CN111068023A

CN111068023A - Traditional Chinese medicine composition for refreshing and application thereof

Info

Publication number: CN111068023A
Application number: CN202010079286.2A
Authority: CN
Inventors: 谢毅强; 罗丽玲; 黄冰菁; 苏运涛; 于星跃; 黄贤明; 许凤琴
Original assignee: Hainan Medical College
Current assignee: Hainan Medical College
Priority date: 2020-02-03
Filing date: 2020-02-03
Publication date: 2020-04-28

Abstract

The invention belongs to the field of medicines, and particularly relates to a refreshing traditional Chinese medicine composition and application thereof. The refreshing traditional Chinese medicine composition comprises the following components in parts by weight: 1-5 parts of rhizoma acori graminei, 1-5 parts of fructus amomi, 2-7 parts of pogostemon cablin, 3-8 parts of mint, 3-8 parts of magnolia flower, 1-5 parts of storax and 1-5 parts of borneol. The traditional Chinese medicine composition and the traditional Chinese medicine sachet prepared from the traditional Chinese medicine composition have remarkable curative effect on improving the sleepiness symptom of a patient, and the difference of the scoring table values of the ESS sleepiness amount before and after the traditional Chinese medicine composition has statistical significance (P is less than 0.05).

Description

Traditional Chinese medicine composition for refreshing and application thereof

Technical Field

The invention belongs to the field of medicines, and particularly relates to a refreshing traditional Chinese medicine composition and application thereof.

Background

Sleep is an important way for balancing yin and yang of a human body, and accounts for one third of life, so the quality of sleep is the basis of half of life quality. Hypersomnia refers to excessive sleep in the daytime, which means frequent sleepiness and thinking in quiet or monotonous environment, and the sleep can be largely irresistible in different degrees on different occasions even in the case of needing to be very clear. Excessive sleep often causes significant distress or impairment of social, work, or other important functions. Hypersomnia is an intractable neurological disease, no radical treatment is available for the disease in modern medicine at present, psychotherapy and small dose of psychostimulant are mostly adopted, but the effect is little or ineffective, and the normal life of people is greatly influenced.

Disclosure of Invention

The invention provides a refreshing traditional Chinese medicine composition and application thereof, which can effectively improve the sleepiness symptom of a patient and have higher application value.

The technical scheme of the invention is realized as follows:

a traditional Chinese medicine composition for refreshing comprises the following components in parts by weight: 1-5 parts of rhizoma acori graminei, 1-5 parts of fructus amomi, 2-7 parts of pogostemon cablin, 3-8 parts of mint, 3-8 parts of magnolia flower, 1-5 parts of storax and 1-5 parts of borneol.

Further, the refreshing traditional Chinese medicine composition comprises the following components in parts by weight: 2 parts of grassleaf sweelflag rhizome, 2 parts of villous amomum fruit, 4 parts of cablin potchouli herb, 5 parts of mint, 5 parts of magnolia flower, 2 parts of storax and 3.5 parts of borneol.

A preparation method of a refreshing traditional Chinese medicine composition comprises the following steps:

according to the formula, calamus, amomum villosum, patchouli, mint, magnolia flower, storax and borneol are respectively taken, impurities are removed, and the medicine is obtained by drying and crushing.

Further, the temperature is controlled to be 50-60 ℃ in the drying process.

Furthermore, the fructus amomi is used after being broken and fried.

The application of the refreshing traditional Chinese medicine composition in preparing preparations for improving hypersomnia.

Furthermore, the refreshing traditional Chinese medicine composition is administrated by smelling.

A traditional Chinese medicine sachet comprises a shell and a content, wherein the content is the traditional Chinese medicine composition.

Further, the shell is made of a breathable material.

Furthermore, in the traditional Chinese medicine sachet, the weight of the traditional Chinese medicine composition is 20-25 g.

