claims description 3
• 229960002621 pembrolizumab Drugs 0.000 claims description 3
• 229910052697 platinum Inorganic materials 0.000 claims description 3
• 229960001196 thiotepa Drugs 0.000 claims description 3
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 3
• 229960005356 urokinase Drugs 0.000 claims description 3
• FLWWDYNPWOSLEO-HQVZTVAUSA-N (2s)-2-[[4-[1-(2-amino-4-oxo-1h-pteridin-6-yl)ethyl-methylamino]benzoyl]amino]pentanedioic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1C(C)N(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FLWWDYNPWOSLEO-HQVZTVAUSA-N 0.000 claims description 2
• JPSHPWJJSVEEAX-OWPBQMJCSA-N (2s)-2-amino-4-fluoranylpentanedioic acid Chemical compound OC(=O)[C@@H](N)CC([18F])C(O)=O JPSHPWJJSVEEAX-OWPBQMJCSA-N 0.000 claims description 2
• CGMTUJFWROPELF-YPAAEMCBSA-N (3E,5S)-5-[(2S)-butan-2-yl]-3-(1-hydroxyethylidene)pyrrolidine-2,4-dione Chemical compound CC[C@H](C)[C@@H]1NC(=O)\C(=C(/C)O)C1=O CGMTUJFWROPELF-YPAAEMCBSA-N 0.000 claims description 2
• YQYGGOPUTPQHAY-KIQLFZLRSA-N (4S)-4-[[(2S)-2-[[(2S)-2-[2-[6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-5-amino-1-[[(4S,7R)-7-[[(2S)-1-[(2S)-6-amino-2-[[(2R)-2-[[(2S)-5-amino-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-4-carboxy-2-hydrazinylbutanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-2-methyl-5,6-dioxooctan-4-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-oxohexyl]hydrazinyl]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-[[(2S)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-hydroxy-3-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC[C@@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(CCCCNN[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)[C@H](C)O)C(C)C)[C@H](C)O YQYGGOPUTPQHAY-KIQLFZLRSA-N 0.000 claims description 2
• FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 claims description 2
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims description 2
• BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 2
• QCXJFISCRQIYID-IAEPZHFASA-N 2-amino-1-n-[(3s,6s,7r,10s,16s)-3-[(2s)-butan-2-yl]-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-10-propan-2-yl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxo-9-n-[(3s,6s,7r,10s,16s)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propa Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N=C2C(C(=O)N[C@@H]3C(=O)N[C@H](C(N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)=O)[C@@H](C)CC)=C(N)C(=O)C(C)=C2O2)C2=C(C)C=C1 QCXJFISCRQIYID-IAEPZHFASA-N 0.000 claims description 2
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims description 2
• PWMYMKOUNYTVQN-UHFFFAOYSA-N 3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-n,n-dimethylpropan-1-amine Chemical compound C1C[Ge](CC)(CC)CCC11CN(CCCN(C)C)CC1 PWMYMKOUNYTVQN-UHFFFAOYSA-N 0.000 claims description 2
• WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims description 2
• NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims description 2
• PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 claims description 2
• WYXSYVWAUAUWLD-SHUUEZRQSA-N 6-azauridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=N1 WYXSYVWAUAUWLD-SHUUEZRQSA-N 0.000 claims description 2
• ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims description 2
• HDZZVAMISRMYHH-UHFFFAOYSA-N 9beta-Ribofuranosyl-7-deazaadenin Natural products C1=CC=2C(N)=NC=NC=2N1C1OC(CO)C(O)C1O HDZZVAMISRMYHH-UHFFFAOYSA-N 0.000 claims description 2
• 108010075348 Activated-Leukocyte Cell Adhesion Molecule Proteins 0.000 claims description 2
• 102000054930 Agouti-Related Human genes 0.000 claims description 2
• 101710127426 Agouti-related protein Proteins 0.000 claims description 2
• CEIZFXOZIQNICU-UHFFFAOYSA-N Alternaria alternata Crofton-weed toxin Natural products CCC(C)C1NC(=O)C(C(C)=O)=C1O CEIZFXOZIQNICU-UHFFFAOYSA-N 0.000 claims description 2
• 102100034594 Angiopoietin-1 Human genes 0.000 claims description 2
• 108010048154 Angiopoietin-1 Proteins 0.000 claims description 2
• 102400000068 Angiostatin Human genes 0.000 claims description 2
• 108010079709 Angiostatins Proteins 0.000 claims description 2
• 101710145634 Antigen 1 Proteins 0.000 claims description 2
• 108020005544 Antisense RNA Proteins 0.000 claims description 2
• 241000700663 Avipoxvirus Species 0.000 claims description 2
• 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 2
• 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 2
• 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 2
• 108010081589 Becaplermin Proteins 0.000 claims description 2
• VGGGPCQERPFHOB-MCIONIFRSA-N Bestatin Chemical compound CC(C)C[C@H](C(O)=O)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1 VGGGPCQERPFHOB-MCIONIFRSA-N 0.000 claims description 2
• 206010005003 Bladder cancer Diseases 0.000 claims description 2
• 108010006654 Bleomycin Proteins 0.000 claims description 2
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims description 2
• 102100023702 C-C motif chemokine 13 Human genes 0.000 claims description 2
• 101710112613 C-C motif chemokine 13 Proteins 0.000 claims description 2
• 102100023703 C-C motif chemokine 15 Human genes 0.000 claims description 2
• 102100023700 C-C motif chemokine 16 Human genes 0.000 claims description 2
• 102100023698 C-C motif chemokine 17 Human genes 0.000 claims description 2
• 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 2
• 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 2
• 102100036849 C-C motif chemokine 24 Human genes 0.000 claims description 2
• 102100021935 C-C motif chemokine 26 Human genes 0.000 claims description 2
• 102100021936 C-C motif chemokine 27 Human genes 0.000 claims description 2
• 101710112538 C-C motif chemokine 27 Proteins 0.000 claims description 2
• 102100021942 C-C motif chemokine 28 Human genes 0.000 claims description 2
• 102100032367 C-C motif chemokine 5 Human genes 0.000 claims description 2
• 102100032366 C-C motif chemokine 7 Human genes 0.000 claims description 2
• 101710155834 C-C motif chemokine 7 Proteins 0.000 claims description 2
• 102100034871 C-C motif chemokine 8 Human genes 0.000 claims description 2
• 101710155833 C-C motif chemokine 8 Proteins 0.000 claims description 2
• 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims description 2
• 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims description 2
• 102100039396 C-X-C motif chemokine 16 Human genes 0.000 claims description 2
• 102100036150 C-X-C motif chemokine 5 Human genes 0.000 claims description 2
• 102100036153 C-X-C motif chemokine 6 Human genes 0.000 claims description 2
• 101710085504 C-X-C motif chemokine 6 Proteins 0.000 claims description 2
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims description 2
• 101710164718 CD166 antigen Proteins 0.000 claims description 2
• 102100038078 CD276 antigen Human genes 0.000 claims description 2
• 101710185679 CD276 antigen Proteins 0.000 claims description 2
• 108010029697 CD40 Ligand Proteins 0.000 claims description 2
• 101150013553 CD40 gene Proteins 0.000 claims description 2
• 102100032937 CD40 ligand Human genes 0.000 claims description 2
• 102000000905 Cadherin Human genes 0.000 claims description 2
• 108050007957 Cadherin Proteins 0.000 claims description 2
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 2
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims description 2
• SHHKQEUPHAENFK-UHFFFAOYSA-N Carboquone Chemical compound O=C1C(C)=C(N2CC2)C(=O)C(C(COC(N)=O)OC)=C1N1CC1 SHHKQEUPHAENFK-UHFFFAOYSA-N 0.000 claims description 2
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims description 2
• 241000700199 Cavia porcellus Species 0.000 claims description 2
• 102000016289 Cell Adhesion Molecules Human genes 0.000 claims description 2
• 108010067225 Cell Adhesion Molecules Proteins 0.000 claims description 2
• 108010082548 Chemokine CCL11 Proteins 0.000 claims description 2
• 108010083701 Chemokine CCL22 Proteins 0.000 claims description 2
• 108010083647 Chemokine CCL24 Proteins 0.000 claims description 2
• 108010083698 Chemokine CCL26 Proteins 0.000 claims description 2
• 108010055166 Chemokine CCL5 Proteins 0.000 claims description 2
• 108010008951 Chemokine CXCL12 Proteins 0.000 claims description 2
• JWBOIMRXGHLCPP-UHFFFAOYSA-N Chloditan Chemical group C=1C=CC=C(Cl)C=1C(C(Cl)Cl)C1=CC=C(Cl)C=C1 JWBOIMRXGHLCPP-UHFFFAOYSA-N 0.000 claims description 2
• 241000193464 Clostridium sp. Species 0.000 claims description 2
• 229920000858 Cyclodextrin Polymers 0.000 claims description 2
• 101100481408 Danio rerio tie2 gene Proteins 0.000 claims description 2
• AUGQEEXBDZWUJY-ZLJUKNTDSA-N Diacetoxyscirpenol Chemical compound C([C@]12[C@]3(C)[C@H](OC(C)=O)[C@@H](O)[C@H]1O[C@@H]1C=C(C)CC[C@@]13COC(=O)C)O2 AUGQEEXBDZWUJY-ZLJUKNTDSA-N 0.000 claims description 2
• AUGQEEXBDZWUJY-UHFFFAOYSA-N Diacetoxyscirpenol Natural products CC(=O)OCC12CCC(C)=CC1OC1C(O)C(OC(C)=O)C2(C)C11CO1 AUGQEEXBDZWUJY-UHFFFAOYSA-N 0.000 claims description 2
• 108010044063 Endocrine-Gland-Derived Vascular Endothelial Growth Factor Proteins 0.000 claims description 2
• 102100023688 Eotaxin Human genes 0.000 claims description 2
• OBMLHUPNRURLOK-XGRAFVIBSA-N Epitiostanol Chemical compound C1[C@@H]2S[C@@H]2C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 OBMLHUPNRURLOK-XGRAFVIBSA-N 0.000 claims description 2
• 241001646716 Escherichia coli K-12 Species 0.000 claims description 2
• 102000018700 F-Box Proteins Human genes 0.000 claims description 2
• 108010066805 F-Box Proteins Proteins 0.000 claims description 2
• 108010039471 Fas Ligand Protein Proteins 0.000 claims description 2
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 2
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims description 2
• 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims description 2
• 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims description 2
• 102000044465 Galectin-7 Human genes 0.000 claims description 2
• 101710115997 Gamma-tubulin complex component 2 Proteins 0.000 claims description 2
• 102000013382 Gelatinases Human genes 0.000 claims description 2
• 108010026132 Gelatinases Proteins 0.000 claims description 2
• 229920001503 Glucan Polymers 0.000 claims description 2
• 102000003886 Glycoproteins Human genes 0.000 claims description 2
• 108090000288 Glycoproteins Proteins 0.000 claims description 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
• 108010051696 Growth Hormone Proteins 0.000 claims description 2
• 108010007712 Hepatitis A Virus Cellular Receptor 1 Proteins 0.000 claims description 2
• 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims description 2
• 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 2
• 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 2
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims description 2
• 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 2
• 101000935638 Homo sapiens Basal cell adhesion molecule Proteins 0.000 claims description 2
• 101000766294 Homo sapiens Branched-chain-amino-acid aminotransferase, mitochondrial Proteins 0.000 claims description 2
• 101000978376 Homo sapiens C-C motif chemokine 15 Proteins 0.000 claims description 2
• 101000978375 Homo sapiens C-C motif chemokine 16 Proteins 0.000 claims description 2
• 101000978362 Homo sapiens C-C motif chemokine 17 Proteins 0.000 claims description 2
• 101000897477 Homo sapiens C-C motif chemokine 28 Proteins 0.000 claims description 2
• 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims description 2
• 101000889133 Homo sapiens C-X-C motif chemokine 16 Proteins 0.000 claims description 2
• 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 claims description 2
• 101000608772 Homo sapiens Galectin-7 Proteins 0.000 claims description 2
• 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims description 2
• 101000614481 Homo sapiens Kidney-associated antigen 1 Proteins 0.000 claims description 2
• 101001018097 Homo sapiens L-selectin Proteins 0.000 claims description 2
• 101000716481 Homo sapiens Lysosome membrane protein 2 Proteins 0.000 claims description 2
• 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 claims description 2
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 2
• 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 claims description 2
• 101001001487 Homo sapiens Phosphatidylinositol-glycan biosynthesis class F protein Proteins 0.000 claims description 2
• 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims description 2
• 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 claims description 2
• 101000668165 Homo sapiens RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 claims description 2
• 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims description 2
• 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
• 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims description 2
• 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 claims description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
• 208000037147 Hypercalcaemia Diseases 0.000 claims description 2
• MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims description 2
• XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims description 2
• XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims description 2
• 108090001061 Insulin Proteins 0.000 claims description 2
• 102000004877 Insulin Human genes 0.000 claims description 2
• 102100025947 Insulin-like growth factor II Human genes 0.000 claims description 2
• 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 claims description 2
• 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 claims description 2
• 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 claims description 2
• 108010043610 KIR Receptors Proteins 0.000 claims description 2
• 102100040442 Kidney-associated antigen 1 Human genes 0.000 claims description 2
• 102000017578 LAG3 Human genes 0.000 claims description 2
• 229920001491 Lentinan Polymers 0.000 claims description 2
• 241000186779 Listeria monocytogenes Species 0.000 claims description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
• 102100026849 Lymphatic vessel endothelial hyaluronic acid receptor 1 Human genes 0.000 claims description 2
• 101710178181 Lymphatic vessel endothelial hyaluronic acid receptor 1 Proteins 0.000 claims description 2
• 102100035304 Lymphotactin Human genes 0.000 claims description 2
• 108090000542 Lymphotoxin-alpha Proteins 0.000 claims description 2
• 102100020983 Lysosome membrane protein 2 Human genes 0.000 claims description 2
• 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 claims description 2
• 229930126263 Maytansine Natural products 0.000 claims description 2
• 102000000440 Melanoma-associated antigen Human genes 0.000 claims description 2
• 108050008953 Melanoma-associated antigen Proteins 0.000 claims description 2
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
• 102000012750 Membrane Glycoproteins Human genes 0.000 claims description 2
• 108010090054 Membrane Glycoproteins Proteins 0.000 claims description 2
• 102000018697 Membrane Proteins Human genes 0.000 claims description 2
• IVDYZAAPOLNZKG-KWHRADDSSA-N Mepitiostane Chemical compound O([C@@H]1[C@]2(CC[C@@H]3[C@@]4(C)C[C@H]5S[C@H]5C[C@@H]4CC[C@H]3[C@@H]2CC1)C)C1(OC)CCCC1 IVDYZAAPOLNZKG-KWHRADDSSA-N 0.000 claims description 2
• 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims description 2
• VFKZTMPDYBFSTM-KVTDHHQDSA-N Mitobronitol Chemical compound BrC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-KVTDHHQDSA-N 0.000 claims description 2
• 229930192392 Mitomycin Natural products 0.000 claims description 2
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 2
• 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 2
• 101100481410 Mus musculus Tek gene Proteins 0.000 claims description 2
• 241000186366 Mycobacterium bovis Species 0.000 claims description 2
• 101150031836 NRCAM gene Proteins 0.000 claims description 2
• 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims description 2
• 102100021852 Neuronal cell adhesion molecule Human genes 0.000 claims description 2
• 101710130688 Neuronal cell adhesion molecule Proteins 0.000 claims description 2
• KGTDRFCXGRULNK-UHFFFAOYSA-N Nogalamycin Natural products COC1C(OC)(C)C(OC)C(C)OC1OC1C2=C(O)C(C(=O)C3=C(O)C=C4C5(C)OC(C(C(C5O)N(C)C)O)OC4=C3C3=O)=C3C=C2C(C(=O)OC)C(C)(O)C1 KGTDRFCXGRULNK-UHFFFAOYSA-N 0.000 claims description 2
• 229930187135 Olivomycin Natural products 0.000 claims description 2
• 206010033128 Ovarian cancer Diseases 0.000 claims description 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
• 108010057150 Peplomycin Proteins 0.000 claims description 2
• 102100035194 Placenta growth factor Human genes 0.000 claims description 2
• 108010069381 Platelet Endothelial Cell Adhesion Molecule-1 Proteins 0.000 claims description 2
• 102100036154 Platelet basic protein Human genes 0.000 claims description 2
• 101710204736 Platelet endothelial cell adhesion molecule Proteins 0.000 claims description 2
• 108090000778 Platelet factor 4 Proteins 0.000 claims description 2
• HFVNWDWLWUCIHC-GUPDPFMOSA-N Prednimustine Chemical compound O=C([C@@]1(O)CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)[C@@H](O)C[C@@]21C)COC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 HFVNWDWLWUCIHC-GUPDPFMOSA-N 0.000 claims description 2
• 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 2
• 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 2
• 102100040126 Prokineticin-1 Human genes 0.000 claims description 2
• 206010060862 Prostate cancer Diseases 0.000 claims description 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
• 108010019674 Proto-Oncogene Proteins c-sis Proteins 0.000 claims description 2
• 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 claims description 2
• 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 claims description 2
• 102100024735 Resistin Human genes 0.000 claims description 2
• 108010047909 Resistin Proteins 0.000 claims description 2
• OWPCHSCAPHNHAV-UHFFFAOYSA-N Rhizoxin Natural products C1C(O)C2(C)OC2C=CC(C)C(OC(=O)C2)CC2CC2OC2C(=O)OC1C(C)C(OC)C(C)=CC=CC(C)=CC1=COC(C)=N1 OWPCHSCAPHNHAV-UHFFFAOYSA-N 0.000 claims description 2
• NSFWWJIQIKBZMJ-YKNYLIOZSA-N Roridin A Chemical compound C([C@]12[C@]3(C)[C@H]4C[C@H]1O[C@@H]1C=C(C)CC[C@@]13COC(=O)[C@@H](O)[C@H](C)CCO[C@H](\C=C\C=C/C(=O)O4)[C@H](O)C)O2 NSFWWJIQIKBZMJ-YKNYLIOZSA-N 0.000 claims description 2
• 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims description 2
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims description 2
• 241000607762 Shigella flexneri Species 0.000 claims description 2
• 102100029957 Sialic acid-binding Ig-like lectin 5 Human genes 0.000 claims description 2
• 101710110535 Sialic acid-binding Ig-like lectin 5 Proteins 0.000 claims description 2
• 102100038803 Somatotropin Human genes 0.000 claims description 2
• 102400000673 Sonic hedgehog protein N-product Human genes 0.000 claims description 2
• 101800001400 Sonic hedgehog protein N-product Proteins 0.000 claims description 2
• 101100215487 Sus scrofa ADRA2A gene Proteins 0.000 claims description 2
• 108091008874 T cell receptors Proteins 0.000 claims description 2
• BXFOFFBJRFZBQZ-QYWOHJEZSA-N T-2 toxin Chemical compound C([C@@]12[C@]3(C)[C@H](OC(C)=O)[C@@H](O)[C@H]1O[C@H]1[C@]3(COC(C)=O)C[C@@H](C(=C1)C)OC(=O)CC(C)C)O2 BXFOFFBJRFZBQZ-QYWOHJEZSA-N 0.000 claims description 2
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
• 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 2
• CGMTUJFWROPELF-UHFFFAOYSA-N Tenuazonic acid Natural products CCC(C)C1NC(=O)C(=C(C)/O)C1=O CGMTUJFWROPELF-UHFFFAOYSA-N 0.000 claims description 2
• 102000036693 Thrombopoietin Human genes 0.000 claims description 2
• 108010041111 Thrombopoietin Proteins 0.000 claims description 2
• 102100034195 Thrombopoietin Human genes 0.000 claims description 2
• 102000006601 Thymidine Kinase Human genes 0.000 claims description 2
• 108020004440 Thymidine kinase Proteins 0.000 claims description 2
• 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims description 2
• 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims description 2
• 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims description 2
• 108060008539 Transglutaminase Proteins 0.000 claims description 2
• UMILHIMHKXVDGH-UHFFFAOYSA-N Triethylene glycol diglycidyl ether Chemical compound C1OC1COCCOCCOCCOCC1CO1 UMILHIMHKXVDGH-UHFFFAOYSA-N 0.000 claims description 2
• 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 claims description 2
• 102100029681 Triggering receptor expressed on myeloid cells 1 Human genes 0.000 claims description 2
• 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 claims description 2
• 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
• 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims description 2
• 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
• 101710187751 Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 claims description 2
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
• 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims description 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims description 2
• 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 claims description 2
• 101710160666 Vascular cell adhesion protein 1 Proteins 0.000 claims description 2
• 102100038234 Vascular endothelial growth factor D Human genes 0.000 claims description 2
• 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 2
• SPJCRMJCFSJKDE-ZWBUGVOYSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 2-[4-[bis(2-chloroethyl)amino]phenyl]acetate Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)C(=O)CC1=CC=C(N(CCCl)CCCl)C=C1 SPJCRMJCFSJKDE-ZWBUGVOYSA-N 0.000 claims description 2
• 235000010489 acacia gum Nutrition 0.000 claims description 2
• 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 2
• ZOZKYEHVNDEUCO-XUTVFYLZSA-N aceglatone Chemical compound O1C(=O)[C@H](OC(C)=O)[C@@H]2OC(=O)[C@@H](OC(=O)C)[C@@H]21 ZOZKYEHVNDEUCO-XUTVFYLZSA-N 0.000 claims description 2
• 229950002684 aceglatone Drugs 0.000 claims description 2
• 229930183665 actinomycin Natural products 0.000 claims description 2
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims description 2
• 229960000473 altretamine Drugs 0.000 claims description 2
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
• ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 claims description 2
• 229960003437 aminoglutethimide Drugs 0.000 claims description 2
• 229960002749 aminolevulinic acid Drugs 0.000 claims description 2
• XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 claims description 2
• 229960001220 amsacrine Drugs 0.000 claims description 2
• BBDAGFIXKZCXAH-CCXZUQQUSA-N ancitabine Chemical compound N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 BBDAGFIXKZCXAH-CCXZUQQUSA-N 0.000 claims description 2
• 229950000242 ancitabine Drugs 0.000 claims description 2
• 230000006907 apoptotic process Effects 0.000 claims description 2
• FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims description 2
• 229960002756 azacitidine Drugs 0.000 claims description 2
• 210000000941 bile Anatomy 0.000 claims description 2
• 230000015572 biosynthetic process Effects 0.000 claims description 2
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical class N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims description 2
• 229960002092 busulfan Drugs 0.000 claims description 2
• 108700002839 cactinomycin Proteins 0.000 claims description 2
• 229950009908 cactinomycin Drugs 0.000 claims description 2
• 239000001506 calcium phosphate Substances 0.000 claims description 2
• 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
• 235000011010 calcium phosphates Nutrition 0.000 claims description 2
• 229940127093 camptothecin Drugs 0.000 claims description 2
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 2
• 229960004117 capecitabine Drugs 0.000 claims description 2
• 229960004562 carboplatin Drugs 0.000 claims description 2
• 229960002115 carboquone Drugs 0.000 claims description 2
• 208000002458 carcinoid tumor Diseases 0.000 claims description 2
• 229960005243 carmustine Drugs 0.000 claims description 2
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
• 229960004316 cisplatin Drugs 0.000 claims description 2
• ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims description 2
• 229960002286 clodronic acid Drugs 0.000 claims description 2
• 239000003184 complementary RNA Substances 0.000 claims description 2
• 229960000684 cytarabine Drugs 0.000 claims description 2
• 229960003901 dacarbazine Drugs 0.000 claims description 2
• 229960000640 dactinomycin Drugs 0.000 claims description 2
• 229960000975 daunorubicin Drugs 0.000 claims description 2
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 2
• 241001493065 dsRNA viruses Species 0.000 claims description 2
• JOZGNYDSEBIJDH-UHFFFAOYSA-N eniluracil Chemical compound O=C1NC=C(C#C)C(=O)N1 JOZGNYDSEBIJDH-UHFFFAOYSA-N 0.000 claims description 2
• 229950010213 eniluracil Drugs 0.000 claims description 2
• 210000003979 eosinophil Anatomy 0.000 claims description 2
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 2
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 2
• 229950002973 epitiostanol Drugs 0.000 claims description 2
• 229930013356 epothilone Natural products 0.000 claims description 2
• 150000003883 epothilone derivatives Chemical class 0.000 claims description 2
• ITSGNOIFAJAQHJ-BMFNZSJVSA-N esorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)C[C@H](C)O1 ITSGNOIFAJAQHJ-BMFNZSJVSA-N 0.000 claims description 2
• 229950002017 esorubicin Drugs 0.000 claims description 2
• 229960001842 estramustine Drugs 0.000 claims description 2
• FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims description 2
• 229960005237 etoglucid Drugs 0.000 claims description 2
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 2
• 229960000390 fludarabine Drugs 0.000 claims description 2
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 2
• 102000006815 folate receptor Human genes 0.000 claims description 2
• 108020005243 folate receptor Proteins 0.000 claims description 2
• 229940044658 gallium nitrate Drugs 0.000 claims description 2
• 229940044627 gamma-interferon Drugs 0.000 claims description 2
• 229960005277 gemcitabine Drugs 0.000 claims description 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
• 229930182470 glycoside Natural products 0.000 claims description 2
• 239000000122 growth hormone Substances 0.000 claims description 2
• UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 claims description 2
• 230000000148 hypercalcaemia Effects 0.000 claims description 2
• 208000030915 hypercalcemia disease Diseases 0.000 claims description 2
• 229940015872 ibandronate Drugs 0.000 claims description 2
• 229960000908 idarubicin Drugs 0.000 claims description 2
• 229950008097 improsulfan Drugs 0.000 claims description 2
• DBIGHPPNXATHOF-UHFFFAOYSA-N improsulfan Chemical compound CS(=O)(=O)OCCCNCCCOS(C)(=O)=O DBIGHPPNXATHOF-UHFFFAOYSA-N 0.000 claims description 2
• 229940125396 insulin Drugs 0.000 claims description 2
• 229960003130 interferon gamma Drugs 0.000 claims description 2
• 229940076144 interleukin-10 Drugs 0.000 claims description 2
• 229940074383 interleukin-11 Drugs 0.000 claims description 2
• 229940117681 interleukin-12 Drugs 0.000 claims description 2
• 102000053460 interleukin-17 receptor activity proteins Human genes 0.000 claims description 2
• 108040001304 interleukin-17 receptor activity proteins Proteins 0.000 claims description 2
• 102000044166 interleukin-18 binding protein Human genes 0.000 claims description 2
• 108010070145 interleukin-18 binding protein Proteins 0.000 claims description 2
• 102000008640 interleukin-21 receptor activity proteins Human genes 0.000 claims description 2
• 108040002099 interleukin-21 receptor activity proteins Proteins 0.000 claims description 2
• 229940028885 interleukin-4 Drugs 0.000 claims description 2
• 229940100602 interleukin-5 Drugs 0.000 claims description 2
• 229940100994 interleukin-7 Drugs 0.000 claims description 2
• 229940096397 interleukin-8 Drugs 0.000 claims description 2
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims description 2
• 229940118526 interleukin-9 Drugs 0.000 claims description 2
• 229960004768 irinotecan Drugs 0.000 claims description 2
• JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims description 2
• 229960000511 lactulose Drugs 0.000 claims description 2
• PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims description 2
• 229940115286 lentinan Drugs 0.000 claims description 2
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims description 2
• 201000005202 lung cancer Diseases 0.000 claims description 2
• 208000020816 lung neoplasm Diseases 0.000 claims description 2
• 210000001077 lymphatic endothelium Anatomy 0.000 claims description 2
• 210000004698 lymphocyte Anatomy 0.000 claims description 2
• 108010019677 lymphotactin Proteins 0.000 claims description 2
• 102000049853 macrophage stimulating protein Human genes 0.000 claims description 2
• 108010053292 macrophage stimulating protein Proteins 0.000 claims description 2
• WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 claims description 2
• AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 claims description 2
• 229960001924 melphalan Drugs 0.000 claims description 2
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims description 2
• 229950009246 mepitiostane Drugs 0.000 claims description 2
• 239000010445 mica Substances 0.000 claims description 2
• 229910052618 mica group Inorganic materials 0.000 claims description 2
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims description 2
• 238000012737 microarray-based gene expression Methods 0.000 claims description 2
• 230000005012 migration Effects 0.000 claims description 2
• 238000013508 migration Methods 0.000 claims description 2
• 229960005485 mitobronitol Drugs 0.000 claims description 2
• 229960003539 mitoguazone Drugs 0.000 claims description 2
• MXWHMTNPTTVWDM-NXOFHUPFSA-N mitoguazone Chemical compound NC(N)=N\N=C(/C)\C=N\N=C(N)N MXWHMTNPTTVWDM-NXOFHUPFSA-N 0.000 claims description 2
• VFKZTMPDYBFSTM-GUCUJZIJSA-N mitolactol Chemical compound BrC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-GUCUJZIJSA-N 0.000 claims description 2
• 229950010913 mitolactol Drugs 0.000 claims description 2
• 238000012243 multiplex automated genomic engineering Methods 0.000 claims description 2
• 229960000951 mycophenolic acid Drugs 0.000 claims description 2
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims description 2
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 2
• 229940053128 nerve growth factor Drugs 0.000 claims description 2
• 229940032018 neurotrophin 3 Drugs 0.000 claims description 2
• KGTDRFCXGRULNK-JYOBTZKQSA-N nogalamycin Chemical compound CO[C@@H]1[C@@](OC)(C)[C@@H](OC)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=C4[C@@]5(C)O[C@H]([C@H]([C@@H]([C@H]5O)N(C)C)O)OC4=C3C3=O)=C3C=C2[C@@H](C(=O)OC)[C@@](C)(O)C1 KGTDRFCXGRULNK-JYOBTZKQSA-N 0.000 claims description 2
• 229950009266 nogalamycin Drugs 0.000 claims description 2
• XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 claims description 2
• CZDBNBLGZNWKMC-MWQNXGTOSA-N olivomycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1)O[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC2O[C@@H](C)[C@H](O)[C@@H](O)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@H](O)[C@H](OC)[C@H](C)O1 CZDBNBLGZNWKMC-MWQNXGTOSA-N 0.000 claims description 2
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 2
• 229960001756 oxaliplatin Drugs 0.000 claims description 2
• 229960002340 pentostatin Drugs 0.000 claims description 2
• FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 claims description 2
• QIMGFXOHTOXMQP-GFAGFCTOSA-N peplomycin Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCCN[C@@H](C)C=1C=CC=CC=1)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C QIMGFXOHTOXMQP-GFAGFCTOSA-N 0.000 claims description 2
• 229950003180 peplomycin Drugs 0.000 claims description 2
• 229950010773 pidilizumab Drugs 0.000 claims description 2
• NJBFOOCLYDNZJN-UHFFFAOYSA-N pipobroman Chemical compound BrCCC(=O)N1CCN(C(=O)CCBr)CC1 NJBFOOCLYDNZJN-UHFFFAOYSA-N 0.000 claims description 2
• 229960000952 pipobroman Drugs 0.000 claims description 2
• 108010017843 platelet-derived growth factor A Proteins 0.000 claims description 2
• 108010000685 platelet-derived growth factor AB Proteins 0.000 claims description 2
• 229960004694 prednimustine Drugs 0.000 claims description 2
• WOLQREOUPKZMEX-UHFFFAOYSA-N pteroyltriglutamic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)C=C1 WOLQREOUPKZMEX-UHFFFAOYSA-N 0.000 claims description 2
