CN111195273A - 一种款冬挥发油提取方法 - Google Patents

一种款冬挥发油提取方法 Download PDF

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CN111195273A
CN111195273A CN201811369347.8A CN201811369347A CN111195273A CN 111195273 A CN111195273 A CN 111195273A CN 201811369347 A CN201811369347 A CN 201811369347A CN 111195273 A CN111195273 A CN 111195273A
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coltsfoot
volatile oil
extraction method
ethanol solution
rhizome
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王俊
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Nanjing Mengyuan Kangde Biotechnology Co Ltd
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Nanjing Mengyuan Kangde Biotechnology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/025—Recovery by solvent extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Fats And Perfumes (AREA)
  • Edible Oils And Fats (AREA)

Abstract

本发明公开了一种款冬挥发油提取方法，属于中药加工技术领域。其特征在于，提取工艺如下：选取款冬新鲜根茎，切碎，浸入70%乙醇溶液中30‑60min，微波辅助提取，温度为50‑70摄氏度，重复二至三次，过滤去渣，活性炭吸附多余杂质，回收乙醇，得到款冬挥发油。本发明简便易行，具有普适性，能进行工业化生产。制得款冬挥发油具有祛痰，止咳，平喘之功效，多用于慢性支气管炎治疗。

Description

一种款冬挥发油提取方法
技术领域：
本发明涉及一种款冬挥发油提取方法，属于中药加工技术领域。
背景技术：
款冬，中药名。分布于分布于中国东北、华北、华东、西北和湖北、湖南、江西、贵州、云南、西藏。常生于山谷湿地或林下。具有润肺下气，祛痰，止咳，平喘之功效。用于慢性支气管炎和哮喘。
学术研究中多从款冬花中提取挥发油，但其新鲜根茎中也含有挥发油成分和菊糖，本发明研究从款冬根茎中提取挥发油，实现款冬的整体有效利用。
发明内容：
本发明目的在于提供一种工业化提取款冬挥发油的方法，成本低，提取辅料易得，适宜批量生产。
一种款冬挥发油提取方法，其特征在于提取工艺如下：
1）选取款冬新鲜根茎作为原料，洗净，切成小段；
2）使用70%乙醇溶液浸泡原料30-60min，微波辅助提取20-40min，温度维持在50-70℃，重复提取2-3次，过滤去渣；
3）将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.1MPA，55-65℃的减压条件下进行减压浓缩，得到款冬挥发油。
根据权利要求1所述一种款冬挥发油提取方法，其特征在于乙醇溶液与款冬根茎的体积比为1：20-1：25。
具体实施方式：
实施例1
一种款冬挥发油提取方法，其特征在于提取工艺如下：
1）选取款冬新鲜根茎作为原料，洗净，切碎；
2）使用70%乙醇溶液浸泡原料60min，微波辅助提取20min，温度维持在70℃，重复提取3次，过滤去渣；
3）将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.8MPA，55℃的减压条件下进行减压浓缩，得到款冬挥发油。
根据权利要求1所述一种款冬挥发油提取方法，其特征在于乙醇溶液与款冬根茎的体积比为1：25。
实施例2
1）选取款冬新鲜根茎作为原料，洗净，切成小段；
2）使用70%乙醇溶液浸泡原料30min，微波辅助提取40min，温度维持在70℃，重复提取3次，过滤去渣；
3）将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.1MPA，65℃的减压条件下进行减压浓缩，得到款冬挥发油。
根据权利要求1所述一种款冬挥发油提取方法，其特征在于乙醇溶液与款冬根茎的体积比为1：20。
实施例3
1）选取款冬新鲜根茎作为原料，洗净，切成小段；
2）使用70%乙醇溶液浸泡原料40min，微波辅助提取30min，温度维持在60℃，重复提取3次，过滤去渣；
3）将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.1MPA，65℃的减压条件下进行减压浓缩，得到款冬挥发油。
2.根据权利要求1所述一种款冬挥发油提取方法，其特征在于乙醇溶液与款冬根茎的体积比为1：25。

Claims (2)

1.一种款冬挥发油提取方法，其特征在于提取工艺如下：
选取款冬新鲜根茎作为原料，洗净，切成小段；
使用70%乙醇溶液浸泡原料30-60min，微波辅助提取20-40min，温度维持在50-70℃，重复提取2-3次，过滤去渣；
将得到浸提液使用活性炭进行吸附去除杂质，回收乙醇，即在-0.1MPA，55-65℃的减压条件下进行减压浓缩，得到款冬挥发油。
2.根据权利要求1所述一种款冬挥发油提取方法，其特征在于乙醇溶液与款冬根茎的体积比为1：20-1：25。
CN201811369347.8A 2018-11-16 2018-11-16 一种款冬挥发油提取方法 Pending CN111195273A (zh)

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