CN111481610A

CN111481610A - Traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of teenagers aggregated population and preparation method thereof

Info

Publication number: CN111481610A
Application number: CN202010417189.XA
Authority: CN
Inventors: 魏佳怡; 魏丹霞; 顾蘅; 杨品璇; 付敏
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-18
Filing date: 2020-05-18
Publication date: 2020-08-04

Abstract

The invention discloses a traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of teenagers aggregated groups and a preparation method thereof, wherein the traditional Chinese medicine slow-release sachet comprises corresponding traditional Chinese medicine formulas aiming at four different constitutions of the teenagers, and specifically comprises a yang-deficiency-quality traditional Chinese medicine formula, a qi-depression-quality traditional Chinese medicine formula, a phlegm-dampness-quality traditional Chinese medicine formula and a mild-quality traditional Chinese medicine formula; the preparation method comprises the following steps: 1) cleaning the raw materials according to the formula of the traditional Chinese medicine, drying the raw materials at the temperature of not higher than 30 ℃ until the water content is 6-8%, and then crushing the raw materials; 2) loading the pulverized medicinal materials into non-woven bag or air-permeable gauze in 15-40g, tightening bag opening, and kneading to obtain medicinal bag; 3) fixing the medicinal bag in the sachet cloth bag, and sealing. The sachet prepared by the invention is designed with a corresponding traditional Chinese medicine formula aiming at student groups with different constitutions, is prepared from pure Chinese herbal medicines, has mild medicine property and strong pertinence and effectiveness, and can prevent cold, alleviate cold symptoms and accelerate the recovery of cold.

Description

Traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of teenagers aggregated population and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of teenager gathering groups and a preparation method thereof.

Background

The final conclusion of the global medical community big discussion at the end of the last century was: the best medicine is not a curative medicine, but a medicine that makes a person non-ill. This is in contrast to the "preventive treatment" thought advocated by traditional Chinese medicine two thousand years ago, and is disharmony. The 'clothes crown therapy' sachet is an important component part for preventing diseases due to the characteristics of simplicity, practicability, economy, convenience, safety and the like.

The book Huangdi's classic on medicine firstly clearly proposes the word of' treating the disease without illness ', and the book Su Wen & four-qi theory of leading to the god of coordination' is characterized in that: "the goddess do not treat diseases and treat diseases, and do not treat diseases in disorder, the goddess have already become the later-stage disease and do not treat the later-stage disease, such as thirst but through the well, fighting and casting awl, not late! ". Advocate the prevention before illness, make various preventive measures, prevent the illness in the bud, thus must not be ill. Posthan zhong jing "jin kui xiao (1 st main, zhang): … … it is known that liver transmits spleen when it is attacked by liver diseases, and it is thought that spleen … … is excessive first. The original text is used for preventing and treating diseases by 'preventing diseases and transforming diseases'. Since the past, doctors are widely and fully developed, the meaning of 'treating diseases before illness' is considered to have two meanings, one is that the diseases are prevented before illness, and the other two are that the diseases and the illnesses are prevented.

The persistent vitality of the sachet in the historical long river is not separated from the traditional Chinese medicine 'clockwork prevention' which bears the traditional Chinese medicine 'the coat-crown therapy'.

Modern medicine considers that various aromatic traditional Chinese medicines in the sachet volatilize around a human body to form a small environment for resisting and sterilizing viruses, meanwhile, the fragrance is used for inducing resuscitation and restoring consciousness, the vital qi can be rectified in the temperature, the vital qi is in the interior, the pathogenic factors cannot be dried, and the mosquito repelling and insect preventing effects can effectively prevent the virus invasion. The same applies to the good use of the incense in India and Thailand areas of dampness and heat.

The lung governs the skin and hair, opens into the nose, and has the fragrance of opening into the nose to prevent cold. The ' smelling of fragrance ' recorded in the compendium of materia medica ' for treating diseases, the skin and hair muscle striae are communicated with the internal organs of the five viscera and the six hollow organs, the traditional Chinese medicinal materials which are carefully selected, such as borneol, sweet osmanthus, cassia bark, mint, calamus and the like, have unique and lasting fragrance, the ' Xiangmu ' 35 types and ' Fangcao ' 56 types are recorded in the compendium of materia medica, the medicine can enter the interior from sweat pores of skin hair orifices through external application, reaches the internal organs through meridians, promotes healthy qi, resists external evil and balances yin and yang, and prevents cold and treats the disease.

It is also recorded that Huatuo is used for treating pulmonary tuberculosis, vomiting and diarrhea by suspending a sachet prepared by loading musk, clove, sandalwood, stemona root and other medicines into Huadiao in the house; the silk fabric is the main material which is firstly applied to the manufacturing of the sachet, has soft, light and thin texture, is convenient to carry, has low requirements on the modeling technology, is convenient to cut and manufacture, and has relatively low unit density, namely, the perfume is not splashed everywhere, and the silk fabric is ventilated and smells are dispersed.

Six exogenous pathogenic factors are pathogenic factors, pathogenic factors are spread internally, pathogenic factors struggle against vital qi, and pathogenic factors are prevailing, which causes diseases. The doctors in the past advocate the cause of the disease caused by external obstruction. For example, Ling Shu Jiu guan Bafeng says: "treat the deficient wind and avoid it. Therefore, the way of the saint to avoid deficiency pathogen in the day, such as avoiding the natural of the cornstone, is also called as the way of avoiding the pathogenic pathogen. "put forward the principle of avoiding evil and preserving health, Zhongjing is in the first cloud of jin Kui Yao L ü e: if one can nourish his mind, it will not cause pathogenic wind to dry the collaterals. "blocking of the adverse factors and bad qi that lead to the onset of the disease is advocated.

All doctors in the past put the treatment of spirit at the head no matter in health preservation or disease treatment. For instance, it advocates to recuperate the spiritual emotion in the book Su Wen, Shang Gu Tian Zhen Lun (ancient Tian-Zhen treatise on the disease). The aromatherapy has obvious effect on preventing and treating the mental disorder diseases, and partial aromatic plants recorded in Shen nong's herbal Jing can induce resuscitation, refresh mind, nourish heart, tranquilize mind, relieve depression and help sleep. Sun Simiao (Beiji Qianjin Yao Fang & Yang sex chapter) primer Qi Kangsheng, … … Happy anger and second difficulty in health preservation; … … Shen Ji Jing san is a five difficult herb. So it is good at regulating and preventing diseases, and is good at spiritual activities. Jin Dynasty Ku hong (elbow backup fast prescription) recorded that realgar such as date pit tied to the left armpit and sleepless for the whole life. Methods of treating insomnia with steamed soybean filled pillows are also described. The experience of wearing cinnabar to wear the body and the head to treat insomnia is introduced in Ben Cao gang mu of Li Shizhen in the Ming Dynasty. When the sachet is worn with a person for a long time or placed on the side of the pillow for rest, the effects of will, mind settling, regret irritability failure, soul failure and five internal organs peace can be achieved.

Modern pharmacological research proves that partial aromatic drugs have central inhibition or excitation effects such as sedation and tranquilization, and the like, and the effect of applying the partial aromatic drugs to prevention and treatment of insomnia and dreaminess, anxiety, depression, climacteric syndrome and other diseases is obvious by clinicians. The aromatic molecules can clean the peripheral air and can permeate into the human body through skin, acupuncture points, channels and collaterals and other ways, particularly, olfactory nerves are stimulated through nasal inhalation, the olfactory nerves transmit stimulation to the brain center, and chemical substances in the medicine promote the release of neurochemical substances to generate the effects of calming, relaxing or exciting; the aromatic molecules also enter the lung from there, undergo gas exchange, enter the blood circulation, and in addition, control the glandular secretion by means of neuromodulation, thus regulating the whole internal environment of the human body. Thus, the effects of refreshing mind, relieving pressure and improving immunity of human body are achieved.

The current medical model is a 'biology-psychology-society-environment' medical model, which is researched and displayed by clinicians: psychological factors account for a significant proportion of the occurrence and changes of human diseases. Modern medicine increasingly attaches importance to psychological factors, which is the cause of disease in traditional Chinese medicine, emotional diseases. The physicians of the past generations derive from long-term clinical experience: emotional damage is an internal environment factor of the occurrence of diseases, and seven emotions of happiness, anger, worry, thinking, sadness, fear and fright are closely related to the five internal organs in traditional Chinese medicine and respectively correspond to corresponding internal organs, if the seven emotions are too much, the qi movement of the internal organs is disordered, the qi and blood are disordered, and the mental activities are abnormal, so the diseases occur. The aromatic medicine can permeate into human body through mouth, nose, muscle striae, acupoints, channels and collaterals, etc., to achieve the effects of promoting qi and blood circulation and balancing yin and yang. Thereby achieving the purposes of inducing resuscitation and refreshing mind, nourishing heart and soothing nerves, and relieving depression and helping sleep.

The 'fragrance wearing method' has obvious effects on preventing and treating exogenous diseases and mental recognition diseases, and because the fragrance-removing and resuscitation-inducing traditional Chinese medicines are arranged in the external-use traditional Chinese medicine, the 'clear yang can emerge from the upper orifices', and through the principle of externally treating and internally regulating the internal-use traditional Chinese medicine, the internal organs can smooth qi and blood, invigorate healthy qi, eliminate pathogenic factors and remove dirt, dispel wind and disperse pathogenic factors and the like, so the external-use traditional Chinese medicine becomes a heart-attaching object for treating the disease in the traditional Chinese medicine for hundreds of years. Modern pharmacological studies have also shown that: most of the traditional Chinese medicines contain volatile oil, and through the mild stimulation effect of substances volatilized in vitro, a plurality of orifices are opened, so that the absorption of volatile medicines through the body surface can be promoted, pathological products can be promoted to be discharged through the orifices, and meanwhile, the traditional Chinese medicines can play a positive role in the emotion and sleep of people.

The cold is a common disease in winter, and is especially suitable for children, teenagers and the elderly. Because the respiratory tract regulation function of children is not developed completely, the study pressure of young people is large, the young people live together, and the qi and blood functions of the viscera of the old people are reduced. The cold refers to an exogenous disease caused by lung defense disorder due to pathogenic factors such as wind, cold, summer heat, dampness and dryness, which is different from influenza with epidemic toxin, for example, the cold is mostly pathogenic factor in winter, the wind is mostly pathogenic factor in spring, the summer is mostly summer heat and dampness, the dryness is mostly dry pathogenic factor in autumn, the cold is related to season of seasons, the cold invades from skin and nose of human body, invades lung defense, causes disharmony of ying and defensive qi, the pathogenic factors compete positively, the lung qi fails to disperse, and is manifested as nasal obstruction, watery nasal discharge, sneeze, headache, aversion to cold, fever, general malaise, floating pulse and other diseases. Western medicine considers that the body cold is mostly caused by virus infection. It is usually caused by weak healthy qi, when the body feels abnormal qi, it can cause epidemic toxin when it is felt, and the disease is caused by the introduction of the pathogenic factors from the interior and exterior, just as in Zhong Yun from Xiao Ke Li: the origin of cold is marked by deficiency of defensive qi, failure of the original house, normal open of the interstice, pathogenic wind deficiency, and defense yang being filtered. "

A large number of facts and researches show that the volatile oil of some traditional Chinese medicines also has the function of preventing influenza viruses, and the mechanism mainly comprises the following three aspects:

1) improving immunity

Influenza virus is intracellular pathogen, and more than 95% of pathogen infection of organisms occurs on mucous membrane or causes diseases by invasion of the mucous membrane. The respiratory mucosa is not only the site of infection by influenza virus, but also the site of host defense against viral infection. The SIGA is a main effect factor of mucosal immunity, has strong antiviral ability, and the increase of the content thereof makes virus not easy to survive on the respiratory tract mucosa, thereby forming an effective defense barrier between a human body and an external environment.

Research shows that the main reason that people with low immune function are easy to generate respiratory tract infection is the reduction of the content of SIgA in the nasopharynx part. SlgA is locally combined with corresponding pathogenic microorganisms on the mucous membrane, inhibits the pathogenic microorganisms from being adsorbed to mucous epithelial cells and blocks the infection of the pathogenic microorganisms. In addition, SlgA also has the functions of immunological rejection and natural antibiotic factor promotion. The aromatic smell emitted from the medicine in the sachet can stimulate nasal mucosa, improve the content of secretory immunoglobulin A (SlgA) on the nasal mucosa, and continuously stimulate the immune system of the organism to promote the generation of antibody. In the experiment of preventing the upper respiratory infection by using the traditional Chinese medicine sachet in the kindergarten, the experts such as Wu Baodel and the like detect the SIgA content and serum IgA, IgG and IgM in saliva before and after hanging the sachet, which indicates that the wearing of the anti-respiratory sachet can increase the levels of SIgA, serum IgA, IgG and IgM in different degrees; PHA skin test tests show that the PHA skin test value of children susceptible to low immune function is changed from a low value to a normal value after the children are hung with the sachet, and the PHA skin test value is consistent with the reduction of clinical incidence.

2) It has inhibitory effect on pathogenic microorganisms in respiratory tract, thereby reducing and alleviating upper respiratory infection.

Research shows that the volatile components of some Chinese medicines have strong inhibiting effect on common respiratory tract pathogenic bacteria of diplococcus pneumoniae and haemophilus influenzae, and also have inhibiting effect on staphylococcus aureus and hemolytic streptococcus. Modern pharmacological research proves that volatile oil components of storax, grassleaf sweelflag rhizome, mint and the like can inhibit various pathogenic microorganisms such as viruses and bacteria and have a certain regulation effect on the immune function of an organism. Modern researches believe that aromatic odor emitted by Chinese herbal medicines in the sachet forms a high-concentration microenvironment around a human body, so that the sachet can purify air, kill and inhibit bacteria, and the key point of the attack of new coronary pneumonia is novel coronavirus.

3) Central excitant action

The aromatic qi of the traditional Chinese medicine sachet can stimulate the anterior lobe of the brain to secrete and release hormones, relieve nerves and improve the sleep quality. The traditional Chinese medicine sachet is worn on Shanzhong acupoint, and can regulate and correct the partial abundance and partial insufficiency of yin and yang of viscera by stimulating local channels and acupoints, wherein the Shanzhong acupoint is located on the front median line of human body and between two nipples. The alarm point of pericardium is the qi meeting of the eight-hui points. This part is the thymus, which is associated with the triple energizer and can participate in the cellular immunity of the body. Is one of the manifestations of defensive qi. Thymus is a central organ for regulating human immunity, and the secreted thymus peptide contains various cell factors with cell activity, which promotes the differentiation, development and maturation of lymphocyte, so that the immature lymphocyte is matured into the lymphocyte with immunocompetence. The medicine has relatively high concentration in thymus part, and can stimulate the regulation of body via nerve-body fluid reflection to form certain antibody and thus raise the immunity of body. The research shows that the aromatic substance has the functions of calming and wakefulness, and the clinical observation of treating the insomnia patients through the sachet proves that the traditional Chinese medicine sachet is matched on the basis of the diagnosis and treatment of the traditional Chinese medicine, so that the insomnia can be effectively improved.

Teenagers, especially students in school are gathered groups, and the teenagers, especially students in school, are usually stressed in learning, frequently feel dizziness and fatigue, vexation and insomnia, are not fragrant when eating grains, and even have group occurrence because of cold caused by resistance reduction. The students can be influenced by taking the medicine and treating the cold. One of the best ways to wear a sachet is.

For the student population, each person has different constitutions and the sensitivity and response to drugs are correspondingly different. Constitutions refer to morphological structures and stable inherent characteristics formed on the basis of innate endowments and acquired aftermath in the life process of human body; the constitution identification is to take the constitution of a human as a cognitive object, grasp the integral factors and individual differences of health and diseases according to the constitution state and the characteristics of different constitution classifications, specify a prevention and treatment principle, and select corresponding treatment, prevention and health preservation methods, thereby carrying out intervention measures of 'adjusting to the human' condition. Therefore, for the prevention of the cold of the student group, the condition of 'in accordance with the individual' is also needed, different sachets are needed to be designed according to different constitutions so as to exert the maximum efficacy of each herb, and the condition that the herb is suitable for the contrary or the herb is not symptomatic is avoided.

At present, part of the sachets on the market are made of non-natural synthetic spices, which can affect the health of users and lose the culture and health care effects of the traditional sachets. The traditional preparation method of the sachet mainly uses the sachet by directly filling medicinal materials or incense powder, has short fragrance retention time and insufficient fragrance, and the formula does not restrict the popularization and application of the sachet aiming at the problems of physical design of students and the like.

Therefore, the market urgently needs to take the thought of 'treating the disease' of the highest boundary of the traditional Chinese medicine, under the guidance of the basic theory of the traditional Chinese medicine, the traditional Chinese medicine raw materials are combined according to the syndrome differentiation and treatment formula aiming at the actual constitution of the students, the traditional Chinese culture is inherited, the life quality of the students is effectively improved, and the effects of removing the disease and building the body are achieved.

The invention aims to develop the corresponding traditional Chinese medicine slow-release sachet for preventing and treating the cold aiming at teenager groups with different constitutions so as to adapt to student groups with different constitutions, and the traditional Chinese medicine slow-release sachet has better pertinence and effectiveness.

Disclosure of Invention

The first purpose of the invention is to provide a traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of teenager gathering groups, and the second purpose of the invention is to provide a preparation method of the traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of the teenager gathering groups.

The first purpose of the invention is realized by that the traditional Chinese medicine slow-release sachet for preventing and treating cold comprises a plurality of corresponding traditional Chinese medicine formulas aiming at different constitutions.

The traditional Chinese medicine slow-release sachet for preventing and treating cold comprises a mild traditional Chinese medicine formula, a yang deficiency traditional Chinese medicine formula, a qi depression traditional Chinese medicine formula, a phlegm dampness traditional Chinese medicine formula and a mild traditional Chinese medicine formula;

the yang-deficiency-constitution-resisting traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3-7g of cubeb, 3-7g of wormwood, 1-3g of angelica dahurica, 1-3g of rhizoma cyperi and 0.5-1.5g of dried orange peel;

the qi depression traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3-7g of albizia flower, 3-7g of mint, 1-3g of rhizoma cyperi and 0.5-1.5g of perilla leaf.

The phlegm-dampness-removing traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 1-3g of storax, 2-4g of borneol, 3-7g of rhizoma acori graminei and 3-7g of mint;

the mild and moderate traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3-8g of mint, 3-8g of cubeb, 2-4g of dried orange peel and 2-6g of albizia flower.

The second purpose of the invention is realized by the following steps:

1) cleaning the raw materials according to the formula of the traditional Chinese medicine, drying the raw materials at the temperature of not higher than 30 ℃ until the water content is 6-8%, and then crushing the raw materials;

2) loading the pulverized medicinal materials into non-woven bag or air-permeable gauze in 15-40g, tightening bag opening, and kneading to obtain medicinal bag for mixing the materials;

3) and (3) fixedly placing the medicinal material bag in a sachet cloth bag, and sealing to obtain the medicinal material bag.

The formula and the effects of the traditional Chinese medicine formula are as follows:

phlegm-dampness-eliminating traditional Chinese medicine formula

Phlegm-dampness refers to the degree of phlegm-dampness accumulation in the body caused by dysfunction of the spleen, which can cause dysfunction of qi, blood and body fluids in transportation and transformation, water-dampness accumulation and accumulation of dampness into phlegm. The symptoms include dizziness, tinnitus, nasal obstruction, nasal discharge, sticky and greasy mouth, and uncomfortable or sticky stool.

The efficacy is as follows: inducing resuscitation and refreshing mind, and avoiding dirty.

Square solution: storax is pungent and warm, enters heart and spleen meridians, can open orifices and avoid dirt; borneol is pungent, bitter and slightly cold, and can enter heart, spleen and lung channels, induce resuscitation and refresh mind; rhizoma Acori Graminei is pungent, bitter and warm, and has effects of dredging heart and stomach channels, and inducing resuscitation; mint, pungent in flavor and cool in property, enters lung and liver meridians, and can clear heat, relieve dizziness, soothe liver and promote qi circulation.

The pharmacological effects of the traditional Chinese medicine raw materials of the formula are as follows:

storax: belongs to resuscitation-inducing traditional Chinese medicines, has pungent and fragrant flavor, induces resuscitation and refreshes mind, is a key medicine for treating apoplexy with symptoms of phlegm syncope, sudden syncope, fright epilepsy and the like, belonging to cold evil and phlegm turbidity internal block and causing coma, and has definite effects of improving brain functions, relieving encephaledema and brain damage on aspects of ultrastructure of central nervous system, circulatory system, brain cells and the like; the storax volatile oil has small molecular weight and high lipophilicity, is easy to permeate blood brain barrier, has strong neuropharmacological action, and has the experiment proof that the storax shortens the sleep time of a pentobarbital sodium mouse and can resist the action of picric acid exciting a central system. Meanwhile, experiments prove that the storax volatile oil can possibly play an anticonvulsant role through GABA nerve regulation pathways, and cinnamic acid is one of the effective components of the storax and has the effects of resisting bacteria, preventing corrosion, benefiting gallbladder, relieving diarrhea, increasing white blood cells and the like.

Borneol: it is also called borneol, named borneol in famous medical records, "borneol fragrance", and is prepared into crystal through artificial extraction and processing, and its main component is dextro borneol, and possesses the functions of inducing resuscitation, dredging orifices, clearing away heat and relieving pain. Research shows that staphylococcus aureus, drug-resistant staphylococcus aureus and white staphylococcus are sensitive to borneol liquid medicine in standard strains and clinical strains of 14 common pathogenic bacteria; borneol also has the function of increasing the barrier permeability of a biological membrane, so that the permeation quantity and the permeation rate of the borneol and most compatible medicines can be increased, and researches prove that the borneol nasal administration can obviously promote the permeability of nasal mucosa blood vessels and cerebral vessels.

Grassleaf sweelflag rhizome: belongs to a medicine for resuscitation and has the pharmacological effects of tranquilizing, resisting convulsion, improving memory reproduction deficiency, relieving cough, eliminating phlegm, relieving spasm, resisting bacteria, resisting arrhythmia, reducing blood fat, inducing resuscitation, resisting tumor and the like.

The mint is a perennial herb of the family Labiatae, has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat and promoting eruption, and is mainly used for treating wind-heat type cold, headache and conjunctival congestion, sore throat, measles imperviousness, rubella pruritus, liver depression and qi stagnation, chest distress and hypochondriac pain, the whole herb contains volatile oil which is called mint oil, the oil mainly contains L-menthol, L-menthone, menthyl esters, D-8-acetoxy carvone and the like.

Traditional Chinese medicine formula for treating yang deficiency

Yang deficiency refers to the condition of a deficient yang-qi, endogenous cold and low reactivity of the body when the zang-fu organs function is disordered. The symptoms are aversion to cold and aversion to cold, or cough with expectoration, nasal discharge, loose stool and clear and profuse urine.

The efficacy is as follows: relieve exterior syndrome, dispel cold, dispel dampness and resolve phlegm.

Square solution: the cubeb litsea cubeba is pungent and warm in nature, enters spleen channels, stomach channels, kidney channels and bladder channels, and can warm the middle-jiao to dispel cold, promote qi circulation and relieve pain; radix Angelicae Dahuricae is pungent and warm in nature, and has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, and relieving nasal obstruction, and it enters lung, spleen, and stomach channels; the flavor of the accessory ingredient is pungent and mild, and the accessory ingredient enters liver, spleen and triple energizer meridians and can sooth liver and relieve depression, regulate qi and relieve epigastric distention; tangerine peel, pericarpium Citri Tangerinae, with pungent and warm nature, enters lung and spleen meridians, and has the actions of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm.

b, Piper cubeba: the active ingredients are dry mature fruits of litsea cubeba of Lauraceae, and have the effects of warming spleen and stomach for dispelling cold, promoting qi circulation and relieving pain, the litsea cubeba has exact curative effects on antipyretic and analgesic effects, antibacterial effects, cardiovascular diseases, cough and asthma relieving, stomach invigorating and gallbladder benefiting effects, the product obtained by performing supercritical CO2 fluid extraction on volatile substances of the litsea cubeba has good effects on analgesia and sedation, and the volatile oil of the litsea cubeba is a spectral antibacterial agent and can effectively kill penicillium, paecilomyces, candida albicans, aspergillus flavus and the like; the volatile oil has good disinfection and corrosion prevention effects, and the citric acid in the volatile oil has good killing effects on larvae of culex pipiens pallens, trichomonas vaginalis and anisakis.

The folium Artemisiae Argyi is perennial herb of Compositae, and the plant has strong fragrance. The main components of the medicine are cineole, camphor, thujone, borneol, umbelliferone and the like. The folium Artemisiae Argyi has effects of regulating qi and blood, dispelling cold and dampness, regulating menstruation, preventing miscarriage, warming channels, stopping bleeding, clearing heat, relieving cough and eliminating phlegm. It can be used for treating menoxenia, abdominal psychroalgia, fetal hemorrhage, threatened abortion, and infertility due to cold womb. The folium artemisiae argyi extract can effectively inhibit bacteria and fungi substances, wherein the main antibacterial component is folium artemisiae argyi volatile oil, a large number of pharmacological studies show that folium artemisiae argyi oil, folium artemisiae argyi water-soaking agent, folium artemisiae argyi alcohol extract, folium artemisiae argyi and folium artemisiae argyi fumigation can inhibit or kill various bacteria, fungi, viruses and mycoplasma, animal experiments of the folium artemisiae argyi volatile oil show that the folium artemisiae argyi volatile oil can promote the elimination of blood lactic acid after exercise and reduce the consumption of liver glycogen, so that the folium artemisiae argyi volatile oil has an anti-fatigue effect.

Radix angelicae: is a perennial big herb, has strong smell, pungent taste, no toxicity in temperature and strong fragrance, and is mainly used for dispelling wind, eliminating dampness, relieving swelling and alleviating pain. It can be used for treating headache, supercilium pain, odontalgia, nasosinusitis, cold-dampness, abdominal pain, intestinal wind, hemorrhoid, leucorrhea with red and white discharge, carbuncle, skin ulcer, pruritus, scabies, and tinea. The angelica dahurica has aromatic smell, and can be used for various aspects such as cosmetics, beauty treatment and health care, spices, food additives and the like besides the medicine supply; the angelica has a certain regulating effect on central nerves: the composition of the total coumarins and the volatile oil of the radix angelicae has a certain prevention effect on rat migraine induced by nitroglycerin, the total volatile oil of the radix angelicae can obviously reduce the content of monoamine neurotransmitters in blood at the periphery, can obviously increase the amount of 5-hydroxytryptamine at the center, and reduces norepinephrine, so that the analgesic effect is generated. In addition, the radix angelicae has strong antibacterial effect and has inhibitory effect on Escherichia coli, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, gram-positive bacteria, human type Mycobacterium tuberculosis and other bacteria.

Rhizoma cyperi: is dried rhizome of Cyperus rotundus L of Cyperaceae, and has fragrant smell and slightly bitter taste. Compendium of materia Medica: cyperus rotundus has mild but not cold qi, and fragrant but fleeting flavor, and its flavor is pungent and dispersing, slightly bitter and descending, and slightly sweet. The efficacy is as follows: to soothe the liver, relieve depression, regulate qi, relieve epigastric distention, regulate menstruation and alleviate pain. The main treatment is as follows: liver qi stagnation, distending pain in chest and hypochondrium, hernia pain, breast pain, qi stagnation in spleen and stomach, abdominal distention, fullness and distention, pain, menoxenia, amenorrhea and dysmenorrhea. The main component of the rhizoma cyperi is volatile oil substance, the volatile oil of the rhizoma cyperi can improve the anxiety behavior of mice, and the mechanism of the volatile oil of the rhizoma cyperi is probably related to the balance of the central cholinergic system and the increase of the 5-HT level of the volatile oil of the rhizoma cyperi; research shows that the alcohol extract of the rhizoma ligustici wallichii and the rhizoma cyperi can improve the levels of Norepinephrine (NE), Dopamine (DA), 5-HT and 5-oxindole acetic acid (5-HIAA) and reduce the contents of Nitric Oxide (NO) and Nitric Oxide Synthase (NOS) by regulating the release of central neurotransmitter and vasoactive substances, thereby achieving the effect of treating migraine. Cyperus rotundus L can also be used for treating insomnia clinically.

Dried orange peel: has the effects of regulating qi, stimulating appetite, eliminating dampness, resolving phlegm and treating spleen and stomach diseases, and belongs to qi-regulating medicines. The dried orange peel contains volatile oil, hesperidin, n-decanal, citral, limonene, octanol and other components, and the volatile oil contained in the dried orange peel has mild stimulation effect on gastrointestinal tract, can promote secretion of digestive juice, eliminate intestinal tract pneumatosis and increase appetite.

Traditional Chinese medicine formula for treating qi stagnation

The constitution of qi stagnation is caused by the relative insufficiency of the function of the liver in smoothing flow of qi, and the liver is the general organ and directs the qi of the whole body to be smooth and free from restriction. If the liver is relatively deficient, qi stagnation is more likely to occur. The symptoms are nasal obstruction and discharge, dysphoria and vomiting, chest distress and discomfort, vexation and sighing, breast or chest and hypochondrium distending pain, or dry mouth and bitter taste.

The efficacy is as follows: move qi and relieve epigastric distention, resolve dampness and resolve depression.

Square solution: the use amount of the albizia flower and the mint is large, the effect of promoting qi circulation and relieving depression is enhanced, the rhizoma cyperi has the effects of soothing liver and relieving depression, regulating qi and relieving epigastric distention, the three medicines are used together to eliminate dampness and move spleen on the basis of qi circulation and depression, the perilla leaf is fragrant in smell, pungent and warm in nature, and the lung and spleen have two meridians, so that the qi is feasible and relieved.

the flos Albizziae is dried flower of Albizziae of Leguminosae. Albizia julibrissin has the functions of relieving depression, regulating blood, calming heart and eliminating carbuncle and swelling, and is mainly used for treating uneasiness, melancholy insomnia, carbuncle and swelling scrofula and fracture and injury of muscles and bones. The main components of the extract comprise lignan glycoside, sisal acid, farnesic acid lactone, albizzia triterpenes lactone methyl and the like. Albizzia julibrissin has a variety of chemical compositions. The main component of the composition is flavonoid, and the secondary component is volatile oil and the like. Researches show that the albizzia julibrissin ethanol extract has an inhibiting effect on vibrio splendidus, vibrio delugi, bacillus megaterium, vibrio anguillarum and vibrio harveyi. The sedative and hypnotic effects of albizia julibrissin are recorded in more documents of all generations. Research shows that the main component of the albizia flower total flavonoids is quercetin through discussing the method for measuring the content of the albizia flower total flavonoids and establishing the purification method. The quercetin is presumed to be an anxiolytic active ingredient in the albizia flower total flavone, and is proved by pharmacological experiments. Another research on the anxiolytic action mechanism of the quercetin shows that: quercetin may exert anxiolytic effects by agonizing 5-HT1A receptor, and may inhibit the synthesis and release of monoamine neurotransmitters.

Purple perilla: also known as Gui Zi, Bai Su, Chi Su, etc., are annual herbaceous plants of the family Labiatae. Has special fragrance and slightly pungent taste, and is preferably leaves intact, purple in color and strong in fragrance. The book Ben Cao Hui Yan (treatise on materia Medica): purple perilla, dispersing cold qi, clearing lung qi, widening middle qi, calming fetus, descending qi, and transforming phlegm qi, is also a miraculous drug for qi. The main treatment is as follows: relieve exterior syndrome, dispel cold, move qi and harmonize stomach. Can be used for treating wind-cold type common cold, cough, emesis, vomiting of pregnancy, and fish and crab poisoning. The perilla contains various chemical components including volatile oil, fatty acid, flavone, phenolic acid and other components, and also contains inorganic elements and vitamins, the volatile oil is the main active component of the perilla and the source of the specific aroma, and the perilla has the effects of tranquilizing, improving memory and resisting depression on the central system.

Four and mild natures Chinese medicine formula mild natures

The nature of peace and peace is the constitution of most people, or good innate endowment, and proper health preservation and regulation of the postnatal life, and is the manifestation of yin-yang harmonization, blood vessel smoothness and five internal organs uniformity, and the people have strong adaptability to four seasons of chills and sunstroke and geographic environment, and are a state of 'healthy qi internal storage and pathogen non-dryness'. The people have ruddy complexion, vigorous energy, strong viscera function status, and good psychological health, and are not easy to suffer from diseases.

The efficacy is as follows: dispel and avoid exogenous pathogenic factors, and regulate and control body and mind.

Square solution: the formula selects the mint and the cubeb which have large dosage and are full-bodied medicines, the mint is pungent and cool in property, the cubeb is pungent and warm in property, the mint and the cubeb are fragrant and flee, the mint and the cubeb can jointly condition yin and yang, the dried tangerine peel is added to enhance the effect of promoting qi circulation, the qi activity of the whole body is smooth, the albizia julibrissin is sweet in taste and neutral in nature, and the depression can be relieved and the nerves are.

The pharmacological actions of the raw materials of the traditional Chinese medicine of the formula are described in the foregoing.

The use method of the traditional Chinese medicine slow-release sachet for preventing and treating cold provided by the invention comprises the following steps: the sachet is placed on the side of the pillow when sleeping every day, and is worn on the chest 3 times a day, and is placed in front of the nose for deep breathing 20 times. Changing the medicinal bag 1 time every 2-4 weeks. The sachet needs to be waterproof and moistureproof when in use, and is cautiously used by pregnant women.

The invention has the beneficial effects that:

1. the sachet prepared by the invention is designed with a corresponding traditional Chinese medicine formula aiming at student groups with different constitutions, is prepared by pure Chinese herbal medicines, has mild medicine property, no adverse side effect and strong pertinence and effectiveness, has the functions of obviously resisting cold virus and enhancing the immunity of nasal mucosa and respiratory tract, and can prevent cold, alleviate cold symptoms and accelerate the recovery of cold;

2. the traditional Chinese medicine raw materials of the traditional Chinese medicine slow-release sachet are dried and crushed in a low-temperature environment, and when the traditional Chinese medicine slow-release sachet is crushed by a common crusher, a large amount of heat is generated in the working process, so that the volatilization rate of volatile oil with aromaticity in the traditional Chinese medicine is accelerated, the use time of the sachet is greatly shortened, and the cost is increased. The low-temperature crushing and drying are adopted, so that the speed of the volatile oil of the traditional Chinese medicine is reduced and even stopped, and the volatile oil components are fully maintained before being filled into the sachet, thereby achieving the purpose of prolonging the service time of the sachet and saving the cost.

3. The traditional Chinese medicine raw materials of the sachet have the crushed particle size of 20-100 meshes, and different crushed particle sizes are set according to the characteristics and volatility of the raw materials, so that the problem that the traditional Chinese medicine raw materials volatilize too fast due to too fine particle sizes or release fragrance slowly due to too coarse particle sizes is solved; in addition, in the invention, the traditional Chinese medicine raw materials are not directly filled in the sachet cloth bag, but are filled in the non-woven cloth bag or the gauze firstly, so that the medicinal material bag can be conveniently aired and replaced, the aromatic substances are prevented from volatilizing too fast, and the raw materials are prevented from leaking out of the sachet cloth bag.

4. The traditional Chinese medicine raw materials of each group of traditional Chinese medicine formula in the invention are cheap and easily available, and the preparation method of the sachet is simple and easy to operate, and is suitable for popularization and use in schools so as to ensure the health and learning of students.

5. The method and the idea of developing the sachets with different traditional Chinese medicine formulas aiming at different constitutions can be applied to the preparation process of preparing other functional sachets.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the teachings of the present invention are intended to fall within the scope of the present invention.

The traditional Chinese medicine slow-release sachet suitable for preventing and treating cold of teenagers gathering groups comprises corresponding traditional Chinese medicine formulas aiming at different constitutions.

The traditional Chinese medicine slow-release sachet for preventing and treating cold comprises a mild traditional Chinese medicine formula, a yang deficiency traditional Chinese medicine formula, a qi depression traditional Chinese medicine formula and a phlegm dampness traditional Chinese medicine formula;

The phlegm-dampness-removing traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 2g of storax, 3g of borneol, 5g of rhizoma acori graminei and 5g of mint;

the yang-deficiency-constitution-resisting traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 5g of cubeb, 5g of wormwood, 2g of angelica dahurica, 2g of rhizoma cyperi and 1g of dried orange peel;

the qi depression traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 5g of albizia flower, 5g of mint, 2g of rhizoma cyperi and 1g of perilla leaf.

The mild and moderate traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 5g of mint, 5g of cubeb, 2g of dried orange peel and 2g of albizia flower.

The preparation method of the traditional Chinese medicine slow-release sachet for preventing and treating cold comprises the following steps:

2) loading the pulverized medicinal materials into non-woven bag or air-permeable gauze in 15-40g, tightening bag opening, and kneading to obtain medicinal bag;

The crushing granularity of the medicinal raw materials is 20-100 meshes.

The medicinal raw materials are crushed to 60 meshes.

In the step 2, the amount of the medicinal materials in each medicinal material bag is 25 g.

The bag opening of the sachet cloth bag is sewn through a fine thread or tightened up through a tightening rope.

In the step 1, the traditional Chinese medicine raw materials are crushed by a low-temperature crusher.

Example 1

The yang-deficiency-constitution-resisting traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3g of cubeb, 3g of wormwood, 1g of angelica dahurica, 1g of rhizoma cyperi and 0.5g of dried orange peel;

weighing the cubeb, the wormwood, the angelica dahurica, the rhizoma cyperi and the dried orange peel according to the formula of the traditional Chinese medicines, cleaning, placing in a low-temperature dryer for drying until the water content is 6%, then placing each traditional Chinese medicine in a low-temperature crusher for crushing to 20 meshes and mixing, wherein the temperature is set to be 18 ℃. Taking 15 g of crushed medicinal materials, filling the crushed medicinal materials into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening by using a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for yang-deficiency and quality student groups and used for preventing and treating cold.

Example 2

The qi depression traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3g of albizia flower, 3g of mint, 1g of rhizoma cyperi and 0.5g of perilla leaf.

Weighing the silk tree flower, the mint, the rhizoma cyperi and the perilla leaf according to the traditional Chinese medicine formula, cleaning, placing in a low-temperature dryer for drying until the water content is 7%, then placing the traditional Chinese medicines in a low-temperature crusher for crushing to 40 meshes, and mixing, wherein the temperature is set to be 15 ℃. Taking 20 g of crushed medicinal materials, packaging into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening by using a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for the qi depression mass student group for preventing and treating the cold.

Example 3

The phlegm-dampness-removing traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 1g of storax, 2g of borneol, 3g of rhizoma acori graminei and 3g of mint;

weighing storax, Borneolum Syntheticum, rhizoma Acori Graminei and herba Menthae according to the above traditional Chinese medicine formula, cleaning, drying in a low temperature dryer to water content of 8%, pulverizing each traditional Chinese medicine in a low temperature pulverizer to 50 mesh, and mixing, wherein the temperature is set at 12 ℃. Taking 25g of crushed medicinal materials, filling the crushed medicinal materials into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening by using a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for the phlegm-dampness student groups.

Example 4

Weighing storax, Borneolum Syntheticum, rhizoma Acori Graminei and herba Menthae according to the above traditional Chinese medicine formula, cleaning, drying in a low temperature dryer to water content of 7%, pulverizing each traditional Chinese medicine in a low temperature pulverizer to 50 mesh, and mixing, wherein the temperature is set at 12 ℃. Taking 14 g of crushed medicinal materials, filling the crushed medicinal materials into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening by using a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for mild and qualitative student groups.

Example 5

weighing the cubeb, the wormwood, the angelica dahurica, the rhizoma cyperi and the dried orange peel according to the formula of the traditional Chinese medicines, cleaning, placing in a low-temperature dryer for drying until the water content is 7%, then placing each traditional Chinese medicine in a low-temperature crusher for crushing to 80 meshes and mixing, wherein the temperature is set to be 15 ℃. Taking 30 g of crushed medicinal materials, packaging into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening by using a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for yang-deficiency and quality student groups and used for preventing and treating cold.

Example 6

Weighing the silk tree flower, the mint, the rhizoma cyperi and the perilla leaf according to the formula of the traditional Chinese medicines, cleaning, placing in a low-temperature dryer for drying until the water content is 8%, then placing the traditional Chinese medicines in a low-temperature crusher for crushing to 60 meshes, and mixing, wherein the temperature is set to be 0 ℃. Taking 25g of crushed medicinal materials, packaging into a non-woven cloth bag or breathable gauze, fastening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly packaging the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening with a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for the students with qi stagnation.

Example 7

weighing storax, Borneolum Syntheticum, rhizoma Acori Graminei and herba Menthae according to the above traditional Chinese medicine formula, cleaning, drying in a low temperature dryer until the water content is 6%, pulverizing each traditional Chinese medicine in a low temperature pulverizer to 100 mesh, and mixing, wherein the temperature is set to-4 ℃. Taking 30 g of crushed medicinal materials, packaging into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening with a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for the phlegm-dampness student group.

Example 8

The mild and moderate traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 6g of mint, 6g of cubeb, 3g of dried orange peel and 3g of albizia flower.

Weighing herba Menthae, fructus Litseae, pericarpium Citri Tangerinae and flos Albizziae according to the above traditional Chinese medicine formula, cleaning, drying in a low temperature dryer until the water content is 6%, pulverizing each traditional Chinese medicine in a low temperature pulverizer to 50 mesh, and mixing, wherein the temperature is set at 12 deg.C. Taking 18 g of crushed medicinal materials, filling the crushed medicinal materials into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and pulling a zipper of the bag opening to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for mild and moderate student groups.

Example 9

The yang-deficiency-constitution-resisting traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 7g of cubeb, 7g of wormwood, 3g of angelica dahurica, 3g of rhizoma cyperi and 1.5g of dried orange peel;

weighing the cubeb, the wormwood, the angelica dahurica, the rhizoma cyperi and the dried orange peel according to the formula of the traditional Chinese medicines, cleaning, placing in a low-temperature dryer for drying until the water content is 6%, then placing each traditional Chinese medicine in a low-temperature crusher for crushing to 90 meshes and mixing, wherein the temperature is set to be-15 ℃. Taking 40g of crushed medicinal materials, putting the medicinal materials into a non-woven cloth bag or breathable gauze, tightening the bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing an elastic band to tighten the bag opening to obtain the traditional Chinese medicine slow-release sachet suitable for yang-deficiency-quality student groups and used for preventing and treating cold.

Example 10

The qi depression traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: albizia flower 7g, peppermint 7g, nutgrass galingale rhizome 3g and perilla leaf 1.5 g.

Weighing the silk tree flower, the mint, the rhizoma cyperi and the perilla leaf according to the formula of the traditional Chinese medicines, cleaning, placing in a low-temperature dryer for drying until the water content is 6%, then placing the traditional Chinese medicines in a low-temperature crusher for crushing to 70 meshes, and mixing, wherein the temperature is set to be 4 ℃. Taking 27 g of crushed medicinal materials, packaging into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally packaging the medicinal material bag by using a sachet cloth bag with a zipper opening, and tightening the zipper to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for the qi depression mass student group.

Example 11

The phlegm-dampness-removing traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3g of storax, 4g of borneol, 7g of rhizoma acori graminei and 7g of mint;

weighing storax, Borneolum Syntheticum, rhizoma Acori Graminei and herba Menthae according to the above traditional Chinese medicine formula, cleaning, drying in a low temperature dryer to water content of 7%, pulverizing each traditional Chinese medicine in a low temperature pulverizer to 30 mesh, and mixing, wherein the temperature is set to-10 ℃. Taking 18 g of crushed medicinal materials, packaging into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and sewing and sealing the opening with a fine thread to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for the phlegm-dampness student group.

Example 12

The mild and moderate traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 8g of mint, 8g of cubeb, 4g of dried orange peel and 6g of albizia flower.

Weighing herba Menthae, fructus Litseae, pericarpium Citri Tangerinae and flos Albizziae according to the above traditional Chinese medicine formula, cleaning, drying in a low temperature dryer to water content of 8%, pulverizing each traditional Chinese medicine in a low temperature pulverizer to 45 mesh, and mixing, wherein the temperature is set at 12 deg.C. Taking 24 g of crushed medicinal materials, filling the crushed medicinal materials into a non-woven cloth bag or breathable gauze, tightening a bag opening, properly kneading to obtain a medicinal material bag, finally tightly wrapping the medicinal material bag with a sachet cloth bag, and tightening the bag opening with a contraction rope to obtain the traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold for the mild and mild student groups.

Clinical data

First, test standard

1. Diagnostic criteria

1.1 the traditional Chinese medicine constitution typing standard:

the judging method comprises the following steps:

1) answer questions and fill in forms: all questions in the "Classification and determination of constitutions Table" are answered.

2) Calculating the transformation score of each constitution, wherein each question is graded according to 5 grades, and an original score and a transformation score are calculated, the original score = the scores of all items are added, the transformation score = [ (original score-item number)/(item number × 4) ] × 100

And (3) judging standard:

the judgment standard is referred to the 'classification judgment standard of traditional Chinese medical constitution' of Chinese medical society in 2009, and is shown in Table 1. Among them, the mild constitutions are normal constitutions, and the other eight constitutions are unbalanced constitutions.

TABLE 1 determination of mild and abnormal constitutions

1.2 Western diagnostic criteria for upper respiratory tract infections:

according to the diagnostic criteria for common upper respiratory tract infection in "practical internal sciences":

(1) there is a history of cold exposure;

(2) local symptoms are the main symptoms, and general symptoms can be present or not obvious;

① local symptoms include sneezing, nasal obstruction, watery nasal discharge, cough, pharyngalgia, hoarseness, and lacrimation.

② aversion to cold, fever, general malaise, headache, dizziness, and soreness of limbs, waist and back.

1.3 the traditional Chinese medicine diagnosis standard of cold:

referring to the standard of common cold diagnosis in "internal science of traditional Chinese medicine":

(1) wind-cold syndrome/pattern

The main symptoms are: severe chills, mild fever, absence of sweat, headache, soreness of limbs and joints, nasal obstruction and loud voice. Sometimes, there is a running nose, and the pulse is superficial or tense.

The secondary symptoms are as follows: itching throat, cough, thin and white sputum, thirst or thirst with desire for hot drinks, and thin, white and moist tongue coating.

(2) Syndrome of wind-heat

The main symptoms are: fever, slight aversion to wind, obstructed sweating, dry throat, or red swelling and pain of tonsillitis in throat, nasal obstruction, yellow and turbid nasal discharge, and superficial and rapid pulse.

The secondary symptoms are as follows: distending pain in the head, cough, sticky or yellow sputum, thirst with desire for water, thin, white, yellowish coating on the tongue, and red sharp edges.

(3) Syndrome of summer-heat and dampness

The main symptoms are: fever, slight aversion to wind, scanty sweats, heavy or painful limbs, runny nose, restlessness, thirst, soft-superficial and rapid pulse.

The secondary symptoms are as follows: dizziness, fullness and pain, cough, sticky phlegm, sticky greasy taste in the mouth, thirst without much drinking, chest distress, nausea, scanty and dark urine, and thin yellow and greasy tongue coating.

(4) The diagnosis standard of qi deficiency cold:

symptoms are: aversion to cold, fever or cold with cold, spontaneous sweating, headache, nasal obstruction, cough, white phlegm, low voice, short breath and lassitude. Tongue pulse condition: pale with white coating and superficial and weak pulse.

(5) The diagnosis standard of the qi depression cold is as follows:

symptoms are: alternating chills and fever, fullness and fullness in the chest and hypochondrium, a silent desire for food, restlessness and vomiting. Or restlessness, dry mouth, bitter taste, and even cough. Tongue pulse condition: a pale-red tongue with thin and white coating and a wiry pulse.

(6) The diagnosis standard of yang deficiency cold:

symptoms are: aversion to cold, even crouching into chills, spontaneous or anhidrotic sweating, white complexion, cold limbs. Tongue pulse condition: the tongue is pale with white coating and the pulse is deep, thready and weak.

1.4 quality of life chart (Fangji dry. quality of life determination method and application [ M ]. Beijing: Beijing medical university Press, 2000:263-

The following problems arise for emotional reasons in your work and daily life of question 5: 5a reducing work or activity time; 5b something that one would like to do is only a part complete; 5c do not care as often.

To the extent that your health or emotional well-being affects your normal social interaction with family, friends' neighbors, or groups.

Problem 9a you feel full life; 9b you are a sensitive person; 9c you are very bad for clarity, and nothing can make you happy; 9d your mind is calm; 9f your mood falls; 9g, you feel exhausted; 9h you are a happy person; 9i you find bored.

Question 10 is unhealthy and affects your social activity (for example, visiting friends)

Subject 11a I seem to be more sick than others; 11b I am as healthy as the surrounding people; 11c I believe my health is deteriorating; 11d my health status was very good.

2. The grading of the disease states is based on the guidelines of clinical research on new Chinese herbs (trial).

3. Exclusion criteria

(1) Patients with severe and severe complications of typical influenza;

(2) other systemic diseases that cause fever (tumors, severe infections, tuberculosis, etc.);

(3) allergic constitution and those allergic to the drugs contained in the sachets of this study.

(4) Severe hepatic and renal insufficiency;

(5) it is forbidden for pregnant women.

4. Rejection and shedding criteria

(1) Patients who quit or are lost;

(2) those who develop allergic reactions or other adverse reactions during the study;

(3) the person who actively requires to quit;

(4) those who do not wear the sachet as specified.

Second, research method

2.1 study Source and grouping

The study brings the student groups with four constitutions of yang deficiency, qi depression, phlegm dampness, and peace and quality into observation.

Through the identification of the special physique of the traditional Chinese medicine, a standard culture student and 16 study peaceful and mild physiques and 12 yang-deficiency physique, qi depression physique and phlegm-dampness physique of the traditional Chinese medicine hospital in the Kunming city of 2018 and 2019 grades are extracted as observation objects, 60 people are totally and symmetrically grouped into an experimental group (a sachet group) and a control group (a blank group) according to the physique, 30 people are grouped into each group, and the male and the female are random. Wherein, age condition: 16 men and 14 women in the observation group are 22-27 years old, and the average age is 24.13 +/-2.82 years old; 14 male and 16 female in the control group, wherein the age is 21-28 years, and the average age is 24.55 +/-3.02 years. The clinical data of sex, age, constitution, health and cold of two groups of patients are not significantly different (P is more than 0.05) after statistical treatment, and the clinical data are comparable.

Note: considering that the primary and middle school students are minors, a group of researchers and schoolers close to the primary and middle school students are selected as clinical study objects.

2.2 Observation time: the observation was continued for 4 weeks.

2.3 Observation index

2.3.1 general information:

on the day of enrollment, the subjects need to fill in basic questionnaires of sex, age, physical information, presence or absence of cold and symptom expression.

2.3.2 therapeutic index:

① no cold (respiratory tract) symptoms;

② local symptoms (nasal obstruction, watery nasal discharge, cough, etc.) and general symptoms (short breath, asthenia, and sweating);

③ improving life quality, improving sleep quality, increasing diet, etc.

④ mental state, relief of depression (anxiety), improvement of mental state, etc.

2.3.2 safety indexes:

the occurrence and manifestation of allergy

2.4 Experimental methods:

2.4.1 experimental group (sachet group):

people with different constitutions wear the sachet aiming at the constitutions, the sachet is placed on the side of a pillow when sleeping every day, the sachet is hung in front of the chest during the day, the sachet is placed in front of the nose 3 times every day, and the people breathe deeply 20 times. The sachet contents were changed 1 time every 2 weeks and worn continuously for 4 weeks.

2.4.2 control (blank): the sachet was not worn.

All the observed objects normally work and study every day, and the WeChat questionnaire reports whether cold symptoms appear or not every week, or the cold symptoms improve, the sleep and the life quality are in psychological states and the like. And recording the course and medication of the traditional Chinese and western medicine combined treatment of the conventional respiratory tract infection in detail.

2.5 curative effect standard of cold:

① no cold symptoms;

② has obvious effect, short course of disease, and no symptom;

③ is effective in relieving clinical symptoms;

④ is ineffective, the clinical symptoms are not improved or worsened.

Statistical method

2.6 adopt Chi²And (5) testing and pairing t testing.

3 results of the experiment

3.1 comparative data of the overall efficacy of the experimental group and the control group are shown in tables 2 and 3.

TABLE 2 comparison of the two groups of combined therapeutic effects

Group of	Number of examples	No symptom appeared	Show effect	Is effective	Invalidation
						Experimental group	30	4	16	7	3
Control group	30	3	8	6	13

TABLE 3 Combined efficacy analysis (%)

Grouping	The rate of no symptoms	Ratio of significant effect	Effective proportion of	Ratio of ineffectivenessExample (b)	Total up to
						Sachet experimental group	13.3%	53.3%	23.3%	10.0%	100%
Blank control group	9.4%	28.1%	18.8%	43.8%	100.0%

After Pearson Chi-Square tes, in this example,

=9.243, degree of freedom 3, P value 0.026, P<0.05。

3.2 quality of life comparison see Table 4.

TABLE 4 comparison of quality of Life of two groups of patients with common cold

Group of	Number of examples	Show effect	Is effective	Invalidation
					Experimental group	30	8	7	15
Control group	30	3	5	24

The Mann-Whitney Test results are shown in tables 5 and 6, with the average rank of the sachet groups in this example being 27.18, the average rank of the control group being 35.55, the average rank of the sum of the ranks in the experimental group being 815.50, and the average rank of the control group being 1137.50. Test statistic Z = -2.123, P value =0.034, P <0.05

4. Safety index observation

When the sachet group is worn, adverse events such as skin rash, pruritus, palpitation, dyspnea, chest distress, rhinitis aggravation and the like do not occur.

5. Conclusion

As can be seen from tables 2 and 3, the curative effect of the experimental group is obviously higher than that of the control group, and the number of the people with cold is lower than that of the control group, so that the symptoms of the patients are obviously relieved, and the disease course is shortened; as can be seen from Table 4, the recovery degree and quality of life of the tested group for common cold are significantly higher than those of the control group. The comprehensive curative effects before and after two groups of interventions are analyzed by Pearson Chi-Square tes: p is less than 0.05, the two groups have obvious and significant difference of statistical significance, and the comprehensive curative effect of the experimental group is considered to be better than that of the blank control group after the sachet is worn for 4 weeks; the quality of life of the two groups is Man-; whitney Test analysis: p is less than 0.05, and the two groups have statistically significant difference, which shows that the improvement of the life quality of the group wearing the sachet is obviously better than that of the control group.

Claims

1. The traditional Chinese medicine slow-release sachet suitable for preventing and treating the cold of the teenager gathering group is characterized by comprising a plurality of corresponding traditional Chinese medicine formulas aiming at different constitutions.

2. The traditional Chinese medicine slow-release sachet suitable for preventing and treating cold for teenager aggregated population, which is characterized in that the traditional Chinese medicine slow-release sachet for preventing and treating cold comprises a yang deficiency quality traditional Chinese medicine formula, a qi depression quality traditional Chinese medicine formula, a phlegm dampness quality traditional Chinese medicine formula and a mild quality traditional Chinese medicine formula;

the qi depression traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3-7g of albizia flower, 3-7g of mint, 1-3g of rhizoma cyperi and 0.5-1.5g of perilla leaf;

the mild and moderate traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 3-7g of mint, 3-7g of cubeb, 1-3g of dried orange peel and 2-4g of albizia flower.

3. The traditional Chinese medicine slow-release sachet suitable for preventing and treating cold for teenagers gathering groups as claimed in claim 2, wherein the phlegm dampness quality traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 2g of storax, 3g of borneol, 5g of rhizoma acori graminei and 5g of mint;

the qi depression traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 5g of albizia flower, 5g of mint, 2g of rhizoma cyperi and 1g of perilla leaf;

4. The preparation method of the traditional Chinese medicine slow-release sachet of claim 1, which is characterized by comprising the following steps:

5. The preparation method of the traditional Chinese medicine slow-release sachet according to claim 4, wherein the medicinal material raw material is pulverized to 20-100 meshes.

6. The method for preparing a slow-release traditional Chinese medicine sachet of claim 5, wherein the medicinal materials are pulverized with a particle size of 60 meshes.

7. The preparation method of the traditional Chinese medicine slow-release sachet according to claim 4, wherein in the step 2, the amount of the medicinal materials in each medicinal material bag is 25 g.

8. The preparation method of the traditional Chinese medicine slow-release sachet according to claim 4, wherein the bag mouth of the sachet cloth bag is sewn by fine thread or tightened by a rope.

9. The method for preparing a traditional Chinese medicine slow-release sachet according to claim 4, wherein in the step 1, the traditional Chinese medicine raw materials are pulverized by a low-temperature pulverizer.