CN111279024B - 动态人重链抗体文库 - Google Patents
动态人重链抗体文库 Download PDFInfo
- Publication number
- CN111279024B CN111279024B CN201780094151.XA CN201780094151A CN111279024B CN 111279024 B CN111279024 B CN 111279024B CN 201780094151 A CN201780094151 A CN 201780094151A CN 111279024 B CN111279024 B CN 111279024B
- Authority
- CN
- China
- Prior art keywords
- hvr
- amino acid
- acid sequence
- seq
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/098299 WO2019036842A1 (en) | 2017-08-21 | 2017-08-21 | DYNAMIC LIBRARIES OF HUMAN HEAVY CHAIN ANTIBODIES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111279024A CN111279024A (zh) | 2020-06-12 |
| CN111279024B true CN111279024B (zh) | 2024-07-19 |
Family
ID=65438261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780094151.XA Active CN111279024B (zh) | 2017-08-21 | 2017-08-21 | 动态人重链抗体文库 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11578426B2 (https=) |
| EP (1) | EP3673101A4 (https=) |
| JP (3) | JP2020537632A (https=) |
| KR (2) | KR20200038996A (https=) |
| CN (1) | CN111279024B (https=) |
| AU (1) | AU2017428737B2 (https=) |
| BR (1) | BR112020003622A2 (https=) |
| CA (1) | CA3072143A1 (https=) |
| IL (1) | IL272696B2 (https=) |
| NZ (1) | NZ761783A (https=) |
| SG (1) | SG11202001551YA (https=) |
| WO (1) | WO2019036842A1 (https=) |
| ZA (1) | ZA202001114B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| NZ761785A (en) | 2017-08-21 | 2025-11-28 | Adagene Inc | Dynamic human antibody light chain libraries |
| IL272696B2 (en) | 2017-08-21 | 2025-01-01 | Adagene Inc | Dynamic human heavy chain antibody libraries |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| CN113966230B (zh) * | 2019-12-24 | 2022-06-07 | 宝船生物医药科技(上海)有限公司 | 抗csf1r分子及其用途 |
| JP2023529557A (ja) | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗ｅｎｐｐ１抗体の阻害 |
| US20230374162A1 (en) * | 2020-10-07 | 2023-11-23 | Amgen Inc. | Rational selection of building blocks for the assembly of multispecific antibodies |
| WO2023193239A1 (en) * | 2022-04-08 | 2023-10-12 | Peter Peizhi Luo | Anti-cd28 antibodies and methods of use thereof |
| KR20260026665A (ko) | 2024-08-20 | 2026-02-27 | 엘지디스플레이 주식회사 | 표시 장치 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0440146A2 (de) * | 1990-02-01 | 1991-08-07 | BEHRINGWERKE Aktiengesellschaft | Herstellung und Verwendung von Genbanken synthetischer menschlicher Antikörper ("synthetische Human-Anti-Körper-Bibliotheken) |
| EP1457559A1 (en) * | 2001-11-22 | 2004-09-15 | Keio University | ARTIFICIAL ANTIBODY LIBRARY WITH SUPER−REPERTORY |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| ES2248127T3 (es) | 1999-10-04 | 2006-03-16 | Medicago Inc. | Metodo para regular la transcripcion de genes foraneos en presencia de nigtrogeno. |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| WO2006120230A2 (en) | 2005-05-12 | 2006-11-16 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| ES2577292T3 (es) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso |
| EP2604279A1 (en) | 2008-03-27 | 2013-06-19 | ZymoGenetics, Inc. | Compositions and methods for inhibiting PDGFRBETA and VEGF-A |
| KR102318383B1 (ko) * | 2010-07-16 | 2021-10-27 | 아디맵 엘엘씨 | 항체 라이브러리 |
| CN103261220B (zh) * | 2010-08-16 | 2016-06-15 | 诺夫免疫股份有限公司 | 用于生成多特异性和多价抗体的方法 |
| CN105247050B (zh) | 2013-03-14 | 2020-06-16 | 天演药业 | 用于文库构建、亲和力结合剂筛选和其表达的整合系统 |
| CN103603057B (zh) | 2013-07-03 | 2016-01-06 | 深圳大学 | 基于可感染病毒颗粒型抗体重链库/轻链库的抗体筛选和制备方法 |
| EP3209776A1 (en) * | 2014-10-22 | 2017-08-30 | Crescendo Biologics Limited | Human vh domain scaffolds |
| CA3289997A1 (en) | 2015-09-20 | 2026-03-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal Antibodies Specific for Fibroblast Growth Factor Receptor 4 (FGFR4) and Methods of Their Use |
| IL272696B2 (en) | 2017-08-21 | 2025-01-01 | Adagene Inc | Dynamic human heavy chain antibody libraries |
| NZ761785A (en) | 2017-08-21 | 2025-11-28 | Adagene Inc | Dynamic human antibody light chain libraries |
-
2017
- 2017-08-21 IL IL272696A patent/IL272696B2/en unknown
- 2017-08-21 SG SG11202001551YA patent/SG11202001551YA/en unknown
- 2017-08-21 NZ NZ761783A patent/NZ761783A/en unknown
- 2017-08-21 US US16/640,679 patent/US11578426B2/en active Active
- 2017-08-21 AU AU2017428737A patent/AU2017428737B2/en active Active
- 2017-08-21 JP JP2020510115A patent/JP2020537632A/ja active Pending
- 2017-08-21 WO PCT/CN2017/098299 patent/WO2019036842A1/en not_active Ceased
- 2017-08-21 BR BR112020003622-6A patent/BR112020003622A2/pt unknown
- 2017-08-21 KR KR1020207007876A patent/KR20200038996A/ko not_active Ceased
- 2017-08-21 EP EP17922682.4A patent/EP3673101A4/en active Pending
- 2017-08-21 CN CN201780094151.XA patent/CN111279024B/zh active Active
- 2017-08-21 KR KR1020247022149A patent/KR102907590B1/ko active Active
- 2017-08-21 CA CA3072143A patent/CA3072143A1/en active Pending
-
2020
- 2020-02-21 ZA ZA2020/01114A patent/ZA202001114B/en unknown
-
2022
- 2022-11-10 JP JP2022180076A patent/JP2023025026A/ja not_active Withdrawn
-
2023
- 2023-01-11 US US18/153,070 patent/US12385162B2/en active Active
-
2024
- 2024-09-20 JP JP2024163531A patent/JP2024178314A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0440146A2 (de) * | 1990-02-01 | 1991-08-07 | BEHRINGWERKE Aktiengesellschaft | Herstellung und Verwendung von Genbanken synthetischer menschlicher Antikörper ("synthetische Human-Anti-Körper-Bibliotheken) |
| EP1457559A1 (en) * | 2001-11-22 | 2004-09-15 | Keio University | ARTIFICIAL ANTIBODY LIBRARY WITH SUPER−REPERTORY |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020003622A2 (pt) | 2020-09-01 |
| CA3072143A1 (en) | 2019-02-28 |
| KR102907590B1 (ko) | 2026-01-05 |
| IL272696A (en) | 2020-04-30 |
| US20200248336A1 (en) | 2020-08-06 |
| AU2017428737A8 (en) | 2020-03-12 |
| JP2024178314A (ja) | 2024-12-24 |
| EP3673101A4 (en) | 2021-03-24 |
| AU2017428737A1 (en) | 2020-03-05 |
| WO2019036842A1 (en) | 2019-02-28 |
| EP3673101A1 (en) | 2020-07-01 |
| US20240240358A1 (en) | 2024-07-18 |
| US12385162B2 (en) | 2025-08-12 |
| IL272696B2 (en) | 2025-01-01 |
| ZA202001114B (en) | 2024-06-26 |
| IL272696B1 (en) | 2024-09-01 |
| SG11202001551YA (en) | 2020-03-30 |
| NZ761783A (en) | 2025-11-28 |
| KR20240110891A (ko) | 2024-07-16 |
| JP2020537632A (ja) | 2020-12-24 |
| KR20200038996A (ko) | 2020-04-14 |
| CN111279024A (zh) | 2020-06-12 |
| US11578426B2 (en) | 2023-02-14 |
| AU2017428737B2 (en) | 2024-02-15 |
| JP2023025026A (ja) | 2023-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |