MX2020003810A - Vacuna contra la periodontitis y composiciones relacionadas y metodos de uso. - Google Patents
Vacuna contra la periodontitis y composiciones relacionadas y metodos de uso.Info
- Publication number
- MX2020003810A MX2020003810A MX2020003810A MX2020003810A MX2020003810A MX 2020003810 A MX2020003810 A MX 2020003810A MX 2020003810 A MX2020003810 A MX 2020003810A MX 2020003810 A MX2020003810 A MX 2020003810A MX 2020003810 A MX2020003810 A MX 2020003810A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen sequence
- sequence
- rgpa
- gingipain
- immunogenic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proveen una composición inmunogenica, una formulación de vacuna periodontal que contiene la composición inmunogenica y métodos para tratar o prevenir la enfermedad periodontal, donde los métodos implican la administración de una cantidad inmunológicamente eficaz de la composición o la formulación de la vacuna a un sujeto; la composición inmunogenica contiene al menos un polipeptido que comprende: una secuencia de antígeno Mfa1 que es sustancialmente homologa a una secuencia de aminoacidos inmunogenica de una proteína fimbrilina de Mfa1 de una bacteria Porphyromona; y una secuencia de antígeno HA1, una secuencia de antígeno HA2 o tanto una secuencia de antígeno HA1 como una secuencia de antígeno HA2, en donde la secuencia de antígeno HA1 es sustancialmente homologa a una secuencia de aminoácidos inmunogenica de un dominio 1 de hemaglutinina de gingipain RgpA contenido en una proteína gingipain RgpA de una bacteria Porphyromona y la secuencia de antígeno HA2 es sustancialmente homologa a una secuencia de aminoácidos inmunogenica de un dominio 2 de hemaglutinina de gingipain RgpA contenido en una proteína gingipain RgpA de una bacteria Porphyromona.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762571582P | 2017-10-12 | 2017-10-12 | |
| PCT/US2018/055496 WO2019075260A1 (en) | 2017-10-12 | 2018-10-11 | VACCINE AGAINST PERIODONTITIS AND ASSOCIATED COMPOSITIONS AND METHOD OF USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020003810A true MX2020003810A (es) | 2020-08-13 |
Family
ID=64110091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003810A MX2020003810A (es) | 2017-10-12 | 2018-10-11 | Vacuna contra la periodontitis y composiciones relacionadas y metodos de uso. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10835590B2 (es) |
| EP (1) | EP3694547A1 (es) |
| JP (2) | JP7258870B2 (es) |
| KR (2) | KR102530966B1 (es) |
| CN (1) | CN111225684A (es) |
| AU (1) | AU2018347511A1 (es) |
| CA (1) | CA3078630A1 (es) |
| EA (1) | EA202090908A1 (es) |
| IL (1) | IL273690A (es) |
| MA (1) | MA50363A (es) |
| MX (1) | MX2020003810A (es) |
| PH (1) | PH12020550239A1 (es) |
| SG (1) | SG11202003147XA (es) |
| WO (1) | WO2019075260A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10835590B2 (en) | 2017-10-12 | 2020-11-17 | Vaxcyte, Inc. | Periodontitis vaccine and related compositions and methods of use |
| CN116751292B (zh) * | 2023-07-31 | 2024-05-14 | 河南大学 | 牙龈卟啉单胞菌Mfa1单克隆抗体及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59128338A (ja) | 1982-12-08 | 1984-07-24 | Kitasato Inst:The | 歯周炎予防用ワクチン及びその製法 |
| NZ267291A (en) | 1993-05-28 | 1997-09-22 | Chiron Corp | Peptide inhibitors of urokinase receptor activity |
| AUPN627595A0 (en) | 1995-10-30 | 1995-11-23 | University Of Melbourne, The | Diagnostics and treatments of periodontal disease |
| WO1997034629A1 (en) | 1996-03-22 | 1997-09-25 | University Of Georgia Research Foundation, Inc. | Immunogenic compositions comprising porphyromonas gingivalis peptides and methods |
