SG11202001551YA - Dynamic human heavy chain antibody libraries - Google Patents
Dynamic human heavy chain antibody librariesInfo
- Publication number
- SG11202001551YA SG11202001551YA SG11202001551YA SG11202001551YA SG11202001551YA SG 11202001551Y A SG11202001551Y A SG 11202001551YA SG 11202001551Y A SG11202001551Y A SG 11202001551YA SG 11202001551Y A SG11202001551Y A SG 11202001551YA SG 11202001551Y A SG11202001551Y A SG 11202001551YA
- Authority
- SG
- Singapore
- Prior art keywords
- heavy chain
- chain antibody
- human heavy
- antibody libraries
- dynamic human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/098299 WO2019036842A1 (en) | 2017-08-21 | 2017-08-21 | Dynamic human heavy chain antibody libraries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202001551YA true SG11202001551YA (en) | 2020-03-30 |
Family
ID=65438261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001551YA SG11202001551YA (en) | 2017-08-21 | 2017-08-21 | Dynamic human heavy chain antibody libraries |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11578426B2 (en) |
| EP (1) | EP3673101A4 (en) |
| JP (2) | JP2020537632A (en) |
| KR (1) | KR20200038996A (en) |
| CN (1) | CN111279024A (en) |
| AU (1) | AU2017428737B2 (en) |
| BR (1) | BR112020003622A2 (en) |
| CA (1) | CA3072143A1 (en) |
| IL (1) | IL272696A (en) |
| SG (1) | SG11202001551YA (en) |
| WO (1) | WO2019036842A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020003459A2 (en) | 2017-08-21 | 2020-08-25 | Adagene Inc. | libraries, non-human animal, phage, antibody light chain, antibodies, methods for preparing a library, for producing an antibody library and for generating a bispecific antibody and kit |
| CN111511762A (en) | 2017-08-21 | 2020-08-07 | 天演药业公司 | anti-CD137 molecules and uses thereof |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| WO2021225954A1 (en) * | 2020-05-04 | 2021-11-11 | The Regents Of The University Of California | Inhibiting anti-enpp1 antibodies |
| WO2023193239A1 (en) * | 2022-04-08 | 2023-10-12 | Peter Peizhi Luo | Anti-cd28 antibodies and methods of use thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DE4002897A1 (en) * | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Synthetic human antibody library |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ES2246502T3 (en) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | TRANSGENIC NON-HUMAN ANIMALS ABLE TO PRODUCE HETEROLOGICAL ANTIBODIES. |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP1709970A1 (en) | 1995-04-27 | 2006-10-11 | Abgenix, Inc. | Human antibodies against EGFR, derived from immunized xenomice |
| CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| ES2248127T3 (en) | 1999-10-04 | 2006-03-16 | Medicago Inc. | METHOD FOR REGULATING THE TRANSCRIPTION OF FOREIGN GENES IN THE PRESENCE OF NIGTROGEN. |
| DE60224720D1 (en) * | 2001-11-22 | 2008-03-06 | Univ Keio | Re |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| EP1879921B1 (en) | 2005-05-12 | 2011-04-27 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| ES2577292T3 (en) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Binding polypeptides with diversified VH / VL hypervariable sequences and consensus |
| WO2009120922A2 (en) | 2008-03-27 | 2009-10-01 | Zymogenetics, Inc. | Compositions and methods for inhibiting pdgfrbeta and vegf-a |
| US9354228B2 (en) * | 2010-07-16 | 2016-05-31 | Adimab, Llc | Antibody libraries |
| ES2537207T3 (en) | 2010-08-16 | 2015-06-03 | Novimmune S.A. | Methods for the generation of multispecific and multivalent antibodies |
| CA2905529C (en) | 2013-03-14 | 2023-03-14 | Adagene Inc. | An integrated system for library construction, affinity binder screening and expression thereof |
| CN103603057B (en) | 2013-07-03 | 2016-01-06 | 深圳大学 | Based on can the antibody screening in infecting virus particle type heavy chain of antibody storehouse/light chain storehouse and preparation method |
| US20170306039A1 (en) * | 2014-10-22 | 2017-10-26 | Crescendo Biologics Limited | Human vh domain scaffolds |
| US11078286B2 (en) | 2015-09-20 | 2021-08-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies specific for fibroblast growth factor receptor 4 (FGFR4) and methods of their use |
| BR112020003459A2 (en) | 2017-08-21 | 2020-08-25 | Adagene Inc. | libraries, non-human animal, phage, antibody light chain, antibodies, methods for preparing a library, for producing an antibody library and for generating a bispecific antibody and kit |
-
2017
- 2017-08-21 JP JP2020510115A patent/JP2020537632A/en active Pending
- 2017-08-21 EP EP17922682.4A patent/EP3673101A4/en active Pending
- 2017-08-21 AU AU2017428737A patent/AU2017428737B2/en active Active
- 2017-08-21 CA CA3072143A patent/CA3072143A1/en active Pending
- 2017-08-21 BR BR112020003622-6A patent/BR112020003622A2/en unknown
- 2017-08-21 WO PCT/CN2017/098299 patent/WO2019036842A1/en unknown
- 2017-08-21 US US16/640,679 patent/US11578426B2/en active Active
- 2017-08-21 CN CN201780094151.XA patent/CN111279024A/en active Pending
- 2017-08-21 KR KR1020207007876A patent/KR20200038996A/en not_active IP Right Cessation
- 2017-08-21 SG SG11202001551YA patent/SG11202001551YA/en unknown
-
2020
- 2020-02-16 IL IL272696A patent/IL272696A/en unknown
-
2022
- 2022-11-10 JP JP2022180076A patent/JP2023025026A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020003622A2 (en) | 2020-09-01 |
| WO2019036842A1 (en) | 2019-02-28 |
| AU2017428737A8 (en) | 2020-03-12 |
| KR20200038996A (en) | 2020-04-14 |
| CA3072143A1 (en) | 2019-02-28 |
| JP2020537632A (en) | 2020-12-24 |
| EP3673101A1 (en) | 2020-07-01 |
| AU2017428737A1 (en) | 2020-03-05 |
| US11578426B2 (en) | 2023-02-14 |
| IL272696A (en) | 2020-04-30 |
| JP2023025026A (en) | 2023-02-21 |
| US20200248336A1 (en) | 2020-08-06 |
| EP3673101A4 (en) | 2021-03-24 |
| CN111279024A (en) | 2020-06-12 |
| AU2017428737B2 (en) | 2024-02-15 |
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