BR112020003622A2 - cadeia pesada de anticorpo, anticorpo, bibliotecas, kit, método de preparo de uma biblioteca, método de produção de uma biblioteca de anticorpos, fago, método de geração de um anticorpo biespecífico e anticorpo biespecífico - Google Patents
cadeia pesada de anticorpo, anticorpo, bibliotecas, kit, método de preparo de uma biblioteca, método de produção de uma biblioteca de anticorpos, fago, método de geração de um anticorpo biespecífico e anticorpo biespecífico Download PDFInfo
- Publication number
- BR112020003622A2 BR112020003622A2 BR112020003622-6A BR112020003622A BR112020003622A2 BR 112020003622 A2 BR112020003622 A2 BR 112020003622A2 BR 112020003622 A BR112020003622 A BR 112020003622A BR 112020003622 A2 BR112020003622 A2 BR 112020003622A2
- Authority
- BR
- Brazil
- Prior art keywords
- hvr
- amino acid
- acid sequence
- seq
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/098299 WO2019036842A1 (en) | 2017-08-21 | 2017-08-21 | DYNAMIC LIBRARIES OF HUMAN HEAVY CHAIN ANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020003622A2 true BR112020003622A2 (pt) | 2020-09-01 |
Family
ID=65438261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020003622-6A BR112020003622A2 (pt) | 2017-08-21 | 2017-08-21 | cadeia pesada de anticorpo, anticorpo, bibliotecas, kit, método de preparo de uma biblioteca, método de produção de uma biblioteca de anticorpos, fago, método de geração de um anticorpo biespecífico e anticorpo biespecífico |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11578426B2 (https=) |
| EP (1) | EP3673101A4 (https=) |
| JP (3) | JP2020537632A (https=) |
| KR (2) | KR20200038996A (https=) |
| CN (1) | CN111279024B (https=) |
| AU (1) | AU2017428737B2 (https=) |
| BR (1) | BR112020003622A2 (https=) |
| CA (1) | CA3072143A1 (https=) |
| IL (1) | IL272696B2 (https=) |
| NZ (1) | NZ761783A (https=) |
| SG (1) | SG11202001551YA (https=) |
| WO (1) | WO2019036842A1 (https=) |
| ZA (1) | ZA202001114B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| NZ761785A (en) | 2017-08-21 | 2025-11-28 | Adagene Inc | Dynamic human antibody light chain libraries |
| IL272696B2 (en) | 2017-08-21 | 2025-01-01 | Adagene Inc | Dynamic human heavy chain antibody libraries |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| CN113966230B (zh) * | 2019-12-24 | 2022-06-07 | 宝船生物医药科技(上海)有限公司 | 抗csf1r分子及其用途 |
| JP2023529557A (ja) | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗ｅｎｐｐ１抗体の阻害 |
| US20230374162A1 (en) * | 2020-10-07 | 2023-11-23 | Amgen Inc. | Rational selection of building blocks for the assembly of multispecific antibodies |
| WO2023193239A1 (en) * | 2022-04-08 | 2023-10-12 | Peter Peizhi Luo | Anti-cd28 antibodies and methods of use thereof |
| KR20260026665A (ko) | 2024-08-20 | 2026-02-27 | 엘지디스플레이 주식회사 | 표시 장치 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE4002897A1 (de) | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| ES2248127T3 (es) | 1999-10-04 | 2006-03-16 | Medicago Inc. | Metodo para regular la transcripcion de genes foraneos en presencia de nigtrogeno. |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| ATE384129T1 (de) * | 2001-11-22 | 2008-02-15 | Univ Keio | Künstliche antikörperbibliothek mit super- repertoire |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| WO2006120230A2 (en) | 2005-05-12 | 2006-11-16 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| ES2577292T3 (es) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso |
| EP2604279A1 (en) | 2008-03-27 | 2013-06-19 | ZymoGenetics, Inc. | Compositions and methods for inhibiting PDGFRBETA and VEGF-A |
| KR102318383B1 (ko) * | 2010-07-16 | 2021-10-27 | 아디맵 엘엘씨 | 항체 라이브러리 |
| CN103261220B (zh) * | 2010-08-16 | 2016-06-15 | 诺夫免疫股份有限公司 | 用于生成多特异性和多价抗体的方法 |
| CN105247050B (zh) | 2013-03-14 | 2020-06-16 | 天演药业 | 用于文库构建、亲和力结合剂筛选和其表达的整合系统 |
| CN103603057B (zh) | 2013-07-03 | 2016-01-06 | 深圳大学 | 基于可感染病毒颗粒型抗体重链库/轻链库的抗体筛选和制备方法 |
| EP3209776A1 (en) * | 2014-10-22 | 2017-08-30 | Crescendo Biologics Limited | Human vh domain scaffolds |
| CA3289997A1 (en) | 2015-09-20 | 2026-03-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal Antibodies Specific for Fibroblast Growth Factor Receptor 4 (FGFR4) and Methods of Their Use |
| IL272696B2 (en) | 2017-08-21 | 2025-01-01 | Adagene Inc | Dynamic human heavy chain antibody libraries |
| NZ761785A (en) | 2017-08-21 | 2025-11-28 | Adagene Inc | Dynamic human antibody light chain libraries |
-
2017
- 2017-08-21 IL IL272696A patent/IL272696B2/en unknown
- 2017-08-21 SG SG11202001551YA patent/SG11202001551YA/en unknown
- 2017-08-21 NZ NZ761783A patent/NZ761783A/en unknown
- 2017-08-21 US US16/640,679 patent/US11578426B2/en active Active
- 2017-08-21 AU AU2017428737A patent/AU2017428737B2/en active Active
- 2017-08-21 JP JP2020510115A patent/JP2020537632A/ja active Pending
- 2017-08-21 WO PCT/CN2017/098299 patent/WO2019036842A1/en not_active Ceased
- 2017-08-21 BR BR112020003622-6A patent/BR112020003622A2/pt unknown
- 2017-08-21 KR KR1020207007876A patent/KR20200038996A/ko not_active Ceased
- 2017-08-21 EP EP17922682.4A patent/EP3673101A4/en active Pending
- 2017-08-21 CN CN201780094151.XA patent/CN111279024B/zh active Active
- 2017-08-21 KR KR1020247022149A patent/KR102907590B1/ko active Active
- 2017-08-21 CA CA3072143A patent/CA3072143A1/en active Pending
-
2020
- 2020-02-21 ZA ZA2020/01114A patent/ZA202001114B/en unknown
-
2022
- 2022-11-10 JP JP2022180076A patent/JP2023025026A/ja not_active Withdrawn
-
2023
- 2023-01-11 US US18/153,070 patent/US12385162B2/en active Active
-
2024
- 2024-09-20 JP JP2024163531A patent/JP2024178314A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3072143A1 (en) | 2019-02-28 |
| KR102907590B1 (ko) | 2026-01-05 |
| IL272696A (en) | 2020-04-30 |
| US20200248336A1 (en) | 2020-08-06 |
| AU2017428737A8 (en) | 2020-03-12 |
| JP2024178314A (ja) | 2024-12-24 |
| EP3673101A4 (en) | 2021-03-24 |
| AU2017428737A1 (en) | 2020-03-05 |
| WO2019036842A1 (en) | 2019-02-28 |
| EP3673101A1 (en) | 2020-07-01 |
| US20240240358A1 (en) | 2024-07-18 |
| CN111279024B (zh) | 2024-07-19 |
| US12385162B2 (en) | 2025-08-12 |
| IL272696B2 (en) | 2025-01-01 |
| ZA202001114B (en) | 2024-06-26 |
| IL272696B1 (en) | 2024-09-01 |
| SG11202001551YA (en) | 2020-03-30 |
| NZ761783A (en) | 2025-11-28 |
| KR20240110891A (ko) | 2024-07-16 |
| JP2020537632A (ja) | 2020-12-24 |
| KR20200038996A (ko) | 2020-04-14 |
| CN111279024A (zh) | 2020-06-12 |
| US11578426B2 (en) | 2023-02-14 |
| AU2017428737B2 (en) | 2024-02-15 |
| JP2023025026A (ja) | 2023-02-21 |
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Legal Events
| Date | Code | Title | Description |
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| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |