CN111094289A - 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 - Google Patents

吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 Download PDF

Info

Publication number
CN111094289A
CN111094289A CN201980004502.2A CN201980004502A CN111094289A CN 111094289 A CN111094289 A CN 111094289A CN 201980004502 A CN201980004502 A CN 201980004502A CN 111094289 A CN111094289 A CN 111094289A
Authority
CN
China
Prior art keywords
groups
alkyl
compound
heterocyclyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980004502.2A
Other languages
English (en)
Other versions
CN111094289B (zh
Inventor
张国宝
陈一千
贺峰
陶维康
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Priority to CN202211303805.4A priority Critical patent/CN115710266A/zh
Publication of CN111094289A publication Critical patent/CN111094289A/zh
Application granted granted Critical
Publication of CN111094289B publication Critical patent/CN111094289B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

本发明公开了一种通式(I)所示的吡啶并嘧啶类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为TLR8激动剂的用途，其中通式(I)的各取代基与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN201980004502.2A 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 Active CN111094289B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211303805.4A CN115710266A (zh) 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201810717585 2018-07-03
CN2018107175857 2018-07-03
CN201811317059 2018-11-07
CN2018113170598 2018-11-07
PCT/CN2019/094310 WO2020007275A1 (zh) 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211303805.4A Division CN115710266A (zh) 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用

Publications (2)

Publication Number Publication Date
CN111094289A true CN111094289A (zh) 2020-05-01
CN111094289B CN111094289B (zh) 2022-11-22

Family

ID=69059273

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201980004502.2A Active CN111094289B (zh) 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
CN202211303805.4A Pending CN115710266A (zh) 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202211303805.4A Pending CN115710266A (zh) 2018-07-03 2019-07-02 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用

Country Status (11)

Country Link
US (1) US20210269439A1 (zh)
EP (1) EP3822271A4 (zh)
JP (1) JP7349456B2 (zh)
KR (1) KR20210028208A (zh)
CN (2) CN111094289B (zh)
AU (1) AU2019299609A1 (zh)
BR (1) BR112020026890A2 (zh)
CA (1) CA3105286A1 (zh)
MX (1) MX2020013785A (zh)
TW (1) TWI823959B (zh)
WO (1) WO2020007275A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021136488A1 (zh) 2020-01-02 2021-07-08 江苏恒瑞医药股份有限公司 一种吡啶并嘧啶类衍生物的结晶形式及其制备方法
WO2022184113A1 (zh) * 2021-03-03 2022-09-09 苏州盛迪亚生物医药有限公司 一种包含吡啶并嘧啶类衍生物的药物组合物及其制备方法
CN116472047A (zh) * 2021-11-05 2023-07-21 中国医药研究开发中心有限公司 芳胺类衍生物及其制备方法和医药用途
WO2023104165A1 (zh) * 2021-12-08 2023-06-15 上海维申医药有限公司 作为TLR7/8激动剂的吡啶[4,3-d]嘧啶类化合物
CN116693527A (zh) * 2022-02-24 2023-09-05 广东东阳光药业股份有限公司 嘧啶并芳香环类化合物及其在药物中的应用
WO2024055879A1 (zh) * 2022-09-16 2024-03-21 四川科伦博泰生物医药股份有限公司 一类双并环化合物、其制备方法及用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1867334A (zh) * 2003-07-22 2006-11-22 詹森药业有限公司 作为c－fms激酶抑制剂的喹啉酮衍生物
CN101115479A (zh) * 2005-02-14 2008-01-30 默克公司 Akt活性抑制剂
US20130109693A1 (en) * 2010-04-28 2013-05-02 Universite D'orleans Derivatives of pyrido [3,2-d] pyrimidine, methods for preparation thereof and therapeutic uses thereof
WO2017048727A1 (en) * 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulators of toll-like recptors for the treatment of hiv
CN107108615A (zh) * 2015-03-04 2017-08-29 吉利德科学公司 Toll样受体调节性4,6‑二氨基‑吡啶并[3,2‑D]嘧啶化合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026052A1 (en) 2000-09-26 2002-04-04 Unilever N.V. Composition comprising a fat phase, vegetable matter and salt
TW201402124A (zh) 2005-08-19 2014-01-16 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
PE20071240A1 (es) 2006-01-17 2008-01-14 Schering Corp Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios
CN102015651B (zh) 2008-03-03 2014-12-31 Irm责任有限公司 作为tlr活性调节剂的化合物和组合物
EP3121162B1 (en) 2008-04-16 2021-05-26 Angus Chemical Company Process for preparing nitrated hydrocarbons and their derivatives
WO2010054279A1 (en) 2008-11-10 2010-05-14 Schering Corporation Compounds for the treatment of inflammatory disorders
EA023536B1 (ru) 2009-08-07 2016-06-30 Глаксосмитклайн Байолоджикалс Са Производные оксоаденина, конъюгированные с фосфо- или фосфонолипидами
WO2011068233A1 (en) 2009-12-03 2011-06-09 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
WO2011139348A2 (en) 2010-04-30 2011-11-10 The Regents Of The University Of California Uses of phospholipid conjugates of synthetic tlr7 agonists
WO2012066336A1 (en) 2010-11-19 2012-05-24 Astrazeneca Ab Benzylamine compounds as toll -like receptor 7 agonists
JP6050329B2 (ja) * 2011-05-18 2016-12-21 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染およびその他の疾患を治療するためのキナゾリン誘導体
US9034336B2 (en) 2011-08-30 2015-05-19 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
TWI560172B (en) * 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
PT2800565T (pt) 2012-01-06 2020-04-29 Scripps Research Inst Compostos de carbamato e processos para a sua preparação e utilização
US9145411B2 (en) 2012-08-02 2015-09-29 Asana Biosciences, Llc Substituted amino-pyrimidine derivatives
EP3350168B1 (en) 2015-09-17 2019-12-18 H. Hoffnabb-La Roche Ag Sulfinylphenyl or sulfonimidoylphenyl benzazepines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1867334A (zh) * 2003-07-22 2006-11-22 詹森药业有限公司 作为c－fms激酶抑制剂的喹啉酮衍生物
CN101115479A (zh) * 2005-02-14 2008-01-30 默克公司 Akt活性抑制剂
US20130109693A1 (en) * 2010-04-28 2013-05-02 Universite D'orleans Derivatives of pyrido [3,2-d] pyrimidine, methods for preparation thereof and therapeutic uses thereof
CN107108615A (zh) * 2015-03-04 2017-08-29 吉利德科学公司 Toll样受体调节性4,6‑二氨基‑吡啶并[3,2‑D]嘧啶化合物
WO2017048727A1 (en) * 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulators of toll-like recptors for the treatment of hiv

Also Published As

Publication number Publication date
CN115710266A (zh) 2023-02-24
JP2021529190A (ja) 2021-10-28
US20210269439A1 (en) 2021-09-02
MX2020013785A (es) 2021-03-25
EP3822271A1 (en) 2021-05-19
TWI823959B (zh) 2023-12-01
JP7349456B2 (ja) 2023-09-22
TW202019925A (zh) 2020-06-01
CN111094289B (zh) 2022-11-22
AU2019299609A1 (en) 2021-01-07
CA3105286A1 (en) 2020-01-09
WO2020007275A1 (zh) 2020-01-09
EP3822271A4 (en) 2022-04-13
BR112020026890A2 (pt) 2021-03-30
KR20210028208A (ko) 2021-03-11

Similar Documents

Publication Publication Date Title
CN111094289B (zh) 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
TWI760390B (zh) 吡唑並雜芳基類衍生物、其製備方法及其在醫藥上的應用
CN110177793B (zh) 杂芳基并吡唑类衍生物、其制备方法及其在医药上的应用
CN111757878A (zh) 一种哒嗪类衍生物抑制剂、其制备方法和应用
JP2021513555A (ja) ピリミジン縮合環式化合物及びその製造方法、並びに使用 本出願は、出願日が２０１８年０２月１３日である中国特許出願ｃｎ２０１８１０１４４１３５．３の優先権、及び出願日が２０１８年０６月２９日である中国特許出願ｃｎ２０１８１０６９２２１１．４の優先権を主張する。本出願は上記中国出願の内容のすべてを引用する。
US20210128559A1 (en) Quinazoline Compounds, Preparation Method, Use, and Pharmaceutical Composition Thereof
WO2022247816A1 (zh) 含氮杂环类化合物、其制备方法及其在医药上的应用
US20220009910A1 (en) Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
WO2022213980A1 (zh) Tyk2抑制剂及其用途
WO2022017494A1 (zh) 一种哒嗪类衍生物自由碱的晶型及其制备方法和应用
WO2022017365A1 (zh) 含硫异吲哚啉类衍生物、其制备方法及其在医药上的应用
WO2022022489A1 (zh) 吲哚稠环类衍生物、其制备方法及其在医药上的应用
CN108779100B (zh) 3,4-二吡啶基吡唑类衍生物、其制备方法及其在医药上的应用
CN111433201B (zh) 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用
WO2022111636A1 (zh) 稠合三环化合物、其制备方法及其在医药上的应用
CN112574212B (zh) 一种嘧啶并五元氮杂环类衍生物、其制备方法及其在医药上的应用
CN109694351B (zh) 苯并氮杂*衍生物、其制备方法及其在医药上的应用
WO2022028389A1 (zh) 稠三环类衍生物、其制备方法及其在医药上的应用
CN114057754A (zh) 含氮桥环类衍生物、其制备方法及其在医药上的应用
RU2778524C2 (ru) Производное пиридопиримидина, способ его получения и его применение в медицине
CN114276351B (zh) 含氮杂环类衍生物、其制备方法及其在医药上的应用
CN109956903B (zh) 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用
JP2024510306A (ja) Ｃｔｌａ－４低分子分解剤及びその使用
CN114057734A (zh) 稠合三环类衍生物、其制备方法及其在医药上的应用
CN114621230A (zh) 含氮杂环化合物、其制备方法及其在医药上的应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant