CN109646526A - A kind of Chinese medicine composition and preparation method thereof for treating depression - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating depression Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating depression.This is used to treat the Chinese medicine composition of depression, and active constituent is prepared from the following raw materials: peppermint, oriental wormwood, cassia seed, rose, pueraria lobata, the root of Dahurain angelica, Flos Albiziae, Os Draconis, raw oyster, magnetite, rhizoma nardostachyos.This is used to treat the Chinese medicine composition of depression, selects aromatics Chinese medicine that pill is made and fills in pillow, sucks the drug ingedient diffused out by schneiderian membrane, has the function that Wen Xiang gets rid of illness.Medicine-filled pillow directly acts on the head of patient, neck, stimulate incidence acupuncture points on the human body, dredge brain qi and blood channels and collaterals, guided drugs to illness station by the leading action of drug, promote absorption of drugs, play the role of soothing liver-qi stagnation, relieving mental strain and helping sleep, appetizing of being amusing, eliminate dampness with aromatics, the blood circulation and nerve modulation to brain have good improvement result.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions and preparation method thereof for treating depression.
Background technique
Depression (Depression) is clinical common emotion Psychopathia Sexualis, belongs to Chinese medicine " melancholia " scope, is Chinese medicine
Learn emotional disorder.Its symptom feature is shown as significantly and persistently depressed, thought slowness and language activity reduction etc., serious person
Even commit suiside.Feeling depressed, it is depressed to be mainly shown as, takes a passive attitude, colder and more detached to surrounding, apathetic；Thinking
It is slow to be mainly shown as that self-assessment is too low, it is unable to subjective initiative problem of perception, hebetude, it is difficult to understand others' meaning；
Language activity reduction is mainly shown as deficiency of QI with disinclination to talk, and happiness is quiet, is reluctant and people associates, slow movement.In recent years, with Chinese society
Economic progress, rhythm of life are accelerated, and study and work pressure increasingly increases, and incidence of depression rises increasingly.According to the world
Health organization announces that the year two thousand twenty depression is only second to the second largest illness of cancer by becoming.
Western medical treatment depression mostly with monoamine oxidase inhibitors, treat by tricyclic, tetracyclic antidepressants etc. at present, though it can
Alleviate its symptom rapidly, but side effect is big, be also easy to produce drug resistance, curative effect worse and worse, and cannot effectively can prevent depression
The recurrence of disease.Western medicine thinks that the cause and onset of disease mechanism of depression is complex, mainly with inherent cause, psychosocial factor
And the factors such as related neural class illness are related.Depression in traditional Chinese medicine be similar to melancholia, mainly with emotional stimulation, physical factors
Etc. in close relations.Traditional Chinese medicine also conducts extensive research depression, is limited primarily to the treatment of traditional Chinese medicine for oral administration.However Chinese medicine
It decocts very complicated, takes time and effort, less adapt to allegro modern life rhythm, and taste is poor, some patientss are difficult to connect
By.And in fact, Traditional Chinese Medicine there are treatment means abundant, it is not limited only to take orally.Thus how to give full play to controlling for Chinese medicine
Characteristic is treated, it is very necessary to develop a kind of honest and clean treatment method just tested of letter.
Summary of the invention
In order to compensate for the shortcomings of the prior art, the present invention provides a kind of reasonable recipe, easy to use, toxic side effect is small,
It is safe and reliable for treating Chinese medicine composition of depression and preparation method thereof, have good soothing liver-qi stagnation, relieving mental strain and helping sleep,
Open it is strongly fragrant be amusing, the effect of eliminating dampness with aromatics.
The present invention is achieved through the following technical solutions:
It is a kind of for treating the Chinese medicine composition of depression, active constituent is prepared from the following raw materials in parts by weight: thin
4~6 parts of lotus, 5~8 parts of oriental wormwood, 10~16 parts of cassia seed, 5~8 parts of rose, 6~8 parts of pueraria lobata, 3~6 parts of the root of Dahurain angelica, Flos Albiziae 5
~8 parts, 12~16 parts of Os Draconis, 12~16 parts of raw oyster, 12~15 parts of magnetite, 6~8 parts of rhizoma nardostachyos.
Preferably, described for treating the Chinese medicine composition of depression, active constituent by following parts by weight raw material
It is made: 5 parts of peppermint, 7 parts of oriental wormwood, 15 parts of cassia seed, 7 parts of rose, 7 parts of pueraria lobata, 5 parts of the root of Dahurain angelica, 7 parts of Flos Albiziae, Os Draconis 15
Part, raw oyster 15,15 parts of magnetite, 7 parts of rhizoma nardostachyos.
Preferably, raw materials used is the prepared slices of Chinese crude drugs.
Preferably, the dosage form of Chinese medicine composition is Chinese kmedicine bolus.
Preferably, the specification of Chinese kmedicine bolus is rde bean size.
Preferably, the Chinese medicine composition is used for pillow inner filler.
The preparation method of the pillow inner filler for being used to treat depression, includes the following steps:
(1) it crushes: each raw material is crushed to the medicinal powder that 100~120 mesh are made；
(2) molding: part medicinal powder being dispensed in coating pan, millet is then placed in, and is made mould with millet and is carried out mechanical molding,
The ball mould of rde bean size is made；
(3) it increases forming: being alternately added water and medicinal powder into coating pan and constantly rotate, until growing up to the water of required specification
Ball；
(4) capping: clear water capping is used；
(5) dry: the water-bindered pill to be dried, 9~10%, drying temperature control is dry at 50~60 DEG C for water content control
It is dry to get the pillow inner filler.
Preferably, millet is placed in water heating before use and boils, and boils and pulls out in 5 seconds.
Preferably, it forms in the water-bindered pill, the weight ratio of millet and medicinal powder is 1:(15~20).
Application method: Chinese kmedicine bolus is filled in pillow and is used.
The pharmaceutical characteristic of each active constituent of the present invention is as follows:
Peppermint: acrid flavour, cool in nature.Enter Liver Channel, lung channel.With head clearing, soothing the liver promoting the circulation of qi, dispelling wind and heat from the body, relieving sore-throat promoting eruption, virtue
Perfume (or spice) is kept away dirty and other effects.Cure mainly anemopyretic cold, warm disease from the beginning of, the more tears of hot eyes, abscess of throat, measles without adequate eruption rubella itch, liver depression gas
It is stagnant, hypochondriac pain uncomfortable in chest.It is applied in we and takes its soothing liver-qi stagnation, the effect of harmonizing emotions.
Oriental wormwood: bitter, pungent, cold nature.Enter spleen, stomach, liver, gallbladder channel.With eliminating dampness and heat, the effect of normalizing gallbladder to cure jaundice.It cures mainly
Jaundice, itchy sore.Modern research shows that oriental wormwood has significant choleretic effect, and there are antipyretic, liver protection and antihypertensive effect.This product grasps the spring
Gas and send out, be apt into liver and gallbladder pass through, be Liver Channel, gallbladder channel guiding drug.Liver Channel, gallbladder channel all uplink heads are pushed up especially on Liver Channel up to mountain peak, with
" governor vessel can be in mountain peak ", governor vessel " and entering to belong to brain ", thus the drug for entering Liver Channel also plays an important role to the adjusting of brain function.Oriental wormwood
Fragrant odour, the pleasant sense of Wen Zhiyou faint scent can be soothing the liver with smooth feelings will, dispels intracorporal aging gas.
Cassia seed: sweet in flavor, bitter, salty, cold nature.Enter Liver Channel, large intestine channel.With calming the liver, heat-clearing improving eyesight, relax bowel and defecation
Effect.Red eye, swell pain is cured mainly, the more tears of photophobia, mesh is secretly unknown, headache, dizziness, dry constipation of intestines.This prescription with its calming liver and clearing heat it
Effect releases the agitation of patients with depression and ponders over excessive caused dizzy.
Rose: sweet in flavor, slight bitter, it is warm-natured.Enter Liver Channel, the spleen channel.With soothing liver-qi stagnation, the effect of promoting blood circulation and stopping pain.Cure mainly liver
Peratodynia, irregular menstruation, injuries from falls as well.This prescription takes its fragrant odour strong, and soothing the liver with smooth feelings will, news makes us the spacious mind of the heart
It is happy, it can be relieved anxiety.
Pueraria lobata: it is sweet in flavor, pungent, it is cool in nature.Enter the spleen channel, stomach meridian, bladder meridian.It brings down a fever with expelling pathogenic factors from muscles and skin, promoting eruption promotes the production of body fluid to quench thirst, rising Yang
The benefits of antidiarrheal.Exterior syndrome fever is cured mainly, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat expels the heat-evil dysentery, splenasthenic diarrhea,
Modern study pueraria lobata can directly expand blood vessel, decline peripheral resistance, and have obvious antihypertensive effect.Pueraria lobata is always that priming enters wing
The guiding drug of Guang warp, bladder meridian circulation pass through neck portion, can be relieved the anxiety in neck portion with it；Bladder meridian enters brain, can be drawn with it
All medicines enter brain, reinforce all medicines to the adjustment effect of brain.
The root of Dahurain angelica: acrid flavour, warm-natured.Enter lung channel, stomach meridian.With relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band, detumescence
The effect of apocenosis.Anemofrigid cold is cured mainly, is had a headache, toothache, rheumatic arthralgia, nasosinusitis, leukorrhagia card, sore and toxic, skin eczema itch.
The root of Dahurain angelica be the stomach channel of foot-Yang-ming special medicine, can priming enter the stomach channel of foot-Yang-ming, the fragrant condiment in both pharmaceutically acceptable and food seasoning it
One, with it with the gas of its fragrance, the benefits of playing stimulating appetite, alleviate the loss of appetite symptom of patient.
Flos Albiziae: it is sweet in flavor, it is mild-natured.Enter the heart channel of Hang-Shaoyin, Liver Channel.Function resolving stagnation for tranquilization.It does not relax suitable for restlessness of asrhenia type and insomnia, depression, is strong
Forget the diseases such as dreaminess.Shennong's Herbal records it can " five viscera settling and will make us happy carefree ".
Os Draconis: it is sweet in flavor, puckery, it is mild-natured.Enter the heart channel of Hang-Shaoyin, Liver Channel, kidney channel.It is calming the liver with tranquillizing the mind by relieving convulsion, astringency inducing
Effect.It cures mainly and has no peace of mind, palpitation and insomnia, frightened epilepsy is demented, dizziness due to hyperactivity of liver-YANG, slips all cards, wet sore pruigo, sore burst for a long time and does not holds back.
This prescription takes the benefits of its calming the liver tranquilizing the mind, alleviates patient and worries beyond measure caused dizziness, impatience and insomnia.
Raw oyster: taste is salty, cold nature.Enter Liver Channel, gallbladder channel, kidney channel.With transquilization with heavy material, calming the liver, resolving hard lump, receive
The effect of holding back astringent method.Confused and worried, insomnia of palpitating with fear is cured mainly, liver-yang hyperactivity is had a dizzy spell, subcutaneous nodule, goiter , lumps in the chest and abdomen, is slipped
All cards, hyperacidity and pain relief.Modem animal experimental study shows that oyster powder has calm, anticonvulsant action.Always keel are with oyster
Herbal pair the benefits of sharing to reinforce calming the liver tranquilizing the mind, alleviates patient and worries beyond measure caused dizziness, impatience and insomnia.
Magnetite: taste is salty, cold in nature.Enter the heart channel of Hang-Shaoyin, Liver Channel, kidney channel.Calming the liver with tranquillizing the mind by relieving convulsion, hearing-improing and eyesight improving, gas of receiving is put down
The effect of asthma.It cures mainly and has no peace of mind, palpitate with fear, insomnia, epilepsy is had a dizzy spell, Hiccough and deaf, blurring of vision, kidney deficiency asthma.This product
For the product of matter principal characteristic pendant, the benefits of sharing with keel, oyster to reinforce calming the liver tranquilizing the mind, alleviate dizzy caused by patient worries beyond measure
Dizzy, impatient and insomnia.
Rhizoma nardostachyos: it is acrid flavour, sweet, it is warm-natured.Enter the spleen channel, stomach meridian.With promoting qi circulation and relieving pain, the strongly fragrant function being amusing is opened.It is bored swollen to cure mainly stomach duct and abdomen,
Pain, worry impairing spleen, do not feel like eating, weak foot due to dampness.Patients with depression mostly loss of appetite, this prescription are opened with its fragrance and strongly fragrant are amusing it
Effect, to promote patient's stimulating appetite.Modern medicine also turns out that rhizoma nardostachyos has calm, stable effect, has an impact to nervous system.
Advantageous effects of the invention:
The present invention provides a kind of Chinese medicine composition for treating depression and its preparation method of Chinese kmedicine bolus agent, according to
It according to Chinese medicine inner disease outer treat rule, selects aromatics Chinese medicine that pill is made and enters in pillow, the medicine diffused out is sucked by schneiderian membrane
Object ingredient has the function that Wen Xiang gets rid of illness；Furthermore medicine-filled pillow directly acts on the head of patient, neck, stimulates incidence acupuncture points on the human body, dredges
Logical brain qi and blood channels and collaterals, are guided drugs to illness station by the leading action of drug, promote absorption of drugs, are played soothing liver-qi stagnation, are calmed the nerves
Sleeping, appetizing of being amusing, the effect eliminated dampness with aromatics, blood circulation and nerve modulation to brain have good improvement result.And
And selected drug is all the product of fragrant odour, can be more preferably absorbed by the body benefit by smell and head term portion acupuncture points on the human body faster
With so that effectively resisting environmental stimuli mitigates negative emotions.
Wherein, peppermint, oriental wormwood, cassia seed, rose enter Liver Channel and discongest liver depression, can be relieved the nervous feelings of depression of patient
Thread；
Sleep disturbance be perplex depressive patients common sympton, Flos Albiziae resolving stagnation for tranquilization be usually used in treat restlessness of asrhenia type and insomnia,
Depression is not relaxed, the double action with relieving mental strain and helping sleep and happy feelings will, and Os Draconis, raw oyster, magnetite be calming the liver, calm peace
Mind, when sleep, act on human body head, and it is bad can be effectively improved patient's sleep quality because caused by worrying beyond measure.
Patients with depression stagnation of liver qi perverse and unreasonable manner violates spleen, and it is white often to will appear the alimentary canals disease such as loss of appetite caused by incoordination between the liver and the spleen
Root of Dahurian angelica pungent-warm perfume (or spice) is dry, is apt to remove Yangming Channel damp evil；Rhizoma nardostachyos acrid flavour promoting the circulation of qi, fragrance are amusing, and the two is all the product of fragrant odour, is easy to
It is absorbed by the body utilization by smell and head term portion acupuncture points on the human body, has the function that out strongly fragrant stomach function regulating of being amusing, to significantly enhance patient's food
It is intended to, improves various symptoms of digestive tract.
With the passing of time Chinese medicine thinks depression in patients, in body often meeting on the one hand the absurd creatures such as raw turbid, hemostasis of phlegm, the generation of absurd creature aggravate
On the one hand the state of depression also can produce other various malaise symptoms of human body.Peppermint, oriental wormwood, rose, Flos Albiziae etc. are all
The product of fragrance, promoting flow of qi and blood circulation relieve stagnation, eliminate dampness with aromatics, and can dispel foul gas in patient body, and news makes patient have a kind of mind clear
The refreshing feeling of gas.
Chinese medicine thinks that head is mainly dispersed with brothers Yang Ming, few sun, all passages through which vital energy circulates of the sun, and it is bright to be included into sun for the root of Dahurain angelica in this composition
Through oriental wormwood is included into shaoyang channel, and pueraria lobata is included into Taiyang channel, other all medicine uplink head may be guided and play a role to enter brain.
To sum up, the Chinese medicine composition that the present invention is used to treat depression, which is filled in pillow, to be used, and disease is treated in sleep
Disease plays the role of soothing liver-qi stagnation, relieving mental strain and helping sleep, appetizing of being amusing, eliminates dampness with aromatics, is effectively improved the depressive state and mistake of patient
The symptoms such as dormancy, loss of appetite, treatment cost is low, and drug side-effect is small, and therapeutic effect is significant, and has saved the time of patient,
Apparent clinical effectiveness is achieved by clinic application.
Specific embodiment:
Below with reference to embodiment, the invention will be further described, but the present invention is not limited thereto, the system in embodiment
Preparation Method is customary preparation methods, is no longer described in detail.
Embodiment 1: this is used to treat the Chinese medicine composition of depression, and the prepared slices of Chinese crude drugs of following portions by weight is taken to be prepared
(every part takes 100g):
6 parts of peppermint, 6 parts of oriental wormwood, 11 parts of cassia seed, 5 parts of rose, 7 parts of pueraria lobata, 4 parts of the root of Dahurain angelica, 5 parts of Flos Albiziae, Os Draconis
12 parts, 12 parts of raw oyster, 13 parts of magnetite, 7 parts of rhizoma nardostachyos.