• UOWVMDUEMSNCAV-WYENRQIDSA-N rachelmycin Chemical compound C1([C@]23C[C@@H]2CN1C(=O)C=1NC=2C(OC)=C(O)C4=C(C=2C=1)CCN4C(=O)C1=CC=2C=4CCN(C=4C(O)=C(C=2N1)OC)C(N)=O)=CC(=O)C1=C3C(C)=CN1 UOWVMDUEMSNCAV-WYENRQIDSA-N 0.000 claims description 2
• 229930002330 retinoic acid Natural products 0.000 claims description 2
• OWPCHSCAPHNHAV-LMONGJCWSA-N rhizoxin Chemical compound C/C([C@H](OC)[C@@H](C)[C@@H]1C[C@H](O)[C@]2(C)O[C@@H]2/C=C/[C@@H](C)[C@]2([H])OC(=O)C[C@@](C2)(C[C@@H]2O[C@H]2C(=O)O1)[H])=C\C=C\C(\C)=C\C1=COC(C)=N1 OWPCHSCAPHNHAV-LMONGJCWSA-N 0.000 claims description 2
• MBABCNBNDNGODA-WPZDJQSSSA-N rolliniastatin 1 Natural products O1[C@@H]([C@@H](O)CCCCCCCCCC)CC[C@H]1[C@H]1O[C@@H]([C@H](O)CCCCCCCCCC[C@@H](O)CC=2C(O[C@@H](C)C=2)=O)CC1 MBABCNBNDNGODA-WPZDJQSSSA-N 0.000 claims description 2
• IMUQLZLGWJSVMV-UOBFQKKOSA-N roridin A Natural products CC(O)C1OCCC(C)C(O)C(=O)OCC2CC(=CC3OC4CC(OC(=O)C=C/C=C/1)C(C)(C23)C45CO5)C IMUQLZLGWJSVMV-UOBFQKKOSA-N 0.000 claims description 2
• 229950006315 spirogermanium Drugs 0.000 claims description 2
• 229960001052 streptozocin Drugs 0.000 claims description 2
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims description 2
• 210000002536 stromal cell Anatomy 0.000 claims description 2
• 229960005353 testolactone Drugs 0.000 claims description 2
• BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 claims description 2
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
• 108010029307 thymic stromal lymphopoietin Proteins 0.000 claims description 2
• 210000001541 thymus gland Anatomy 0.000 claims description 2
• YFTWHEBLORWGNI-UHFFFAOYSA-N tiamiprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC(N)=NC2=C1NC=N2 YFTWHEBLORWGNI-UHFFFAOYSA-N 0.000 claims description 2
• 229950011457 tiamiprine Drugs 0.000 claims description 2
• 102000003601 transglutaminase Human genes 0.000 claims description 2
• 229960001727 tretinoin Drugs 0.000 claims description 2
• PXSOHRWMIRDKMP-UHFFFAOYSA-N triaziquone Chemical compound O=C1C(N2CC2)=C(N2CC2)C(=O)C=C1N1CC1 PXSOHRWMIRDKMP-UHFFFAOYSA-N 0.000 claims description 2
• 229960004560 triaziquone Drugs 0.000 claims description 2
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
• 229930013292 trichothecene Natural products 0.000 claims description 2
• KVJXBPDAXMEYOA-CXANFOAXSA-N trilostane Chemical compound OC1=C(C#N)C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@]32O[C@@H]31 KVJXBPDAXMEYOA-CXANFOAXSA-N 0.000 claims description 2
• 229960001670 trilostane Drugs 0.000 claims description 2
• 229960001099 trimetrexate Drugs 0.000 claims description 2
• NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 claims description 2
• HDZZVAMISRMYHH-LITAXDCLSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O HDZZVAMISRMYHH-LITAXDCLSA-N 0.000 claims description 2
• 229950009811 ubenimex Drugs 0.000 claims description 2
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
• 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 claims description 2
• 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 claims description 2
• 229960003048 vinblastine Drugs 0.000 claims description 2
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims description 2
• 229960004528 vincristine Drugs 0.000 claims description 2
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims description 2
• UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 claims description 2
• 229960004355 vindesine Drugs 0.000 claims description 2
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims description 2
• 229960002066 vinorelbine Drugs 0.000 claims description 2
• 229920001221 xylan Polymers 0.000 claims description 2
• 150000004823 xylans Chemical class 0.000 claims description 2
• KFYRPLNVJVHZGT-UHFFFAOYSA-N Amitriptyline hydrochloride Chemical compound Cl.C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KFYRPLNVJVHZGT-UHFFFAOYSA-N 0.000 claims 6
• 102100034872 Kallikrein-4 Human genes 0.000 claims 6
• 102100040733 Zinc finger protein 395 Human genes 0.000 claims 6
• 108010024383 kallikrein 4 Proteins 0.000 claims 6
• 108010010995 MART-1 Antigen Proteins 0.000 claims 5
• 208000003837 Second Primary Neoplasms Diseases 0.000 claims 5
• 230000003362 replicative effect Effects 0.000 claims 5
• 239000000090 biomarker Substances 0.000 claims 4
• 230000003211 malignant effect Effects 0.000 claims 4
• 206010004146 Basal cell carcinoma Diseases 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 claims 3
• 208000009458 Carcinoma in Situ Diseases 0.000 claims 3
• 235000008733 Citrus aurantifolia Nutrition 0.000 claims 3
• 206010053574 Immunoblastic lymphoma Diseases 0.000 claims 3
• 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 3
• 102000005741 Metalloproteases Human genes 0.000 claims 3
• 108010006035 Metalloproteases Proteins 0.000 claims 3
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
• 235000011941 Tilia x europaea Nutrition 0.000 claims 3
• 102000005924 Triose-Phosphate Isomerase Human genes 0.000 claims 3
• 108700015934 Triose-phosphate isomerases Proteins 0.000 claims 3
• 206010054094 Tumour necrosis Diseases 0.000 claims 3
• 230000003190 augmentative effect Effects 0.000 claims 3
• 108010018828 cadherin 5 Proteins 0.000 claims 3
• 239000004571 lime Substances 0.000 claims 3
• 208000003747 lymphoid leukemia Diseases 0.000 claims 3
• 201000010879 mucinous adenocarcinoma Diseases 0.000 claims 3
• 208000025113 myeloid leukemia Diseases 0.000 claims 3
• 206010041823 squamous cell carcinoma Diseases 0.000 claims 3
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 2
• INZOTETZQBPBCE-NYLDSJSYSA-N 3-sialyl lewis Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@H](O)CO)[C@@H]([C@@H](NC(C)=O)C=O)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 INZOTETZQBPBCE-NYLDSJSYSA-N 0.000 claims 2
• ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 claims 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
• 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 2
• 241000321096 Adenoides Species 0.000 claims 2
• 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 2
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 2
• 206010058354 Bronchioloalveolar carcinoma Diseases 0.000 claims 2
• 102100029761 Cadherin-5 Human genes 0.000 claims 2
• 208000006332 Choriocarcinoma Diseases 0.000 claims 2
• 102100027995 Collagenase 3 Human genes 0.000 claims 2
• 102100035784 Decorin Human genes 0.000 claims 2
• 102100036462 Delta-like protein 1 Human genes 0.000 claims 2
• 102100037985 Dickkopf-related protein 3 Human genes 0.000 claims 2
• 101710099550 Dickkopf-related protein 3 Proteins 0.000 claims 2
• 102100026748 Fatty acid-binding protein, intestinal Human genes 0.000 claims 2
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 2
• 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 2
• 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims 2
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 2
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 2
• 208000008999 Giant Cell Carcinoma Diseases 0.000 claims 2
• 108010090290 Growth Differentiation Factor 2 Proteins 0.000 claims 2
• 102100040892 Growth/differentiation factor 2 Human genes 0.000 claims 2
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
• 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 claims 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
• 102000004372 Insulin-like growth factor binding protein 2 Human genes 0.000 claims 2
• 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 claims 2
• 102000004369 Insulin-like growth factor-binding protein 4 Human genes 0.000 claims 2
• 108090000969 Insulin-like growth factor-binding protein 4 Proteins 0.000 claims 2
• 102100033096 Interleukin-17D Human genes 0.000 claims 2
• 102000004125 Interleukin-1alpha Human genes 0.000 claims 2
• 108010066979 Interleukin-27 Proteins 0.000 claims 2
• 108010067003 Interleukin-33 Proteins 0.000 claims 2
• 102000017761 Interleukin-33 Human genes 0.000 claims 2
• 102000007330 LDL Lipoproteins Human genes 0.000 claims 2
• 102100026553 Mannose-binding protein C Human genes 0.000 claims 2
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 2
• 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 2
• 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 2
• 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 2
• 102000015336 Nerve Growth Factor Human genes 0.000 claims 2
• 206010029260 Neuroblastoma Diseases 0.000 claims 2
• 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 claims 2
• 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 claims 2
• 108090000630 Oncostatin M Proteins 0.000 claims 2
• 102000004264 Osteopontin Human genes 0.000 claims 2
• 102100029837 Probetacellulin Human genes 0.000 claims 2
• 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 2
• 102100038246 Retinol-binding protein 4 Human genes 0.000 claims 2
• 201000001542 Schneiderian carcinoma Diseases 0.000 claims 2
• 102100030416 Stromelysin-1 Human genes 0.000 claims 2
• 102100028848 Stromelysin-2 Human genes 0.000 claims 2
• 102100024333 Toll-like receptor 2 Human genes 0.000 claims 2
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
• 102000008790 VE-cadherin Human genes 0.000 claims 2
• 208000008383 Wilms tumor Diseases 0.000 claims 2
• 208000036676 acute undifferentiated leukemia Diseases 0.000 claims 2
• 208000009956 adenocarcinoma Diseases 0.000 claims 2
• 210000002534 adenoid Anatomy 0.000 claims 2
• 208000002517 adenoid cystic carcinoma Diseases 0.000 claims 2
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
• 230000001093 anti-cancer Effects 0.000 claims 2
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 2
• 108091006374 cAMP receptor proteins Proteins 0.000 claims 2
• 208000029742 colonic neoplasm Diseases 0.000 claims 2
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
• 230000003511 endothelial effect Effects 0.000 claims 2
• 201000004933 in situ carcinoma Diseases 0.000 claims 2
• 102000003898 interleukin-24 Human genes 0.000 claims 2
• 108090000237 interleukin-24 Proteins 0.000 claims 2
• 239000000787 lecithin Substances 0.000 claims 2
• 235000010445 lecithin Nutrition 0.000 claims 2
• 201000000014 lung giant cell carcinoma Diseases 0.000 claims 2
• 208000025036 lymphosarcoma Diseases 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 2
• 201000006894 monocytic leukemia Diseases 0.000 claims 2
• 201000008026 nephroblastoma Diseases 0.000 claims 2
• RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 2
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 2
• 230000002792 vascular Effects 0.000 claims 2
• LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
• NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 claims 1
• AGNGYMCLFWQVGX-AGFFZDDWSA-N (e)-1-[(2s)-2-amino-2-carboxyethoxy]-2-diazonioethenolate Chemical compound OC(=O)[C@@H](N)CO\C([O-])=C\[N+]#N AGNGYMCLFWQVGX-AGFFZDDWSA-N 0.000 claims 1
• VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
• 102100039583 116 kDa U5 small nuclear ribonucleoprotein component Human genes 0.000 claims 1
• VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 1
• FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 claims 1
• 108030001751 ADAM 17 endopeptidases Proteins 0.000 claims 1
• 101150054149 ANGPTL4 gene Proteins 0.000 claims 1
• 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 claims 1
• 208000016557 Acute basophilic leukemia Diseases 0.000 claims 1
• 206010000871 Acute monocytic leukaemia Diseases 0.000 claims 1
• 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 claims 1
• 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 claims 1
• 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 claims 1
• 102100027211 Albumin Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 208000037540 Alveolar soft tissue sarcoma Diseases 0.000 claims 1
• 102100034608 Angiopoietin-2 Human genes 0.000 claims 1
• 108010048036 Angiopoietin-2 Proteins 0.000 claims 1
• 102100033402 Angiopoietin-4 Human genes 0.000 claims 1
• 108700042530 Angiopoietin-Like Protein 4 Proteins 0.000 claims 1
• 102100025674 Angiopoietin-related protein 4 Human genes 0.000 claims 1
• 108010009906 Angiopoietins Proteins 0.000 claims 1
• 102000009840 Angiopoietins Human genes 0.000 claims 1
• 201000003076 Angiosarcoma Diseases 0.000 claims 1
• 108010071619 Apolipoproteins Proteins 0.000 claims 1
• 102000007592 Apolipoproteins Human genes 0.000 claims 1
• 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims 1
• 241000271566 Aves Species 0.000 claims 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
• 230000003844 B-cell-activation Effects 0.000 claims 1
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
• 101710172654 Basal cell adhesion molecule Proteins 0.000 claims 1
• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
• 208000013165 Bowen disease Diseases 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 102100031173 CCN family member 4 Human genes 0.000 claims 1
• 101710137353 CCN family member 4 Proteins 0.000 claims 1
• 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 claims 1
• 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 1
• 241000178270 Canarypox virus Species 0.000 claims 1
• AOCCBINRVIKJHY-UHFFFAOYSA-N Carmofur Chemical compound CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O AOCCBINRVIKJHY-UHFFFAOYSA-N 0.000 claims 1
• 102400001321 Cathepsin L Human genes 0.000 claims 1
• 108090000624 Cathepsin L Proteins 0.000 claims 1
• 102100037182 Cation-independent mannose-6-phosphate receptor Human genes 0.000 claims 1
• 101710145225 Cation-independent mannose-6-phosphate receptor Proteins 0.000 claims 1
• 229930186147 Cephalosporin Natural products 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 241001420153 Chemerina Species 0.000 claims 1
• 102000016950 Chemokine CXCL1 Human genes 0.000 claims 1
• 108010014419 Chemokine CXCL1 Proteins 0.000 claims 1
• 206010008583 Chloroma Diseases 0.000 claims 1
• 206010008685 Chondritis Diseases 0.000 claims 1
• 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 1
• 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 1
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
• 102000003780 Clusterin Human genes 0.000 claims 1
• 108090000197 Clusterin Proteins 0.000 claims 1
• 108050005238 Collagenase 3 Proteins 0.000 claims 1
• 108010078546 Complement C5a Proteins 0.000 claims 1
• 102000003706 Complement factor D Human genes 0.000 claims 1
• 108090000059 Complement factor D Proteins 0.000 claims 1
• 102000012192 Cystatin C Human genes 0.000 claims 1
• 108010061642 Cystatin C Proteins 0.000 claims 1
• 108090000738 Decorin Proteins 0.000 claims 1
• 101710112750 Delta-like protein 1 Proteins 0.000 claims 1
• 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 claims 1
• 102100024361 Disintegrin and metalloproteinase domain-containing protein 9 Human genes 0.000 claims 1
• 101710116121 Disintegrin and metalloproteinase domain-containing protein 9 Proteins 0.000 claims 1
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 claims 1
• 206010014733 Endometrial cancer Diseases 0.000 claims 1
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
• 206010057649 Endometrial sarcoma Diseases 0.000 claims 1
• 102000056372 ErbB-3 Receptor Human genes 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 208000032027 Essential Thrombocythemia Diseases 0.000 claims 1
• JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
• 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
• 208000001382 Experimental Melanoma Diseases 0.000 claims 1
• 208000009331 Experimental Sarcoma Diseases 0.000 claims 1
• 108050008832 Fatty acid-binding protein, intestinal Proteins 0.000 claims 1
• 101710153349 Fibroblast growth factor 19 Proteins 0.000 claims 1
• 201000008808 Fibrosarcoma Diseases 0.000 claims 1
• 102100035139 Folate receptor alpha Human genes 0.000 claims 1
• 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 1
• 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 1
• 102100021265 Frizzled-2 Human genes 0.000 claims 1
• 101710140946 Frizzled-2 Proteins 0.000 claims 1
• 102100021262 Frizzled-3 Human genes 0.000 claims 1
• 101710140944 Frizzled-3 Proteins 0.000 claims 1
• 102100035233 Furin Human genes 0.000 claims 1
• 108090001126 Furin Proteins 0.000 claims 1
• 101710142641 G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 claims 1
• 101710142639 G-protein coupled receptor-associated sorting protein 2 Proteins 0.000 claims 1
• 108010001517 Galectin 3 Proteins 0.000 claims 1
• 102100039558 Galectin-3 Human genes 0.000 claims 1
• 102100028652 Gamma-enolase Human genes 0.000 claims 1
• 102000002068 Glycopeptides Human genes 0.000 claims 1
• 108010015899 Glycopeptides Proteins 0.000 claims 1
• 108010054017 Granulocyte Colony-Stimulating Factor Receptors Proteins 0.000 claims 1
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims 1
• 102100039622 Granulocyte colony-stimulating factor receptor Human genes 0.000 claims 1
• 206010066476 Haematological malignancy Diseases 0.000 claims 1
• 208000001258 Hemangiosarcoma Diseases 0.000 claims 1
• 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
• 102000001554 Hemoglobins Human genes 0.000 claims 1
• 108010054147 Hemoglobins Proteins 0.000 claims 1
• 229920002971 Heparan sulfate Polymers 0.000 claims 1
• 241000709721 Hepatovirus A Species 0.000 claims 1
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000017662 Hodgkin disease lymphocyte depletion type stage unspecified Diseases 0.000 claims 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
• 101000608799 Homo sapiens 116 kDa U5 small nuclear ribonucleoprotein component Proteins 0.000 claims 1
• 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 claims 1
• 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 claims 1
• 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims 1
• 101000911337 Homo sapiens Fatty acid-binding protein, intestinal Proteins 0.000 claims 1
• 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims 1
• 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 1
• 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims 1
• 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims 1
• 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 claims 1
• 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
• 101000665882 Homo sapiens Retinol-binding protein 4 Proteins 0.000 claims 1
• 101000711796 Homo sapiens Sclerostin Proteins 0.000 claims 1
• 101000863883 Homo sapiens Sialic acid-binding Ig-like lectin 9 Proteins 0.000 claims 1
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 1
• 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 1
• 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 claims 1
• 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
• 210000005131 Hürthle cell Anatomy 0.000 claims 1
• 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
• 101710184277 Insulin-like growth factor 1 receptor Proteins 0.000 claims 1
• 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims 1
• 102000019223 Interleukin-1 receptor Human genes 0.000 claims 1
• 108050006617 Interleukin-1 receptor Proteins 0.000 claims 1
• 102100035014 Interleukin-17 receptor B Human genes 0.000 claims 1
• 101710186071 Interleukin-17 receptor B Proteins 0.000 claims 1
• 108010002386 Interleukin-3 Proteins 0.000 claims 1
• 102100023437 Junctional adhesion molecule-like Human genes 0.000 claims 1
• 206010023256 Juvenile melanoma benign Diseases 0.000 claims 1
• 102100038298 Kallikrein-14 Human genes 0.000 claims 1
• 101710115806 Kallikrein-14 Proteins 0.000 claims 1
• 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
• 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 claims 1
• 102100039020 Kunitz-type protease inhibitor 2 Human genes 0.000 claims 1
• 101710165138 Kunitz-type protease inhibitor 2 Proteins 0.000 claims 1
• 108010092694 L-Selectin Proteins 0.000 claims 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
• 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 1
• 108010007622 LDL Lipoproteins Proteins 0.000 claims 1
• 108010092277 Leptin Proteins 0.000 claims 1
• 102000016267 Leptin Human genes 0.000 claims 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
• 206010024305 Leukaemia monocytic Diseases 0.000 claims 1
• 102000019298 Lipocalin Human genes 0.000 claims 1
• 108050006654 Lipocalin Proteins 0.000 claims 1
• 102000013519 Lipocalin-2 Human genes 0.000 claims 1
• 108010051335 Lipocalin-2 Proteins 0.000 claims 1
• 108010028921 Lipopeptides Proteins 0.000 claims 1
• 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
• 102100026238 Lymphotoxin-alpha Human genes 0.000 claims 1
• 102100026894 Lymphotoxin-beta Human genes 0.000 claims 1
• 108090000362 Lymphotoxin-beta Proteins 0.000 claims 1
• 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 claims 1
• 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 claims 1
• 102000005727 Mammaglobin A Human genes 0.000 claims 1
• 108010031030 Mammaglobin A Proteins 0.000 claims 1
• 108010087870 Mannose-Binding Lectin Proteins 0.000 claims 1
• 108010090665 Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Proteins 0.000 claims 1
• 108010076497 Matrix Metalloproteinase 10 Proteins 0.000 claims 1
• 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 claims 1
• 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 claims 1
• 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 claims 1
• 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
• 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
• 208000007054 Medullary Carcinoma Diseases 0.000 claims 1
• 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 1
• 102100024289 Metalloproteinase inhibitor 4 Human genes 0.000 claims 1
• 108050006579 Metalloproteinase inhibitor 4 Proteins 0.000 claims 1
• 229940121738 Metalloproteinase-4 inhibitor Drugs 0.000 claims 1
• 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 1
• 206010057269 Mucoepidermoid carcinoma Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• 101000904718 Mus musculus Transmembrane glycoprotein NMB Proteins 0.000 claims 1
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
• 102100030397 N-acetylmuramoyl-L-alanine amidase Human genes 0.000 claims 1
• 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims 1
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
• 108050003738 Neural cell adhesion molecule 1 Proteins 0.000 claims 1
• 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 claims 1
• 102100030411 Neutrophil collagenase Human genes 0.000 claims 1
• 101710118230 Neutrophil collagenase Proteins 0.000 claims 1
• 102100037369 Nidogen-1 Human genes 0.000 claims 1
• 206010029488 Nodular melanoma Diseases 0.000 claims 1
• 101710107897 Nucleosome assembly protein Proteins 0.000 claims 1
• 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 102000004140 Oncostatin M Human genes 0.000 claims 1
• 102100025386 Oxidized low-density lipoprotein receptor 1 Human genes 0.000 claims 1
• 101710199789 Oxidized low-density lipoprotein receptor 1 Proteins 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 229930182555 Penicillin Natural products 0.000 claims 1
• 108010047320 Pepsinogen A Proteins 0.000 claims 1
• 101710171421 Phosphoprotein 32 Proteins 0.000 claims 1
• 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 1
• 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 1
• 102000013566 Plasminogen Human genes 0.000 claims 1
• 108010051456 Plasminogen Proteins 0.000 claims 1
• 108010001014 Plasminogen Activators Proteins 0.000 claims 1
• 102000001938 Plasminogen Activators Human genes 0.000 claims 1
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
• 108010048233 Procalcitonin Proteins 0.000 claims 1
• 102000003946 Prolactin Human genes 0.000 claims 1
• 108010057464 Prolactin Proteins 0.000 claims 1
• 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
• 102000016611 Proteoglycans Human genes 0.000 claims 1
• 108010067787 Proteoglycans Proteins 0.000 claims 1
• 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
• 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
• 102100032350 Protransforming growth factor alpha Human genes 0.000 claims 1
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
• 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
• 101710137011 Retinol-binding protein 4 Proteins 0.000 claims 1
• 102100034201 Sclerostin Human genes 0.000 claims 1
• 108050007990 Secreted frizzled-related protein 3 Proteins 0.000 claims 1
• 102100030053 Secreted frizzled-related protein 3 Human genes 0.000 claims 1
• 101710141012 Secreted protein A Proteins 0.000 claims 1
• 102100029965 Sialic acid-binding Ig-like lectin 9 Human genes 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 101710108790 Stromelysin-1 Proteins 0.000 claims 1
• 101710108792 Stromelysin-2 Proteins 0.000 claims 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
• 102100035721 Syndecan-1 Human genes 0.000 claims 1
• 108090000058 Syndecan-1 Proteins 0.000 claims 1
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
• 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
• 206010057644 Testis cancer Diseases 0.000 claims 1
• 239000004098 Tetracycline Chemical class 0.000 claims 1
• 102100026966 Thrombomodulin Human genes 0.000 claims 1
• 108010079274 Thrombomodulin Proteins 0.000 claims 1
• 108010000499 Thromboplastin Proteins 0.000 claims 1
• 102000009843 Thyroglobulin Human genes 0.000 claims 1
• 108010034949 Thyroglobulin Proteins 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 102100030859 Tissue factor Human genes 0.000 claims 1
• 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 1
• 108010060888 Toll-like receptor 2 Proteins 0.000 claims 1
• 102000004338 Transferrin Human genes 0.000 claims 1
• 108090000901 Transferrin Proteins 0.000 claims 1
• 102000011117 Transforming Growth Factor beta2 Human genes 0.000 claims 1
• 101800000304 Transforming growth factor beta-2 Proteins 0.000 claims 1
• 108090001027 Troponin Proteins 0.000 claims 1
• 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 1
• 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 claims 1
• 208000025865 Ulcer Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
• 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 102100020722 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Human genes 0.000 claims 1
• 101710160039 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Proteins 0.000 claims 1
• 102100036021 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Human genes 0.000 claims 1
• 101710160038 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Proteins 0.000 claims 1
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
• 208000006336 acinar cell carcinoma Diseases 0.000 claims 1
• 239000012190 activator Substances 0.000 claims 1
• 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 1
• 208000020990 adrenal cortex carcinoma Diseases 0.000 claims 1
• 201000005188 adrenal gland cancer Diseases 0.000 claims 1
• 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
• 201000006966 adult T-cell leukemia Diseases 0.000 claims 1
• 108010081667 aflibercept Proteins 0.000 claims 1
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
• 102000012005 alpha-2-HS-Glycoprotein Human genes 0.000 claims 1
• 108010075843 alpha-2-HS-Glycoprotein Proteins 0.000 claims 1
• FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 claims 1
• 108010074861 alpha-factor (Saccharomyces cerevisiae) Proteins 0.000 claims 1
• 208000006431 amelanotic melanoma Diseases 0.000 claims 1
• 230000002707 ameloblastic effect Effects 0.000 claims 1
• 229940126575 aminoglycoside Drugs 0.000 claims 1
• 108010069801 angiopoietin 4 Proteins 0.000 claims 1
• 230000001355 anti-mycobacterial effect Effects 0.000 claims 1
• 239000003926 antimycobacterial agent Chemical class 0.000 claims 1
• 108010055066 asparaginylendopeptidase Proteins 0.000 claims 1
• 229960003852 atezolizumab Drugs 0.000 claims 1
• 229950002916 avelumab Drugs 0.000 claims 1
• 229950011321 azaserine Drugs 0.000 claims 1
• 208000016894 basaloid carcinoma Diseases 0.000 claims 1
• 201000000450 basaloid squamous cell carcinoma Diseases 0.000 claims 1
• 208000003373 basosquamous carcinoma Diseases 0.000 claims 1
• 229960000397 bevacizumab Drugs 0.000 claims 1
• 210000001109 blastomere Anatomy 0.000 claims 1
• 229940112869 bone morphogenetic protein Drugs 0.000 claims 1
• 201000009480 botryoid rhabdomyosarcoma Diseases 0.000 claims 1
• 201000010983 breast ductal carcinoma Diseases 0.000 claims 1
• 208000003362 bronchogenic carcinoma Diseases 0.000 claims 1
• 190000008236 carboplatin Chemical compound 0.000 claims 1
• 229960003261 carmofur Drugs 0.000 claims 1
• 229940124587 cephalosporin Drugs 0.000 claims 1
• 150000001780 cephalosporins Chemical class 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 claims 1
• 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
• 201000011050 comedo carcinoma Diseases 0.000 claims 1
• 230000001054 cortical effect Effects 0.000 claims 1
• HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims 1
• 150000004985 diamines Chemical class 0.000 claims 1
• 238000009792 diffusion process Methods 0.000 claims 1
• 229960003638 dopamine Drugs 0.000 claims 1
• 208000037828 epithelial carcinoma Diseases 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 229960005420 etoposide Drugs 0.000 claims 1
• 210000003195 fascia Anatomy 0.000 claims 1
• 230000003328 fibroblastic effect Effects 0.000 claims 1
• 229940124307 fluoroquinolone Drugs 0.000 claims 1
• IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
• 229940028334 follicle stimulating hormone Drugs 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 210000004907 gland Anatomy 0.000 claims 1
• 230000000762 glandular Effects 0.000 claims 1
• 201000007574 granular cell carcinoma Diseases 0.000 claims 1
• 201000009277 hairy cell leukemia Diseases 0.000 claims 1
• 230000002008 hemorrhagic effect Effects 0.000 claims 1
• 210000003494 hepatocyte Anatomy 0.000 claims 1
• 229940084986 human chorionic gonadotropin Drugs 0.000 claims 1
• 229940116978 human epidermal growth factor Drugs 0.000 claims 1
• 210000004276 hyalin Anatomy 0.000 claims 1
• 229940068935 insulin-like growth factor 2 Drugs 0.000 claims 1
• 229960005386 ipilimumab Drugs 0.000 claims 1
• DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims 1
• 208000022013 kidney Wilms tumor Diseases 0.000 claims 1
• 210000003292 kidney cell Anatomy 0.000 claims 1
• 208000003849 large cell carcinoma Diseases 0.000 claims 1
• 229940067606 lecithin Drugs 0.000 claims 1
• 206010024217 lentigo Diseases 0.000 claims 1
• 229940039781 leptin Drugs 0.000 claims 1
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 1
• 230000000610 leukopenic effect Effects 0.000 claims 1
• 229940041028 lincosamides Drugs 0.000 claims 1
• 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 1
• 208000037841 lung tumor Diseases 0.000 claims 1
• 230000002912 lymphogenic effect Effects 0.000 claims 1
• 210000003712 lysosome Anatomy 0.000 claims 1
• 230000001868 lysosomic effect Effects 0.000 claims 1
• 201000000564 macroglobulinemia Diseases 0.000 claims 1
• 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
• 229940041033 macrolides Drugs 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 208000000516 mast-cell leukemia Diseases 0.000 claims 1
• 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 1
• 230000000684 melanotic effect Effects 0.000 claims 1
• 108010009956 metallopeptidase-1 Proteins 0.000 claims 1
• 229940041009 monobactams Drugs 0.000 claims 1
• BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 claims 1
• 201000005987 myeloid sarcoma Diseases 0.000 claims 1
• 208000001611 myxosarcoma Diseases 0.000 claims 1
• LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 claims 1
• 210000000581 natural killer T-cell Anatomy 0.000 claims 1
• 210000000822 natural killer cell Anatomy 0.000 claims 1
• GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims 1
• 229940097998 neurotrophin 4 Drugs 0.000 claims 1
• 108010008217 nidogen Proteins 0.000 claims 1
• 201000000032 nodular malignant melanoma Diseases 0.000 claims 1
• 208000029809 non-keratinizing sinonasal squamous cell carcinoma Diseases 0.000 claims 1
• 229950005848 olivomycin Drugs 0.000 claims 1
• 201000008968 osteosarcoma Diseases 0.000 claims 1
• 108010071584 oxidized low density lipoprotein Proteins 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 201000010198 papillary carcinoma Diseases 0.000 claims 1
• 150000002960 penicillins Chemical class 0.000 claims 1
• 229940127126 plasminogen activator Drugs 0.000 claims 1
• 239000003910 polypeptide antibiotic agent Chemical class 0.000 claims 1
• CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims 1
• 229940097325 prolactin Drugs 0.000 claims 1
• 230000012743 protein tagging Effects 0.000 claims 1
• 208000029817 pulmonary adenocarcinoma in situ Diseases 0.000 claims 1
• 229950010131 puromycin Drugs 0.000 claims 1
• 150000007660 quinolones Chemical class 0.000 claims 1
• 108091006084 receptor activators Proteins 0.000 claims 1
• 239000002464 receptor antagonist Substances 0.000 claims 1
• 229940044551 receptor antagonist Drugs 0.000 claims 1
• FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 claims 1
• QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 claims 1
• 229960003147 reserpine Drugs 0.000 claims 1
• 210000001995 reticulocyte Anatomy 0.000 claims 1
• 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
• VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 claims 1
• 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 claims 1
• 208000014212 sarcomatoid carcinoma Diseases 0.000 claims 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
• 201000008157 scrotal carcinoma Diseases 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 201000000849 skin cancer Diseases 0.000 claims 1
• 206010040882 skin lesion Diseases 0.000 claims 1
• 231100000444 skin lesion Toxicity 0.000 claims 1
• 208000000649 small cell carcinoma Diseases 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 208000011584 spitz nevus Diseases 0.000 claims 1
• 229940090374 stivarga Drugs 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 208000028210 stromal sarcoma Diseases 0.000 claims 1
• 201000010033 subleukemic leukemia Diseases 0.000 claims 1
• 229940124530 sulfonamide Drugs 0.000 claims 1
• 150000003456 sulfonamides Chemical class 0.000 claims 1
• 229940034785 sutent Drugs 0.000 claims 1
• 201000003120 testicular cancer Diseases 0.000 claims 1
• 235000019364 tetracycline Nutrition 0.000 claims 1
• 150000003522 tetracyclines Chemical class 0.000 claims 1
• 229940040944 tetracyclines Drugs 0.000 claims 1
• 229960002175 thyroglobulin Drugs 0.000 claims 1
• 201000002510 thyroid cancer Diseases 0.000 claims 1
• 239000012581 transferrin Substances 0.000 claims 1
• 229940099456 transforming growth factor beta 1 Drugs 0.000 claims 1
• 229940072041 transforming growth factor beta 2 Drugs 0.000 claims 1
• 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
• 230000005945 translocation Effects 0.000 claims 1
• LZAJKCZTKKKZNT-PMNGPLLRSA-N trichothecene Chemical compound C12([C@@]3(CC[C@H]2OC2C=C(CCC23C)C)C)CO1 LZAJKCZTKKKZNT-PMNGPLLRSA-N 0.000 claims 1
• 229940035893 uracil Drugs 0.000 claims 1
• 229960005088 urethane Drugs 0.000 claims 1
• 208000007089 vaccinia Diseases 0.000 claims 1
• 208000008662 verrucous carcinoma Diseases 0.000 claims 1
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
• 229960002760 ziv-aflibercept Drugs 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 abstract description 14
• 239000003814 drug Substances 0.000 abstract description 8
• 235000018102 proteins Nutrition 0.000 description 27
• 230000000813 microbial effect Effects 0.000 description 23
• 238000011282 treatment Methods 0.000 description 20
• 235000014633 carbohydrates Nutrition 0.000 description 16
• 239000002609 medium Substances 0.000 description 14
• 241000894007 species Species 0.000 description 14
• 108091027967 Small hairpin RNA Proteins 0.000 description 13
• 241001465754 Metazoa Species 0.000 description 12
• 230000037396 body weight Effects 0.000 description 12
• 235000013305 food Nutrition 0.000 description 12
• 239000003183 carcinogenic agent Substances 0.000 description 11
• 229910052500 inorganic mineral Inorganic materials 0.000 description 11
• 235000010755 mineral Nutrition 0.000 description 11
• 239000011707 mineral Substances 0.000 description 11
• 241000699666 Mus <mouse, genus> Species 0.000 description 10
• 238000004519 manufacturing process Methods 0.000 description 10
• 239000000463 material Substances 0.000 description 10
• 210000001519 tissue Anatomy 0.000 description 10
• 239000012830 cancer therapeutic Substances 0.000 description 9
• 108091033319 polynucleotide Proteins 0.000 description 9
• 102000040430 polynucleotide Human genes 0.000 description 9
• 239000002157 polynucleotide Substances 0.000 description 9
• 239000000047 product Substances 0.000 description 9
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 8
• 230000000692 anti-sense effect Effects 0.000 description 8
• 201000010989 colorectal carcinoma Diseases 0.000 description 8
• 238000009472 formulation Methods 0.000 description 8
• 238000002347 injection Methods 0.000 description 8
• 239000007924 injection Substances 0.000 description 8
• 239000000546 pharmaceutical excipient Substances 0.000 description 8
• 239000000126 substance Substances 0.000 description 8
• 239000006228 supernatant Substances 0.000 description 8
• 229940088594 vitamin Drugs 0.000 description 8
• 229930003231 vitamin Natural products 0.000 description 8
• 235000013343 vitamin Nutrition 0.000 description 8
• 239000011782 vitamin Substances 0.000 description 8
• 108091028043 Nucleic acid sequence Proteins 0.000 description 7
• 108091034117 Oligonucleotide Proteins 0.000 description 7
• 201000010099 disease Diseases 0.000 description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
• 239000007884 disintegrant Substances 0.000 description 7
• 150000002632 lipids Chemical class 0.000 description 7
• 244000005700 microbiome Species 0.000 description 7
• 229920002472 Starch Polymers 0.000 description 6
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
• 230000000295 complement effect Effects 0.000 description 6
• 239000012141 concentrate Substances 0.000 description 6
• 230000009368 gene silencing by RNA Effects 0.000 description 6
• 238000012544 monitoring process Methods 0.000 description 6
• 150000002772 monosaccharides Chemical class 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• 238000002360 preparation method Methods 0.000 description 6
• 230000002829 reductive effect Effects 0.000 description 6
• 235000019698 starch Nutrition 0.000 description 6
• 238000001356 surgical procedure Methods 0.000 description 6
• 230000004614 tumor growth Effects 0.000 description 6
• 229920001817 Agar Polymers 0.000 description 5
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 5
• 206010027476 Metastases Diseases 0.000 description 5
• 230000002411 adverse Effects 0.000 description 5
• 239000008272 agar Substances 0.000 description 5
• 239000003153 chemical reaction reagent Substances 0.000 description 5
• 150000002016 disaccharides Chemical class 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 210000004962 mammalian cell Anatomy 0.000 description 5
• 239000008194 pharmaceutical composition Substances 0.000 description 5
• 230000009467 reduction Effects 0.000 description 5
• 230000010076 replication Effects 0.000 description 5
• 238000002271 resection Methods 0.000 description 5
• 230000001988 toxicity Effects 0.000 description 5
• 231100000419 toxicity Toxicity 0.000 description 5
• 238000005199 ultracentrifugation Methods 0.000 description 5
• 150000003722 vitamin derivatives Chemical class 0.000 description 5
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• 241000098811 Asinibacterium lactis Species 0.000 description 4
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
• 108010010803 Gelatin Proteins 0.000 description 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
• 208000019025 Hypokalemia Diseases 0.000 description 4
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
• 239000000074 antisense oligonucleotide Substances 0.000 description 4
• 238000012230 antisense oligonucleotides Methods 0.000 description 4
• 208000035269 cancer or benign tumor Diseases 0.000 description 4
• 239000002775 capsule Substances 0.000 description 4
• 238000002659 cell therapy Methods 0.000 description 4
• 239000002552 dosage form Substances 0.000 description 4
• 239000003925 fat Substances 0.000 description 4
• 235000019197 fats Nutrition 0.000 description 4
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
• 229920000159 gelatin Polymers 0.000 description 4
• 235000019322 gelatine Nutrition 0.000 description 4
• 235000011852 gelatine desserts Nutrition 0.000 description 4
• 230000002068 genetic effect Effects 0.000 description 4
• 230000036541 health Effects 0.000 description 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
• 230000005764 inhibitory process Effects 0.000 description 4
• 238000007918 intramuscular administration Methods 0.000 description 4
• 238000007912 intraperitoneal administration Methods 0.000 description 4
• 238000002955 isolation Methods 0.000 description 4
• 239000002207 metabolite Substances 0.000 description 4
• 230000009401 metastasis Effects 0.000 description 4
• 208000024896 potassium deficiency disease Diseases 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• 239000003755 preservative agent Substances 0.000 description 4
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
• 150000003839 salts Chemical class 0.000 description 4
• 239000004055 small Interfering RNA Substances 0.000 description 4
• 229940032147 starch Drugs 0.000 description 4
• 239000008107 starch Substances 0.000 description 4
• 238000003860 storage Methods 0.000 description 4
• 230000009466 transformation Effects 0.000 description 4
• 241000282472 Canis lupus familiaris Species 0.000 description 3
• 206010013975 Dyspnoeas Diseases 0.000 description 3
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
• 229920000881 Modified starch Polymers 0.000 description 3
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 3
• 108010016790 RNA-Induced Silencing Complex Proteins 0.000 description 3
• 102000000574 RNA-Induced Silencing Complex Human genes 0.000 description 3
• 108091030071 RNAI Proteins 0.000 description 3
• 241000700159 Rattus Species 0.000 description 3
• 239000007983 Tris buffer Substances 0.000 description 3
• 239000000443 aerosol Substances 0.000 description 3
• MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 3
• 229940088710 antibiotic agent Drugs 0.000 description 3
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
• 239000011230 binding agent Substances 0.000 description 3
• 239000006172 buffering agent Substances 0.000 description 3
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 description 3
• 229930195731 calicheamicin Natural products 0.000 description 3
• 235000010980 cellulose Nutrition 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 239000001913 cellulose Substances 0.000 description 3
• 210000001072 colon Anatomy 0.000 description 3
• 235000009508 confectionery Nutrition 0.000 description 3
• 238000011498 curative surgery Methods 0.000 description 3
• 235000014113 dietary fatty acids Nutrition 0.000 description 3
• POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 3
• 238000001035 drying Methods 0.000 description 3
• 201000006549 dyspepsia Diseases 0.000 description 3
• 239000000194 fatty acid Substances 0.000 description 3
• 229930195729 fatty acid Natural products 0.000 description 3
• 150000004665 fatty acids Chemical class 0.000 description 3
• 238000001914 filtration Methods 0.000 description 3
• 238000007710 freezing Methods 0.000 description 3
• 230000008014 freezing Effects 0.000 description 3
• 210000001035 gastrointestinal tract Anatomy 0.000 description 3
• 238000001727 in vivo Methods 0.000 description 3
• 230000002601 intratumoral effect Effects 0.000 description 3
• 230000007774 longterm Effects 0.000 description 3
• 239000000314 lubricant Substances 0.000 description 3
• 239000003094 microcapsule Substances 0.000 description 3
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
• 239000008108 microcrystalline cellulose Substances 0.000 description 3
• 229940016286 microcrystalline cellulose Drugs 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 239000002777 nucleoside Substances 0.000 description 3
• 150000003833 nucleoside derivatives Chemical class 0.000 description 3
• 229910052760 oxygen Inorganic materials 0.000 description 3
• 235000015927 pasta Nutrition 0.000 description 3
• 239000008188 pellet Substances 0.000 description 3
• 238000004321 preservation Methods 0.000 description 3
• 230000002335 preservative effect Effects 0.000 description 3
• 230000005855 radiation Effects 0.000 description 3
• 239000000523 sample Substances 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• 235000014347 soups Nutrition 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 230000008685 targeting Effects 0.000 description 3
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
• 229960005486 vaccine Drugs 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
• 201000004384 Alopecia Diseases 0.000 description 2
• 108020000948 Antisense Oligonucleotides Proteins 0.000 description 2
• 208000006820 Arthralgia Diseases 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 102100027314 Beta-2-microglobulin Human genes 0.000 description 2
• 102100023995 Beta-nerve growth factor Human genes 0.000 description 2
• 102400001242 Betacellulin Human genes 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 102000014914 Carrier Proteins Human genes 0.000 description 2
• 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• 206010011793 Cystitis haemorrhagic Diseases 0.000 description 2
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
• SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
• 102000001301 EGF receptor Human genes 0.000 description 2
• 108060006698 EGF receptor Proteins 0.000 description 2
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
• 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 description 2
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
• 102100030335 Midkine Human genes 0.000 description 2
• 108010092801 Midkine Proteins 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• 208000000112 Myalgia Diseases 0.000 description 2
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
• 101710163270 Nuclease Proteins 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 102100037419 Pituitary tumor-transforming gene 1 protein-interacting protein Human genes 0.000 description 2
• 206010035664 Pneumonia Diseases 0.000 description 2
• 208000003251 Pruritus Diseases 0.000 description 2
• MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 2
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
• 108091028664 Ribonucleotide Proteins 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 102000013275 Somatomedins Human genes 0.000 description 2
• UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 2
• MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 2
• DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 238000009098 adjuvant therapy Methods 0.000 description 2
• 235000010443 alginic acid Nutrition 0.000 description 2
• 229920000615 alginic acid Polymers 0.000 description 2
• 229940024606 amino acid Drugs 0.000 description 2
• 235000001014 amino acid Nutrition 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• 239000000440 bentonite Substances 0.000 description 2
• 229910000278 bentonite Inorganic materials 0.000 description 2
• 235000012216 bentonite Nutrition 0.000 description 2
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
• 108091008324 binding proteins Proteins 0.000 description 2
• 229960002685 biotin Drugs 0.000 description 2
• 235000020958 biotin Nutrition 0.000 description 2
• 239000011616 biotin Substances 0.000 description 2
• 238000004820 blood count Methods 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 210000000481 breast Anatomy 0.000 description 2
• 229940041514 candida albicans extract Drugs 0.000 description 2
• 230000015556 catabolic process Effects 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 210000003679 cervix uteri Anatomy 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 210000002808 connective tissue Anatomy 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• 238000005138 cryopreservation Methods 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
• 201000003146 cystitis Diseases 0.000 description 2
• 238000006731 degradation reaction Methods 0.000 description 2
• 238000002716 delivery method Methods 0.000 description 2
• 235000011850 desserts Nutrition 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 239000006185 dispersion Substances 0.000 description 2
• 208000002173 dizziness Diseases 0.000 description 2
• 235000020669 docosahexaenoic acid Nutrition 0.000 description 2
• UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
• 229960004679 doxorubicin Drugs 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 206010013781 dry mouth Diseases 0.000 description 2
• 230000002183 duodenal effect Effects 0.000 description 2
• 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• 235000019152 folic acid Nutrition 0.000 description 2
• 239000011724 folic acid Substances 0.000 description 2
• 229960000304 folic acid Drugs 0.000 description 2
• 235000003599 food sweetener Nutrition 0.000 description 2
• 238000005194 fractionation Methods 0.000 description 2
• 238000004108 freeze drying Methods 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 239000001963 growth medium Substances 0.000 description 2
• 210000003128 head Anatomy 0.000 description 2
• 235000013402 health food Nutrition 0.000 description 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
• 210000005260 human cell Anatomy 0.000 description 2
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
• VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 230000001571 immunoadjuvant effect Effects 0.000 description 2
• 239000000568 immunological adjuvant Substances 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 230000036512 infertility Effects 0.000 description 2
• 230000007803 itching Effects 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 238000002372 labelling Methods 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• 230000004060 metabolic process Effects 0.000 description 2
• 239000003475 metalloproteinase inhibitor Substances 0.000 description 2
• 230000002906 microbiologic effect Effects 0.000 description 2
• 235000013336 milk Nutrition 0.000 description 2
• 239000008267 milk Substances 0.000 description 2
• 210000004080 milk Anatomy 0.000 description 2
• 210000000066 myeloid cell Anatomy 0.000 description 2
• 201000000050 myeloid neoplasm Diseases 0.000 description 2
• 210000003739 neck Anatomy 0.000 description 2
• 235000015097 nutrients Nutrition 0.000 description 2
• 239000003921 oil Substances 0.000 description 2
• 235000019198 oils Nutrition 0.000 description 2
• 210000001672 ovary Anatomy 0.000 description 2
• 239000001301 oxygen Substances 0.000 description 2
• SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 2
• 239000006072 paste Substances 0.000 description 2
• 244000052769 pathogen Species 0.000 description 2
• 230000001717 pathogenic effect Effects 0.000 description 2
• 239000001814 pectin Substances 0.000 description 2
• 235000010987 pectin Nutrition 0.000 description 2
• 229920001277 pectin Polymers 0.000 description 2
• 238000002203 pretreatment Methods 0.000 description 2
• 210000002307 prostate Anatomy 0.000 description 2
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 2
• 230000000306 recurrent effect Effects 0.000 description 2
• 239000002336 ribonucleotide Substances 0.000 description 2
• 125000002652 ribonucleotide group Chemical group 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 235000017557 sodium bicarbonate Nutrition 0.000 description 2
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
• 229920003109 sodium starch glycolate Polymers 0.000 description 2
• 239000008109 sodium starch glycolate Substances 0.000 description 2
• 229940079832 sodium starch glycolate Drugs 0.000 description 2
• 230000009870 specific binding Effects 0.000 description 2
• UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 2
• 210000002784 stomach Anatomy 0.000 description 2
• 239000003765 sweetening agent Substances 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• 210000003932 urinary bladder Anatomy 0.000 description 2
• 210000004291 uterus Anatomy 0.000 description 2
• 230000035899 viability Effects 0.000 description 2
• 229940011671 vitamin b6 Drugs 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 239000012138 yeast extract Substances 0.000 description 2
• 235000013618 yogurt Nutrition 0.000 description 2
• NNJPGOLRFBJNIW-HNNXBMFYSA-N (-)-demecolcine Chemical compound C1=C(OC)C(=O)C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-HNNXBMFYSA-N 0.000 description 1
• BITHHVVYSMSWAG-KTKRTIGZSA-N (11Z)-icos-11-enoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCC(O)=O BITHHVVYSMSWAG-KTKRTIGZSA-N 0.000 description 1
• XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
• GEHPRJRWZDWFBJ-FOCLMDBBSA-N (2E)-2-heptadecenoic acid Chemical compound CCCCCCCCCCCCCC\C=C\C(O)=O GEHPRJRWZDWFBJ-FOCLMDBBSA-N 0.000 description 1
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
• AHOKKYCUWBLDST-QYULHYBRSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=CC=C1 AHOKKYCUWBLDST-QYULHYBRSA-N 0.000 description 1
• XRBSKUSTLXISAB-XVVDYKMHSA-N (5r,6r,7r,8r)-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole-6-carboxylic acid Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H](CO)[C@@H]2C(O)=O)=C1 XRBSKUSTLXISAB-XVVDYKMHSA-N 0.000 description 1
• XRBSKUSTLXISAB-UHFFFAOYSA-N (7R,7'R,8R,8'R)-form-Podophyllic acid Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C(CO)C2C(O)=O)=C1 XRBSKUSTLXISAB-UHFFFAOYSA-N 0.000 description 1
• YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
• DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
• ATNNLHXCRAAGJS-QZQOTICOSA-N (e)-docos-2-enoic acid Chemical compound CCCCCCCCCCCCCCCCCCC\C=C\C(O)=O ATNNLHXCRAAGJS-QZQOTICOSA-N 0.000 description 1
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
• FONKWHRXTPJODV-DNQXCXABSA-N 1,3-bis[2-[(8s)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3h-pyrrolo[3,2-e]indole-6-carbonyl]-1h-indol-5-yl]urea Chemical class C1([C@H](CCl)CN2C(=O)C=3NC4=CC=C(C=C4C=3)NC(=O)NC=3C=C4C=C(NC4=CC=3)C(=O)N3C4=CC(O)=C5NC=C(C5=C4[C@H](CCl)C3)C)=C2C=C(O)C2=C1C(C)=CN2 FONKWHRXTPJODV-DNQXCXABSA-N 0.000 description 1
• VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
• TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
• ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
• YIMDLWDNDGKDTJ-QLKYHASDSA-N 3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin Chemical compound N1([C@H]2C[C@@H](O[C@@H](C)[C@H]2O)O[C@H]2C[C@@](O)(CC=3C(O)=C4C(=O)C=5C=CC=C(C=5C(=O)C4=C(O)C=32)OC)C(=O)CO)CCOCC1C#N YIMDLWDNDGKDTJ-QLKYHASDSA-N 0.000 description 1
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
• IDPUKCWIGUEADI-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]uracil Chemical compound ClCCN(CCCl)C1=CNC(=O)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• 208000035657 Abasia Diseases 0.000 description 1
• 208000004998 Abdominal Pain Diseases 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 201000010000 Agranulocytosis Diseases 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 208000000044 Amnesia Diseases 0.000 description 1
• 229920000945 Amylopectin Polymers 0.000 description 1
• 229920000856 Amylose Polymers 0.000 description 1
• 206010002198 Anaphylactic reaction Diseases 0.000 description 1
• 208000019901 Anxiety disease Diseases 0.000 description 1
• 101100468645 Arabidopsis thaliana RHD3 gene Proteins 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 206010003591 Ataxia Diseases 0.000 description 1
• NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
• 208000037157 Azotemia Diseases 0.000 description 1
• 235000021357 Behenic acid Nutrition 0.000 description 1
• 229940122361 Bisphosphonate Drugs 0.000 description 1
• 206010065553 Bone marrow failure Diseases 0.000 description 1
• 206010006002 Bone pain Diseases 0.000 description 1
• DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 1
• 102100036842 C-C motif chemokine 19 Human genes 0.000 description 1
• 101710112622 C-C motif chemokine 19 Proteins 0.000 description 1
• 101710098309 C-X-C motif chemokine 13 Proteins 0.000 description 1
• 229940045513 CTLA4 antagonist Drugs 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000589875 Campylobacter jejuni Species 0.000 description 1
• 208000031229 Cardiomyopathies Diseases 0.000 description 1
• 206010048610 Cardiotoxicity Diseases 0.000 description 1
• 108090000994 Catalytic RNA Proteins 0.000 description 1
• 102000053642 Catalytic RNA Human genes 0.000 description 1
• 208000002177 Cataract Diseases 0.000 description 1
• 229940124957 Cervarix Drugs 0.000 description 1
• GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
• XCDXSSFOJZZGQC-UHFFFAOYSA-N Chlornaphazine Chemical compound C1=CC=CC2=CC(N(CCCl)CCCl)=CC=C21 XCDXSSFOJZZGQC-UHFFFAOYSA-N 0.000 description 1
• MKQWTWSXVILIKJ-LXGUWJNJSA-N Chlorozotocin Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)NC(=O)N(N=O)CCCl MKQWTWSXVILIKJ-LXGUWJNJSA-N 0.000 description 1
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
• 241000723346 Cinnamomum camphora Species 0.000 description 1
• 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
• 206010010741 Conjunctivitis Diseases 0.000 description 1
• 206010010774 Constipation Diseases 0.000 description 1
• 208000034656 Contusions Diseases 0.000 description 1
• 206010010904 Convulsion Diseases 0.000 description 1
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
• 206010011224 Cough Diseases 0.000 description 1
• 244000303965 Cyamopsis psoralioides Species 0.000 description 1
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 1
• GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
• AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• 230000004543 DNA replication Effects 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 1
• 206010011878 Deafness Diseases 0.000 description 1
• 206010051055 Deep vein thrombosis Diseases 0.000 description 1
• 208000005156 Dehydration Diseases 0.000 description 1
• NNJPGOLRFBJNIW-UHFFFAOYSA-N Demecolcine Natural products C1=C(OC)C(=O)C=C2C(NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-UHFFFAOYSA-N 0.000 description 1
• 108010053770 Deoxyribonucleases Proteins 0.000 description 1
• 102000016911 Deoxyribonucleases Human genes 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
• 206010013786 Dry skin Diseases 0.000 description 1
• 208000000059 Dyspnea Diseases 0.000 description 1
• 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
• 206010014418 Electrolyte imbalance Diseases 0.000 description 1
• SAMRUMKYXPVKPA-VFKOLLTISA-N Enocitabine Chemical compound O=C1N=C(NC(=O)CCCCCCCCCCCCCCCCCCCCC)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 SAMRUMKYXPVKPA-VFKOLLTISA-N 0.000 description 1
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
• 206010015150 Erythema Diseases 0.000 description 1
• 241001302654 Escherichia coli Nissle 1917 Species 0.000 description 1
• 108700039887 Essential Genes Proteins 0.000 description 1
• 239000001856 Ethyl cellulose Substances 0.000 description 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 108060002716 Exonuclease Proteins 0.000 description 1
• 101150089023 FASLG gene Proteins 0.000 description 1
• 208000002633 Febrile Neutropenia Diseases 0.000 description 1
• 206010016807 Fluid retention Diseases 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• 240000006927 Foeniculum vulgare Species 0.000 description 1
• 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
• 208000000666 Fowlpox Diseases 0.000 description 1
• 102000005698 Frizzled receptors Human genes 0.000 description 1
• 108010045438 Frizzled receptors Proteins 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• 208000003098 Ganglion Cysts Diseases 0.000 description 1
• 206010061979 Genital pain Diseases 0.000 description 1
• 208000010412 Glaucoma Diseases 0.000 description 1
• 229920002527 Glycogen Polymers 0.000 description 1
• 206010018687 Granulocytopenia Diseases 0.000 description 1
• 101150031823 HSP70 gene Proteins 0.000 description 1
• 206010018852 Haematoma Diseases 0.000 description 1
• 208000002375 Hand-Foot Syndrome Diseases 0.000 description 1
• 206010019233 Headaches Diseases 0.000 description 1
• 206010019280 Heart failures Diseases 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• 206010019851 Hepatotoxicity Diseases 0.000 description 1
• 108091027305 Heteroduplex Proteins 0.000 description 1
• 101100118545 Holotrichia diomphalia EGF-like gene Proteins 0.000 description 1
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 description 1
• 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
• 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
• 108700020121 Human Immunodeficiency Virus-1 rev Proteins 0.000 description 1
• VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
• 206010020597 Hyperchloraemia Diseases 0.000 description 1
• 208000002682 Hyperkalemia Diseases 0.000 description 1
• 206010067725 Hyperlipasaemia Diseases 0.000 description 1
• 206010020669 Hypermagnesaemia Diseases 0.000 description 1
• 208000029422 Hypernatremia Diseases 0.000 description 1
• 206010020751 Hypersensitivity Diseases 0.000 description 1
• 206010020772 Hypertension Diseases 0.000 description 1
• 201000001431 Hyperuricemia Diseases 0.000 description 1
• 208000004044 Hypesthesia Diseases 0.000 description 1
• 208000003623 Hypoalbuminemia Diseases 0.000 description 1
• 208000029663 Hypophosphatemia Diseases 0.000 description 1
• 208000001953 Hypotension Diseases 0.000 description 1
• 229940124672 IMA901 Drugs 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000037982 Immune checkpoint proteins Human genes 0.000 description 1
• 108091008036 Immune checkpoint proteins Proteins 0.000 description 1
• 206010022095 Injection Site reaction Diseases 0.000 description 1
• 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
• 102100020881 Interleukin-1 alpha Human genes 0.000 description 1
• 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
• 108091092195 Intron Proteins 0.000 description 1
• 229920001202 Inulin Polymers 0.000 description 1
• 206010022971 Iron Deficiencies Diseases 0.000 description 1
• 102000002698 KIR Receptors Human genes 0.000 description 1
• 108010062028 L-BLP25 Proteins 0.000 description 1
• 241000186660 Lactobacillus Species 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 239000005639 Lauric acid Substances 0.000 description 1
• 235000021353 Lignoceric acid Nutrition 0.000 description 1
• CQXMAMUUWHYSIY-UHFFFAOYSA-N Lignoceric acid Natural products CCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 CQXMAMUUWHYSIY-UHFFFAOYSA-N 0.000 description 1
• OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
• GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 1
• 102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 240000002129 Malva sylvestris Species 0.000 description 1
• 235000006770 Malva sylvestris Nutrition 0.000 description 1
• 240000004658 Medicago sativa Species 0.000 description 1
• 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 208000026139 Memory disease Diseases 0.000 description 1
• 206010027406 Mesothelioma Diseases 0.000 description 1
• 108050006599 Metalloproteinase inhibitor 1 Proteins 0.000 description 1
• 241000736262 Microbiota Species 0.000 description 1
• ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
• 241000258113 Monases Species 0.000 description 1
• 206010028116 Mucosal inflammation Diseases 0.000 description 1
• 201000010927 Mucositis Diseases 0.000 description 1
• 208000007101 Muscle Cramp Diseases 0.000 description 1
• 208000009525 Myocarditis Diseases 0.000 description 1
• 235000021360 Myristic acid Nutrition 0.000 description 1
• TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
• 206010028813 Nausea Diseases 0.000 description 1
• 206010028851 Necrosis Diseases 0.000 description 1
• 206010029155 Nephropathy toxic Diseases 0.000 description 1
• 206010029350 Neurotoxicity Diseases 0.000 description 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
• 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 1
• 108010047956 Nucleosomes Proteins 0.000 description 1
• 206010030113 Oedema Diseases 0.000 description 1
• 206010030216 Oesophagitis Diseases 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 206010031009 Oral pain Diseases 0.000 description 1
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
• 240000007594 Oryza sativa Species 0.000 description 1
• 235000007164 Oryza sativa Nutrition 0.000 description 1
• 102100040557 Osteopontin Human genes 0.000 description 1
• 206010033109 Ototoxicity Diseases 0.000 description 1
• 238000012408 PCR amplification Methods 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 229930012538 Paclitaxel Natural products 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 235000021314 Palmitic acid Nutrition 0.000 description 1
• 235000021319 Palmitoleic acid Nutrition 0.000 description 1
• 206010033557 Palpitations Diseases 0.000 description 1
• VREZDOWOLGNDPW-ALTGWBOUSA-N Pancratistatin Chemical compound C1=C2[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)[C@@H]3NC(=O)C2=C(O)C2=C1OCO2 VREZDOWOLGNDPW-ALTGWBOUSA-N 0.000 description 1
• VREZDOWOLGNDPW-MYVCAWNPSA-N Pancratistatin Natural products O=C1N[C@H]2[C@H](O)[C@H](O)[C@H](O)[C@H](O)[C@@H]2c2c1c(O)c1OCOc1c2 VREZDOWOLGNDPW-MYVCAWNPSA-N 0.000 description 1
• 206010033661 Pancytopenia Diseases 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 239000001888 Peptone Substances 0.000 description 1
• 108010080698 Peptones Proteins 0.000 description 1
• 201000007100 Pharyngitis Diseases 0.000 description 1
• 244000046052 Phaseolus vulgaris Species 0.000 description 1
• 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
• 108010089430 Phosphoproteins Proteins 0.000 description 1
• 102000007982 Phosphoproteins Human genes 0.000 description 1
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
• 206010034960 Photophobia Diseases 0.000 description 1
• 206010034972 Photosensitivity reaction Diseases 0.000 description 1
• KMSKQZKKOZQFFG-HSUXVGOQSA-N Pirarubicin Chemical compound O([C@H]1[C@@H](N)C[C@@H](O[C@H]1C)O[C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1CCCCO1 KMSKQZKKOZQFFG-HSUXVGOQSA-N 0.000 description 1
• 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 1
• 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 description 1
• 206010035742 Pneumonitis Diseases 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 108010039918 Polylysine Proteins 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 208000001431 Psychomotor Agitation Diseases 0.000 description 1
• 206010061924 Pulmonary toxicity Diseases 0.000 description 1
• 206010037660 Pyrexia Diseases 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 206010038063 Rectal haemorrhage Diseases 0.000 description 1
• 206010038111 Recurrent cancer Diseases 0.000 description 1
• 208000001647 Renal Insufficiency Diseases 0.000 description 1
• 206010038743 Restlessness Diseases 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 108020004422 Riboswitch Proteins 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 241000831652 Salinivibrio sharmensis Species 0.000 description 1
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
• 108091081021 Sense strand Proteins 0.000 description 1
• 108010047827 Sialic Acid Binding Immunoglobulin-like Lectins Proteins 0.000 description 1
• 102000007073 Sialic Acid Binding Immunoglobulin-like Lectins Human genes 0.000 description 1
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 241000194019 Streptococcus mutans Species 0.000 description 1
• 241000194023 Streptococcus sanguinis Species 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 208000005400 Synovial Cyst Diseases 0.000 description 1
• 108010034610 TG4010 Proteins 0.000 description 1
• 108700012920 TNF Proteins 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 244000269722 Thea sinensis Species 0.000 description 1
• JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
• 208000007536 Thrombosis Diseases 0.000 description 1
• 208000009205 Tinnitus Diseases 0.000 description 1
• 102000005353 Tissue Inhibitor of Metalloproteinase-1 Human genes 0.000 description 1
• 102000005354 Tissue Inhibitor of Metalloproteinase-2 Human genes 0.000 description 1
• 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
• 206010044221 Toxic encephalopathy Diseases 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 108020004566 Transfer RNA Proteins 0.000 description 1
• SHGAZHPCJJPHSC-NWVFGJFESA-N Tretinoin Chemical compound OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NWVFGJFESA-N 0.000 description 1
• 206010046788 Uterine haemorrhage Diseases 0.000 description 1
• 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 description 1
• 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 description 1
• 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
• 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 description 1
• 206010047249 Venous thrombosis Diseases 0.000 description 1
• 108010066342 Virus Receptors Proteins 0.000 description 1
• 102000018265 Virus Receptors Human genes 0.000 description 1
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
• 229930003779 Vitamin B12 Natural products 0.000 description 1
• 229930003268 Vitamin C Natural products 0.000 description 1
• 229930003316 Vitamin D Natural products 0.000 description 1
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
• 229930003427 Vitamin E Natural products 0.000 description 1
• 229930003448 Vitamin K Natural products 0.000 description 1
• 206010047791 Vulvovaginal dryness Diseases 0.000 description 1
• 101001076308 Xenopus laevis Insulin-like growth factor III Proteins 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• NKVLDFAVEWLOCX-GUSKIFEASA-N [(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-4,5-dihydroxy-6-methyloxan-2-yl] (4ar,5r,6as,6br,9s,10s,12ar)-10-[(2r,3r,4s, Chemical compound O([C@H]1[C@H](O)CO[C@H]([C@@H]1O)O[C@H]1[C@H](C)O[C@H]([C@@H]([C@@H]1O)O)O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]1OC(=O)[C@]12CCC(C)(C)CC1C1=CCC3[C@@]([C@@]1(C[C@H]2O)C)(C)CCC1[C@]3(C)CC[C@@H]([C@@]1(C)C=O)O[C@@H]1O[C@@H]([C@H]([C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)CO2)O)[C@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O)C(=O)NCCCCCCCCCCCC)[C@@H]1OC[C@](O)(CO)[C@H]1O NKVLDFAVEWLOCX-GUSKIFEASA-N 0.000 description 1
• UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
• XZSRRNFBEIOBDA-CFNBKWCHSA-N [2-[(2s,4s)-4-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1h-tetracen-2-yl]-2-oxoethyl] 2,2-diethoxyacetate Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)C(OCC)OCC)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 XZSRRNFBEIOBDA-CFNBKWCHSA-N 0.000 description 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
• HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
• CKQGGZRXIMXVGF-BTVCFUMJSA-N [N].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O Chemical compound [N].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O CKQGGZRXIMXVGF-BTVCFUMJSA-N 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 125000002015 acyclic group Chemical group 0.000 description 1
• BYRVKDUQDLJUBX-JJCDCTGGSA-N adozelesin Chemical compound C1=CC=C2OC(C(=O)NC=3C=C4C=C(NC4=CC=3)C(=O)N3C[C@H]4C[C@]44C5=C(C(C=C43)=O)NC=C5C)=CC2=C1 BYRVKDUQDLJUBX-JJCDCTGGSA-N 0.000 description 1
• 229950004955 adozelesin Drugs 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• 235000013334 alcoholic beverage Nutrition 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
• 150000008052 alkyl sulfonates Chemical class 0.000 description 1
• 229940100198 alkylating agent Drugs 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
• 231100000360 alopecia Toxicity 0.000 description 1
• 229940087168 alpha tocopherol Drugs 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
• DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
• 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• QSIYTPCKNAPAJY-UHFFFAOYSA-N aluminum;ethoxy-oxido-oxophosphanium;2-(trichloromethylsulfanyl)isoindole-1,3-dione Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O.C1=CC=C2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C2=C1 QSIYTPCKNAPAJY-UHFFFAOYSA-N 0.000 description 1
• 230000036783 anaphylactic response Effects 0.000 description 1
• 208000003455 anaphylaxis Diseases 0.000 description 1
• 239000003098 androgen Substances 0.000 description 1
• 229940030486 androgens Drugs 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 238000011394 anticancer treatment Methods 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 229940045687 antimetabolites folic acid analogs Drugs 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 229940045688 antineoplastic antimetabolites pyrimidine analogues Drugs 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 230000005975 antitumor immune response Effects 0.000 description 1
• 230000036506 anxiety Effects 0.000 description 1
• 230000036528 appetite Effects 0.000 description 1
• 235000019789 appetite Nutrition 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• 230000006793 arrhythmia Effects 0.000 description 1
• 206010003119 arrhythmia Diseases 0.000 description 1
• 229940072107 ascorbate Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 206010003549 asthenia Diseases 0.000 description 1
• 108010045569 atelocollagen Proteins 0.000 description 1
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
• 150000001541 aziridines Chemical class 0.000 description 1
• 210000000270 basal cell Anatomy 0.000 description 1
• 235000013405 beer Nutrition 0.000 description 1
• 229940116226 behenic acid Drugs 0.000 description 1
• 108010081355 beta 2-Microglobulin Proteins 0.000 description 1
• DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
• 235000013361 beverage Nutrition 0.000 description 1
• 239000012867 bioactive agent Substances 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 230000001851 biosynthetic effect Effects 0.000 description 1
• 150000004663 bisphosphonates Chemical class 0.000 description 1
• 229950006844 bizelesin Drugs 0.000 description 1
• 208000034158 bleeding Diseases 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• 210000001185 bone marrow Anatomy 0.000 description 1
• 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 1
• 235000008429 bread Nutrition 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 229960001948 caffeine Drugs 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
• 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• 229960000846 camphor Drugs 0.000 description 1
• 229930008380 camphor Natural products 0.000 description 1
• 229940015062 campylobacter jejuni Drugs 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 231100000259 cardiotoxicity Toxicity 0.000 description 1
• 210000000845 cartilage Anatomy 0.000 description 1
• BBZDXMBRAFTCAA-AREMUKBSSA-N carzelesin Chemical compound C1=2NC=C(C)C=2C([C@H](CCl)CN2C(=O)C=3NC4=CC=C(C=C4C=3)NC(=O)C3=CC4=CC=C(C=C4O3)N(CC)CC)=C2C=C1OC(=O)NC1=CC=CC=C1 BBZDXMBRAFTCAA-AREMUKBSSA-N 0.000 description 1
• 229950007509 carzelesin Drugs 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 230000021164 cell adhesion Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 235000013351 cheese Nutrition 0.000 description 1
• 230000035605 chemotaxis Effects 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 235000015218 chewing gum Nutrition 0.000 description 1
• 229940112822 chewing gum Drugs 0.000 description 1
• 229950008249 chlornaphazine Drugs 0.000 description 1
• 229960001480 chlorozotocin Drugs 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 229910052804 chromium Inorganic materials 0.000 description 1
• 239000011651 chromium Substances 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
• 239000007399 clostridium medium Substances 0.000 description 1
• AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
• 208000010877 cognitive disease Diseases 0.000 description 1
• 230000005757 colony formation Effects 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 238000004440 column chromatography Methods 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000005494 condensation Effects 0.000 description 1
• 230000036461 convulsion Effects 0.000 description 1
• 238000010411 cooking Methods 0.000 description 1
• 235000014510 cooky Nutrition 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 208000029078 coronary artery disease Diseases 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000002577 cryoprotective agent Substances 0.000 description 1
• 238000002681 cryosurgery Methods 0.000 description 1
• 235000021438 curry Nutrition 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 229940097362 cyclodextrins Drugs 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 230000002354 daily effect Effects 0.000 description 1
• 235000019543 dairy drink Nutrition 0.000 description 1
• 235000013365 dairy product Nutrition 0.000 description 1
• 230000018044 dehydration Effects 0.000 description 1
• 238000006297 dehydration reaction Methods 0.000 description 1
• 229960005052 demecolcine Drugs 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 230000000368 destabilizing effect Effects 0.000 description 1
• 229950003913 detorubicin Drugs 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 238000011026 diafiltration Methods 0.000 description 1
• 238000000502 dialysis Methods 0.000 description 1
• WVYXNIXAMZOZFK-UHFFFAOYSA-N diaziquone Chemical compound O=C1C(NC(=O)OCC)=C(N2CC2)C(=O)C(NC(=O)OCC)=C1N1CC1 WVYXNIXAMZOZFK-UHFFFAOYSA-N 0.000 description 1
• 229950002389 diaziquone Drugs 0.000 description 1
• 235000015872 dietary supplement Nutrition 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 101150052825 dnaK gene Proteins 0.000 description 1
• 229940090949 docosahexaenoic acid Drugs 0.000 description 1
• KFEVDPWXEVUUMW-UHFFFAOYSA-N docosanoic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 KFEVDPWXEVUUMW-UHFFFAOYSA-N 0.000 description 1
• ZWAOHEXOSAUJHY-ZIYNGMLESA-N doxifluridine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ZWAOHEXOSAUJHY-ZIYNGMLESA-N 0.000 description 1
• 229950005454 doxifluridine Drugs 0.000 description 1
• NOTIQUSPUUHHEH-UXOVVSIBSA-N dromostanolone propionate Chemical compound C([C@@H]1CC2)C(=O)[C@H](C)C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](OC(=O)CC)[C@@]2(C)CC1 NOTIQUSPUUHHEH-UXOVVSIBSA-N 0.000 description 1
• 229950004683 drostanolone propionate Drugs 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 230000037336 dry skin Effects 0.000 description 1
• 229960005501 duocarmycin Drugs 0.000 description 1
• VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 description 1
• 229930184221 duocarmycin Natural products 0.000 description 1
• 210000001198 duodenum Anatomy 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• FSIRXIHZBIXHKT-MHTVFEQDSA-N edatrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CC(CC)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FSIRXIHZBIXHKT-MHTVFEQDSA-N 0.000 description 1
• 229950006700 edatrexate Drugs 0.000 description 1
• 235000013399 edible fruits Nutrition 0.000 description 1
• 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
• JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
• IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 1
• 229940108623 eicosenoic acid Drugs 0.000 description 1
• BITHHVVYSMSWAG-UHFFFAOYSA-N eicosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCC(O)=O BITHHVVYSMSWAG-UHFFFAOYSA-N 0.000 description 1
• 238000004520 electroporation Methods 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 210000003372 endocrine gland Anatomy 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 229950011487 enocitabine Drugs 0.000 description 1
• 229960001904 epirubicin Drugs 0.000 description 1
• 208000001780 epistaxis Diseases 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 208000006881 esophagitis Diseases 0.000 description 1
• 235000019325 ethyl cellulose Nutrition 0.000 description 1
• 229920001249 ethyl cellulose Polymers 0.000 description 1
• ZXUMUPVQYAFTLF-UHFFFAOYSA-N etryptamine Chemical compound C1=CC=C2C(CC(N)CC)=CNC2=C1 ZXUMUPVQYAFTLF-UHFFFAOYSA-N 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 102000013165 exonuclease Human genes 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 206010016256 fatigue Diseases 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 235000019985 fermented beverage Nutrition 0.000 description 1
• 229960004642 ferric ammonium citrate Drugs 0.000 description 1
• 230000035558 fertility Effects 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 206010016766 flatulence Diseases 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 1
• 229960000961 floxuridine Drugs 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 150000002224 folic acids Chemical class 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000021588 free fatty acids Nutrition 0.000 description 1
• 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
• 235000013376 functional food Nutrition 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
• 230000030279 gene silencing Effects 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 230000002518 glial effect Effects 0.000 description 1
• 229940096919 glycogen Drugs 0.000 description 1
• 150000002337 glycosamines Chemical group 0.000 description 1
• 150000002338 glycosides Chemical class 0.000 description 1
• 102000035122 glycosylated proteins Human genes 0.000 description 1
• 108091005608 glycosylated proteins Proteins 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 201000000079 gynecomastia Diseases 0.000 description 1
• 208000024963 hair loss Diseases 0.000 description 1
• 230000003676 hair loss Effects 0.000 description 1
• 231100000869 headache Toxicity 0.000 description 1
• 230000010370 hearing loss Effects 0.000 description 1
• 231100000888 hearing loss Toxicity 0.000 description 1
• 208000016354 hearing loss disease Diseases 0.000 description 1
• 210000002216 heart Anatomy 0.000 description 1
• 208000018578 heart valve disease Diseases 0.000 description 1
• 208000024798 heartburn Diseases 0.000 description 1
• BTIJJDXEELBZFS-UHFFFAOYSA-K hemin Chemical compound [Cl-].[Fe+3].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 BTIJJDXEELBZFS-UHFFFAOYSA-K 0.000 description 1
• 201000002802 hemorrhagic cystitis Diseases 0.000 description 1
• 208000005252 hepatitis A Diseases 0.000 description 1
• 231100000304 hepatotoxicity Toxicity 0.000 description 1
• 230000007686 hepatotoxicity Effects 0.000 description 1
• IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
• 150000002402 hexoses Chemical class 0.000 description 1
• 235000012907 honey Nutrition 0.000 description 1
• 238000001794 hormone therapy Methods 0.000 description 1
• 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
• 229960001330 hydroxycarbamide Drugs 0.000 description 1
• 208000033849 hyperamylasemia Diseases 0.000 description 1
• 201000001421 hyperglycemia Diseases 0.000 description 1
• 201000005991 hyperphosphatemia Diseases 0.000 description 1
• 208000000069 hyperpigmentation Diseases 0.000 description 1
• 230000003810 hyperpigmentation Effects 0.000 description 1
• 208000006575 hypertriglyceridemia Diseases 0.000 description 1
• 208000034783 hypoesthesia Diseases 0.000 description 1
• 235000015243 ice cream Nutrition 0.000 description 1
• 210000003405 ileum Anatomy 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 230000005934 immune activation Effects 0.000 description 1
• 239000012651 immune agonist Substances 0.000 description 1
• 229940044680 immune agonist Drugs 0.000 description 1
• 230000005746 immune checkpoint blockade Effects 0.000 description 1
• 230000003308 immunostimulating effect Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 201000001881 impotence Diseases 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 108091005434 innate immune receptors Proteins 0.000 description 1
• 206010022437 insomnia Diseases 0.000 description 1
• 235000014109 instant soup Nutrition 0.000 description 1
• 102000028416 insulin-like growth factor binding Human genes 0.000 description 1
• 108091022911 insulin-like growth factor binding Proteins 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
• 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
• 229940029339 inulin Drugs 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 239000004313 iron ammonium citrate Substances 0.000 description 1
• 235000000011 iron ammonium citrate Nutrition 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 201000006370 kidney failure Diseases 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 238000002430 laser surgery Methods 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 201000002364 leukopenia Diseases 0.000 description 1
• 231100001022 leukopenia Toxicity 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 235000020778 linoleic acid Nutrition 0.000 description 1
• OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
• 229960004488 linolenic acid Drugs 0.000 description 1
• KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 230000005976 liver dysfunction Effects 0.000 description 1
• 229960002247 lomustine Drugs 0.000 description 1
• YROQEQPFUCPDCP-UHFFFAOYSA-N losoxantrone Chemical compound OCCNCCN1N=C2C3=CC=CC(O)=C3C(=O)C3=C2C1=CC=C3NCCNCCO YROQEQPFUCPDCP-UHFFFAOYSA-N 0.000 description 1
• 229950008745 losoxantrone Drugs 0.000 description 1
• 208000012866 low blood pressure Diseases 0.000 description 1
• 210000001165 lymph node Anatomy 0.000 description 1
• 230000034701 macropinocytosis Effects 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 1
• 239000002370 magnesium bicarbonate Substances 0.000 description 1
• 229910000022 magnesium bicarbonate Inorganic materials 0.000 description 1
• 235000014824 magnesium bicarbonate Nutrition 0.000 description 1
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
• 239000001095 magnesium carbonate Substances 0.000 description 1
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
• 235000019341 magnesium sulphate Nutrition 0.000 description 1
• HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
• 239000012092 media component Substances 0.000 description 1
• 210000002752 melanocyte Anatomy 0.000 description 1
• 230000006984 memory degeneration Effects 0.000 description 1
• 208000023060 memory loss Diseases 0.000 description 1
• 230000009245 menopause Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 235000010981 methylcellulose Nutrition 0.000 description 1
• 238000001471 micro-filtration Methods 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 229960000350 mitotane Drugs 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 235000019426 modified starch Nutrition 0.000 description 1
• 229910052750 molybdenum Inorganic materials 0.000 description 1
• 239000011733 molybdenum Substances 0.000 description 1
• 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
• 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
• 235000019799 monosodium phosphate Nutrition 0.000 description 1
• 239000006872 mrs medium Substances 0.000 description 1
• 229940051875 mucins Drugs 0.000 description 1
• 208000013465 muscle pain Diseases 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• 229950006780 n-acetylglucosamine Drugs 0.000 description 1
• 208000011309 nasal bleeding Diseases 0.000 description 1
• 230000008693 nausea Effects 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 210000005170 neoplastic cell Anatomy 0.000 description 1
• 231100000417 nephrotoxicity Toxicity 0.000 description 1
• 230000007694 nephrotoxicity Effects 0.000 description 1
• 231100000228 neurotoxicity Toxicity 0.000 description 1
• 230000007135 neurotoxicity Effects 0.000 description 1
• 239000003900 neurotrophic factor Substances 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• 238000007481 next generation sequencing Methods 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 229960003512 nicotinic acid Drugs 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 229960001420 nimustine Drugs 0.000 description 1
• VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 239000002853 nucleic acid probe Substances 0.000 description 1
• 229940023146 nucleic acid vaccine Drugs 0.000 description 1
• 210000001623 nucleosome Anatomy 0.000 description 1
• 231100000862 numbness Toxicity 0.000 description 1
• 239000006916 nutrient agar Substances 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 238000006384 oligomerization reaction Methods 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 231100000262 ototoxicity Toxicity 0.000 description 1
• 201000003733 ovarian melanoma Diseases 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 238000011499 palliative surgery Methods 0.000 description 1
• VREZDOWOLGNDPW-UHFFFAOYSA-N pancratistatine Natural products C1=C2C3C(O)C(O)C(O)C(O)C3NC(=O)C2=C(O)C2=C1OCO2 VREZDOWOLGNDPW-UHFFFAOYSA-N 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 229940055726 pantothenic acid Drugs 0.000 description 1
• 235000019161 pantothenic acid Nutrition 0.000 description 1
• 239000011713 pantothenic acid Substances 0.000 description 1
• 235000019319 peptone Nutrition 0.000 description 1
• 208000008494 pericarditis Diseases 0.000 description 1
• 208000033808 peripheral neuropathy Diseases 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 150000003905 phosphatidylinositols Chemical class 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 150000008300 phosphoramidites Chemical class 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 239000011574 phosphorus Substances 0.000 description 1
• 230000036211 photosensitivity Effects 0.000 description 1
• SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
• 230000001766 physiological effect Effects 0.000 description 1
• 230000006461 physiological response Effects 0.000 description 1
• 235000021110 pickles Nutrition 0.000 description 1
• NUKCGLDCWQXYOQ-UHFFFAOYSA-N piposulfan Chemical compound CS(=O)(=O)OCCC(=O)N1CCN(C(=O)CCOS(C)(=O)=O)CC1 NUKCGLDCWQXYOQ-UHFFFAOYSA-N 0.000 description 1
• 229950001100 piposulfan Drugs 0.000 description 1
• 229960001221 pirarubicin Drugs 0.000 description 1
• 231100000374 pneumotoxicity Toxicity 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 229920000656 polylysine Polymers 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
• 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 239000006041 probiotic Substances 0.000 description 1
• 230000000529 probiotic effect Effects 0.000 description 1
• 235000018291 probiotics Nutrition 0.000 description 1
• CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
• 229960000624 procarbazine Drugs 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 229940023143 protein vaccine Drugs 0.000 description 1
• 201000001474 proteinuria Diseases 0.000 description 1
• 210000001938 protoplast Anatomy 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 208000005069 pulmonary fibrosis Diseases 0.000 description 1
• 230000007047 pulmonary toxicity Effects 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
• 235000008160 pyridoxine Nutrition 0.000 description 1
• 239000011677 pyridoxine Substances 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• 108700022487 rRNA Genes Proteins 0.000 description 1
• 230000003439 radiotherapeutic effect Effects 0.000 description 1
• 108010014186 ras Proteins Proteins 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 238000010992 reflux Methods 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 206010039083 rhinitis Diseases 0.000 description 1
• 235000019192 riboflavin Nutrition 0.000 description 1
• 229960002477 riboflavin Drugs 0.000 description 1
• 239000002151 riboflavin Substances 0.000 description 1
• 108020004418 ribosomal RNA Proteins 0.000 description 1
• 108091092562 ribozyme Proteins 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 235000015067 sauces Nutrition 0.000 description 1
• 235000013580 sausages Nutrition 0.000 description 1
• 235000014102 seafood Nutrition 0.000 description 1
• 208000011581 secondary neoplasm Diseases 0.000 description 1
• 229910052711 selenium Inorganic materials 0.000 description 1
• 239000011669 selenium Substances 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 208000013220 shortness of breath Diseases 0.000 description 1
• 235000021309 simple sugar Nutrition 0.000 description 1
• 201000009890 sinusitis Diseases 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
• 239000012064 sodium phosphate buffer Substances 0.000 description 1
• 235000014214 soft drink Nutrition 0.000 description 1
• ICXJVZHDZFXYQC-UHFFFAOYSA-N spongistatin 1 Natural products OC1C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC2(O2)CC(OC)CC2CC(=O)C(C)C(OC(C)=O)C(C)C(=C)CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC2C(O)C(CC(=C)CC(O)C=CC(Cl)=C)OC1C2C ICXJVZHDZFXYQC-UHFFFAOYSA-N 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 238000001694 spray drying Methods 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 230000010473 stable expression Effects 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 238000000859 sublimation Methods 0.000 description 1
• 230000008022 sublimation Effects 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 238000000856 sucrose gradient centrifugation Methods 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 239000012134 supernatant fraction Substances 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
• UMHMOGFSSCTSNY-XSJWQOAGSA-N tecemotide Chemical compound CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](C(=O)NCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]2N(CCC2)C(=O)[C@H](C)NC(=O)[C@H]2N(CCC2)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC=2NC=NC=2)NC(=O)[C@H](C)NC(=O)[C@H]2N(CCC2)C(=O)[C@H]2N(CCC2)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CCC1 UMHMOGFSSCTSNY-XSJWQOAGSA-N 0.000 description 1
• 229950001399 tecemotide Drugs 0.000 description 1
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
• 229960001278 teniposide Drugs 0.000 description 1
• QZZGJDVWLFXDLK-UHFFFAOYSA-N tetracosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(O)=O QZZGJDVWLFXDLK-UHFFFAOYSA-N 0.000 description 1
• 230000004797 therapeutic response Effects 0.000 description 1
• 235000019157 thiamine Nutrition 0.000 description 1
• 229960003495 thiamine Drugs 0.000 description 1
• 239000011721 thiamine Substances 0.000 description 1
• KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
• 206010043554 thrombocytopenia Diseases 0.000 description 1
• 231100000886 tinnitus Toxicity 0.000 description 1
• 229960000984 tocofersolan Drugs 0.000 description 1
• AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 229960000303 topotecan Drugs 0.000 description 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 238000012549 training Methods 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 230000002103 transcriptional effect Effects 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1
• AUALKMYBYGCYNY-UHFFFAOYSA-E triazanium;2-hydroxypropane-1,2,3-tricarboxylate;iron(3+) Chemical compound [NH4+].[NH4+].[NH4+].[Fe+3].[Fe+3].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O AUALKMYBYGCYNY-UHFFFAOYSA-E 0.000 description 1
• 150000003327 trichothecene derivatives Chemical class 0.000 description 1
• ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
• RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
• 150000004043 trisaccharides Chemical class 0.000 description 1
• 229960000875 trofosfamide Drugs 0.000 description 1
• UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 description 1
• 239000006150 trypticase soy agar Substances 0.000 description 1
• DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
• 229960001055 uracil mustard Drugs 0.000 description 1
• 150000003673 urethanes Chemical class 0.000 description 1
• 229940045145 uridine Drugs 0.000 description 1
• 208000019206 urinary tract infection Diseases 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 235000019155 vitamin A Nutrition 0.000 description 1
• 239000011719 vitamin A Substances 0.000 description 1
• 235000019163 vitamin B12 Nutrition 0.000 description 1
• 239000011715 vitamin B12 Substances 0.000 description 1
• 235000019158 vitamin B6 Nutrition 0.000 description 1
• 239000011726 vitamin B6 Substances 0.000 description 1
• 235000019154 vitamin C Nutrition 0.000 description 1
• 239000011718 vitamin C Substances 0.000 description 1
• 235000019166 vitamin D Nutrition 0.000 description 1
• 239000011710 vitamin D Substances 0.000 description 1
• 150000003710 vitamin D derivatives Chemical class 0.000 description 1
• 235000019165 vitamin E Nutrition 0.000 description 1
• 229940046009 vitamin E Drugs 0.000 description 1
• 239000011709 vitamin E Substances 0.000 description 1
• 235000019168 vitamin K Nutrition 0.000 description 1
• 239000011712 vitamin K Substances 0.000 description 1
• 150000003721 vitamin K derivatives Chemical class 0.000 description 1
• 229940045997 vitamin a Drugs 0.000 description 1
• 229940046008 vitamin d Drugs 0.000 description 1
• 229940046010 vitamin k Drugs 0.000 description 1
• 230000004584 weight gain Effects 0.000 description 1
• 235000019786 weight gain Nutrition 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 239000002023 wood Substances 0.000 description 1
• 229940053867 xeloda Drugs 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
• FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
• 229960000641 zorubicin Drugs 0.000 description 1
• 239000002076 α-tocopherol Substances 0.000 description 1
• 235000004835 α-tocopherol Nutrition 0.000 description 1