CN114209784B

CN114209784B - Traditional Chinese medicine nerve-regulating composition and sachet for assisting sleep based on aromatherapy

Info

Publication number: CN114209784B
Application number: CN202111637906.0A
Authority: CN
Inventors: 孙建华; 裴丽霞; 陈璐; 吴晓亮; 陈明真
Original assignee: Jiangsu Provincial Hospital of Chinese Medicine
Current assignee: Jiangsu Provincial Hospital of Chinese Medicine
Priority date: 2021-12-29
Filing date: 2021-12-29
Publication date: 2023-04-25
Anticipated expiration: 2041-12-29
Also published as: CN114209784A

Abstract

The invention discloses a traditional Chinese medicine nerve-regulating composition for assisting sleep based on aromatherapy, which comprises the following components in parts by mass: 15-30 parts of cypress leaves, 15-30 parts of lavender, 12-25 parts of bamboo leaves, 12-25 parts of lemon grass, 10-20 parts of radix scutellariae, 9-15 parts of rose and 9-13 parts of albizia flower. The traditional Chinese medicine mind-regulating sachet for assisting sleep based on the aromatherapy disclosed by the invention has the remarkable clinical effects of nourishing heart, resolving depression, soothing nerves and assisting sleep by adopting a specific formula to prepare the traditional Chinese medicine composition and matching cypress leaves, lavender, bamboo leaf hearts, lemon grass, baikal skullcap roots, roses and albizia flowers.

Description

Traditional Chinese medicine nerve-regulating composition and sachet for assisting sleep based on aromatherapy

Technical Field

The invention belongs to the field of traditional Chinese medicine health maintenance, and particularly relates to a traditional Chinese medicine mind-regulating sachet for assisting sleep based on aromatherapy.

Background

Along with the gradual acceleration of the social rhythm, the physical and psychological pressure of people is gradually increased, and the incidence rate of insomnia is also increased year by year. According to research and investigation, the incidence rate of insomnia in China reaches 45.4%, the incidence rate in the United states reaches 32-35%, the incidence rate in the United kingdom reaches 10-14%, the incidence rate in Finnish reaches 11.9%, and the incidence rate in Japan reaches 21%. In recent years, with the popularization of electronic products, such as mobile phones, etc., the biological clock of a human body is disturbed, and young people often show insomnia or wakefulness. The insomnia can be caused by stress, anxiety, depression, tension, agitation, anger or excessive thinking caused by various contradictions and difficulties in life and work of middle-aged people. With age, the prevalence of insomnia increases. Compared with the young and middle-aged people, the old people are easy to cause deficiency of qi and blood, insomnia and dreaminess due to deficiency of the body and the fatigue and heart. On the other hand, the middle-aged and elderly people often accompany basic diseases such as climacteric syndrome, hypertension, malnutrition, diabetes and the like, so that endocrine disturbance of human bodies is easy to cause neurasthenia and insomnia. Long-term insomnia also increases the chance of developing cardiovascular disease, anxiety, depression, hypertension, stroke, obesity, and other diseases.

The clinically commonly used drugs for treating insomnia comprise benzodiazepine drugs, such as escitalopram, triazolam, temazepam and the like; non-benzodiazepines, such as zaleplon, zopiclone, zolpidem, and the like; melatonin drugs such as temeprosant, ramelteon, agomelatine and the like; and antidepressants such as tricyclic antidepressants, selective serotonin reuptake inhibitors, etc. Although modern medical medicaments have a certain curative effect on insomnia, patients have adverse reactions such as tolerance, addiction, medicament dependence and the like after long-term administration, but not medicament treatments such as cognitive therapy, behavior therapy and the like, and the medicament has the characteristic of no side effect, but few therapists with sufficient domestic experience have high treatment cost and lower compliance of patients.

Disclosure of Invention

The invention aims to: aiming at the defects of the prior art, the invention provides the traditional Chinese medicine mind-regulating sachet for assisting sleep based on aromatherapy, which has the functions of nourishing the heart and soothing the nerves, has no side effect, is fragrant in smell, is easy to accept, and is simple to manufacture and convenient to use.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

a traditional Chinese medicine nerve-regulating composition for assisting sleep based on aromatherapy comprises the following components in parts by mass:

15-30 parts of cypress leaves, 15-30 parts of lavender, 12-25 parts of bamboo leaves, 12-25 parts of lemon grass, 10-20 parts of radix scutellariae, 9-15 parts of rose and 9-13 parts of albizia flower.

The traditional Chinese medicine used in the formula of the invention:

bai Shushe: the Chinese medicinal composition has warm nature, pleasant fragrance, can tonify heart and spleen, nourish liver and kidney, is a good medicament for nourishing heart and soothing nerves, contains aromatic oil, can make people feel happy, has the effects of calming nerves, tranquilizing and soothing nerves, and is particularly suitable for patients with palpitation, dysphoria and insomnia symptoms caused by deficiency of long-term illness.

Lavender: the medicines frequently used by Uygur medicine have warm nature, and have the effects of clearing orifices and nourishing brain, activating tendons and strengthening muscles, resisting bacteria and diminishing inflammation, relieving spasm and pain, dispelling wind and cold, and tranquilizing and allaying excitement. Most researches at present use lavender essential oil aromatherapy, which proves that the lavender essential oil aromatherapy can regulate the physiology and the psychology of a human body, has the effects of tranquilizing, hypnotizing and soothing the nerves, can relax the human body, and can relieve negative moods such as anxiety, depression and the like. In addition, since lavender contains linalyl acetate and linalool, both of them can exert parasympathetic nervous system stimulation effects, and when linalyl acetate and linalool are inhaled into the body, hypothalamus, hippocampus, lymphatic system, olfactory bulb, etc. can exert anesthesia and sedation effects, respectively. The lavender is selected as one of the sachet medicines, and has the effects of tranquilizing, relaxing, hypnotizing and soothing the nerves.

