CN111298048A - 一种治疗新型冠状病毒肺炎的中药组合物及其应用 - Google Patents
一种治疗新型冠状病毒肺炎的中药组合物及其应用 Download PDFInfo
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Abstract
本发明属于中医药技术领域，具体涉及一种治疗新型冠状病毒肺炎（COVID‑19）的中药组合物及其应用。包括以下重量份的原料药制成：蜜麻黄8‑12份、苦杏仁8‑12份、甘草8‑12份、石膏25‑35份、菊花8‑12份、连翘12‑18份、地龙8‑12份、浙贝母8‑12份、茯苓15‑25份、陈皮8‑12份、防风8‑12份、桑叶8‑12份、桔梗4‑8份、前胡8‑12份、炒薏苡仁15‑25份、白前8‑12份。本发明具有疏风解表，清肺泄热平喘的功效，用于COVID‑19普通型证属邪热壅肺证者的治疗具有显著疗效。
Description
技术领域
本发明属于中医药技术领域，具体涉及一种治疗新型冠状病毒肺炎（COVID-19）的中药组合物及其应用。
背景技术
新型冠状病毒肺炎，简称“新冠肺炎”（COVID-19）是一种新型冠状病毒感染引起的急性呼吸道传染病。其传染性强，自发现迅速肆虐全国。因此在COVID-19疫苗尚未研制成功并广泛应用于临床之前，积极防治COVID-19,防止其发病，截断其由轻型转重型具有极其重要的意义。
目前西医治疗以加强支持治疗，保证充分热量，注意水、电解质平衡，必要时予以氧疗、进行抗病毒治疗和抗菌治疗为主。中医药治疗在预防发病，改善临床症状，防止轻型转重症，重症转危重症方面都有明显的优势。
因此，需要设计一种普遍有效的、毒副作用小的防治新型冠状病毒肺炎（COVID-19）的中药组合物及其应用。
发明内容
针对上述现有技术，本发明的目的是提供一种治疗新型冠状病毒肺炎（COVID-19）的中药组合物及其应用。
本发明具有疏风解表，清肺泄热平喘的功效。用于COVID-19普通型证属邪热壅肺证者的治疗具有显著疗效。
为实现上述目的，本发明采用下述技术方案：
一种治疗新型冠状病毒肺炎的中药组合物，包括以下重量份的原料药制成：
蜜麻黄8-12份、苦杏仁8-12份、甘草8-12份、石膏25-35份、菊花8-12份、连翘12-18份、地龙8-12份、浙贝母8-12份、茯苓15-25份、陈皮8-12份、防风8-12份、桑叶8-12份、桔梗4-8份、前胡8-12份、炒薏苡仁15-25份、白前8-12份。
进一步的，优选包括以下重量份的原料药制成：
蜜麻黄10份、苦杏仁10份、甘草10份、石膏30份、菊花10份、连翘15份、地龙10份、浙贝母10份、茯苓20份、陈皮10份、防风10份、桑叶10份、桔梗6份、前胡10份、炒薏苡仁20份、白前10份。
上述中药组合物在制备治疗新型冠状病毒肺炎的药物制剂中的应用。
一种治疗新型冠状病毒肺炎的中药组合物的中药颗粒剂，以上述的中药组合物为有效成分。
本方以麻杏石甘汤和桑菊饮化裁，其中麻杏石甘汤出自张仲景之《伤寒论》，方药组成：蜜麻黄、苦杏仁、石膏、甘草。本方具有辛凉宣泄，清肺平喘之效，蜜麻黄辛温，宣肺解表而平喘；石膏辛甘大寒，清泻肺胃之热以生津，两药相辅，共为君药。石膏倍于麻黄制麻黄温热之性，整方不失为辛凉之剂，麻黄得石膏则宣肺平喘而不助热。苦杏仁味苦，降利肺气而平喘，与蜜麻黄升降相因,甘草和诸药，共奏辛凉宣泄，清肺平喘功效。桑菊饮出自吴鞠通《温病条辨》，方药组成：桑叶、菊花、杏仁、连翘、桔梗、芦根、甘草、薄荷。本方具有疏风清热，宣肺止咳功效。方中桑叶味甘苦性凉，疏散上焦风热，且善走肺络，能清宣肺热而止咳嗽，用以为君。菊花散风热，清利头目而肃肺；杏仁、桔梗宣利肺气而止咳，三者共为臣药。连翘清热解毒共为佐药。甘草调和诸药，为使，且与桔梗相合而利咽喉。本方在前方基础上加入地龙、防风加强祛风止咳之功，配以茯苓、陈皮、炒薏苡仁、前胡、白前、浙贝化痰止咳，其中茯苓、陈皮健脾理气化痰，炒薏苡仁健脾化湿，“脾为生痰之源，肺为贮痰之器”，使痰去而新痰不生。诸药相伍，使上焦风热得以疏散，肺气得以宣畅，则表证解，咳嗽止。以上中药不含法定标准中标识有毒性及现代毒理学证明有毒性的药材，不含十八反、十九畏配伍禁忌，各药味用量未超过标准规定。
具体实施方式
实施例1
原料组成：
蜜麻黄10g、苦杏仁10g、甘草10g、石膏30g、菊花10g、连翘15g、地龙10g、浙贝母10g、茯苓20g、陈皮10g、防风10g、桑叶10g、桔梗6g、前胡10g、炒薏苡仁20g、白前10g。
实施例2
原料组成：
蜜麻黄8g、苦杏仁8g、甘草8g、石膏25g、菊花8g、连翘12g、地龙8g、浙贝母8g、茯苓15g、陈皮8g、防风8g、桑叶8g、桔梗4g、前胡8g、炒薏苡仁15g、白前8g。
实施例3
原料组成：
蜜麻黄12g、苦杏仁12g、甘草12g、石膏35g、菊花12g、连翘18g、地龙12g、浙贝母12g、茯苓25g、陈皮12g、防风12g、桑叶12g、桔梗8g、前胡12g、炒薏苡仁25g、白前12g。
实施例4
原料组成：
蜜麻黄9g、苦杏仁9g、甘草11g、石膏27g、菊花11g、连翘15g、地龙11g、浙贝母11g、茯苓17g、陈皮11g、防风9g、桑叶11g、桔梗5g、前胡9g、炒薏苡仁22g、白前11g。
临床试验表明，本发明具有疏风解表，清肺泄热平喘的功效。用于COVID-19普通型证属邪热壅肺证者的治疗具有显著疗效。
治疗典型病例一：
患者使用本实施例1的中药组合物
患者，男，44岁，已婚。主诉：发热7天。咳嗽干咳为主，伴右侧胸部隐痛，有近期武汉游玩1周史。淋巴细胞百分比4.9%，中性粒细胞百分比88.5%；肺部CT示：两肺多发异常密度影。病毒核酸抗体检测阳性。诊断：COVID-19（普通型）。治疗：服药1周后精神改善，干咳较前明显减轻，右侧胸痛亦减，大小便尚可。1周后复查胸部CT示：两肺多发异常密度影，对比前片，病灶较前吸收缩小。继续服药1周后诸症状消失，无发热，病毒核酸两次检测均阴性后出院。
治疗典型病例二：
患者使用本实施例4的中药组合物
患者，男，35岁，已婚。主诉：咳嗽咳痰4天，发热1天。伴疲倦，头晕，无呼吸困难。病毒核酸抗体检测阳性。诊断：COVID-19（普通型）。治疗：服药2天热退，1周后诸症消失。2周后复查两次病毒核酸阴性后出院。
选取36例患者，随机分为治疗组与对照组；治疗组20例，年龄16岁-72岁，中位50岁。对照组16例，年龄19岁-69岁，中位44岁。观察期2周。2组性别及年龄差异均无统计学意义（P＞0.05）。
治疗组西医对症治疗加予本发明实施例1所制中药颗粒剂，每天1剂，饭后分两次，100ml温开水冲服。2周为1疗程，一般治疗1个疗程。对照组西医常规治疗，不给中药治疗。
运用SPSS19.0统计软件，各组间均数比较采用单因素方差分析，组间两两比较采样、检验。P＜0.05为差异有显著性。
表1：治疗组和对照组的有效率分析：
表1中，痊愈：症状和体征消失，一般生命体征正常，检验检查各项指标均正常。显效：症状明显减轻。有效：症状稍微减轻。无效：转为重症、危重症。
表1为治疗组和对照组总体疗效比较，采用本发明中药颗粒组合能够提高COVID-19的治愈率，有效地改善临床症状，减少病情转为重症甚至危重症，并且无毒副作用，治疗组与对照组相比，P＜0.05，具有可比性。
Claims (4)
1.一种治疗新型冠状病毒肺炎的中药组合物，其特征在于包括以下重量份的原料药制成：
蜜麻黄8-12份、苦杏仁8-12份、甘草8-12份、石膏25-35份、菊花8-12份、连翘12-18份、地龙8-12份、浙贝母8-12份、茯苓15-25份、陈皮8-12份、防风8-12份、桑叶8-12份、桔梗4-8份、前胡8-12份、炒薏苡仁15-25份、白前8-12份。
2.根据权利要求1所述的治疗新型冠状病毒肺炎的中药组合物，其特征在于优选包括以下重量份的原料药制成：
蜜麻黄10份、苦杏仁10份、甘草10份、石膏30份、菊花10份、连翘15份、地龙10份、浙贝母10份、茯苓20份、陈皮10份、防风10份、桑叶10份、桔梗6份、前胡10份、炒薏苡仁20份、白前10份。
3.权利要求1所述的中药组合物在制备治疗新型冠状病毒肺炎的药物制剂中的应用。
4.一种治疗新型冠状病毒肺炎的中药组合物的中药颗粒剂，其特征在于，以权利要求1所述的中药组合物为有效成分。
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| WO2022009442A1 (ja) * | 2020-07-07 | 2022-01-13 | 三徳 石塚 | 新型コロナウィルス感染症治療薬組成物とその活用方法 |
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