EA202090908A1 - Вакцина и связанные композиции для лечения пародонтита и способ применения - Google Patents
Вакцина и связанные композиции для лечения пародонтита и способ примененияInfo
- Publication number
- EA202090908A1 EA202090908A1 EA202090908A EA202090908A EA202090908A1 EA 202090908 A1 EA202090908 A1 EA 202090908A1 EA 202090908 A EA202090908 A EA 202090908A EA 202090908 A EA202090908 A EA 202090908A EA 202090908 A1 EA202090908 A1 EA 202090908A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- sequence
- antigen
- immunogenic
- composition
- gingipain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Предложены иммуногенная композиция, вакцинный состав для пародонтита, содержащий указанную иммуногенную композицию, и способы лечения или предупреждения заболевания пародонта, где указанные способы включают введение субъекту иммунологически эффективного количества указанной композиции или вакцинного состава. Иммуногенная композиция содержит по меньшей мере один полипептид, содержащий последовательность антигена Mfa1, по существу, гомологичную иммуногенной аминокислотной последовательности из белка фимбрилина Mfa1 бактерии Porphyromonas; и последовательность антигена HA1, последовательность антигена HA2 или как последовательность антигена HA1, так и последовательность антигена HA2, где указанная последовательность антигена HA1, по существу, гомологична иммуногенной аминокислотной последовательности из домена 1 гемагглютинина гингипаина RgpA, содержащегося в белке гингипаине RgpA бактерии Porphyromonas, и указанная последовательность антигена HA2, по существу, гомологична иммуногенной аминокислотной последовательности из домена 2 гемагглютинина гингипаина RgpA, содержащегося в белке гингипаине RgpA бактерии Porphyromonas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762571582P | 2017-10-12 | 2017-10-12 | |
| PCT/US2018/055496 WO2019075260A1 (en) | 2017-10-12 | 2018-10-11 | VACCINE AGAINST PERIODONTITIS AND ASSOCIATED COMPOSITIONS AND METHOD OF USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202090908A1 true EA202090908A1 (ru) | 2020-10-29 |
Family
ID=64110091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090908A EA202090908A1 (ru) | 2017-10-12 | 2018-10-11 | Вакцина и связанные композиции для лечения пародонтита и способ применения |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10835590B2 (ru) |
| EP (1) | EP3694547A1 (ru) |
| JP (2) | JP7258870B2 (ru) |
| KR (2) | KR102530966B1 (ru) |
| CN (1) | CN111225684A (ru) |
| AU (1) | AU2018347511A1 (ru) |
| CA (1) | CA3078630A1 (ru) |
| EA (1) | EA202090908A1 (ru) |
| IL (1) | IL273690A (ru) |
| MA (1) | MA50363A (ru) |
| MX (1) | MX2020003810A (ru) |
| PH (1) | PH12020550239A1 (ru) |
| SG (1) | SG11202003147XA (ru) |
| WO (1) | WO2019075260A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10835590B2 (en) | 2017-10-12 | 2020-11-17 | Vaxcyte, Inc. | Periodontitis vaccine and related compositions and methods of use |
| CN116751292B (zh) * | 2023-07-31 | 2024-05-14 | 河南大学 | 牙龈卟啉单胞菌Mfa1单克隆抗体及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59128338A (ja) | 1982-12-08 | 1984-07-24 | Kitasato Inst:The | 歯周炎予防用ワクチン及びその製法 |
| NZ267291A (en) | 1993-05-28 | 1997-09-22 | Chiron Corp | Peptide inhibitors of urokinase receptor activity |
| AUPN627595A0 (en) | 1995-10-30 | 1995-11-23 | University Of Melbourne, The | Diagnostics and treatments of periodontal disease |
| WO1997034629A1 (en) | 1996-03-22 | 1997-09-25 | University Of Georgia Research Foundation, Inc. | Immunogenic compositions comprising porphyromonas gingivalis peptides and methods |
| US6833262B1 (en) | 1999-04-21 | 2004-12-21 | University Of Georgia Research Foundation, Inc. | Polypeptide having amidolytic activity for a serpin |
| AUPQ065299A0 (en) * | 1999-05-28 | 1999-06-24 | University Of Sydney, The | A method of prophylaxis and treatment and agents useful for same |
| AUPQ485999A0 (en) * | 1999-12-24 | 2000-02-03 | Csl Limited | P. gingivalis antigenic composition |
| US7378101B2 (en) * | 2001-12-21 | 2008-05-27 | Pfizer, Inc. | Vaccine for periodontal disease |
| GB0411150D0 (en) | 2004-05-19 | 2004-06-23 | Queen Mary & Westfield College | Vaccine |
| BR112012002429A2 (pt) | 2009-08-02 | 2016-11-08 | Sanofi Pasteur Ltd | polipeptídeos de porphyromonas gingivalis |
| EP2533794A4 (en) * | 2010-02-12 | 2014-04-23 | Univ Sydney | PROTEIN DOMAINS AND ASSOCIATED USES |
| WO2011130544A2 (en) | 2010-04-14 | 2011-10-20 | Sutro Biopharma, Inc. | Monitoring a dynamic system by liquid chromatography-mass spectrometry |
| PL2906592T3 (pl) | 2012-10-12 | 2019-07-31 | Sutro Biopharma, Inc. | Proteolityczna inaktywacja wybranych białek w ekstraktach bakteryjnych dla ulepszonej ekspresji |
| EP3365027B1 (en) * | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu specific antibodies and their use in inhibiting biofilm |
| US10835590B2 (en) | 2017-10-12 | 2020-11-17 | Vaxcyte, Inc. | Periodontitis vaccine and related compositions and methods of use |
-
2018
- 2018-10-11 US US16/158,155 patent/US10835590B2/en active Active
- 2018-10-11 MA MA050363A patent/MA50363A/fr unknown
- 2018-10-11 KR KR1020207013299A patent/KR102530966B1/ko active IP Right Grant
- 2018-10-11 CN CN201880065401.1A patent/CN111225684A/zh active Pending
- 2018-10-11 WO PCT/US2018/055496 patent/WO2019075260A1/en active Application Filing
- 2018-10-11 SG SG11202003147XA patent/SG11202003147XA/en unknown
- 2018-10-11 JP JP2020520602A patent/JP7258870B2/ja active Active
- 2018-10-11 KR KR1020237015301A patent/KR20230066660A/ko not_active Application Discontinuation
- 2018-10-11 CA CA3078630A patent/CA3078630A1/en active Pending
- 2018-10-11 EP EP18797289.8A patent/EP3694547A1/en active Pending
- 2018-10-11 MX MX2020003810A patent/MX2020003810A/es unknown
- 2018-10-11 EA EA202090908A patent/EA202090908A1/ru unknown
- 2018-10-11 AU AU2018347511A patent/AU2018347511A1/en active Pending
-
2020
- 2020-03-29 IL IL273690A patent/IL273690A/en unknown
- 2020-04-08 PH PH12020550239A patent/PH12020550239A1/en unknown
-
2021
- 2021-05-05 US US17/308,872 patent/US11701414B2/en active Active
-
2023
- 2023-04-05 JP JP2023061241A patent/JP2023098935A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240226259A9 (en) | 2024-07-11 |
| CA3078630A1 (en) | 2019-04-18 |
| JP2020536925A (ja) | 2020-12-17 |
| AU2018347511A8 (en) | 2020-06-11 |
| MA50363A (fr) | 2020-08-19 |
| US10835590B2 (en) | 2020-11-17 |
| US20240131134A1 (en) | 2024-04-25 |
| AU2018347511A1 (en) | 2020-05-21 |
| KR102530966B1 (ko) | 2023-05-15 |
| WO2019075260A1 (en) | 2019-04-18 |
| JP2023098935A (ja) | 2023-07-11 |
| JP7258870B2 (ja) | 2023-04-17 |
| MX2020003810A (es) | 2020-08-13 |
| PH12020550239A1 (en) | 2021-02-15 |
| US20210361756A1 (en) | 2021-11-25 |
| SG11202003147XA (en) | 2020-05-28 |
| IL273690A (en) | 2020-05-31 |
| CN111225684A (zh) | 2020-06-02 |
| US11701414B2 (en) | 2023-07-18 |
| EP3694547A1 (en) | 2020-08-19 |
| BR112020006500A2 (pt) | 2020-10-13 |
| US20190192645A1 (en) | 2019-06-27 |
| KR20230066660A (ko) | 2023-05-16 |
| KR20200070302A (ko) | 2020-06-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201991065A1 (ru) | Вакцина против свиного парвовируса | |
| NO20004972D0 (no) | Derivater av pneumokokkiske kolinbindende proteiner | |
| EA201892493A1 (ru) | Жидкая композиция нейротоксина, стабилизированная триптофаном или тирозином | |
| EA202091318A1 (ru) | Препарат, содержащий аденовирус группы b | |
| AR081809A1 (es) | Composiciones farmaceuticas que comprenden un polipeptido que comprende al menos un motivo cxxc y antigenos heterologos y usos de las mismas | |
| EA202090908A1 (ru) | Вакцина и связанные композиции для лечения пародонтита и способ применения | |
| PE20200722A1 (es) | Metodos de terapia genica del factor viii (fviii) | |
| WO2017214596A8 (en) | Compositions and methods for preventing and treating zika virus infection | |
| EA201692279A1 (ru) | Способ уменьшения иммуногенности белка и пептида | |
| BR112022005687A2 (pt) | Vacinas contra o hbv e métodos para tratar o hbv | |
| EA202091690A1 (ru) | Иммуногенная композиция, содержащая стафилококковые антигены | |
| EA202091769A1 (ru) | Вакцины против вируса гриппа и пути их применения | |
| HRP20220011T1 (hr) | Nova stabilna formulacija za fxia protutijela | |
| EA202190310A1 (ru) | Белок для лечения воспалительных заболеваний | |
| BR112022012473A2 (pt) | Composição de tratamento capilar, e, métodos para tratar cabelo, para melhorar a condição do cabelo e para diminuir o ph do cabelo | |
| WO2023094713A3 (en) | Coronavirus vaccine | |
| EA201991015A1 (ru) | Модифицированные пептиды | |
| EA202192925A1 (ru) | Твердые формы ингибитора glyt1 | |
| EA201892320A1 (ru) | Способ лечения или предупреждения остеоартрита | |
| EA201591108A1 (ru) | Слитый гормон роста человека и альбумин, составы и их применения | |
| Camacho et al. | Towards a non-living vaccine against Shigella flexneri: from the inactivation procedure to protection studies | |
| EA202191145A1 (ru) | Вакцина виб 4/91 с гетерологичным шиповидным белком | |
| BR112022003639A2 (pt) | Agente bioestimulante para tratamento de plantas e/ou de sementes de plantas | |
| EA202090802A1 (ru) | Пептидная композиция для лечения повреждений, связанных с возбуждающей нейротоксичностью | |
| BR112015013625A2 (pt) | adjuvante de vacinação, preparação e vacinas contendo o mesmo |