Bamboo leaf core: cool nature, entering heart, lung and stomach meridians, faint scent and penetrating heart, can guide the medicines into heart, clear heart and relieve restlessness, clear summer heat and remove dampness, has the effects of clearing away dysphoria heat in the body, clearing away pathogenic heat of heart (bag), promoting urination and guiding heat downwards, and has good effects on people with dizziness, insomnia and lassitude caused by damp-heat in the body.

Lemon grass: namely citronella has warm nature and lemon fragrance, and can dispel wind, relieve exterior syndrome, remove blood stasis, dredge collaterals, calm the heart and tranquilize the mind. Studies show that the volatile oil (such as venezuelan streptococci and the like) contained in the composition has antifungal effect, citronellic acid has paralytic effect on mice, and has the effect of inhibiting smooth muscle on isolated rabbit intestinal specimens.

Radix Scutellariae Baicalensis: the traditional Chinese medicine composition has the advantages of cold property, slight qi, heart, lung, gall and large intestine channels, purging excessive fire, removing dampness and heat, and modern pharmacological researches show that the composition contains baicalin, can inhibit positive condition reflex of mice, reduce nerve excitability, has obvious effects on shortening sleep latency and prolonging sleep duration, and is compatible with bamboo leaf hearts and lemon grass to serve as ministerial drugs.

Rose: the invention takes the fragrant qi of the rose to sooth liver and promote qi circulation. Flos Rosae Rugosae are commonly used clinically for treating various clinical symptoms caused by liver depression and qi stagnation. The heart system diseases such as sleep disorder and the like are treated by using roses in the teaching of Shandong university of traditional Chinese medicine Liu Chinian, and the clinical effect is remarkable. Modern pharmacological studies show that the rose extract acts on mice to reduce the time of falling asleep of the mice, and the exploring activity and movement of the mice are reduced, which indicates that the rose has central inhibitory activity. The rose has a plurality of volatile oil components, and can be prepared into rose essential oil, rose perfume and the like through industrial extraction.

Albizia flower: neutral nature, slightly fragrant smell, entering heart and spleen meridians. Has effects of regulating heart, stimulating appetite, regulating qi-flowing, tranquilizing mind, and resolving stagnation. Can be used for treating insomnia, dreaminess, dysphoria, depression, hypomnesis, etc. The Shen Ben Cao Jing has the effects of soothing the nerves and resolving depression, i.e. soothing the five viscera and the mind, and is happy and careless. "combined with flos Rosae Rugosae, it can strengthen tranquillization and resolve depression, and can significantly relieve insomnia and vexation.

In the concept of Chinese medicine, the human body is an organic whole, and is structurally indistinct, physiologically interrelated, mutually restricted, pathologically interrelated and mutually damaged, so that the method of regulating the balance of yin and yang of the whole body is necessary during treatment. The invention uses the whole concept of traditional Chinese medicine as the treatment guiding thought, uses the medicine with aromatic channeling property, has Bai Shushe property in the prescription, has faint scent and pleasant taste, and has the effects of tranquilizing, calming and soothing the nerves; the lavender has warm nature and aromatic flavor, the fragrance can relax human body and heart, and relieve negative moods such as anxiety and depression, and researches show that the lavender contains linalyl acetate and linalool, which can play a role in stimulating a parasympathetic nervous system, and when the linalyl acetate and linalool are absorbed into the body, the lower part of thalamus, hippocampus, lymphatic system, olfactory bulb and the like can play a role in paralysis and sedation respectively, and the lavender is the same as cypress She Xiangwu; the bamboo leaf heart enters heart, lung and stomach meridians, has faint scent and is transparent, the heart is cleared and restlessness is relieved, internal deficiency fire is cleared, and heart (pericarp) evil heat is cleared; the lemon grass (namely citronella) has lemon fragrance, calms the heart and calms the mind, and researches show that the volatile oil (such as venezuelan streptococci and the like) contained in the lemon grass has antifungal effect, the citronella has paralytic effect on mice, and the citronella has the effect of inhibiting smooth muscle on an isolated rabbit intestine specimen; the radix scutellariae enters heart, lung, gall and large intestine channels, has slight qi, purges excessive fire, removes damp heat, and modern pharmacological researches show that the radix scutellariae containing baicalin can inhibit positive condition reflex of mice, reduce nerve excitability, has obvious effects on shortening sleep latency and prolonging sleep duration, and is compatible with the bamboo leaf heart and the lemon grass to be ministerial drugs; the rose flower is warm in nature, enters liver and spleen channels, has rich qi and aromatic, and can relieve emotion, soothe liver, reduce internal heat, regulate qi to alleviate depression, regulate endocrine and achieve the effect of improving insomnia; the flos albiziae is sweet in taste and flat in nature, enters heart and spleen channels, has the effects of harmonizing heart mind, stimulating appetite, regulating qi, soothing nerves and resolving depression, is applied to treating insomnia and dreaminess, dysphoria with deficiency, mood depression, hypomnesis and the like, is combined with the flos rosae rugosae to serve as an adjuvant, can strengthen the effect of soothing nerves, and can remarkably relieve the expression of insomnia and dysphoria. The whole formula is fastened to the traditional Chinese medicine for treating insomnia, and the heart-fire exuberance, liver depression transforming into fire and phlegm-heat internal disturbance cause the mind to be restless, or the heart-spleen deficiency, heart deficiency timidity, yin deficiency fire exuberance cause the pathogenesis of heart-mind malnutrition and the like, and the whole formula is used as a treatment guiding thought, and aromatic medicaments with the effects of sedation, depression relief, heart nourishing, tranquillization and the like are selected to be made into sachets, when the aromatic medicaments continuously emit aroma, the volatile aromatic active ingredients slowly aggregate in the pillow Zhou Che, and are absorbed by a patient through local skin mucous membrane, oral cavity, nasal cavity or pharyngeal mucous membrane, and the volatile active ingredients in the air can act on olfactory nerves of the patient, so that the effects of happiness, tranquillization, pressure relief, ventilation and aroma smelling of the patient are achieved, and the sleeping quality and the life quality of the patient are improved.

On the basis of the compound, aiming at main causes of insomnia groups of different ages, other raw material components are respectively added for targeted treatment. The middle-aged traditional Chinese medicine mind-regulating sleep-aiding sachet is used for middle-aged people with insomnia caused by heart fire exuberance, liver depression transforming into fire and phlegm heat internal disturbance, and further comprises the following raw materials in parts by weight: 12-25 parts of gentian, 12-25 parts of gardenia, 10-20 parts of exocarpium citri rubrum and 9-15 parts of coptis chinensis, so as to achieve the effects of purging pathogenic fire, relieving restlessness, dredging collaterals, resolving stagnation, clearing heart fire, tranquillizing, tranquilizing and hypnotizing.

Gentian root: cold in nature, entering liver and gallbladder meridians can clear heat and dry dampness, purge liver and arrest convulsion. The herbal preparation has the heat-clearing effect that gentian, which is the positive herb of foot jueyin and shaoyang, can purge fire greatly, but with assistance, all kinds of fire are treated. It is indicated for excessive fire in liver and kidney. The 'Bie Lu' describes the efficacy of clearing heat and arresting convulsion, namely 'removing heat in stomach, warming qi at the time, purging heat and promoting diuresis, removing intestinal parasites, tonifying liver and gall qi and arresting convulsion'. Modern pharmacological researches show that the compound contains the gentian with central inhibition effect, can reduce spontaneous activities and directional reflexes of mice, and prolongs sleeping time of pentobarbital sodium and chloral hydrate; swertiamarin has effects of inhibiting central nervous system, and relieving pain and tranquilizing. The gentian is selected as one of the sachet medicines, has the effects of clearing heat, arresting convulsion, tranquilizing, allaying excitement and helping sleep, and is especially suitable for young patients suffering from insomnia caused by exuberant liver fire and stomach heat.

Gardenia jasminoides ellis: cold nature, slight qi, entering heart, lung and triple energizer channels, and has the effects of protecting liver, promoting bile flow, tranquilizing mind, etc. The Ming Yi Bie Ji (miscellaneous records of famous physicians) records that the efficacy of purging fire and relieving restlessness is that the recipe is 'cold and nontoxic'. Is mainly used for treating conjunctival congestion and pain, chest heat, large intestine heat, heart vexation, and stomach heat. The Chinese medicine "like" cloud. Pestle is used finely. Zhi Zi is used for restlessness and chest pain. The invention takes the effects of reducing pathogenic fire and relieving restlessness and is used for treating young patients with dysphoria and insomnia.

Orange: warm nature, entering lung and spleen meridians, fragrant smell, refreshing, medicinal efficacy and spirit, and can dry dampness, promote qi and resolve phlegm. The medicine definition records the efficacy of resolving masses and promoting qi circulation: exocarpium Citri rubrum, pungent in nature can move transversely to dissipate nodulation and bitter in nature can move straight down, so it is the essential herb for promoting qi. "Chinese medicine dictionary" as: "Huazhou orange with pungent, bitter and warm nature and functions of resolving phlegm, regulating qi-flowing, strengthening spleen, promoting digestion, and treating chest phlegm stagnation, cough and asthma, vomiting and hiccup, and food stagnation. The invention takes the effects of drying dampness and regulating qi, and is used for treating patients with chest distress and qi stagnation insomnia.

Coptis root: cold nature, slight qi, entering heart, spleen, stomach, liver, gallbladder and large intestine meridians, it can clear heat and dry dampness, purge fire and detoxify, and is used for treating damp-heat distention and fullness, high fever and unconsciousness, excessive heart fire, vexation and insomnia. The book of channels dredging symptoms records the efficacy of relieving restlessness and tranquillizing: the patients with restlessness in heart can not lie down, which is yin deficiency, yin deficiency can not purge fire, yang excess can be purged from the heart for more than two or three days, and yin deficiency is also essential for the patients, therefore, donkey-hide gelatin, peony and egg are yellow, no non-yin-saving product is available, but only Qin Lian is used for purging fire, and Qin Zhi Yi Lian is used for stopping one by one, and Qin Zhi Lian is used for stopping four by one, so that any one of the coptis is the only one, and no one side is known to be enough.

Aiming at the senile traditional Chinese medicine mind-regulating sleep-aiding sachet used by the elderly with insomnia caused by heart-spleen deficiency, heart deficiency timidity and yin deficiency fire excess, the senile traditional Chinese medicine mind-regulating sleep-aiding sachet comprises the following raw materials in parts by weight: 12-25 parts of cinnamon, 12-25 parts of rhizoma anemarrhenae, 10-20 parts of radix codonopsis and 9-15 parts of radix astragali preparata, so as to achieve the effects of tonifying heart and spleen, tonifying qi and nourishing blood, transporting heart and kidney, soothing nerves, stabilizing mind and hypnotizing.

Cinnamon: big heat, strong smell, tonifying fire and yang, inducing fire to enter source, dispelling cold and relieving pain, warming meridians and activating collaterals. Modern pharmacological researches show that cinnamaldehyde contained in cinnamon has obvious sedative effect on mice, is characterized by reduced spontaneous activity, has sedative effect on excessive activity generated by methamphetamine, movement disorder generated by a stick rotating test, prolonged anesthesia time of sodium cyclohexabarbiturate and the like, and can relieve dyspepsia and flatulence by matching cinnamon essential oil, and is especially suitable for old patients suffering from insomnia caused by chronic diseases, weak qi and blood, aversion to cold, cold limbs and spleen yang deficiency.

Rhizoma anemarrhenae: cold in nature, entering lung, stomach and kidney meridians can clear heat and purge fire, promote fluid production and moisten dryness, cool heart and remove heat. "drug theory" cloud: rhizoma anemarrhenae is mainly used for treating dysphoria, bone heat overstrain, straw mat overstrain, kidney qi overstrain, aversion to cold and deficiency, and dry mouth due to deficiency of patients after production. The invention takes the middle fire purging and is good at clearing and moistening, and is used for the elderly patients with insomnia caused by yin deficiency and fire excess, bone steaming and hectic fever, night sweat, vexation and the like.

Radix codonopsis pilosulae: the Chinese medicinal composition has the effects of relieving nature, entering spleen and lung channels, having special fragrance, tonifying middle-jiao and Qi, strengthening spleen and benefiting lung, and can be used for treating spleen and lung weakness, short breath, palpitation, loose stool, dyspnea due to deficiency, cough due to deficiency, internal heat, diabetes and the like. The "Bencao from New" states: "tonify middle-jiao and Qi, harmonize spleen and stomach, relieve polydipsia". Weak middle-jiao qi, which is used for regulating and tonifying, is very mild. Modern pharmacological studies show that the injection, aqueous extract and methanol extract of dangshen can obviously reduce the autonomous activity of mice by intraperitoneal injection. The intraperitoneal injection of the radix codonopsis injection can obviously prolong the anesthesia time of diethyl ether to mice, increase the number of sleeping mice caused by the sub-threshold hypnotic dose of the sodium isopentobarbital and prolong the sleeping time of the mice caused by the sodium isopentobarbital. The codonopsis pilosula saponin can also obviously prolong the sleeping time of mice caused by the cyclohexabarbital. The intraperitoneal injection of the dangshen injection can obviously prolong the incubation period of the mice with convulsion caused by the strychnine nitrate and the pentylterrain. The invention takes the effects of sedation, hypnosis, anticonvulsant and the like.

Radix astragali Preparata: the Chinese medicinal composition has the effects of slightly warming the sex, slightly activating qi-flowing, entering lung, spleen, liver and kidney channels, tonifying qi, strengthening the middle-jiao, inducing diuresis and relieving edema, and is used for treating qi deficiency and hypodynamia, sinking of middle-jiao, spontaneous perspiration due to exterior deficiency, sallow blood deficiency, internal heat and diabetes and the like. The invention takes the effects of tonifying qi and strengthening middle-jiao, and is used for the elderly patients suffering from lack of movement, qi deficiency and weakness and insomnia accompanied by fatigue and hypodynamia.

The invention also provides a traditional Chinese medicine mind-regulating sachet, which is prepared from medicinal powder prepared from the traditional Chinese medicine mind-regulating composition, and can be worn with a person, placed at a bedside or at a body side during sleeping or at rest, and pleasant fragrance continuously acts on a body to achieve the effects of dredging collaterals, resolving depression, nourishing heart, soothing nerves, calming and hypnotizing and the like. The aromatherapy is characterized in that the whole concept of the traditional Chinese medicine is taken as a treatment guiding idea, the plant compatibility formula with aromatic smell is used for preparing the sachet, the medicine property of the fragrance channeling is taken, and the functions of internal menstruation and viscera can be regulated through channels and collaterals, so that the effects of balancing qi and blood, yin and yang, calming and hypnotizing are achieved; on the other hand, when volatile aromatic substances in the aromatic medicine directly act on local skin mucous membrane or are inhaled by a patient through nasal cavities, the active ingredients volatilized into the air can stimulate olfactory nerves of the patient, so that the patient is happy in mood, calm and calm, relieve pressure, improve sleeping quality of the patient, and further improve working and life quality. The traditional Chinese medicine mind-regulating sachet has aromatic smell which is easy to be accepted by patients, has obvious effects of regulating spirit and helping sleep, is quite simple in manufacturing method and is quite convenient to use.

The invention further provides a preparation method of the traditional Chinese medicine refreshing sachet, which comprises the steps of weighing raw material components according to the formula, removing impurities, drying, grinding into coarse powder, uniformly mixing, filling into a medicinal powder bag, then placing into a sachet, and tightening a bag opening.

Preferably, the weight of the traditional Chinese medicine powder in each sachet is 35-50 g.

Preferably, the drying temperature is controlled between 50 and 60 ℃.

Preferably, the powder bag is made of non-woven fabric.

Preferably, the sachet is made of cotton cloth, and preferably a green sachet is used.

The beneficial effects are that:

the traditional Chinese medicine considers that insomnia, namely sleep disorder, belongs to insomnia in traditional Chinese medicine, namely insomnia, sleeping failure, eye failure, and the like, relates to a plurality of systems such as nerves, endocrine, immunity and the like, is closely related to psychological, social, environmental and other aspects, and is tired due to excessive anxiety, and heart and spleen are damaged; the yang is not crossed with yin, and the heart and kidney are not crossed with each other; hyperactivity of fire due to yin deficiency and upward disturbance of liver yang; heart deficiency timidity, mental confusion; or stomach qi disharmony, night restlessness and other etiology and pathogenesis, the traditional Chinese medicine treatment takes heart nourishing, depression relieving and nerve soothing as the treatment principle. The traditional Chinese medicine mind-regulating sachet for assisting sleep based on the aromatherapy is prepared by adopting a specific formula, and has remarkable clinical effects of nourishing heart, resolving depression and soothing nerves by matching cypress leaves, lavender, bamboo leaf cores, lemon grass, radix scutellariae, roses and flos albiziae; and for middle-aged people with insomnia caused by heart fire exuberance, liver depression transforming into fire, phlegm heat internal disturbance, radix Gentianae, fructus Gardeniae, exocarpium Citri rubrum and Coptidis rhizoma are added to achieve effects of purging pathogenic fire, relieving restlessness, dredging collaterals, resolving stagnation, clearing heart fire, tranquilizing mind, and hypnotizing; for the elderly with insomnia caused by heart-spleen deficiency, heart deficiency timidity, and heart-mind malnutrition due to yin deficiency and fire excess, cortex Cinnamomi, rhizoma anemarrhenae, radix Codonopsis and radix astragali Preparata can be added to achieve effects of invigorating heart and spleen, invigorating qi and nourishing blood, transporting heart and kidney, tranquilizing mind and hypnotizing. The traditional Chinese medicine compound sachet is scientific in proportion, can coordinate and promote each component to play a role of synergy, is aromatic and pleasant, is easy to accept by patients, is simple to manufacture and convenient to use, has definite efficacy, does not find adverse reaction, is safe to use, and can promote standardized traditional Chinese medicine compound sachet to assist in treating insomnia. The traditional Chinese medicine composition is absorbed by human body through the modes of air transmission of volatile components, continuous passing through oral cavity, nasal cavity, pharyngeal cavity mucous membrane or skin mucous membrane and the like, and plays a role.

Detailed Description

The invention will be better understood from the following examples.

Example 1:

a traditional Chinese medicine refreshing sachet for assisting sleep based on aromatherapy comprises the following components in parts by weight: bai Shushe 25g, 23g of lavender, 18g of bamboo leaf core, 18g of lemon grass, 10g of baical skullcap root, 15g of rose and 15g of silktree albizia flower.

The preparation method comprises the following steps:

the preparation method comprises removing impurities from folium Platycladi, lavender, herba Lophatheri, herba Cymbopogonis Citrari, scutellariae radix, flos Rosae Rugosae, and flos Albiziae, drying at 55deg.C, pulverizing into coarse powder, mixing, packaging into nonwoven medicinal powder bag, and packaging into cotton cloth sachet to obtain common type. The health care tea is used for helping sleep and tranquillizing young people, can be placed at a bed head during sleeping or placed at a body side during resting, has pleasant fragrance continuously acting on a body, and can generally achieve the effects of purging pathogenic fire and relieving restlessness, dredging collaterals and resolving stagnation, clearing heart fire and tranquillizing, and hypnotizing.

Example 2:

a traditional Chinese medicine refreshing sachet for assisting sleep based on aromatherapy comprises the following components in parts by weight: bai Shushe 25g, 23g of lavender, 18g of bamboo leaf core, 18g of lemon grass, 10g of baical skullcap root, 15g of rose, 15g of silktree albizia flower, 13g of gentian, 13g of gardenia, 13g of exocarpium citri rubrum and 13g of coptis chinensis.

The preparation method comprises the following steps:

the preparation method comprises removing impurities from folium Platycladi, lavender, herba Lophatheri, herba Cymbopogonis Citrari, scutellariae radix, flos Rosae Rugosae, flos Albiziae, radix Gentianae, fructus Gardeniae, exocarpium Citri rubrum, and Coptidis rhizoma, drying at 55deg.C, pulverizing into coarse powder, mixing, packaging into nonwoven medicinal powder bag, and placing into cotton cloth sachet to obtain middle-aged capsule. The health care tea is used for helping sleep and tranquillizing the middle-aged, can be placed at the head of a bed or at the body when sleeping, has pleasant fragrance continuously acting on the body, and can generally achieve the effects of purging pathogenic fire, relieving restlessness, dredging collaterals, resolving stagnation, clearing heart fire, tranquillizing and hypnotizing.

Example 3:

a traditional Chinese medicine refreshing sachet for assisting sleep based on aromatherapy comprises the following components in parts by weight: bai Shushe 25g, 23g of lavender, 18g of bamboo leaf core, 18g of lemon grass, 10g of baical skullcap root, 15g of rose, 15g of silktree albizia flower, 13g of cinnamon, 13g of rhizoma anemarrhenae, 13g of pilose asiabell root and 13g of radix astragali Preparata.

The preparation method comprises the following steps:

removing impurities from folium Platycladi, lavender, herba Lophatheri, herba Cymbopogonis Citrari, scutellariae radix, flos Rosae Rugosae, flos Albiziae, cortex Cinnamomi, rhizoma anemarrhenae, radix Codonopsis, and radix astragali Preparata, drying at 55deg.C, pulverizing into coarse powder, mixing, packaging into nonwoven medicinal powder bag, and packaging into cotton cloth sachet to obtain senile type capsule. The health care pillow is used for helping sleep and tranquillizing the elderly, can be placed at a bed head during sleeping or placed at a body side during resting, has pleasant fragrance continuously acting on a body, and can generally achieve the effects of tonifying heart and spleen, tonifying qi and nourishing blood, transporting heart and kidney, tranquillizing and hypnotizing.

1. Clinical data

1.1 case Source

Cases are from insomnia patients in acupuncture rehabilitation department, massage department and neurology department of Jiangsu province 5 month 2020 to 2021, and the patients are randomly classified into a control group (normal type) and an aromatic group (normal type), a control group (middle-aged type) and an aromatic group (middle-aged type), a control group (senile type) and an aromatic group (senile type) according to the serial numbers of the patients in the group entering sequence, and 15 cases of each group are used.

1.2 inclusion criteria

(1) Meets the standards of traditional Chinese medicine diagnosis and Western medicine diagnosis;

(2) The sex is unlimited, the age is 19-35, the age is 36-59, the age is middle-aged, and the age is above 60 years old;

(3) No other similar clinical researchers were enrolled;

(4) Signing an informed consent form, and voluntarily participating in the study;

(5) Pittsburgh Sleep Quality Index (PSQI) scale score >7;

(6) No hypnotic, sedative or analgesic drugs are taken, or the drugs are taken but stopped for more than 2 weeks.

1.3 exclusion criteria

Any one of the following conditions is excluded:

(1) Pregnant women, lactating women and gestational planners;

(2) Allergic to the aromatic drug tested;

(3) Patients with primary diseases such as other serious circulatory system, hematopoietic system, digestive system, endocrine system, etc., psychosis and malignant tumor;

(4) All systemic diseases such as pain, fever, cough, operation, etc. caused by external environmental interference factors.

1.4 termination test criteria

(1) The patient with serious adverse events stops the clinical trial of the case according to the judgment of doctors;

(2) The subject is reluctant to continue the clinical trial during the course of the clinical trial and presents the physician with a request to withdraw from the clinical trial.

1.5 drop and reject criteria

(1) Non-compliance with inclusion criteria or discovery of non-compliance after inclusion;

(2) Poor compliance, failure to follow the treatment regimen;

(3) Those who have a change in condition or are unable to continue treatment for some reason;

(4) The relevant test information of the patient is lost.

1.6 diagnostic criteria for insomnia

Diagnostic criteria for traditional Chinese medicine: referring to the diagnosis standard of ' insomnia ' in the traditional Chinese medicine department disease diagnosis curative effect standard of the Chinese medical industry standard of the people's republic of China in 2016, the following is defined: a. difficulty in falling asleep or sleeping and easy to wake, insomnia after waking, and difficulty in sleeping for the serious people at night; b. often accompanied by headache, dizziness, palpitation, amnesia, dreaminess, etc.; c. no abnormalities were found by inspection with each system and laboratory.

Western diagnostic criteria: referring to the diagnosis standard of insomnia in China Insomnia diagnosis and treatment guide, compiled by the China sleep study, 2017, the following is defined: a. has one or more of the following symptoms: difficulty falling asleep; not deeply sleeping; is easy to wake up; the sleeping is not easy to fall after waking up; conditions such as discomfort after waking, fatigue or daytime sleepiness; b. there is a serious stress or impairment in social, home, academic, behavioral, educational, or other important physical functions; c. the symptoms occur 3 times per week and last for more than 1 month; d. and the secondary insomnia caused by somatic diseases is eliminated.

1.7 grouping method

For insomnia patients in acupuncture rehabilitation, massage and neurology clinics in Jiangsu province between 5 months 2020 and 2021, cases meeting the standard are screened, the patients are randomly divided into a control group (common type) and an aromatic group (common type), the control group (middle-aged type) and the aromatic group (middle-aged type), the control group (senile type) and the aromatic group (senile type) by using a random number table according to the serial numbers of the patients in the group, and 15 cases of each group are obtained.

1.8 general data

See table 1, two groups of tested patients using the common traditional Chinese medicine mind-regulating sachet have 30 cases, wherein 13 cases of men and 17 cases of women have no obvious difference in gender and have comparability as shown by the chi-square test, and p=0.713 > 0.05. 30 patients in the middle-aged traditional Chinese medicine mind-regulating sachet are tested, wherein 14 men and 16 women are tested by chi-square, and P=0.464 >0.05, which shows that the two groups have no obvious difference in gender and are comparable; 30 patients in total using the senile traditional Chinese medicine mind-regulating sachet, wherein 17 men and 13 women, tested by chi-square, have no obvious difference in gender and are comparable.

Table 1 comparison of gender among groups

2. Method of

2.1 methods of treatment

The semen Vaccariae seed ear pressure therapy is used as basic treatment for insomnia patients (main acupoint: shenmen, heart, subcortical, pillow, sympathology and endocrine; and according to syndrome differentiation, acupoint selection: liver depression transforming into fire, liver, phlegm heat internal disturbance, stomach, yin deficiency fire hyperactivity, spleen with heart and spleen deficiency, gallbladder with heart and gallbladder qi deficiency, liver) for all the control groups and aromatic groups.

The method for treating the patients with the aromatic group by using basic treatment is characterized in that a common traditional Chinese medicine refreshing sachet, a middle-aged traditional Chinese medicine refreshing sachet or an old traditional Chinese medicine refreshing sachet are respectively added at the same time of using basic treatment, and the operation methods are as follows: ten minutes before falling asleep, the user needs to adjust himself to be in a state of being ready for sleeping, sit on the bed, find a comfortable sitting posture, but sit straight, close eyes, breathe deeply, relax, and so on for 3 rounds. Then the mouth of the sachet is opened and placed in front of the nose, the fragrance is deeply inhaled, then the mouth is opened and exhaled, the process is repeated for 5-8 times, then the mouth of the sachet is slightly tightened and placed at the side of the pillow to fall asleep, after the next day of awakening, the mouth of the sachet is tightened, and then the sachet is placed in a transparent plastic sealing bag, the mouth is sealed, and the sachet is placed in a shady place to prevent the volatilization of active ingredients. (in the pre-test, the sachets are found to be operated according to the use method, each sachet can be used for 2-3 weeks, so that in order to ensure the curative effect of the sachets, the sachets are replaced 1 time after 2 weeks of treatment, and 2 sachets are obtained for the whole treatment course of patients).

The treatment course of the six groups of patients is 4 weeks. The notes are as follows:

(1) The patient is instructed to press each auricular point as required for half an hour before sleeping each night, and to press each auricular point as required for 5 times each day.

(2) If the acupoints of ear pressure are loosened too much, the patient should be replaced in time for various reasons and the replacement time is not reached yet.

(3) Spraying anything on the sachet is forbidden so as not to influence the drug effect.

(4) The sachet is sealed and placed in a cool place in the daytime to prevent the volatilization of the active ingredients.

(5) During the study period, coffee and strong tea were not consumed as much as possible, and no vigorous exercise and no stay up were performed before sleep.

(6) If the sachet is lost in use or fails for other reasons, the sachet should be timely given to the patient.

(7) The patient is instructed to use the sachet as required every night.

2.2 observation time points and observation indices

For each patient tested, the "sleep duration" was determined on the day of group entry and after 4 weeks of treatment using a unified smart bracelet; filling a 'sleep quality' scale (each item 0-3 scores: well score 0, well score 1, poor score 2, poor score 3) in the Pittsburgh Sleep Quality Index (PSQI) on the day of group entry and after 4 weeks of treatment; subjects assessed the overall impression (healed, significant effect, slightly effective, ineffective) for a 4 week course of treatment after 4 weeks of treatment.

Adverse reactions and adverse events were recorded in subjects over time throughout the study.

2.3 statistical methods

All the data are input, classified and stored. All data were statistically analyzed using Excel and SPSS25.0 statistical software. The counting data are described by using the number and percentage of cases, the comparison between groups is performed by using chi-square test, and the grading data are performed by using Wilcoxon rank sum test. If the measurement data accords with normal distribution, t test (variance alignment test is carried out between groups, 0.05 is used as a test level, and the t test corrected by a Satterthwaite method is selected when the variances are uneven), covariance analysis is adopted for other data, and the like. Assuming that the test uniformly uses a double-sided test, test statistics and corresponding P values are given, with P <0.05 as statistically significant and P <0.01 as highly statistically significant.

3 results

3.1 comparison of sleep time period for groups after 4 weeks of aromatherapy treatment

Table 2 comparison of sleep duration

Note that: * P <0.05, < P <0.01

As shown in table 2, after the aromatherapy treatment for 4 weeks, the sleep time of the control group (normal type) is 6.05 (95% ci: 5.82-6.27), the sleep time of the aromatic group (normal type) is 6.44 (95% ci: 6.22-6.67), and the two groups have significant difference (p=0.016), which indicates that the traditional Chinese medicine refreshing sachet (normal type) can increase the sleep time of young insomnia patients;

after 4 weeks of aromatherapy treatment, the sleep duration of the control group (middle-aged type) is 5.74 (95% CI: 5.56-5.91), the sleep duration of the aromatic group (middle-aged type) is 6.10 (95% CI: 5.92-6.27), and the two groups have obvious difference (P=0.006), which indicates that the traditional Chinese medicine refreshing sachet (middle-aged type) can increase the sleep duration of middle-aged insomnia patients.

After treatment with aromatherapy for 4 weeks, the control group (senile type) had a sleep duration of 4.37 (95% CI: 4.31-4.64), the aromatic group (senile type) had a sleep duration of 4.86 (95% CI: 4.59-4.91), and the two groups had a significant difference (P=0.025), indicating that the traditional Chinese medicine refreshing sachet (senile type) of the invention can increase the sleep duration of senile insomnia patients.

3.2 comparison of sleep quality for groups after 4 weeks of aromatherapy treatment

Table 3 sleep quality score comparison

Note that: * P <0.05, < P <0.01

As shown in table 3, after 4 weeks of aromatherapy treatment, the sleep quality score of the control group (normal type) was 2.27 (95% CI: 1.77-2.63), the sleep quality score of the aromatic group (normal type) was 1.40 (95% CI: 1.04-1.89), and there was a significant difference between the two groups (p=0.02), indicating that the traditional Chinese medicine mind-regulating sachet (normal type) of the present invention can improve the sleep quality of young insomnia patients;

after 4 weeks of aromatherapy treatment, the sleep quality score of the control group (middle-aged type) is 2.07 (95% CI: 1.69-2.43), the sleep quality score of the aromatic group (middle-aged type) is 1.27 (95% CI: 0.90-1.65), and the two groups have significant differences (P=0.005), which indicates that the traditional Chinese medicine nerve-regulating sachet (middle-aged type) can improve the sleep quality of middle-aged insomnia patients.

After 4 weeks of aromatherapy treatment, the sleep quality score of the control group (senile type) is 2.53 (95% CI: 2.15-2.79), the sleep quality score of the aromatic group (senile type) is 1.93 (95% CI: 1.68-2.32), and the two groups have obvious difference (P=0.048), which indicates that the traditional Chinese medicine refreshing sachet (senile type) can improve the sleep quality of senile insomnia patients.

3.3 comparison of clinical efficacy of groups after 4 weeks of aromatherapy treatment

Table 4 comparison of clinical efficacy

As shown in table 4, after the aromatherapy treatment for 4 weeks, the control group (normal type) has overall evaluation effectiveness of 8 cases (60%, including cure, effect and effectiveness), the overall evaluation has 2 cases (13%, including cure and effect), the aromatic group (normal type) has overall evaluation effectiveness of 13 cases (87%), the overall evaluation has 8 cases (53%), and the two groups have significant difference in cure rate (P < 0.05), which indicates that the traditional Chinese medicine mind-regulating sachet (normal type) has significant curative effect on young insomnia patients;

after the aromatherapy treatment is carried out for 4 weeks, the overall evaluation efficiency of a control group (middle-aged type) is 6 cases (40%), the overall evaluation is more than 1 case (7%), the overall evaluation efficiency of an aromatic group (middle-aged type) is 10 cases (67%), the overall evaluation is more than 8 cases (53%), and the two groups of cure rates have significant differences (P < 0.05), so that the traditional Chinese medicine refreshing sachet (middle-aged type) has significant curative effects on middle-aged insomnia patients;

after the treatment of the aromatherapy for 4 weeks, the overall evaluation efficiency of a control group (senile type) is 8 cases (53%), the overall evaluation is more than 2 cases (13%), the overall evaluation efficiency of an aromatic group (senile type) is 11 cases (73%), the overall evaluation is more than 4 cases (27%), and the overall effective rate and the cure rate both show that the traditional Chinese medicine mind-regulating sachet (senile type) has a certain clinical curative effect on senile insomnia patients.

3.4 adverse events

During the course of the test, none of the 90 subjects had seen any adverse effect.

3.5 conclusion

The invention takes the whole concept of traditional Chinese medicine as the treatment guiding idea, and selects the proper aromatic tranquillizing medicament from yin-yang attribute, nature and taste and channel tropism based on aromatherapy: 15-30 parts of cypress leaves, 15-30 parts of lavender, 12-25 parts of bamboo leaves, 12-25 parts of lemon grass, 10-20 parts of radix scutellariae, 9-15 parts of rose and 9-13 parts of albizia flower. On the basis of the compound, aiming at the main symptoms of insomnia groups of different ages, other raw material components are respectively added for targeted treatment, wherein the traditional Chinese medicine mind-regulating sleep-aiding sachet used by middle-aged people suffering from insomnia caused by heart fire exuberance, liver depression transforming into fire and phlegm heat internal disturbance is also prepared from the following raw materials in parts by weight: 12-25 parts of gentian, 12-25 parts of gardenia, 10-20 parts of exocarpium citri rubrum and 9-15 parts of coptis chinensis. The invention can be placed at the bed head or at the body side when sleeping, and pleasant fragrance continuously acts on the organism, so that the effects of purging pathogenic fire, relieving restlessness, dredging collaterals, resolving stagnation, clearing heart fire, tranquillizing, tranquilizing and hypnotizing can be achieved.

Aiming at the traditional Chinese medicine mind-regulating sleep-aiding sachet used by the elderly with insomnia caused by heart-spleen deficiency, heart deficiency timidity and yin deficiency fire excess, the traditional Chinese medicine mind-regulating sleep-aiding sachet is prepared from the following raw materials in parts by weight: 12-25 parts of cinnamon, 12-25 parts of rhizoma anemarrhenae, 10-20 parts of radix codonopsis pilosulae and 9-15 parts of radix astragali preparata. The invention can be placed at the bed head or at the body side when sleeping, and pleasant fragrance continuously acts on the organism, so that the effects of tonifying heart and spleen, tonifying qi and nourishing blood, transporting heart and kidney, soothing nerves and stabilizing mind and hypnotizing can be achieved.

The invention is based on aromatherapy, uses the plant compatibility formula with aromatic smell to prepare the sachet, takes the drug property of the fragrance, can conduct internal menstrual qi through channels and collaterals, and regulates viscera functions, thereby achieving the effects of balancing qi and blood, yin and yang, calming and hypnotizing; on the other hand, when volatile aromatic substances in the aromatic medicine directly act on local skin mucous membrane or are inhaled by a patient through nasal cavities, the active ingredients volatilized into the air can stimulate olfactory nerves of the patient, so that the patient is happy in mood, calm and calm, relieve pressure, improve sleeping quality of the patient, and further improve working and life quality. The traditional Chinese medicine mind-regulating sachet has the advantages of aromatic smell, easy acceptance by patients, obvious mind-regulating and sleep-aiding effects, no dependence on patients, no side effect, high safety in clinical use, simple preparation method and convenient use.

The invention provides a thought and a method for assisting sleep by using traditional Chinese medicine to regulate spirit and a method for realizing the technical scheme, the method and the way are a plurality of, the above is only a preferred embodiment of the invention, and it should be pointed out that a plurality of improvements and modifications can be made by a person of ordinary skill in the art without departing from the principle of the invention, and the improvements and the modifications are also regarded as the protection scope of the invention. The components not explicitly described in this embodiment can be implemented by using the prior art.

Claims

1. A traditional Chinese medicine composition for regulating spirit based on aromatherapy to assist sleep is characterized by comprising basic components and additional components,

wherein, the basic components consist of the following traditional Chinese medicines in parts by mass:

15-30 parts of cypress leaves, 15-30 parts of lavender, 12-25 parts of bamboo leaves, 12-25 parts of lemon grass, 10-20 parts of radix scutellariae, 9-15 parts of rose and 9-13 parts of albizia flowers;

the additional components are classified into middle-aged type or elderly type:

the Chinese traditional medicine consists of the following traditional Chinese medicines in parts by mass: 12-25 parts of gentian, 12-25 parts of cape jasmine, 10-20 parts of exocarpium citri rubrum and 9-15 parts of coptis chinensis;

the senile type traditional Chinese medicine comprises the following traditional Chinese medicines in parts by weight: 12-25 parts of cinnamon, 12-25 parts of rhizoma anemarrhenae, 10-20 parts of radix codonopsis pilosulae and 9-15 parts of radix astragali preparata.

2. A traditional Chinese medicine mind-regulating sachet, which is characterized by comprising medicinal powder prepared from the traditional Chinese medicine mind-regulating composition of claim 1.

3. The preparation method of the traditional Chinese medicine nerve-regulating sachet according to claim 2, which is characterized in that the raw material components are weighed according to the formula amount, the impurities are removed, the raw material components are dried, then the raw material components are crushed into coarse powder, the coarse powder is uniformly mixed, the coarse powder is filled into a medicinal powder bag, and then the medicinal powder bag is put into a sachet, and the sachet mouth is tightened to obtain the traditional Chinese medicine nerve-regulating sachet.

4. The method for preparing the traditional Chinese medicine nerve-regulating sachet according to claim 3, wherein the weight of the traditional Chinese medicine powder in each sachet is 35-50 g.

5. The method for preparing the traditional Chinese medicine nerve-regulating sachet according to claim 3, wherein the drying temperature is controlled to be 50-60 ℃.

6. The method for preparing the traditional Chinese medicine nerve-regulating sachet according to claim 3, wherein the medicine powder bag is made of non-woven fabric.

7. The method for preparing the traditional Chinese medicine nerve-regulating sachet according to claim 3, wherein the sachet is made of cotton cloth.