The present embodiment is used to treat the Chinese medicine composition of depression, and dosage form is Chinese kmedicine bolus, is prepared using following steps:
(1) it crushes: each raw material is crushed to the medicinal powder that 100~120 mesh are made；
(2) molding: part medicinal powder being dispensed in coating pan, millet is then placed in, and is made mould with millet and is carried out mechanical molding,
The ball mould of rde bean size is made, millet is placed in water heating before use and boils, boils and pull out in 5 seconds；
(3) it increases forming: being alternately added water and medicinal powder into coating pan and constantly rotate, until growing up to the water of required specification
Ball forms in the water-bindered pill, and the weight ratio of millet and medicinal powder is 1:20；
(4) capping: clear water capping is used；
(5) dry: the water-bindered pill to be dried, 9~10%, drying temperature control is dry at 50~60 DEG C for water content control
It is dry to get the pillow inner filler.
Embodiment 2: this is used to treat the Chinese medicine composition of depression, and the prepared slices of Chinese crude drugs of following portions by weight is taken to be prepared
(every part takes 100g):
4 parts of peppermint, 5 parts of oriental wormwood, 10 parts of cassia seed, 7 parts of rose, 6 parts of pueraria lobata, 3 parts of the root of Dahurain angelica, 7 parts of Flos Albiziae, Os Draconis
16 parts, 14 parts of raw oyster, 16 parts of magnetite, 8 parts of rhizoma nardostachyos.
The preparation method is the same as that of Example 1.
Embodiment 3: this is used to treat the Chinese medicine composition of depression, and the prepared slices of Chinese crude drugs of following portions by weight is taken to be prepared
(every part takes 100g):
4 parts of peppermint, 6 parts of oriental wormwood, 14 parts of cassia seed, 7 parts of rose, 6 parts of pueraria lobata, 5 parts of the root of Dahurain angelica, 7 parts of Flos Albiziae, Os Draconis
15 parts, 15 parts of raw oyster, 14 parts of magnetite, 8 parts of rhizoma nardostachyos.
The preparation method is the same as that of Example 1.
Embodiment 4: this is used to treat the Chinese medicine composition of depression, and the prepared slices of Chinese crude drugs of following portions by weight is taken to be prepared
(every part takes 100g):
5 parts of peppermint, 8 parts of oriental wormwood, 12 parts of cassia seed, 8 parts of rose, 7 parts of pueraria lobata, 6 parts of the root of Dahurain angelica, 8 parts of Flos Albiziae, Os Draconis
13 parts, 13 parts of raw oyster, 12 parts of magnetite, 7 parts of rhizoma nardostachyos.
The preparation method is the same as that of Example 1.
Embodiment 5: this is used to treat the Chinese medicine composition of depression, and the prepared slices of Chinese crude drugs of following portions by weight is taken to be prepared
(every part takes 100g):
6 parts of peppermint, 7 parts of oriental wormwood, 15 parts of cassia seed, 6 parts of rose, 8 parts of pueraria lobata, 4 parts of the root of Dahurain angelica, 6 parts of Flos Albiziae, Os Draconis
14 parts, 13 parts of raw oyster, 15 parts of magnetite, 6 parts of rhizoma nardostachyos.
The preparation method is the same as that of Example 1.
Test example:
1. research object
1.1 case sources
64 cases are all from the out-patient in November, 2016 in June, 2018 Hospital Attached to Shandong Chinese Medical Univ..
According to random digits table, it is randomly divided into treatment group and control group, control group uses oral western medicine Deanxit, and treatment group is in Western medicine
On the basis of plus with this medicine-filled pillow.
Treatment group 32, wherein male 13, female 19；Age 23-62 years old, average (48.6 ± 11.35) year；Course of disease 0.5-
3 years, average (1.56 ± 0.55) year.
Control group 32, wherein male 14, female 18；Age 25-60 years old, average (46.4 ± 10.25) year；Course of disease 0.6-
3.5 years, average (1.62 ± 0.63) year.The general information of two groups of cases be statistically analyzed display be comparable (p >
0.05)。
1.2 diagnostic criteria
1.2.1 Western medicine diagnostic criteria
According to depression related in " the Chinese Spirit classification of diseases scheme and diagnostic criteria " third edition (2001.CCMD-3)
Diagnostic criteria is determined.Wherein the standard of symptom is mainly based on depressed, and at least meets four following:
(1) hebetude, no pleasant feeling.
(2) psychomotor activity is sluggish or intense.
(3) deficient in energy or tired sense.
(4) self-assessment is too low, feels guilty or have ashamed sense.
(5) appetite stimulator, apathetic depressed or weight are substantially reduced.
(6) it feels thinking ability decline or the imagination is difficult.
(7) it often has the thought of injury oneself or has the behavior of suicide, self inflicted injury.
(8) sleep disturbance difficulty falling asleep, early awakening or hypersomnia.
(9) sexual hypoesthesia.
1.2.2 tcm diagnosis standard
This disease belongs to Chinese medicine melancholia scope, the Standards for Diagnosis and Curative Effect of Chinese Medical Symptom compiled and edit with reference to State Administration of Traditional Chinese Medicine
(1994) and " new Chinese medicine guideline of clinical investigations " (2002) formulate following standard:
Melancholia diagnostic criteria: because of emotional discomfort, depression and stagnation of QI and cause a disease, with the kind sorrow of depression, irritable emotion or irritability is kind cries
For primary symptom.
Liver qi stagnation type diagnostic criteria: (1) primary symptom: depressed emotion, grievance be intended to cry, sighing frequently；(2) simultaneous disease: insomnia is good for
Forget, being irritable and getting angry easily, belch hiccup, receives less, feels restless, fullness in chest and hypochondrium.Pink tongue, tongue fur is thin white, veins string.Primary symptom is indispensable, adds simultaneous
Disease 2 or more, with reference to tongue vein, that is, diagnosable.
1.3 case selection standard
1.3.1 it is included in standard
(1) meet traditional Chinese and western medicine diagnostic criteria, and Hamilton depressive scale (HAMD) scoring is suffered from 8-35 points of light moderate
Person.
(2) Chinese medical discrimination is syndrome of stagnation of liver qi person.
(3) age is between 18~70 years old.
(4) nearly January did not took other antidepressants.
(5) agree to and the person that signs informed consent form.
1.3.2 exclusion criteria
(1) it does not meet diagnostic criteria and is included in standard person.
(2) organic disease and physical disease of this disease symptoms can be caused by excluding schizophrenia, affect psychosis etc.
Patient.
(3) have a serious cardiovascular and cerebrovascular disease, liver, kidney, hematopoiesis and enterogastric diseases people.
(4) gestation or nursing period patient.
1.3.3 standard is rejected
Enter group case but met following one person, has been rejected:
(1) mistaken diagnosis, accidentally receive.
(2) it does not affect the treatment full judgement person without treatment record or data.
(3) add the drug persons with other treatment depression during treating again.
1.3.4 fall off standard
Because group case that enters that following reason does not complete treatment is considered as and falls off:
(1) patient voluntarily bolter.
(2) lost to follow-up.
(3) compliance is poor, occurs influencing other illnesss for the treatment of, serious adverse events etc..
2. research method
2.1 group technology
Using completely random group technology, using table of random number, selected patients are divided into 2 groups according to the ratio of 1:1, i.e.,
Treatment group and control group, every group 32.
2.2 treatment method
2.2.1 control group
Oral western medicine Deanxit: being produced, tablet by Denmark H.Lundbeck, and every 0.5mg containing Flupentixol and Mei Li are bent
Pungent 10mg, drug registration number: H20130126.The medicine comes from Hospital Attached to Shandong Chinese Medical Univ.'s outpatient service.Method of administration: oral
Administration.It is adult: daily 2, morning and noon each 1；Gerontal patient: daily 1, morning is oral.
2.2.2 treatment group
Oral western medicine Deanxit, the same control group of method.On the basis of Western medicine, adds and treated with this medicine-filled pillow.With above-mentioned Chinese medicine water
Ball fills pillow, and in pure cotton pillowcase in pillow outer cover.Shi Yiben medicine-filled pillow of sleeping replaces conventional pillow.Polybag is used after getting up
The storage of this medicine-filled pillow is wrapped up, is distributed to prevent pharmacological property too fast.
2.3 the course for the treatment of
Continuous treatment 8 weeks are 1 course for the treatment of, evaluate curative effect after 1 course for the treatment of.New pillow inner filler is used instead after treating 4 weeks, with
Exempt from pharmacological property diverging excessively to affect the treatment.
2.4 observation index
Curative effect index: (1) with HAMD Measuring scale assessing to the curative effect of disease.
(2) with tcm syndrome Measuring scale assessing to the curative effect of tcm syndrome.
2.5 curative effect determinate standard
(1) curative effect of disease standards of grading: scoring according to HAMD scale, and institute's score value is higher, and depression in patients degree is got over
Height, the state of an illness are heavier.The state of an illness is divided into according to score:
Without depression: total score < 8 divides；
Fen≤8 point minor depressive: Zong, less than 20 points；
Fen≤20 point modest depression: Zong are less than or equal to 35 points；
Severe depression: total score is greater than 35 points.
(2) curative effect is determined according to the HAMD deduction rate that Chinese Medical Association formulates；
Scoring × 100% before HAMD deduction rate=(scoring after scoring-treatment before treating)/treatment.
It cures: HAMD deduction Shuai≤75%；
It is effective: HAMD deduction Shuai≤50%, < 75%；
It is effective: HAMD deduction Shuai≤25%, < 50%；
It is invalid: HAMD deduction rate < 25%.
(3) tcm syndrome criterion of therapeutical effect:
Therapeutic index=(pre-treatment score-post treatment integral)/pre-treatment score × 100%.
It cures: n≤80%；
It is effective: n≤50%, < 80%；
It is effective: n≤30%, < 50%；
It is invalid: n < 30%.
Total effective rate=(cure+effective+effectively)/total cases × 100%.
2.6 statistical procedures methods
After the test, data application SPSS22.0 software package is for statistical analysis.Enumeration data mean ± standard deviation
(x ± s) is indicated, paired t-test is relatively used in group, and comparison among groups use independent samples t test.It is more each using Chi-square Test
Enumeration data between group is that difference has statistical significance with p < 0.05.
3. result of study
(x ± s) is compared in 1 two groups of table pretherapy and post-treatment HAMD scorings
Note: 1. p < 0.05, compared with before same group for the treatment of；2. p < 0.05, compared with after control group treatment.
Two groups of pretherapy and post-treatment HAMD scorings are compared, and are examined through t, by 1 result of table as it can be seen that two groups can effectively reduce patient
Depression scores, with treatment before compared with have significant difference (p < 0.05)；Compared with the control group, scoring subtracts for treatment group after treatment
Few more significant, the two, which compares, significant difference (p < 0.05).
2 two groups of HAMD deduction rate curative effects of table compare (%)
Note: 1. p < 0.05, compared with after control group treatment.
Two groups of HAMD deduction rate curative effects compare, through X2It examines, as seen from the results in Table 2, treatment group's effective percentage is apparently higher than pair
According to group, two groups relatively have significant difference (p < 0.05).
3 two groups of pretherapy and post-treatment TCM syndrome evaluations of table compare (x ± s)
Note: 1. p < 0.05, compared with before same group for the treatment of；2. p < 0.05, compared with after control group treatment.
Two groups of pretherapy and post-treatment TCM syndrome evaluations compare, and examine through t, by 3 result of table as it can be seen that two groups can effectively reduce
The TCM syndrome evaluation of patient has significant difference (p < 0.05) compared with before treatment；After treatment treatment group compared with the control group,
The reduction of scoring is more significant, and the two, which compares, significant difference (p < 0.05).
4 two groups of tcm syndrome curative effects of table compare (%)
Note: 2. p < 0.05, compared with after control group treatment.
Two groups of tcm syndrome curative effects compare, through X2It examines, as seen from the results in Table 4, treatment group's effective percentage is apparently higher than control
Group, two groups relatively have significant difference (p < 0.05).
Finally it should be noted that embodiment is the optimal specific embodiment of the present invention, it is not limited to this
Invention, although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, according to
It is so possible to modify the technical solutions described in the foregoing embodiments, or part of technical characteristic is equally replaced
It changes.All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention
Protection scope within.
Claims (9)
1. it is a kind of for treating the Chinese medicine composition of depression, it is characterized in that: raw material of its active constituent by following parts by weight
It is made: 4~6 parts of peppermint, 5~8 parts of oriental wormwood, 10~16 parts of cassia seed, 5~8 parts of rose, 6~8 parts of pueraria lobata, 3~6 parts of the root of Dahurain angelica,
5~8 parts of Flos Albiziae, 12~16 parts of Os Draconis, 12~16 parts of raw oyster, 12~15 parts of magnetite, 6~8 parts of rhizoma nardostachyos.
2. it is according to claim 1 for treating the Chinese medicine composition of depression, it is characterized in that: its active constituent is by following
The raw material of parts by weight is made: 5 parts of peppermint, 7 parts of oriental wormwood, and 15 parts of cassia seed, 7 parts of rose, 7 parts of pueraria lobata, 5 parts of the root of Dahurain angelica, silk tree
Spend 7 parts, 15 parts of Os Draconis, raw oyster 15,15 parts of magnetite, 7 parts of rhizoma nardostachyos.
3. it is according to claim 1 for treating the Chinese medicine composition of depression, it is characterized in that: raw materials used drink for Chinese medicine
Piece.
4. -2 is described in any item for treating the Chinese medicine composition of depression according to claim 1, it is characterized in that: Chinese traditional medicine composition
The dosage form of object is Chinese kmedicine bolus.
5. it is according to claim 4 for treating the Chinese medicine composition of depression, it is characterized in that: the specification of Chinese kmedicine bolus is
Rde bean size.
6. -2 is described in any item for treating the Chinese medicine composition of depression according to claim 1, it is characterized in that: the Chinese medicine
Composition is used for pillow inner filler.
7. -2 is described in any item for treating the preparation method of the Chinese medicine composition of depression, feature according to claim 1
It is: includes the following steps:
(1) it crushes: each raw material is crushed to the medicinal powder that 100~120 mesh are made；
(2) molding: part medicinal powder being dispensed in coating pan, millet is then placed in, and is made mould with millet and is carried out mechanical molding, is made
The ball mould of rde bean size；
(3) it increases forming: being alternately added water and medicinal powder into coating pan and constantly rotate, until growing up to the water-bindered pill of required specification；
(4) capping: clear water capping is used；
(5) dry: the water-bindered pill to be dried, 9~10%, in 50~60 DEG C of dryings, i.e., drying temperature controls for water content control
Obtain the pillow inner filler.
8. it is according to claim 7 for treating the preparation method of the Chinese medicine composition of depression, it is characterized in that: millet exists
It is placed in water heating before use to boil, boils and is pulled out in 5 seconds.
9. it is according to claim 7 for treating the preparation method of the Chinese medicine composition of depression, it is characterized in that: molding water
In ball, the weight ratio of millet and medicinal powder is 1:(15~20).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279797A (en) * | 2019-07-30 | 2019-09-27 | 济宁市中医院 | A kind of depression prevention and treatment Chinese medicine tea-drinking |
| CN113398194A (en) * | 2021-07-30 | 2021-09-17 | 重庆市中医院 | Traditional Chinese medicine composition for soothing nerves and aiding sleep and U-shaped inhalant |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006206556A (en) * | 2005-01-31 | 2006-08-10 | Ota Isan:Kk | Cerebral memorizing function-lowering symptom-recovering agent and method for preparing the same |
| CN105497575A (en) * | 2014-10-17 | 2016-04-20 | 侯霞 | Traditional Chinese medicinal preparation for treating dysthymia |
| CN105561195A (en) * | 2016-01-22 | 2016-05-11 | 徐毅 | Traditional Chinese medicine composition for treating depression |
-
2019
- 2019-02-20 CN CN201910126112.4A patent/CN109646526B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006206556A (en) * | 2005-01-31 | 2006-08-10 | Ota Isan:Kk | Cerebral memorizing function-lowering symptom-recovering agent and method for preparing the same |
| CN105497575A (en) * | 2014-10-17 | 2016-04-20 | 侯霞 | Traditional Chinese medicinal preparation for treating dysthymia |
| CN105561195A (en) * | 2016-01-22 | 2016-05-11 | 徐毅 | Traditional Chinese medicine composition for treating depression |
Non-Patent Citations (4)
| Title |
|---|
| 姜默琳: "近5年中药复方抗抑郁机制研究进展", 《中华中医药杂志》 * |
| 张媛: "《中药制剂技术》", 31 August 2012, 河南科学技术出版社 * |
| 王瑞芳: "《实用中药安全应用分析》", 31 July 2018, 科学技术文献出版社 * |
| 高学敏: "《中药学》", 30 June 2017, 中国协和医科大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279797A (en) * | 2019-07-30 | 2019-09-27 | 济宁市中医院 | A kind of depression prevention and treatment Chinese medicine tea-drinking |
| CN110279797B (en) * | 2019-07-30 | 2021-06-01 | 刘瑛丽 | Traditional Chinese medicine tea drink for preventing and treating depression |
| CN113398194A (en) * | 2021-07-30 | 2021-09-17 | 重庆市中医院 | Traditional Chinese medicine composition for soothing nerves and aiding sleep and U-shaped inhalant |
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