CN111225684A - 牙周炎疫苗和相关组合物及使用方法 - Google Patents

牙周炎疫苗和相关组合物及使用方法 Download PDF

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Publication number
CN111225684A
CN111225684A CN201880065401.1A CN201880065401A CN111225684A CN 111225684 A CN111225684 A CN 111225684A CN 201880065401 A CN201880065401 A CN 201880065401A CN 111225684 A CN111225684 A CN 111225684A
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CN
China
Prior art keywords
sequence
amino acid
porphyromonas
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880065401.1A
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English (en)
Chinese (zh)
Inventor
J·费尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaxcyte Inc
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Sutrovax Inc
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Publication date
Application filed by Sutrovax Inc filed Critical Sutrovax Inc
Publication of CN111225684A publication Critical patent/CN111225684A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201880065401.1A 2017-10-12 2018-10-11 牙周炎疫苗和相关组合物及使用方法 Pending CN111225684A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762571582P 2017-10-12 2017-10-12
US62/571,582 2017-10-12
PCT/US2018/055496 WO2019075260A1 (en) 2017-10-12 2018-10-11 VACCINE AGAINST PERIODONTITIS AND ASSOCIATED COMPOSITIONS AND METHOD OF USE

Publications (1)

Publication Number Publication Date
CN111225684A true CN111225684A (zh) 2020-06-02

Family

ID=64110091

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880065401.1A Pending CN111225684A (zh) 2017-10-12 2018-10-11 牙周炎疫苗和相关组合物及使用方法

Country Status (14)

Country Link
US (3) US10835590B2 (enExample)
EP (1) EP3694547A1 (enExample)
JP (2) JP7258870B2 (enExample)
KR (2) KR102530966B1 (enExample)
CN (1) CN111225684A (enExample)
AU (1) AU2018347511A1 (enExample)
CA (1) CA3078630A1 (enExample)
EA (1) EA202090908A1 (enExample)
IL (1) IL273690A (enExample)
MA (1) MA50363A (enExample)
MX (1) MX2020003810A (enExample)
PH (1) PH12020550239A1 (enExample)
SG (1) SG11202003147XA (enExample)
WO (1) WO2019075260A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020003810A (es) * 2017-10-12 2020-08-13 Vaxcyte Inc Vacuna contra la periodontitis y composiciones relacionadas y metodos de uso.
WO2025019900A1 (en) * 2023-07-26 2025-01-30 Denteric Pty Ltd Chimeric protein vaccine
CN116751292B (zh) * 2023-07-31 2024-05-14 河南大学 牙龈卟啉单胞菌Mfa1单克隆抗体及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047961A1 (en) * 1999-12-24 2001-07-05 Csl Limited P. gingivalis antigenic composition
WO2017066719A2 (en) * 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
JPS59128338A (ja) 1982-12-08 1984-07-24 Kitasato Inst:The 歯周炎予防用ワクチン及びその製法
ATE182336T1 (de) 1993-05-28 1999-08-15 Chiron Corp Peptidinhibitoren der urokinaserezeptor-aktivität
AUPN627595A0 (en) 1995-10-30 1995-11-23 University Of Melbourne, The Diagnostics and treatments of periodontal disease
AU742668B2 (en) 1996-03-22 2002-01-10 Morehouse School Of Medicine Immunogenic compositions comprising porphyromonas gingivalis peptides and methods
US6833262B1 (en) 1999-04-21 2004-12-21 University Of Georgia Research Foundation, Inc. Polypeptide having amidolytic activity for a serpin
AUPQ065299A0 (en) 1999-05-28 1999-06-24 University Of Sydney, The A method of prophylaxis and treatment and agents useful for same
US7378101B2 (en) 2001-12-21 2008-05-27 Pfizer, Inc. Vaccine for periodontal disease
GB0411150D0 (en) 2004-05-19 2004-06-23 Queen Mary & Westfield College Vaccine
BR112012002429A2 (pt) 2009-08-02 2016-11-08 Sanofi Pasteur Ltd polipeptídeos de porphyromonas gingivalis
AU2011214908A1 (en) 2010-02-12 2012-09-20 Sydney West Area Health Services (Swahs) Protein domains and uses therefor
US9040253B2 (en) 2010-04-14 2015-05-26 Sutro Biopharma, Inc. Method for enhancing recombinant protein production by cell-free protein expression system
CA2887355C (en) 2012-10-12 2023-03-07 Sutro Biopharma, Inc. Proteolytic inactivation of select proteins in bacterial extracts for improved expression
MX2020003810A (es) 2017-10-12 2020-08-13 Vaxcyte Inc Vacuna contra la periodontitis y composiciones relacionadas y metodos de uso.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047961A1 (en) * 1999-12-24 2001-07-05 Csl Limited P. gingivalis antigenic composition
WO2017066719A2 (en) * 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DONGYING BAI ET AL: "Immunoreactive antigens recognized in serum samples from mice intranasally immunized with Porphyromonas gingivalis outer membrane vesicles", 《PATHOGENS AND DISEASE》 *
FRAZER L T ET AL: "Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection", 《VACCINE》 *
GIBSON FRANK C III ET AL: "Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1", 《INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY》 *
N. LI ET AL: "Gingipains from Porphyromonas gingivalis - complex domain structures confer diverse functions", 《EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY》 *
NAKAO RYOMA ET AL: "Assessment of outer membrane vesicles of periodontopathic bacteriumPorphyromonas gingivalisas possible mucosal immunogen", 《VACCINE》 *
PAUL D. VEITH ET AL: "Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence Factors", 《JOURNAL OF PROTEOME RESEARCH》 *
RYOMA NAKAO ET AL: "Outer Membrane Vesicles of Porphyromonas gingivalis Elicit a Mucosal Immune Response", 《PLOS ONE》 *

Also Published As

Publication number Publication date
US20210361756A1 (en) 2021-11-25
SG11202003147XA (en) 2020-05-28
PH12020550239A1 (en) 2021-02-15
IL273690A (en) 2020-05-31
JP2020536925A (ja) 2020-12-17
CA3078630A1 (en) 2019-04-18
EP3694547A1 (en) 2020-08-19
JP2023098935A (ja) 2023-07-11
BR112020006500A2 (pt) 2020-10-13
US20240226259A9 (en) 2024-07-11
EA202090908A1 (ru) 2020-10-29
MA50363A (fr) 2020-08-19
KR20200070302A (ko) 2020-06-17
US11701414B2 (en) 2023-07-18
US12121575B2 (en) 2024-10-22
JP7258870B2 (ja) 2023-04-17
WO2019075260A1 (en) 2019-04-18
KR102530966B1 (ko) 2023-05-15
AU2018347511A1 (en) 2020-05-21
US20240131134A1 (en) 2024-04-25
US10835590B2 (en) 2020-11-17
US20190192645A1 (en) 2019-06-27
MX2020003810A (es) 2020-08-13
AU2018347511A8 (en) 2020-06-11
KR20230066660A (ko) 2023-05-16

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Address after: Delaware, USA

Applicant after: Vaxcyte

Address before: California, USA

Applicant before: SUTROVAX, Inc.

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