JP2020537632A - ダイナミックヒト重鎖抗体ライブラリー - Google Patents

ダイナミックヒト重鎖抗体ライブラリー Download PDF

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Publication number
JP2020537632A
JP2020537632A JP2020510115A JP2020510115A JP2020537632A JP 2020537632 A JP2020537632 A JP 2020537632A JP 2020510115 A JP2020510115 A JP 2020510115A JP 2020510115 A JP2020510115 A JP 2020510115A JP 2020537632 A JP2020537632 A JP 2020537632A
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Prior art keywords
hvr
seq
amino acid
acid sequence
formula
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JP2020510115A
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English (en)
Japanese (ja)
Inventor
ピーター ペイチー ルオ，
ピーター ペイチー ルオ，
ヤン リー，
ヤン リー，
ファンヨン トゥー，
ファンヨン トゥー，
Original Assignee
アダジーン インコーポレイテッド
アダジーン インコーポレイテッド
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Publication of JP2020537632A publication Critical patent/JP2020537632A/ja
Priority to JP2022180076A priority Critical patent/JP2023025026A/ja
Priority to JP2024163531A priority patent/JP2024178314A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2020510115A 2017-08-21 2017-08-21 ダイナミックヒト重鎖抗体ライブラリー Pending JP2020537632A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022180076A JP2023025026A (ja) 2017-08-21 2022-11-10 ダイナミックヒト重鎖抗体ライブラリー
JP2024163531A JP2024178314A (ja) 2017-08-21 2024-09-20 ダイナミックヒト重鎖抗体ライブラリー

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/098299 WO2019036842A1 (en) 2017-08-21 2017-08-21 DYNAMIC LIBRARIES OF HUMAN HEAVY CHAIN ANTIBODIES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022180076A Division JP2023025026A (ja) 2017-08-21 2022-11-10 ダイナミックヒト重鎖抗体ライブラリー

Publications (1)

Publication Number Publication Date
JP2020537632A true JP2020537632A (ja) 2020-12-24

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020510115A Pending JP2020537632A (ja) 2017-08-21 2017-08-21 ダイナミックヒト重鎖抗体ライブラリー
JP2022180076A Withdrawn JP2023025026A (ja) 2017-08-21 2022-11-10 ダイナミックヒト重鎖抗体ライブラリー
JP2024163531A Pending JP2024178314A (ja) 2017-08-21 2024-09-20 ダイナミックヒト重鎖抗体ライブラリー

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022180076A Withdrawn JP2023025026A (ja) 2017-08-21 2022-11-10 ダイナミックヒト重鎖抗体ライブラリー
JP2024163531A Pending JP2024178314A (ja) 2017-08-21 2024-09-20 ダイナミックヒト重鎖抗体ライブラリー

Country Status (13)

Country Link
US (2) US11578426B2 (https=)
EP (1) EP3673101A4 (https=)
JP (3) JP2020537632A (https=)
KR (2) KR20200038996A (https=)
CN (1) CN111279024B (https=)
AU (1) AU2017428737B2 (https=)
BR (1) BR112020003622A2 (https=)
CA (1) CA3072143A1 (https=)
IL (1) IL272696B2 (https=)
NZ (1) NZ761783A (https=)
SG (1) SG11202001551YA (https=)
WO (1) WO2019036842A1 (https=)
ZA (1) ZA202001114B (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. Anti-cd137 molecules and use thereof
NZ761785A (en) 2017-08-21 2025-11-28 Adagene Inc Dynamic human antibody light chain libraries
IL272696B2 (en) 2017-08-21 2025-01-01 Adagene Inc Dynamic human heavy chain antibody libraries
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
WO2019148444A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Anti-ctla4 antibodies and methods of making and using the same
CN113966230B (zh) * 2019-12-24 2022-06-07 宝船生物医药科技(上海)有限公司 抗csf1r分子及其用途
JP2023529557A (ja) 2020-05-04 2023-07-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗ｅｎｐｐ１抗体の阻害
US20230374162A1 (en) * 2020-10-07 2023-11-23 Amgen Inc. Rational selection of building blocks for the assembly of multispecific antibodies
WO2023193239A1 (en) * 2022-04-08 2023-10-12 Peter Peizhi Luo Anti-cd28 antibodies and methods of use thereof
KR20260026665A (ko) 2024-08-20 2026-02-27 엘지디스플레이 주식회사 표시 장치

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WO2003044198A1 (fr) * 2001-11-22 2003-05-30 Keio University Banque d'anticorps artificiels dotee d'un super repertoire
JP2013534130A (ja) * 2010-07-16 2013-09-02 アディマブ， エルエルシー 抗体ライブラリー
JP2013539461A (ja) * 2010-08-16 2013-10-24 ノビミューン エスアー 多重特異性多価抗体の生成方法
WO2016062989A1 (en) * 2014-10-22 2016-04-28 Crescendo Biologics Limited Human vh domain scaffolds

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Publication number Publication date
BR112020003622A2 (pt) 2020-09-01
CA3072143A1 (en) 2019-02-28
KR102907590B1 (ko) 2026-01-05
IL272696A (en) 2020-04-30
US20200248336A1 (en) 2020-08-06
AU2017428737A8 (en) 2020-03-12
JP2024178314A (ja) 2024-12-24
EP3673101A4 (en) 2021-03-24
AU2017428737A1 (en) 2020-03-05
WO2019036842A1 (en) 2019-02-28
EP3673101A1 (en) 2020-07-01
US20240240358A1 (en) 2024-07-18
CN111279024B (zh) 2024-07-19
US12385162B2 (en) 2025-08-12
IL272696B2 (en) 2025-01-01
ZA202001114B (en) 2024-06-26
IL272696B1 (en) 2024-09-01
SG11202001551YA (en) 2020-03-30
NZ761783A (en) 2025-11-28
KR20240110891A (ko) 2024-07-16
KR20200038996A (ko) 2020-04-14
CN111279024A (zh) 2020-06-12
US11578426B2 (en) 2023-02-14
AU2017428737B2 (en) 2024-02-15
JP2023025026A (ja) 2023-02-21

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