CN111100078A - 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型 - Google Patents

3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型 Download PDF

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CN111100078A
CN111100078A CN201911273119.5A CN201911273119A CN111100078A CN 111100078 A CN111100078 A CN 111100078A CN 201911273119 A CN201911273119 A CN 201911273119A CN 111100078 A CN111100078 A CN 111100078A
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free base
cancer
anhydrous crystalline
anhydrous
phosphate
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J·贝格豪森
P·K·卡帕
J·麦肯纳
J·斯莱德
R·吴
Z·杜
F·施托瓦塞尔
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Novartis AG
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    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/4965Non-condensed pyrazines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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CN201911273119.5A 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型 Pending CN111100078A (zh)

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US26715509P 2009-12-07 2009-12-07
US61/267,155 2009-12-07
CN2010800550783A CN102639510A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型

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CN201510484635.8A Pending CN105061332A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型
CN201911278014.9A Pending CN111269186A (zh) 2009-12-07 2010-12-06 激酶抑制剂及其盐的晶型
CN201911273119.5A Pending CN111100078A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型
CN2010800550783A Pending CN102639510A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型
CN201911272657.2A Pending CN111100077A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型

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CN201510484635.8A Pending CN105061332A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型
CN201911278014.9A Pending CN111269186A (zh) 2009-12-07 2010-12-06 激酶抑制剂及其盐的晶型

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CN201911272657.2A Pending CN111100077A (zh) 2009-12-07 2010-12-06 3-(2,6-二氯-3,5-二甲氧基-苯基)-1-{6-[4-(4-乙基-哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基-脲及其盐的晶型

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