| US6833262B1 (en) | 1999-04-21 | 2004-12-21 | University Of Georgia Research Foundation, Inc. | Polypeptide having amidolytic activity for a serpin |
| AUPQ065299A0 (en) * | 1999-05-28 | 1999-06-24 | University Of Sydney, The | A method of prophylaxis and treatment and agents useful for same |
| AUPQ485999A0 (en) * | 1999-12-24 | 2000-02-03 | Csl Limited | P. gingivalis antigenic composition |
| US7378101B2 (en) * | 2001-12-21 | 2008-05-27 | Pfizer, Inc. | Vaccine for periodontal disease |
| GB0411150D0 (en) | 2004-05-19 | 2004-06-23 | Queen Mary & Westfield College | Vaccine |
| BR112012002429A2 (pt) | 2009-08-02 | 2016-11-08 | Sanofi Pasteur Ltd | polipeptídeos de porphyromonas gingivalis |
| EP2533794A4 (en) * | 2010-02-12 | 2014-04-23 | Univ Sydney | PROTEIN DOMAINS AND ASSOCIATED USES |
| WO2011130544A2 (en) | 2010-04-14 | 2011-10-20 | Sutro Biopharma, Inc. | Monitoring a dynamic system by liquid chromatography-mass spectrometry |
| PL2906592T3 (pl) | 2012-10-12 | 2019-07-31 | Sutro Biopharma, Inc. | Proteolityczna inaktywacja wybranych białek w ekstraktach bakteryjnych dla ulepszonej ekspresji |
| EP3365027B1 (en) * | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu specific antibodies and their use in inhibiting biofilm |
| US10835590B2 (en) | 2017-10-12 | 2020-11-17 | Vaxcyte, Inc. | Periodontitis vaccine and related compositions and methods of use |
-
2018
- 2018-10-11 US US16/158,155 patent/US10835590B2/en active Active
- 2018-10-11 MA MA050363A patent/MA50363A/fr unknown
- 2018-10-11 KR KR1020207013299A patent/KR102530966B1/ko active IP Right Grant
- 2018-10-11 CN CN201880065401.1A patent/CN111225684A/zh active Pending
- 2018-10-11 WO PCT/US2018/055496 patent/WO2019075260A1/en active Application Filing
- 2018-10-11 SG SG11202003147XA patent/SG11202003147XA/en unknown
- 2018-10-11 JP JP2020520602A patent/JP7258870B2/ja active Active
- 2018-10-11 KR KR1020237015301A patent/KR20230066660A/ko not_active Application Discontinuation
- 2018-10-11 CA CA3078630A patent/CA3078630A1/en active Pending
- 2018-10-11 EP EP18797289.8A patent/EP3694547A1/en active Pending
- 2018-10-11 MX MX2020003810A patent/MX2020003810A/es unknown
- 2018-10-11 EA EA202090908A patent/EA202090908A1/ru unknown
- 2018-10-11 AU AU2018347511A patent/AU2018347511A1/en active Pending
-
2020
- 2020-03-29 IL IL273690A patent/IL273690A/en unknown
- 2020-04-08 PH PH12020550239A patent/PH12020550239A1/en unknown
-
2021
- 2021-05-05 US US17/308,872 patent/US11701414B2/en active Active
-
2023
- 2023-04-05 JP JP2023061241A patent/JP2023098935A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240226259A9 (en) | 2024-07-11 |
| CA3078630A1 (en) | 2019-04-18 |
| JP2020536925A (ja) | 2020-12-17 |
| AU2018347511A8 (en) | 2020-06-11 |
| MA50363A (fr) | 2020-08-19 |
| US10835590B2 (en) | 2020-11-17 |
| US20240131134A1 (en) | 2024-04-25 |
| AU2018347511A1 (en) | 2020-05-21 |
| KR102530966B1 (ko) | 2023-05-15 |
| WO2019075260A1 (en) | 2019-04-18 |
| JP2023098935A (ja) | 2023-07-11 |
| JP7258870B2 (ja) | 2023-04-17 |
| PH12020550239A1 (en) | 2021-02-15 |
| US20210361756A1 (en) | 2021-11-25 |
| SG11202003147XA (en) | 2020-05-28 |
| IL273690A (en) | 2020-05-31 |
| CN111225684A (zh) | 2020-06-02 |
| US11701414B2 (en) | 2023-07-18 |
| EA202090908A1 (ru) | 2020-10-29 |
| EP3694547A1 (en) | 2020-08-19 |
| BR112020006500A2 (pt) | 2020-10-13 |
| US20190192645A1 (en) | 2019-06-27 |
| KR20230066660A (ko) | 2023-05-16 |
| KR20200070302A (ko) | 2020-06-17 |
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