CN1111345C - The breeding method and the Chinese medicine preparation of natural selenium-rich red sage root traditional Chinese medicine - Google Patents
The breeding method and the Chinese medicine preparation of natural selenium-rich red sage root traditional Chinese medicine Download PDFInfo
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- CN1111345C CN1111345C CN98114174A CN98114174A CN1111345C CN 1111345 C CN1111345 C CN 1111345C CN 98114174 A CN98114174 A CN 98114174A CN 98114174 A CN98114174 A CN 98114174A CN 1111345 C CN1111345 C CN 1111345C
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Abstract
The present invention relates to a kind of breeding method and Chinese medicine preparation of the natural selenium-rich red sage root, employing is executed the selenium method and is cultivated natural selenium-rich red sage root traditional Chinese medicine, the Se content standard that is used to prevent and treat cardiovascular and cerebrovascular disease that is provided in the conventional red sage root crude drug consumption by every day is is provided, solved that inorganic selenium is excessive a severe toxicity, the key problem in technology of restriction clinical practice, and can be by adjusting Radix Salviae Miltiorrhizae rich in selenium and common red sage root formula rate, Radix Salviae Miltiorrhizae rich in selenium preparation and the serial Radix Salviae Miltiorrhizae rich in selenium Chinese medicinal formulae of producing different selenium contents are used for clinical, the inventive method is simple, condition is easily controlled, rich stable selenium content, operation need not increase equipment and change original production red sage root sheet, pharmaceutical technologies such as injection, market prospects are very wide, are small investments, economic benefit is huge, high in technological content new and high technology.
Description
Affiliated technical field
The present invention relates to a kind of breeding method and Chinese medicine preparation of natural selenium-rich red sage root traditional Chinese medicine.
Background technology
In the research field of Chinese medicine and trace element, more and more deep about the research of the red sage root and selenium both at home and abroad, great deal of research results shows that both all have coronary artery dilating, increase coronary blood flow, dwindle experimental myocardial infarction area, quicken cell repair; Cardiovascular pharmacological effects such as anticoagulation, reduction platelet aggregation, prevention thrombosis and calcium antagonism.At the provincial and ministerial level and the state natural sciences fund important function for of research that we bear and finish over nearly 20 years proves; selenium can reduce experimental ischemic myocardium inner lipid peroxide content; keep cell membrane system permeability function; diaphragm system architecture integrality; postpone Ultrastructural damage; promote the synthetic of protein, the subject study that the postgraduate that we cultivate finishes proves that similar action and intensity that red sage formulation has selenium are more obvious.Clinically, Chinese medicinal formulaes such as single and compound Danshen Root tablet, injection are prevented and treated one of first-selected Chinese medicine of cardiovascular and cerebrovascular disease to become present China, and its market prospects are very wide.Homemade compound danshen dripping pills with its determined curative effect, active constituent content is accurate and advantage such as formulation advanced person, passed through the evaluation of FDA (FDA) the end of the year 1997, become the unique tcm product that enters the clinical trial of American I I-III phase new drug, realized that Chinese herbal medicine enters the historical breakthrough in western developed country medicine main flow market.After selenium prophylaxis Keshan disease cardiomyopathy obtained remarkable result, existing selenium was treated reports such as angina pectoris, miocardial infarction, the hypertension of pregnancy and tumour in China.In the developmental research of selenium-enriched health care product, China develops nutrient and healthcare products such as rich selenium tea, selenium-enriched garlic prevention coronary heart disease and cancer and selenium rich of egg, Se-enriched honey in succession.On the achievement in research of existing selenium-enriched health care product, though so far still the end see the natural research report that is rich in micro-traditional Chinese medicine, think the upright topic of this research according to abundant, technical scheme is feasible, can obtain expected results.Based on red sage root Chinese medicinal formulae is to prevent and treat clinically at present to account for one of first-selected Chinese medicine of first cardiovascular and cerebrovascular disease of the cause of the death, trace elements of selenium has also been obtained important progress in application such as angiocardiopathy and developmental research, but the low drug effect that influences of red sage root crude drug selenium content, inorganic selenium is excessive a severe toxicity and use, limited clinical practice, how to make inorganic selenium transform organic selenium, develop more effective natural selenium-rich red sage root traditional Chinese medicine and prescription thereof, capture rapidly and enlarge domestic and international existing single and the common red sage root tablet of compound, pill, medical markets such as injection, it is wide to have become current market prospects, the hot subject that potential economic benefit is huge.
Summary of the invention
The present invention adopts the various selenium methods of executing for overcoming the above problems, and directly cultivates the natural selenium-rich red sage root, develops more effective natural selenium-rich red sage root Chinese medicinal formulae, for a frontier is opened up in the research of Chinese herbal medicine.
The present invention adopts following one to execute the selenium method in red sage root cultivation process all can cultivate and be used for clinical natural selenium-rich red sage root traditional Chinese medicine:
A, usefulness selenite are with 27～270mg selenium/m
2Dosage be mixed with the aqueous solution, spray is uniformly watered in the ditch of planting red sage root seedling, carries out field management behind the earthing;
B, usefulness selenite are with 135～360mg selenium/m
2Dosage, blending uniformly is in the chemical fertilizer or organic farmyard manure of sulfur-bearing not, when plantation, during seedling stage or bud stage be manured into soil;
C, usefulness selenite are with 27～135mg selenium/m
2Dosage be mixed with the aqueous solution, mix in the chemical fertilizer of sulfur-bearing not or the organic farmyard manure respectively uniformly when plantation, during seedling stage and bud stage be manured into soil continuously.
With selenite with 135～360mg selenium/m
2Dosage be mixed with the aqueous solution, carry out foliage spray in seedling stage or bud stage; Also available 27～135mg selenium/m
2Dosage be mixed with the aqueous solution, carry out foliage spray continuously at when plantation, seedling stage and bud stage respectively.
The seedling of selecting for use in red sage root cultivation process comprises root segment, cuttage, plant division, seed seedling-raising, and they all can adopt above-mentioned method to execute selenium and handle.
Can directly make Chinese medicine preparation with the natural selenium-rich red sage root traditional Chinese medicine that method is as mentioned above cultivated: single Radix Salviae Miltiorrhizae rich in selenium tablet, pimpled rubber wafer, pill, injection and spray and compound Radix Salviae Miltiorrhizae rich in selenium tablet, pill, injection and spray.
The selenium content average of the natural selenium-rich red sage root that said method is cultivated is 38.2 μ g selenium/g dry weight red sage root crude drug, execute the preceding selenium content of selenium and increase by 470 times, the selenium that is provided in the conventional red sage root crude drug consumption by every day is is provided is used to prevent and treat the content standard of angiocardiopathy, solved the key problem in technology that severe toxicity restriction clinical practice is arranged because of inorganic selenium is excessive, by adjusting Radix Salviae Miltiorrhizae rich in selenium and common red sage root formula rate, the Radix Salviae Miltiorrhizae rich in selenium prescription that can produce different selenium contents is used for clinical, and provides more effectively Radix Salviae Miltiorrhizae rich in selenium medicine series to the prevention and the treatment of cardio-cerebrovascular diseases; This breeding method is simple, condition is easily controlled, its selenium accumulation amount stable, is suitable for establishing in large scale and promotes, and can improve red sage root output; New drug is gone into operation need not increase equipment, also need not change pharmaceutical technologies such as original production red sage root tablet, injection, and market prospects are very wide, really belong to a small investment, huge, the high in technological content invention technology of economic benefit.
Embodiment
The present invention adopts the different selenium methods of executing directly to cultivate the natural selenium-rich red sage root, and details are as follows for concrete grammar (is example with the root segment cultivation method):
1, adopt red sage root root segment cultivation method, whole ground applies not phosphorus, potash fertilizer or the farmyard manure of sulfur-bearing during the Waking of Insects (3rd solar term), and 12 centimetres of line-spacings are pressed in the thin leveling of deep ploughing rake, open 12 centimetres of dark ditches; Select underground sturdy, the cerise kind root of passing the winter, get the stage casing, the root segment that is cut into 6～7 centimeter length is prepared plantation, by 9～12 centimetres of spacing in the rows root segment is inserted in the ditch, and the flat ditch of back earthing waters.Carry out conventional field management vegetative period, gather in the crops the Beginning of Winter.Key problem in technology is to execute the technical finesse of selenium:
A, be mixed with 27mg selenium/m respectively with sodium selenite
2Low dosage, 135mg selenium/m
2Middle dosage, 270mg selenium/m
2The sodium selenite aqueous solution of high dose waters in the zanjon of holding successfully earthing in the spray uniformly of root segment plantation back respectively.Carry out the red sage root vegetative period and cultivate conventional field management;
B, with sodium selenite respectively with 135mg selenium/m
2Low dosage, 270mg selenium/m
2Middle dosage, 360mg selenium/m
2High dose is mixed its blending uniformly in the phosphorus of equal not sulfur-bearing, the potash fertilizer adding soil, applies when plantation, carries out the conventional field management of the red sage root cultivation vegetative period.
2, the natural selenium-rich red sage root traditional Chinese medicine of cultivating with said method is made Chinese medicine preparation:
Radix Salviae Miltiorrhizae rich in selenium parenteral solution: by former single danshen injections pharmaceutical technology preparation, the every milliliter of suitable Radix Salviae Miltiorrhizae rich in selenium crude drug of soup 2～4g, 2 milliliters every.
Compound Radix Salviae Miltiorrhizae rich in selenium sheet composition proportion (unit of weight: the g/1000 sheet):
Radix Salviae Miltiorrhizae rich in selenium 215 pseudo-ginseng 141 borneols 8
Coronary disease Radix Salviae Miltiorrhizae rich in selenium sheet composition proportion (unit of weight: the g/1000 sheet):
Radix Salviae Miltiorrhizae rich in selenium 200 pseudo-ginseng 200 add dalbergia heartwood oil 1.75ml.
Claims (4)
1, a kind of breeding method of natural selenium-rich red sage root traditional Chinese medicine is to adopt following one to execute the selenium method in red sage root cultivation process all can cultivate and be used for clinical natural selenium-rich red sage root traditional Chinese medicine:
A, usefulness selenite are with 27～270mg selenium/m
2Dosage be mixed with the aqueous solution, spray is uniformly watered in the ditch of planting red sage root seedling, carries out field management behind the earthing;
B, usefulness selenite are with 135～360mg selenium/m
2Dosage, blending uniformly is in the chemical fertilizer or organic farmyard manure of sulfur-bearing not, when plantation, during seedling stage or bud stage be manured into soil;
C, usefulness selenite are with 27～135mg selenium/m
2Dosage be mixed with the aqueous solution, mix in the chemical fertilizer of sulfur-bearing not or the organic farmyard manure respectively uniformly when plantation, during seedling stage and bud stage be manured into soil continuously.
2, the breeding method of a kind of natural selenium-rich red sage root traditional Chinese medicine according to claim 1 uses selenite with 135～360mg selenium/m
2Dosage be mixed with the aqueous solution, carry out foliage spray in seedling stage or bud stage; Also available 27～135mg selenium/m
2Dosage be mixed with the aqueous solution, carry out foliage spray continuously at when plantation, seedling stage and bud stage respectively.
3, the breeding method of a kind of natural selenium-rich red sage root traditional Chinese medicine according to claim 1, the seedling of selecting for use in the described red sage root cultivation process comprises root segment, cuttage, plant division, seed seedling-raising, and they all can adopt the method described in claim 1 to execute the selenium processing.
4, the natural selenium-rich red sage root traditional Chinese medicine of cultivating with method according to claim 1 can directly be made Chinese medicine preparation: single Radix Salviae Miltiorrhizae rich in selenium tablet, pimpled rubber wafer, pill, injection and spray and compound Radix Salviae Miltiorrhizae rich in selenium tablet, pill, injection and spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98114174A CN1111345C (en) | 1998-07-22 | 1998-07-22 | The breeding method and the Chinese medicine preparation of natural selenium-rich red sage root traditional Chinese medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98114174A CN1111345C (en) | 1998-07-22 | 1998-07-22 | The breeding method and the Chinese medicine preparation of natural selenium-rich red sage root traditional Chinese medicine |
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| Publication Number | Publication Date |
|---|---|
| CN1204452A CN1204452A (en) | 1999-01-13 |
| CN1111345C true CN1111345C (en) | 2003-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN98114174A Expired - Fee Related CN1111345C (en) | 1998-07-22 | 1998-07-22 | The breeding method and the Chinese medicine preparation of natural selenium-rich red sage root traditional Chinese medicine |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120704B (en) * | 2007-08-07 | 2011-06-15 | 朱宜元 | Method for producing selenium-rich jujube bud tea |
| CN102715001A (en) * | 2011-12-31 | 2012-10-10 | 西北农林科技大学 | Planting method of novel variety of red-rooted salvia |
| CN102792840A (en) * | 2012-08-15 | 2012-11-28 | 苏州硒谷科技有限公司 | Organic selenium-rich dendrobium candidum and cultivation method thereof |
| CN103385095A (en) * | 2013-07-01 | 2013-11-13 | 句容根生药材有限公司 | Salvia miltiorrhiza planting method for enriching nutriment of rhizomes |
| CN104054480A (en) * | 2014-06-06 | 2014-09-24 | 卞佳林 | Method for raising salvia miltiorrhiza seedlings by cutting |
| CN106806632A (en) * | 2015-11-30 | 2017-06-09 | 张恩林 | A kind of selenium-rich beverage with reduction high lithemia effect |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058879A (en) * | 1991-09-07 | 1992-02-26 | 陕西省中国科学院西北植物研究所 | The artificial cultivation method of rich selenium tea |
| CN1088725A (en) * | 1993-10-30 | 1994-07-06 | 黑龙江省普阳农场 | A kind of method of producing selenium-enriched crop products |
| HUT67245A (en) * | 1992-07-10 | 1995-03-28 | Szekesfehervari Suetoeipari Va | Process for production and industrial manufacture of nat ive substances and finished products enriched in selenium |
| CN1175346A (en) * | 1996-08-08 | 1998-03-11 | 中国科学院水利部水土保持研究所 | Method for producing selenium-enriched wolfberry fruit |
-
1998
- 1998-07-22 CN CN98114174A patent/CN1111345C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058879A (en) * | 1991-09-07 | 1992-02-26 | 陕西省中国科学院西北植物研究所 | The artificial cultivation method of rich selenium tea |
| HUT67245A (en) * | 1992-07-10 | 1995-03-28 | Szekesfehervari Suetoeipari Va | Process for production and industrial manufacture of nat ive substances and finished products enriched in selenium |
| CN1088725A (en) * | 1993-10-30 | 1994-07-06 | 黑龙江省普阳农场 | A kind of method of producing selenium-enriched crop products |
| CN1175346A (en) * | 1996-08-08 | 1998-03-11 | 中国科学院水利部水土保持研究所 | Method for producing selenium-enriched wolfberry fruit |
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| CN1204452A (en) | 1999-01-13 |
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