Has the advantages that:

lethargy is mainly caused by spleen deficiency, damp encumbrance and yang deficiency. The pathogenic dampness-turbidity tends to stagnate the spleen, the spleen yang is not risen, and the turbid yin is not descended, so that the damp-turbidity obstructs the clear orifices. The head is the association of all the yang, and if it is masked by damp turbidity, then the clear yang will not rise and the turbid yin will not fall, resulting in drowsiness and lethargy. Therefore, the treatment criteria of eliminating turbid pathogen with aromatics and enlivening spleen for resuscitation can be determined. According to the treatment method, the refreshing composition is prepared: rhizoma acori graminei and pogostemon cablin are used as monarch drugs, fructus amomi, magnolia flower and mint are used as ministerial drugs, and storax and borneol are used as assistant drugs. Wherein the grassleaf sweelflag rhizome is pungent, bitter and warm in nature, enters heart and stomach channels, and can induce resuscitation and refresh mind; guang Huo Xiang is pungent in flavor and slightly warm in nature, and enters spleen, stomach and lung meridians, and can dispel turbid pathogen with aromatics, harmonize middle energizer and arrest vomiting, relieving exterior syndrome and relieving summer-heat; the two herbs are combined together to achieve the action of inducing resuscitation and refreshing mind, and resolving dampness and invigorating spleen to achieve the effect of giving consideration to both exterior and interior. Fructus amomi is pungent in taste and warm in nature, has the efficacies of resolving dampness and stimulating appetite, warming spleen and checking diarrhea, regulating qi and preventing miscarriage, and is not strong in volatility, so that the fructus amomi needs to be fried after breaking shells; the fructus amomi is baked after breaking the shell to improve the volatility of the fructus amomi, the fragrant smell can be easily diffused, and the volatile oil of the fructus amomi contains the effective components, so that the function of resolving dampness and inducing resuscitation can be diffused through fragrance after breaking the shell and frying. The mint is pungent in flavor and cool in property, enters lung and liver meridians, and can clear heat, promote eyesight, soothe liver and promote qi circulation; magnolia flower is warm in nature, has the actions of resolving phlegm, tonifying lung and qi, and is especially good for honey-soaked. Storax has pungent and warm flavor, enters heart and spleen meridians, and can induce resuscitation and remove filth; borneol is pungent, bitter and slightly cold, and can enter heart, spleen and lung channels to induce resuscitation and refresh mind, and the two can assist the whole formula to enhance the efficacy of inducing resuscitation and refreshing mind. The whole formula has proper compatibility, and fully volatilizes the effects of inducing resuscitation, refreshing mind, avoiding dirt, and activating spleen with fragrance.

The traditional Chinese medicines in the formula, such as borneol, fructus amomi, rhizoma acori graminei, storax, pogostemon cablin and the like, contain volatile oil components, can directly act on local skin mucous membranes, and has the effects of diminishing inflammation, sterilizing, dilating blood vessels, refreshing and strengthening brain and the like. The traditional Chinese medicine sachet prepared by taking the composition as an active ingredient has a remarkable curative effect on improving the sleepiness symptom of a patient, and the grading table values of the ESS sleepiness amount before and after the traditional Chinese medicine sachet is worn by the patient have statistical significance (P is less than 0.05).

Detailed Description

The invention will be better understood by reference to the following description taken in conjunction with the specific embodiments.

Example 1

A traditional Chinese medicine composition for refreshing comprises the following components in parts by weight: 1g of grassleaf sweelflag rhizome, 1g of villous amomum fruit (fried), 2g of cablin potchouli herb, 3g of mint, 3g of magnolia flower, 1g of storax and 1g of borneol.

according to the formula, respectively taking calamus, fructus amomi, cablin potchouli herb, mint, magnolia flower, storax and borneol, removing impurities, drying at 50-60 ℃, and crushing to obtain the traditional Chinese medicine composition.

The stir-frying method of the amomum villosum comprises the following steps: taking 100g of fructus amomi as an example, 2g of salt is dissolved in 40ml of water, then 100g of hulled fructus amomi is added for moistening for 1 hour, and stir-frying is carried out at 100 ℃ for 25min to become brown.

Example 2

A traditional Chinese medicine composition for refreshing comprises the following components in parts by weight: 5g of grassleaf sweelflag rhizome, 5g of villous amomum fruit, 7g of cablin potchouli herb, 8g of mint, 8g of magnolia flower, 5g of storax and 5g of borneol.

Example 3

A traditional Chinese medicine composition for refreshing comprises the following components in parts by weight: 2g of grassleaf sweelflag rhizome, 2g of villous amomum fruit (fried), 4g of cablin potchouli herb, 5g of mint, 5g of magnolia flower, 2g of storax and 3.5g of borneol.

The stir-frying method of fructus Amomi is the same as that of example 1.

The traditional Chinese medicine composition prepared by the embodiment can be prepared into corresponding products according to the preference of a patient, such as sachets, pouches, air fresheners, incensing agents and the like, and the effective components are volatilized into the air and directly act on local skin mucous membranes or are inhaled by the patient to play a therapeutic role.

Example 4

A traditional Chinese medicine sachet comprises a shell and a content, wherein the content is the traditional Chinese medicine composition in any one embodiment. The shell is made of air-permeable materials, such as non-woven fabrics, cotton and linen and the like.

The invention discloses a Chinese medicinal composition for investigating the medicinal effect

1 study object

50 sleepiness patients are randomly selected through questionnaire survey in the experiment, and the sleepiness diagnosis standard in Chinese mental disease classification and diagnosis standard, namely the sleepiness diagnosis standard in the traditional Chinese medicine industry of the people's republic of China, sleep disorder occurs 3 times at least every week, excessive sleepiness is caused for at least one month, the sleep time is prolonged almost every day, or the people cannot stay at sleep in the daytime, and the ESS sleepiness scale^[3]Scoring>9 points, no serious physical and mental diseases, and better understanding and communication ability. Those with allergic constitution are excluded; eliminating acute attack stage of respiratory diseases; eliminate pregnant women, lying-in women, children, patients with serious mental diseases and disturbance of consciousness; eliminating organic somnolence caused by pain, fever, trauma, operation and other factors; excluding patients with serious primary diseases of cardiovascular and cerebrovascular diseases, lung diseases, liver diseases, kidney diseases and hemopoietic system diseases; eliminating sleepy people caused by alcohol abuse or psychotropic drug abuse and dependence. 9 male and 41 female, age 19-40, mean (23.38 + -0.01) year, course 1 month to 1 year, mean (0.588 + -0.001) year. Subjects signed informed consent and voluntarily participated in the study, and used their own former and later control experiments to explore efficacy.

2 course of the study

An inclusion questionnaire and a curative effect evaluation questionnaire are prepared, wherein the ① inclusion questionnaire comprises general information (name, sex, age, occupation, medical history and the like of a patient), an ESS hypersomnia evaluation table and relative information of hypersomnia diagnosis standards of Chinese mental disease classification and diagnosis standards, and the ② curative effect evaluation questionnaire comprises patient information, an ESS hypersomnia evaluation table and hypersomnia curative effect judgment standards of Chinese mental disease classification and diagnosis standards of the Ministry of health.

20 to 25g of the traditional Chinese medicine composition prepared in the embodiment 1 to 3 of the invention is randomly taken, and then is added with proper filler, sealed and added with a cotton-linen cloth bag with good air permeability to prepare the sachet for patients to use. The amounts used in the examples are as follows.

TABLE 1 sachet dosage statistics for the experiments

	Dosage (g)	Number of sachets
			Example 1	20	16
Example 2	25	17
			Example 3	23.5	17

3 research methods

51 test groups randomly administered the above prepared sachets, and worn with them, no matter day and night, no matter indoor and outdoor, and no other therapeutic drugs should be taken during the test period. And carrying out periodic tracking recording; the medicine in the sachet is changed when the smell of the sachet becomes light every two weeks, and follow-up investigation is carried out, wherein 1 month is taken as the service cycle.

4 observation index

4.1 ESS hypersomnia Scale the ESS hypersomnia scale was used to evaluate and compare the sleep before and after the patient's experiment. The ESS sleepiness scale has 8 items, the scoring standard is that the selected 0, 1, 2 and 3 are corresponding scores, the score of a normal person is within 7.6, and if the score is more than 9, sleepiness is prompted. Higher scores indicate a more pronounced tendency to lethargy. (the specific score items are as follows)

Somnolence Scale (ESS) was designed by Epworth hospital, melbourne, australia, and clinical application results suggest that ESS is a very simple questionnaire for self-assessment of daytime sleepiness by patients.

The probability score of dozing and drowsiness was determined as follows:

total points are as follows:

note that the criteria for the ① score are never 0 points, rarely 1 points, sometimes 2 points, often 3 points, and ② points, if the sum of the scores exceeds 9 points, sleepiness may be present.

4.2 Classification and diagnosis Standard of Chinese mental diseases adopts the therapeutic effect judgment standard of hypersomnia in Classification and diagnosis Standard of Chinese mental diseases of Ministry of health.

Total effective rate is the cure rate plus effective rate. (the specific score items are as follows)

Criteria for determining the efficacy of drowsiness in the Chinese Classification and diagnosis of mental disorders are as follows. The clinical efficacy was evaluated comprehensively by measuring objective indices of the degree of daytime sleepiness (1 hour of noon has been included) before and after treatment:

the drowsiness symptom disappears, the spirit is obviously improved, and the daily sleeping time is less than or equal to 6 hours and less than or equal to 7 hours. Has the effects of improving symptoms and improving spirit, and the daily sleeping time is less than or equal to 9 hours after 7 hours. No effect, no substantial improvement in symptoms.

5 results

5.1 comparison of scores on the ESS hypersomnia Scale for 50 hypersomnic patients before and after the experiment

The ESS sleepiness scale of the patient before the experiment is divided into (13.4 +/-0.1) points, the ESS sleepiness scale of the patient after the experiment is divided into (9.4 +/-0.1) points, the score is obviously lower than the score before the experiment, and the difference has statistical significance (P < 0.05). See table 2 for details.

TABLE 2 comparison of xx hypersomnic patients ESS hypersomnia Scale scores before and after the experiment (X + -s)

5.250 subjects with effective rate of treating hypersomnia

The total effective rate of the hypersomnia treatment of the patients in the experimental group is 94% (7 patients are cured, 40 patients are effective, and 3 patients are ineffective). See table 3 for details.

TABLE 350 effective rate of treating hypersomnia of study subjects

Group of	Recovery method	Is effective	Invalidation	Total effective
					Number of people (human)	7	40	3	47
Ratio (%)	14	80	6	94

In order to better illustrate the effect of the technical scheme of the invention, specific curative effect comparisons before and after the use of 10 patients are randomly extracted.

(1) Name: sex of yellow: age of the woman: age 21

The main complaints are: repeatedly sleepy for more than 3 months.

And (3) diagnosis: somnolence (phlegm dampness encumbering the spleen)

The course of the disease is as follows: since about March, the patient often feels drowsy, lassitude, heavy head like a roll, and stuffiness and oppression in chest and epigastrium. Poor appetite, swollen and large tongue with white, thick and greasy coating and soft-superficial and slow pulse.

Treatment: the medicinal materials in the sachets are replaced when the scent of the sachets becomes light every 2 weeks without being worn around the clock or indoors or outdoors.

After the follow-up feedback of the re-diagnosis, the sleep quality is obviously improved after 2 weeks.

(2) Name: a certain gender of qiu: age of the woman: age 22

The main complaints are: intermittently sleeps for more than half a year.

And (3) diagnosis: somnolence (spleen qi deficiency)

The course of the disease is as follows: in the last half year, the patient usually feels sleepy, fatigue, sleepy and especially after meals. Poor appetite, loose stool, pale complexion, thin and white coating and weak pulse.

The follow-up feedback of the re-diagnosis is realized, and the sleep quality is improved after 4 weeks.

(3) Name: min a certain sex: age of the male: age 23

The main complaints are: sleepiness lasts for more than one month.

And (3) diagnosis: somnolence (spleen encumbered with dampness)

The course of the disease is as follows: in the last month, the patient often felt drowsy and sleeped. With heaviness of limbs, fullness and oppression in the chest and epigastrium, white, thick and greasy tongue coating, and soft and slippery pulse.

After the follow-up feedback of the re-diagnosis, the sleep quality is improved after 1 week.

(4) Name: certain sex of luo: age of the woman: age 26 years old

The main complaints are: intermittently sleeps for more than half a year.

And (3) diagnosis: somnolence (yang qi deficiency)

The course of the disease is as follows: in the last half of the year, the patient often suffers from lassitude, fatigue, lassitude and no speaking desire. Aversion to cold, cold limbs, easy amnesia, white tongue coating and thready and weak pulse.

(5) Name: aging a certain sex: age of the male: age 30

The main complaints are: intermittently sleeps for more than one year.

And (3) diagnosis: somnolence (spleen qi deficiency)

The course of the disease is as follows: in recent years, the patient often feels sleepy and sleeps and has no spirit. Poor appetite, loose stool, sallow complexion, white tongue coating and thready pulse.

The follow-up feedback of the re-diagnosis is realized, and the sleep quality is improved after 3 weeks.

(6) Name: certain sex panne: age of the woman: age 36

The main complaints are: and sleepiness is intermittently kept for more than 3 months.

