CN111110761A - 一种牡荆油提取方法 - Google Patents

一种牡荆油提取方法 Download PDF

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Publication number
CN111110761A
CN111110761A CN201811295594.8A CN201811295594A CN111110761A CN 111110761 A CN111110761 A CN 111110761A CN 201811295594 A CN201811295594 A CN 201811295594A CN 111110761 A CN111110761 A CN 111110761A
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Prior art keywords
extracting
vitex
negundo
ethanol solution
ethanol
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CN201811295594.8A
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苏刘花
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Nanjing Zelang Medical Technology Co Ltd
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Nanjing Zelang Medical Technology Co Ltd
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Priority to CN201811295594.8A priority Critical patent/CN111110761A/zh
Publication of CN111110761A publication Critical patent/CN111110761A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/025—Recovery by solvent extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fats And Perfumes (AREA)

Abstract

本发明公开了一种牡荆油提取方法，属于中药加工技术领域。其特征在于，提取工艺如下：选取牡荆叶，切碎，浸入70%乙醇溶液中30‑60min，微波辅助提取，温度为50‑70摄氏度，重复二至三次，过滤去渣，活性炭吸附多余杂质，回收乙醇，得到牡荆油。本发明简便易行，具有普适性，能进行工业化生产。制得牡荆油具有祛痰，止咳，平喘之功效，多用于慢性支气管炎治疗。

Description

一种牡荆油提取方法
技术领域
本发明涉及一种牡荆油提取方法，属于中药加工技术领域。
背景技术
牡荆油，中药名。为马鞭草科植物牡荆的叶提取的挥发油。分布于华东及河北、湖南、湖北、广东、广西、四川、贵州。具有祛痰，止咳，平喘之功效。用于慢性支气管炎。该品为淡黄色至橙黄色的澄清液体，具特殊的香气，味微辛辣，市面上多用于制牡荆油胶丸。
发明内容
本发明目的在于提供一种工业化提取牡荆油的方法，成本低，提取辅料易得，适宜批量生产。
一种牡荆油提取方法，其特征在于提取工艺如下：
1）选取牡荆叶作为原料，洗净，切碎；
2）使用70%乙醇溶液浸泡原料30-60min，微波辅助提取20-40min，温度维持在50-70℃，重复提取2-3次，过滤去渣；
3）将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.1MPA，55-65℃的减压条件下进行减压浓缩，得到牡荆油。
根据权利要求1所述一种牡荆油提取方法，其特征在于乙醇溶液与牡荆碎叶的体积比为1：20-1：25。
具体实施方式：
实施例1
一种牡荆油提取方法，其特征在于提取工艺如下：
1）选取牡荆叶作为原料，洗净，切碎；
2）使用70%乙醇溶液浸泡原料30-60min，微波辅助提取20-40min，温度维持在50-70℃，重复提取2-3次，过滤去渣；
3）将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.8MPA，55-65℃的减压条件下进行减压浓缩，得到牡荆油。
根据权利要求1所述一种牡荆油提取方法，其特征在于乙醇溶液与牡荆碎叶的体积比为1：20-1：25。

Claims (2)

1.一种牡荆油提取方法，其特征在于提取工艺如下：
1）选取牡荆叶作为原料，洗净，切碎；
2）使用70%乙醇溶液浸泡原料30-60min，微波辅助提取20-40min，温度维持在50-70℃，重复提取2-3次，过滤去渣；
将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.1MPA，55-65℃的减压条件下进行减压浓缩，得到牡荆油。
2.根据权利要求1所述一种牡荆油提取方法，其特征在于乙醇溶液与牡荆碎叶的体积比为1：20-1：25。
CN201811295594.8A 2018-11-01 2018-11-01 一种牡荆油提取方法 Pending CN111110761A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811295594.8A CN111110761A (zh) 2018-11-01 2018-11-01 一种牡荆油提取方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811295594.8A CN111110761A (zh) 2018-11-01 2018-11-01 一种牡荆油提取方法

Publications (1)

Publication Number Publication Date
CN111110761A true CN111110761A (zh) 2020-05-08

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CN (1) CN111110761A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113318232A (zh) * 2021-05-25 2021-08-31 广州白云山星群(药业)股份有限公司 牡荆油制剂的制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113318232A (zh) * 2021-05-25 2021-08-31 广州白云山星群(药业)股份有限公司 牡荆油制剂的制备方法
CN113318232B (zh) * 2021-05-25 2021-12-14 广州白云山星群(药业)股份有限公司 牡荆油制剂的制备方法

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Application publication date: 20200508