And (3) diagnosis: somnolence (spleen encumbered with dampness)

The course of the disease is as follows: in the last 3 months, the patient often sleeps and sleeps. Sometimes accompanied by heavy head, heavy limbs, poor appetite, loose stool, sallow complexion, white and greasy tongue coating, and thready and weak pulse.

Treatment: the Chinese patent medicine, Shenling Baizhu san, is taken orally, and 14 days is a treatment course. The auxiliary treatment adopts the portable south medicine refreshing sachet which is not divided into day and night and indoor and outdoor, and the medicinal materials in the sachet are replaced when the smell of the sachet becomes light every 2 weeks.

The follow-up feedback of the re-diagnosis is realized, and the sleep quality is improved after 2 weeks.

(7) Name: sex of leaf: age of the male: age 51 years old

The main complaints are: intermittently sleeps for more than one year.

And (3) diagnosis: somnolence (spleen encumbered with dampness)

The course of the disease is as follows: in the last year, the patient often becomes drowsy and sleepy. With heaviness of limbs, fullness and oppression in the chest and epigastrium, white, thick and greasy tongue coating, and soft and slippery pulse.

Treatment: the medicinal materials in the sachets are replaced when the fragrance becomes weak every 2 weeks without day and night or indoor and outdoor wearing of the sachets.

(8) Name: flood a certain sex: age of the woman: age 75 years old

The main complaints are: intermittently sleeps for more than half a year.

And (3) diagnosis: somnolence (spleen qi deficiency)

Treatment: the medicinal materials in the sachets are replaced when the scent of the sachets becomes weak in 2 weeks without being worn around day and night or indoors and outdoors.

(9) Name: sex of yellow: age of the woman: age 37

The main complaints are: intermittently sleeps for more than one year.

And (3) diagnosis: somnolence (spleen qi deficiency)

The course of the disease is as follows: in recent years, the patient often feels sleepy and sleeps and has no spirit. A poor appetite, loose stool, sallow complexion, white tongue coating and a thready pulse.

Treatment: the south medicine refreshing sachet is worn with a person, the medicinal materials in the sachet are replaced when the smell of the sachet becomes light every 2 weeks without being divided into day and night and indoor and outdoor.

(10) Name: and (3) Guo of a certain sex: age of the male: age 40

The main complaints are: the sleep is intermittently maintained for 3 months and is aggravated for one week.

And (3) diagnosis: somnolence (yang qi deficiency)

The course of the disease is as follows: in the last 3 months, the patient is often tired, hypodynamia, lassitude and laziness in speaking. Aversion to cold, cold limbs, and easy amnesia. The tongue coating is white and the pulse is thready and weak.

The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.

Claims

1. The traditional Chinese medicine composition for refreshing is characterized by comprising the following components in parts by weight: 1-5 parts of rhizoma acori graminei, 1-5 parts of fructus amomi, 2-7 parts of pogostemon cablin, 3-8 parts of mint, 3-8 parts of magnolia flower, 1-5 parts of storax and 1-5 parts of borneol.

2. The refreshing traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 2 parts of grassleaf sweelflag rhizome, 2 parts of villous amomum fruit, 4 parts of cablin potchouli herb, 5 parts of mint, 5 parts of magnolia flower, 2 parts of storax and 3.5 parts of borneol.

3. The preparation method of the refreshing traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following steps:

4. The method for preparing a refreshing traditional Chinese medicine composition according to claim 3, which is characterized in that: the temperature is controlled to be 50-60 ℃ in the drying process.

5. The method for preparing a refreshing traditional Chinese medicine composition according to claim 3, which is characterized in that: the fructus amomi is used after being broken and fried.

6. Use of the refreshing Chinese medicinal composition of claim 1 or 2 for preparing a preparation for improving hypersomnia.

7. The use of claim 6, wherein: the refreshing traditional Chinese medicine composition is administrated by smelling, through skin and/or mucous membrane.

8. A traditional Chinese medicine sachet comprises a shell and contents, and is characterized in that: the content is the traditional Chinese medicine composition.

9. The traditional Chinese medicine sachet of claim 9, wherein: the shell is made of a breathable material.

10. The traditional Chinese medicine sachet of claim 9, wherein: in the traditional Chinese medicine sachet, the weight of the traditional Chinese medicine composition is 20-25 g.